Experiencia en el uso de terapia biológica en pacientes con infección por el virus de la inmunodeficiencia humana y psoriasis

Abstract

IntroductionCutaneous pathologies are frequent on VIH patients, it has been described that this group of people has a similar if not higher prevalence of psoriasis, and however, there is little evidence on the usage of biological medication on these patients. The objective of this study is to describe sociodemographic and clinical characteristics of the VIH psoriasis patients that are treated with biological therapy at high complexity hospital. Materials and methodsObservational descriptive cross-sectional study conducted in Bogota, Colombia between 2016 and 2021. The sociodemographic, clinical and treatment characteristics in patients with HIV and psoriasis on biological therapy treated at a reference center. ResultsTwenty-one patients were included, 15 (71.43%) male and 6 (28.57) female, with an average age of 42.66 years old (SD 10.23). They all presented plaque psoriasis. Out of all patients, 52% had comorbidities of metabolic origin. The first-line biological treatment used the most was Ustekinumab (33%), Adalimumab (23.81%) and Etanercept (23.81%) followed by Secukinumab (9.52%), Ixekizumab (4.76%) and Guselkumab (4.76%); 52% didn’t register any infectious event. A statistically significant difference was evidenced on the PASI scores before and after 6 months of treatment (t = 12.05, p < 0.000). Similarly, improvement in CD4 count after first and second-line biologic therapy, regardless of mechanism of action. ConclusionsThis is the first study in our country that describes the usage of biological medication on VIH-Psoriasis patients, revealing the decrease on the PASI and increase on the CD4 count alongside antiretroviral medication.