Pruritus is a common complication among end-stage renal disease patients. It affects approximatevely 40-90% of these patients. Although it highly affects their life quality, it remains underdiagnosed and very poorly cared for. The objective of this work is to describe the frequency of this entity, its risk factors, and its relationship with the quality of life of patients on peritoneal dialysis. This is a cross-sectional survey of 27 end-stage renal disease patients treated with peritoneal dialysis (PD). The pruritus was assessed by the following tests: the global VAS-UP scale and the DLQI (Dermatolgy life quality index). The quality of life was measured by adapted and validated questionnaires (KDQoL-SF36) and according to the Karnovsky index. The descriptive study included 15males and 12 females. the mean age was 45.74 years (21–77 years). Eleven patients were on automated peritoneal dialysis (APD) and 16 patients on continuous ambulatory peritoneal dialysis (CAPD). The mean duration of dialysis was 45.77 ± 25 months. Four patients had retained urine output (> 1000 mL per 24 h). Moderate to extreme pruritus was reported in 29.6% of patients. Average SF-36 scores ranged from 38.8 (limitations due to physical condition) to 61.1 points (life and relationships with others). The mean KDQoL scores ranged from 41.2 (burden of kidney disease) to 65.1 points (symptoms / problems). Karnovsky's average index was 76.3%. The intensity of the pruritus was significantly associated with a decrease in the Karnovsky index (p = 0.03). This study underscores the fairly high prevalence of pruritus in peritoneal dialysis patients.