Abstract
Pruritus in autoimmune and inflammatory dermatoses is a common symptom that can be severe and affect the quality of life of patients. In some diseases, pruritus is related to disorders activity and severity or may occur independent of the disease. Despite the high prevalence, the symptom is still underrated and there are only a few trials investigating the efficacy of drugs for disease-specific pruritus. In this review, the characteristics and possible pathomechanisms of pruritus in various dermatoses like autoimmune bullous diseases, connective tissue diseases as well as autoimmune-associated dermatoses (atopic dermatitis, psoriasis vulgaris) is illustrated. Additionally, studies analyzing the antipruritic treatment are discussed. Summarizing, the prevalence of pruritus in these diseases demonstrates the importance for symptom recognition and the need for an efficient antipruritic therapy.
Highlights
Pruritus in Autoimmune and Inflammatory DermatosesClaudia Zeidler 1, Manuel Pedro Pereira 1, Flavien Huet 2,3, Laurent Misery 2,3, Kerstin Steinbrink 1 and Sonja Ständer 1*
Autoimmune diseases occur due to a deregulated immune response directed to the body own tissues
In this review we provide an overview of the most relevant autoimmune dermatoses focusing on pruritus, including, pathophysiological mechanisms, clinical features and when available anti-pruritic treatment options (Table 1)
Summary
Claudia Zeidler 1, Manuel Pedro Pereira 1, Flavien Huet 2,3, Laurent Misery 2,3, Kerstin Steinbrink 1 and Sonja Ständer 1*. Specialty section: This article was submitted to Autoimmune and Autoinflammatory. Pruritus in autoimmune and inflammatory dermatoses is a common symptom that can be severe and affect the quality of life of patients. Pruritus is related to disorders activity and severity or may occur independent of the disease. The symptom is still underrated and there are only a few trials investigating the efficacy of drugs for disease-specific pruritus. The characteristics and possible pathomechanisms of pruritus in various dermatoses like autoimmune bullous diseases, connective tissue diseases as well as autoimmune-associated dermatoses (atopic dermatitis, psoriasis vulgaris) is illustrated. Studies analyzing the antipruritic treatment are discussed. Summarizing, the prevalence of pruritus in these diseases demonstrates the importance for symptom recognition and the need for an efficient antipruritic therapy
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