Prevalence Of Dry Eye Research Articles

Evaluation of Ocular Surface and Meibomian Glands in Patients With Scleroderma.

To evaluate the prevalence of dry eye and meibomian gland dysfunction in patients with scleroderma. A total of 32 patients with scleroderma (study group) and 31 healthy subjects (control group) were enrolled. Besides routine ophthalmologic evaluation, Schirmer 1 test, tear break-up time, tear osmolarity, ocular surface staining with fluorescein (Oxford score), and Ocular Surface Disease Index (OSDI) score, meibomian gland dysfunction evaluation (foamy tears, telangiectasia of the eyelid, eyelid contour abnormalities, and meibomian plugs), and meibography were performed. Sixty-four eyes of 32 patients with scleroderma and 62 eyes of 31 healthy individuals were evaluated. Mean ages of the study group was 48.34 ± 9.73 years (21-62 years) and of the control group was 45.84 ± 4.42 years (38-54 years) (P = 0.067). Mean duration of systemic sclerosis or scleroderma in study group was 9.78 ± 7.40 years (1-30 years). Mean tear break-up time was shorter in study group than that in the control group (P < 0.0005). No statistical differences were detected for osmolarity, OSDI score, and Schirmer 1 values between groups (P = 0.051, P = 0.053, and P = 0.358, respectively). The prevalence of grade 1 and higher Oxford score was higher in the study group (P < 0.0005). Upper meiboscores of grade 1 and higher were found to be more common in the study group than those in the control group (P = 0.036). The presence of foamy tears and telangiectasia of the eyelids were significantly higher in the study group (P = 0.002 and P = 0.002, respectively). OSDI score was the only significantly correlated data with disease duration (Spearman ρ coefficient = 0.396, P = 0.001). Evaporative type dry eye is more common in patients with scleroderma than the healthy population.

A study of the correlation between smartphone usage and dry eye in medical students at a tertiary care center

Background: CVS and dry eye disease due to computers, in general, is well documented, butspecific literature on smartphone usage leading to these conditions is limited. This study aims toestimate the prevalence of dry eye and determine the effect of duration of use on the CVSsymptoms in college-going smartphone users. Aims: (1) To find a correlation between smartphoneusage and dry eye(2)To find the prevalence of dry eye disease in the smartphone using collegestudents (3)To study whether the duration and pattern of smartphone usage has a bearing on theseverity of CVS symptoms. Materials and Methods: 394 medical students using smartphones forover a year and without pre-existing dry eye disease or ocular surface pathology were included. Tearfilm parameters were estimated. The duration of use and smartphone settings were correlated withthe prevalence of dry eye and computer vision syndrome symptoms. Results: The prevalence of dryeye was 20.81%. The average DED score was 1.56±0.234, and 1.35±0.248 respectively in the DEDand non-DED group with a p-value of 0.0001. The most common CVS symptoms were fatigue (54%in DED,44% in non-DED) and heaviness in both groups (60.9% in DED, 45% in non-DED group.).Conclusions: There was a statistically significant increase in the DED symptom score and theprevalence of CVS symptoms with increasing duration of use and daily exposure to smartphones.

PREVALENCE OF DRY EYE IN PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN: A HOSPITAL BASED COMPARATIVE STUDY.

Objectives: This present study was to evaluate the prevalence and severity of dry eye with respect to age in premenopausal and postmenopausal women.&#x0D; Methods: Visual acuity was assessed on Snellen’s chart and anterior segment evaluation was done with slit lamp biomicroscope. Ocular surface Disease Index (OSDI) questionnaire was completed and grading done. Dry eye evaluation was done with Schirmer I, by placing a special filter paper in the lower fornix and Tear film Break-Up time was done by an impregnated fluorescein strip moistened with saline which was instilled into the lower fornix.&#x0D; Results: 64(32%), 42(21%) and 35(17.5%) women were belonged in age group of 61-70 years, &gt; 7o years and 51-60 years respectively. dry eye was seen in 6(6%) premenopausal and 47(47%) in postmenopausal women. Higher prevalence of dry eye 29(45.31%) was seen in age 61-70 years. 11(26.19%) prevalence was seen in age &gt; 70 years. Premenopausal women had mainly 6(100%) mild dry eye. 22(46.81%) Postmenopausal women had 22(46.81%), 14(29.79%) and 11(23.40%) mild, moderate and severe grade of dry eye respectively.&#x0D; Conclusions: Dry eye was commonly seen in older age postmenopausal women. Premenopausal women had mainly mild dry eye. Postmenopausal women had commonly mild to moderate grade of dry eye. Hence, early detection of dry eye is important to arrest the progression of dry eye as well as to prevent the complications that can reduce corneal transparency and reduce vision. Environmental and behavioural modifications such as taking breaks while reading, keeping the computer monitors at eye level, use of UV protective glasses and humidification of the environment can be tried.&#x0D; Keywords: Dry eye, premenopausal, postmenopausal, age group

Evaluation of tear film in cases of rheumatoid arthritis

To evaluate the tear film and calculate the prevalence of dry eye in Rheumatoid Arthritis patients based on disease activity. A cross-sectional study of 50 Rheumatoid Arthritis patients was performed in the Department of Ophthalmology, Smt. Kashibai Navale Medical College and Hospital, Pune. C-Reactive Protein (CRP), and Rheumatoid Factor (RF) labs were done. All patients underwent complete ophthalmic evaluation including assessment of visual acuity. Tear film assessment was done by calculating the Tear Meniscus Height (TMH) on Anterior Segment-Optical Coherence Tomography (AS-OCT). Fifty patients were studied. 44 were females and 6 were males with a mean age of 47.34 ± 10.33years. TMH was abnormal (≤300 microns) in 31 (62%) patients. RF was positive in 31 (62%) patients while CRP was raised (&amp;#62;3.0mg/L) in 30 (60%) patients. RF Positivity had a significant correlation with abnormal TMH values (ꭓ² = 5.15, p=.02). Raised CRP was not significantly associated with abnormal TMH values (ꭓ² = 0.39, p=.54).Conclusion: Dry eye evaluation should be considered in RA patients irrespective of the disease activity.

Prevalence and Risk Factors of Severe Dry Eye in Bangladesh-Based Factory Garment Workers.

This study sought to evaluate the prevalence of dry eye and meibomian gland dysfunction (MGD) and the associated factors of severe dry eye symptoms (SDES) among garments worker of Gazipur, Bangladesh. We prospectively collected cross-sectional data for 1050 garments workers of a factory (70% response). All participants had an evaluation of the Ocular Surface Disease Index (OSDI), and a detailed ophthalmic examination including tear breakup time (TBUT), ocular surface fluorescein staining, and Schirmer’s I test. MGD grading was based on the viscosity/color and ease of manual expression of meibum. Mean age of participants was 35.5 ± 12.1 years; 53.8% were women. The prevalence of dry eye (OSDI > 12) was 64.2% (95% CI 61.2–67.1%). OSDI was not significantly different between sex or age-groups but associated with increasing MGD grade (p < 0.001), reduced TBUT (<5 s) [p < 0.001], and reduced Schirmer’s test (<5 mm) [p < 0.001]. Thirty-five percent had SDES (OSDI > 32). Using univariate logistic regressions, SDES was associated with older age (Odds Ratio (OR) 1.01, 95% Confidence Interval [1.005–1.03] per year increase) and male sex (OR 1.76, 95% CI: 1.36–2.27). When adjusted for age and sex, SDES were strongly associated with increase in MGD severity grading (OR 188, 95% CI: 91–390). However, in multivariate regression, TBUT, but not MGD severity, became the only significant determinant of SDES (OR 13.0, 95% CI: 6.3–27.0, for every 1 s decrease in TBUT). MGD is common in garments workers, contributing to dry eye symptoms in addition to other tear parameters. Reduced tear stability is associated with SDES.

Dry eyes in patients with pseudoexfoliation –A descriptive study

Introduction: Pseudoexfoliation syndrome is seen commonly above 60 years of age. It can lead to various complications such as poor dilatation of pupil, increased IOP and intraoperative complications such as zonular dehiscence or capsular rupture, vitreous loss and subluxation of intraocular lens. Pseudoexfoliative glaucoma is one of the common types of secondary open angle glaucoma. Pseudoexfoliation syndrome can also cause ocular surface disorders due to tear film instability. Hence this study was done to assess the prevalence of dry eyes in patients with pseudoexfoliation. Materials and Methods: This was a descriptive study which involved 150 eyes with pseudoexfoliation syndrome. Tear secretion assessment was done using Schirmer’s test I. Then the tear film stability was evaluated using Tear break-up time(TBUT). Ocular surface damage was assessed using Fluorescein staining and Lissamine green staining. Result: Schirmer’s test I, 144 eyes out of 150 eyes had Schirmer’s test value more than 15 mm (96%) . 4 eyes (2.6%) had value between 10-15 mm .2 eyes (1.4%) had value between 5-10 mm.Six eyes with dry eye syndrome were identified by Schirmer’s test I. Tear breakup time was decreased in 3 eyes (between 7-9 seconds). Three eyes with dry eye syndrome were identified by TBUT test. Fluorescein staining was positive in one eye. Lissamine staining was positive in 2 eyes with score of 2 and 3. In this study of pseudoexfoliation patients, there were 9 eyes(6%) with dry eye syndrome. Conclusion: Early recognition of dry eye syndrome in patients with pseudoexfoliation syndrome can reduce ocular morbidity and prevent a significant compromise in their quality of life. Keywords: Pseudoexfoliation, Dry eye syndrome.

Prevalence of symptomatic dry eye in breast cancer patients undergoing systemic adjuvant treatment: A cross-sectional study

ObjectivesTo investigate the prevalence of symptomatic dry eye (SDE) on women undergoing systemic adjuvant therapy for breast cancer and its association with treatment settings. MethodsWoman undergoing breast cancer systemic adjuvant therapy were included in exposure group. An age-matched non-treatment control group was recruited. This cross-sectional questionnaire-based study utilised validated Ocular Surface Disease Index (OSDI) and NCCN-FACT-Breast Cancer Symptom Index (NFBSI-16) questionnaires to determine the presence of SDE and investigate other breast cancer treatment complications. Additionally, demographic data and medical histories were collected. ResultsOf 423 eligible participants, 200 in each of the control group and the exposure group were included in the final analysis. The prevalence of SDE was 59.0% in breast cancer patients with adjuvant treatment, statistically significantly higher than 25.5% in the control group (P < 0.01). Additionally, exposure group experienced higher prevalence of moderate and severe SDE, which were 20.0% and 19.5% respectively compared with 9.0% and 4.0% in the control group (P = 0.002, P < 0.001). There was a significantly high prevalence of SDE among patients who had received over four cycles of systemic therapy (71.0%, P < 0.001) and the application of targeted therapy (71.2%, P = 0.014). The severity of SDE positively correlated with the cycles of treatment administered. ConclusionSDE was significantly predominant in women with breast cancer undergoing systemic adjuvant treatment. Our findings suggest dry eye assessments among patients receiving more than four cycles of chemotherapy or targeted therapy, thus early revealing possible dry eye conditions to both patients and clinicians for further specialized examination and treatment.

DRY-EYE DISEASE AMONG MEDICAL PROFESSIONALS IN A TERTIARY CARE HOSPITAL IN WESTERN UP DURING THE LOCKDOWN PERIOD 2020 – A CROSSSECTIONAL STUDY.

Objective : To estimate the prevalence of dry-eye disease (DED) among medical professionals in a tertiary care hospital in Western UP during the lockdown period 2020. Materials &amp; Methods : This was a cross-sectional hospital-based, observational study from 7th May 2020 till 14th May 2020, that included 50 medical professionals as subjects. The study compares the increase in the number of hours spent on Visual Display Terminals (VDTs) before and during the lockdown period 2020. This in-turn led to numerous ill-effects on human beings, out of which ocular manifestations like dry-eye disease has been on the rise. The study has been carried out in the form of questionnaire survey data – Ocular Surface Disease Index (OSDI) asking about the symptoms and various other parameters, related to dry eye. Results : The mean number of hours spent on VDTs before lockdown was 2.82±1.32 hours and during lockdown was 6.26±4.76 hours. In accordance with the OSDI scoring, 23/50 subjects developed DED. Out of these, 28% (14/50) had mild DED, 16% (8/50) had moderate DED, and only 2% (1/50) had severe DED. Prevalence of dry eye was directly proportionate to exposure time to VDT during the lockdown. Conclusion : The prevalence of dry-eye disease (DED) among medical professionals during the lockdown period 2020 was 46%. This was attributed to the increased dependence on VDTs for various purposes.

Dry Eyes, Ocular Lubricants, and Use of Systemic Medications Known or Suspected to Cause Dry Eyes in Residents of Aged Care Services.

Ocular issues are common, burdensome, and under-researched among residents of aged care services. This study aims to investigate the prevalence of dry eyes or use of ocular lubricants among residents, and the possible association with systemic medications known or suspected to cause dry eyes. A cross-sectional study of 383 residents of six aged care services in South Australia was conducted. Data were extracted from participants’ medical histories, medication charts, and validated assessments. The main exposure was systemic medications known to cause, contribute to, or aggravate dry eyes. The primary outcome was documented dry eyes or regular administration of ocular lubricants. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between systemic medications and dry eyes/use of ocular lubricants. Dry eyes were documented for 53 (13.8%) residents and 98 (25.6%) residents were administered ocular lubricants. Overall, 116 (30.3%) residents had documented dry eyes/used ocular lubricants. Of these, half (n = 58) were taking a medication known to cause, contribute to, or aggravate dry eyes. Taking one or more medications listed as known to cause dry eyes was associated with having dry eyes/use of ocular lubricants (OR 1.83, 95% CI 1.15–2.94). In sub-analyses, no individual medication was associated with dry eyes/use of ocular lubricants. Dry eyes and use of ocular lubricants are common in residential aged care. Our hypothesis generating findings suggest the need for further research into the clinical significance of systemic medications as a possible cause of dry eyes.

Prevalence of Dry Eye and its Subtypes in an Elderly Population with Cataracts in Indonesia.

PurposeTo describe the prevalence of dry eye disease (DED) and its subtypes in elderly population with cataracts prior to surgery in Jakarta, Indonesia.Patients and MethodsForty-nine eyes of 49 patients (16 males, 33 females; mean age: 66.6 years) planned for phacoemulsification surgery were consecutively recruited from two tertiary eye hospitals in this hospital-based cross-sectional study. Symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire, and the patient was defined as symptomatic if their OSDI score was ≥13. Objective examinations included the noninvasive tear film break up time (NIBUT) and Schirmer tests. The results were deemed abnormal if they were <10 seconds and <10 mm for NIBUT and Schirmer, respectively.ResultsParticipants were classified into four groups: DED (positive symptoms and short NIBUT), preclinical dry eye (positive symptoms without short NIBUT), predisposition to dry eye (short NIBUT without symptoms), and normal group. Median OSDI score was 12.5 (0–45.0), NIBUT was 10.4 (5.1–28.9) seconds, and Schirmer score was 8.0 (2.0–28.0) mm. The prevalence of DED, preclinical dry eye, and predisposition to dry eye were 22.5%, 22.5%, and 26.5%, respectively, while the other 28.5% subjects were normal. The DED group had significantly lower Schirmer test results (4.0 [2–17] mm) compared to all other groups. Older age (>70 years) was associated with poorer NIBUT and Schirmer test results and a significant difference between age groups was observed, especially in males.ConclusionDry eye is a common problem among the elderly population with cataracts in Indonesia. Almost half of the subjects presented with dry eye symptoms and either categorized as DED or preclinical dry eye, while more than one quarter were predisposed to dry eye. Care must be taken prior to cataract surgery to rule out existing dry eye with additional attention on those presenting without any symptoms as dry eye may develop after surgery.

Dry Eye Epidemiology in Patients before Cataract Surgery

Purpose. To evaluate the prevalence, clinical and pathogenetic variants and statistically significant risk factors of dry eye (DE) in patients before cataract surgery. Patients and Methods. 600 age-related and complicated cataract patients (70.6 ± 7.8 years old; 269 men, 331 women) were examined. Visometry and biomicroscopy with photographic recording of the lens state and assessment of its opacities according to the LOCS III classification were used to cataract revealing. OSDI testing, lipid interferential test, TBUT, Shirmer-1, -2 tests, visual and OCT meniscometry, evaluation of epitheliopaty and microerosion (with vital staining), compression Norn test in Korb modification, visual and OCT LIPCOF assessment, lid viper epitheliopathy evaluation, anterior segment of the eye photoregistration with computer morphometry were performed to assess the ocular surface condition. The structure of the DE risk factors, was studied both in DE patients and non-DE subjects with calculation of the Pearson xi-square test. To estimate the strength of the connection between the etiological condition and the DE, the normalized value of the Pearson coefficient (C´) was used. Results. The dry eye prevalence was 53.2 % (of them, 25.5 % was mild, 27.7 % — moderate, by Brzhesky). Subclinical DE prevalence was 27 %. Clinical and pathogenetic variants of mild DE included: isolated lipid deficiency (71.9 %), lipid-mucin deficiency (28.1 %). In patients with moderate DE were identified: aqueous-lipid-mucin deficiency (54.8 %), aqueous-lipid deficiency (37.95 %), isolated aqueous deficiency (7.2 %). The most significant systemic-organ DE risk factors were: diabetes mellitus (C´ = 0.302; in 18.8 % DE patients), female sex (C´ = 0.240; in 62.1 % de patients), allergy (С´ = 0.233; in 23.2 % DE patients). Local risk factors most significantly associated with DE were: meibomian glands dysfunction (С´ = 0.58; in 77.7 % DE patients), chronic blepharitis (С´ = 0.233; in 23.2 % DE patients), pterygium (С´ = 0.276; in 13.2 % DE patients), allergic conjunctivitis (С´ = 0.21; in 21.3 % DE patients). Among the exogenous risk factors, the most significant were: the use of medication affecting tear production or tear film stability (С´ = 0.485; in 89.03 % DE patients), preservative eye drops instillation (С´ = 0.2975; in 56.1 % DE patients). Conclusion. In our opinion, data on the high DE prevalence in cataract patients (53.2 %) should be taken into account when planning cataract surgery, since perioperative correction of the ocular surface condition can increase the surgical treatment efficiency, predictability and safety. The data on the structure of significant risk factors and clinical and pathogenetic DE variants in cataract patients can be the basis for the development of measures to ensure timely DE detection and implementation of reasonable therapy. The risk factor most significantly associated with DE in cataract patients was the meibomian gland dysfunction (MGD) (Pearson xi-square test = 88.542, p &lt; 0.001, С´ = 0.58; “relatively strong” strength). Considering the modifiability of this risk factor (MGD), as well as its high prevalence (77.7 %), it can be considered that eye lids hygiene may be a reasonable therapy in most DE and cataract patients before phacoemulsification.

Prevalence of dry eye in computer users

Computer and video display users complain of eye irritation due to changes in tear film and decreased blink rate. Therefore purpose of this study was to know the prevalence of dry eye in computer users.A prospective study was done in 120 eyes of 60 clerical staff working on computer for more than 4 hours/day in a medical college. A detailed ocular examination with assessment of dry eye was done with TBUT, SCHIRMER’S test, tear meniscus height and a questionnaire about dry eye.The prevalence of dry among computer users of this group was found to be 18%.Prevalence of dry eye is increasing in the computer users. We also created awareness about dry eye among them.

Prevalence of dry eyes in patients with Type-2 diabetes mellitus

To estimate the prevalence of dry eyes in patients with Type-2 diabetes mellitus and to compare various tests of dry eye.An analytical cross sectional study was conducted on 150 patients diagnosed with Type 2 diabetes mellitus. Dry eyes symptoms were assessed using Ocular surface disease index (OSDI) questionnaire and graded according to severity. The diagnosis was confirmed by positive Ocular surface staining pattern with fluorescein, Tear film breakup time test (TBUT) or Schirmers test. Severity of dry eyes was determined and prevalence calculated.The prevalence rate of dry eye disease among diabetics was calculated as 36% on the basis of Ocular surface disease index. Mild, moderate and severe dry eyes were present in 16%, 16% and 4% patients respectively. TBUT showed very good agreement with highest diagnostic accuracy. Schirmers test and Fluorescein test had good and moderate agreement respectively.Diabetes mellitus associated dry eye disease (DMDES) is the most frequent diabetic complication in clinical practice. Clinical trials are warranted to confirm the effects of the currently applied drugs in diabetes-associated DES for a better outcome in such patients. Our study can act as a stepping stone for larger multi-centric studies to gain more information about this largely unrecognized problem of diabetes associated dry eye disease.

A Multicenter Study of the Prevalence of Dry Eye Disease in Chinese Refractive Surgery Candidates

Objective: The aim of this study was to determine the prevalence of preoperative dry eye disease and evaluate tear film function in refractive surgery candidates in China. Methods: In this prospective noninterventional cross-sectional study, refractive surgical candidates from 13 preselected eye hospitals in China were recruited from July 2015 to February 2016. Patient histories, subjective symptoms, tear film breakup time (TBUT), ocular surface fluorescein staining, and Schirmer I tests (SIT), were assessed to conduct subgroup analysis. Results: A total of 1,849 patients were recruited, 41.4% were diagnosed with dry eye disease (766/1,849) and 44.9% (830/1,849) of subjects had a positive history of contact lens (CL) wear. The overall mean TBUT and SIT values were 7.3 ± 3.7 s and 15.2 ± 8.8 mm, respectively. The total prevalence of ocular surface fluorescein staining was 23.46% (422/1,849); 44.62% of patients had TBUT <5 s and 23.20% of patients had SIT <5 mm. CL wearers were observed to have a higher prevalence of dry eye than non-CL wearers (54.1 vs. 35.2%, OR = 2.17, 95% CI: 1.77–2.65). Conclusions: In this study, the most common abnormal finding in dry eye disease was tear film instability. A high proportion of refractive surgery candidates have preexisting dry eye disease and a history of CL wear prior to surgery. Careful attention should be given to the evaluation of preoperative dry eye in refractive surgery candidates.

Altered mucins and aquaporins indicate dry eye outcome in patients undergoing Vitreo-retinal surgery.

Vitreo-retinal (VR) surgeries induce conjunctival changes. However, there are no study reports regarding prevalence and severity of dry eye after these surgeries. This study evaluated dry eye outcome after VR surgery. Patients undergoing VR surgery classified as scleral buckle and microincision vitrectomy surgery (n = 44, mean age: 56.09±10.2 years) were recruited. Dry eye evaluation was done before and 8 weeks after surgery (2 weeks after omitting topical eye drops). Conjunctival imprint cytology for goblet cell count and tear Mucin 5AC (MUC5AC) protein estimation was done. Gene expressions of MUC5AC, MUC4, MUC16, Aquaporin 4 (AQP4) and AQP5 were analyzed in the conjunctival imprint cells by qPCR. None of the patients exhibited clinical signs of dry eye after VR surgery. But the conjunctival goblet cell density (GCD) was significantly lowered post-VR surgery (63% cases, **p = 0.012) with no alterations in the tear MUC5AC protein. Post-VR surgery, the conjunctival cell gene expression of MUC4, MUC16 and AQP4 were significantly increased (*p = 0.025, *p = 0.05 and *p = 0.02 respectively) and AQP5 was significantly lowered (*p = 0.037), with no change in MUC5AC expression. Tear cytokines were significantly increased post-VR surgery (anti-inflammatory: IL1RA, IL4, IL5, IL9, FGF; PDGFbb and pro-inflammatory: IL2, IL6, IL15, GMCSF and IFNg). Though clinical signs of dry eye were not observed after VR surgery, ocular surface changes in the form of reduced GCD, altered MUC5AC, MUC4, MUC16, AQP4, AQP5 and cytokines are suggestive of dry eye outcome at the molecular level especially inpatients aged above 51 years, especially female gender and those who are diabetic.

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands

PurposeTo investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories. MethodsA cross-sectional association study including 79,866 voluntary participants aged 20–94 years of the population-based Lifelines Cohort Study in the Netherlands. ResultsOverall, 9.1% of participants had dry eye disease as measured by the Women's Health Study dry eye questionnaire. Prevalence of dry eye symptoms were particularly prevalent in 20–30 years olds. Dry eye was associated with comorbidities in almost all body systems, including musculoskeletal, gastro-intestinal, ophthalmic, autoimmune, psychiatric, pain, functional, dermatological and atopic disorders. Numerous independent risk factors were discovered or confirmed, with strong associations for female sex, contact lens use, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, eye surgery including cataract and laser refractive surgery, keratoconus, osteoarthritis, connective tissue diseases, atherosclerosis, Graves' disease, autistic disorder, depression, ‘burnout’, Crohn's disease, sarcoid, lichen planus, rosacea, liver cirrhosis, sleep apnea, sinusitis, thyroid function, and air pollution (NO2). High blood pressure and high BMI were strongly associated with less dry eye, as was current smoking, while ex-smokers had more dry eye. No clear link between dry eye and lipid or blood glucose levels was found. ConclusionsThis study on dry eye confirmed but also refuted many risk factors from smaller epidemiological studies, and discovered numerous new risk factors in multiple etiological categories. The finding that dry eye symptoms are particularly common in young adults is concerning, and warrants further study.

Analysis of Clinical and Regional Distribution Characteristics of Obstructive Meibomian Gland Dysfunction in China: A Multicenter Study

ABSTRACT Purpose: To analyze the clinical and regional distribution characteristics of obstructive meibomian gland dysfunction (OMGD) in China. Methods: A total of 2900 patients (2900 eyes) diagnosed with OMGD were enrolled in this multicenter, cross-sectional, observational study. The Ocular Surface Disease Index (OSDI), tear film breakup time (FBUT), Schirmer test (SI), lipid layer thickness (LLT), OMGD grade, meibomian gland loss score (Meiboscore), meibum expressibility score (MES), meibum quality score (MQS), Lid margin abnormality score(LMS) and other tear film stability markers were evaluated. Results: The prevalence of dry eye in OMGD patients was 89%. There were gender differences among OMGD patients in the 30–39 and 50–59 years age groups (p < .05), and FBUT, Meiboscore, MES and MQS were significantly different among different OMGD grades (p < .05). There were significant differences in the detection indexes of OMGD patients in the six regions (p < .05), except LLT (p = .329). According to the Qinling-Huaihe River in China, OMGD patients were divided into the North Group (Shenyang and Beijing) and South Group (Wuhan, Changsha, Chongqing, and Chengdu). There was a significant difference in the detection indexes, except LLT (p = .600), between the two groups (p < .05). FBUT was significantly correlated with the OSDI (r = −0.131; p < .000). Meiboscore and LLT were significantly correlated with the OMGD grade (r = 0.299 and r = 0.106; p < .001). Age, LMS and MQS were significantly correlated with Meiboscore (r = 0.415, r = 0.256 and r = 0.328; p < .001). Conclusions: The prevalence of dry eye was high among OMGD patients. OMGD patients in different age groups may show different gender distributions. The symptoms of patients showed variation among subgroups with different OMGD grades and among different regions.

Evaluation of the Prevalence and Risk Factors of Dry Eye in Young Population

Methods: It was a prospective observational study, conducted in 500 patients (1000 eyes), who visited at outpatient department of pediatric ophthalmology of our tertiary eye care center. All patients were screened for ocular surface disease index. Of those, having score >13 were further evaluated for the dry eye tests. The 60 eyes of 30 patients were selected and studied for the causes, types of dry eye.

Risk Factors for Inflammatory Dry Eye in Young Adults in Twenties

Purpose : As inflammation is suggested as a core drive factor for dry eye, in this study the effects of contact lens wear and corneal refractive surgery on inflammatory dry eye were investigated in Korean twenties. Methods : Eighty-one adults (162 eyes) in their twenties who had no ocular disease were evaluated by 'Matrix Metalloproteinase-9 (MMP-9)' test as known biomarker for inflammatory dry eye and 'OSDI/conjunctival hyperemia' test for screening of inflammatory dry eye. We analyzed prevalence and risk factors of inflammatory dry eye based on two inflammatory dry eye tests, and analyzed them using Chi-square test and logistic regression. The statistical significance level was p＜0.050. Results : The prevalence of inflammatory dry eye evaluated by MMP-9 and OSDI/conjunctival hyperemia tests in all subjects was shown 77.15% and 64.31%, respectively. The prevalence of inflammatory dry eye in contact lens wearer group with two tests was 85.23% and 75.00%, respectively, and that in the non-wearer group was 67.57% and 52.70%, respectively. The risk of inflammatory dry eye in contact lens wears was 2.77 times (OR 2.77, 95% CI 1.29~5.99), and 2.69 times (OR 2.69, 95% CI 1.39~5.23) higher than non contact lens wearers, respectively. The prevalence of inflammatory dry eye in corneal refractive surgery group compared with non operative group was not significantly different (p=0.682 and p=0.370, respectively). Conclusion : It was confirmed that the prevalence of inflammatory dry eye in Korean twenties was very high, and the odds ratio of inflammatory dry eye was 2 times higher than contact lens wearers. Therefore, the contact lens care education for contact lens weareres would be necessary to prevent inflammatory dry eye.

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