Prevalence Of Cardiac Arrest Research Articles

Prevalence and Associated Factors Affecting Outcomes of Adult Patients with Cardiac Arrest Who Receive Cardiopulmonary Resuscitation in Emergency Department of a Tertiary Hospital

Background Cardiopulmonary resuscitation (CPR) aims at restoring spontaneous circulation in a victim of cardiac arrest. This study intends to find out the demographic information of cardiac arrest patients, their outcomes and the possible factors that could affect the outcomes.MethodsA hospital-based cross-sectional study was conducted at Dhulikhel Hospital to investigate cardiac arrest outcomes among patients aged over 14 years who either presented with or developed cardiac arrest in the Emergency Department. Data were documented and, then entered into Microsoft Excel and analyzed using SPSS. Descriptive statistics were used to summarize categorical and continuous variables, while a Chi-square test (p < 0.05) assessed associations between selected variables and CPR outcomes.ResultsThe majority of patients were over 65 years old (31.9%), with the smallest group under 25 years (10.1%). Regarding gender distribution 34.8% were female. Trauma was present in 24.6% of cases, while 48.9% were witnessed by bystanders but none of them received CPR. Initial rhythm was predominantly asystole (87%). CPR lasted for 20-40 minutes in 47.8% of cases and over 40 minutes in 14.5%, averaging 24.1 minutes. 40.6% patients had ROSC after CPR while 59.4% had no Return of Spontaneous Circulation (ROSC). Statistically significant associations with CPR outcomes were found for sex, site of cardiac arrest, trauma, witnessed events, CPR duration, and intubation (p-value <0.05).Conclusions Our hospital experiences a high prevalence of cardiac arrest and has comparable ROSC rate. Statistically significant variables associated with outcomes of CPR were, sex, site of cardiac arrest, Trauma, Witnessed event, Duration of CPR and Intubation.

Associated Factors of Patients' Survival in Out of Hospital Cardiac Arrest; a Cross-sectional Study.

Chinese populations have an increasingly high prevalence of cardiac arrest. This study aimed to investigate the prehospital associated factors of survival to hospital admission and discharge among out-of-hospital cardiac arrest (OHCA) adult cases in Macao Special Administrative Region (SAR), China. Baseline characteristics as well as prehospital factors of OHCA patients were collected from publicly accessible medical records and Macao Fire Services Bureau, China. Demographic and other prehospital OHCA characteristics of patients who survived to hospital admission and discharge were analyzed using multivariate logistic regression analysis. A total of 904 cases with a mean age of 74.2±17.3 (range: 18-106) years were included (78%>65 years, 62% male). Initial shockable cardiac rhythm was the strongest predictor for survival to both hospital admission (OR=3.57, 95% CI: 2.26-5.63; p<0.001) and discharge (OR=12.40, 95% CI: 5.70-26.96; p<0.001). Being male (OR=1.63, 95% CI:1.08-2.46; p =0.021) and the lower emergency medical service (EMS) response time (OR=1.62, 95% CI: 1.12-2.34; p =0.010) were also associated with a 2-fold association with survival to hospital admission. In addition, access to prehospital defibrillation (OR=4.25, 95% CI: 1.78-10.12; p <0.001) had a 4-fold association with survival to hospital discharge. None of these associations substantively increased with age. The major OHCA predictors of survival were initial shockable cardiac rhythm, being male, lower EMS response time, and access to prehospital defibrillation. These findings indicate a need for increased public awareness and more education.

Abstract 18883: Inflammatory Bowel Disease is Not Significantly Associated With Cardiac Arrest in STEMI Patients

Introduction: Systemic inflammatory diseases, such as psoriasis, lupus, and rheumatoid arthritis, have exhibited a strong association with an increased incidence of cardiovascular events over a patient’s lifetime. However, there is limited information regarding outcomes, particularly cardiac arrest, in STEMI patients with concurrent IBD. Thus, our study aims to assess potential outcomes, including cardiac arrest, in STEMI patients with IBD, utilizing a nationally representative sample of adult individuals in the United States, with a specific focus on MACE and associated risk factors. Our study provides valuable insights into the cardiovascular implications and associated risk factors in this unique patient population. Methods: The US-based National Inpatient Sample was queried between 2015 and 2020 using ICD-10 codes for adults ≥ 18 years with STEMI with and without IBD. The adjusted odds ratio of index hospitalization outcomes was calculated using a multivariate logistic regression analysis. Results: Overall, 3,960 out of 898,525 (0.44%) STEMI patients reported a history of IBD. Patients with IBD were predominantly middle aged, white, and female compared to non-IBD patients. STEMI patients with IBD had similar CVD risk factors (specifically hypertension and obesity) than non-IBD patients (P &gt; 0.05), however the prevalence of smoking and diabetes were lower in IBD patients (P &lt; 0.001). Notably, STEMI patients with IBD had a lower prevalence of cardiac arrest compared to their non-IBD counterparts (P &lt; 0.001). However on adjustment for baseline CVD risk factors and hospital characteristics, no significant difference was appreciated (P = 0.25) (Table 1). Conclusions: In a nationally representative adult US population IBD was not shown to confer an increased risk of cardiac arrest in patients with a history of STEMI. These findings underscore the need for further investigation to elucidate the complex relationship between IBD and cardiovascular outcomes.

Adults Are Not Just Large Kids: Caring for Adults in Pediatric Hospitals.

Adults Are Not Just Large Kids: Caring for Adults in Pediatric Hospitals.

Abstract 221: Machine Learning Algorithms For The Prognostication Of Return Of Spontaneous Circulation

Introduction: Several factors are known to influence return of spontaneous circulation (ROSC) following out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA). Machine learning (ML) methods are capable of analyzing large datasets to elucidate the clinical and prognostic value of specific variables. In cardiac arrest, ML may help identify predictors of ROSC in OCHA and ICHA. Purpose: The present systematic review summarizes the literature on ML algorithms used to predict ROSC in OHCA and IHCA. Methods: PubMed, EMBASE, Web of Science, and Cochrane were searched to identify articles. Studies on human subjects with OHCA or IHCA which used ML methods to predict ROSC were included. Results: A total of 4,094 studies were identified through a literature search. Ten were included in the final analysis with a total sample size of 240,798 patients (240,798 (93%) male). Studies used logistic regression (n=7), random forest models (n=2), or deep learning (n=1). Sociodemographic variables beyond age (n=8) and sex (n=5) were not used. Variables used for predicting ROSC included age (n=8), type of rhythm (n=7), witnessed arrest (n=5), and time to emergency services arrival (n=5). Most models were built using data from OHCA patients (n=7), with only three focused on IHCA. Studies utilized a variety of parameters for reporting the prognostic value of their models, including predictive accuracy (69%-99%), area under the receiver operating characteristic curve (0.71-0.83), sensitivity (50.2%-76.0%), and specificity (61.0%-92.9%). Conclusion: Despite the prevalence of cardiac arrest and advances in AI, only ten studies examined ML in the prognostication of ROSC. Logistic regression was predominantly used in the included studies, and there is a paucity of data on the efficacy of deep learning models. Furthermore, heterogeneity in the predictive efficacy of studied ML models merits additional work and the need for large-scale trials comparing ML to conventional methods and clinician judgment. Critically, there is also a need for greater data inclusivity in model development, understanding that marginalized populations are less likely to receive CPR.

Abstract P346: Cardiac Arrest During Delivery Hospitalization And Severe Hypertensive Disorders Of Pregnancy, United States, 2017-2019

Background: Cardiac arrest is a rare and sometimes fatal maternal complication. Severe hypertensive disorders of pregnancy (HDP) including preeclampsia with severe features, eclampsia, and Hemolysis, Elevated Liver enzymes, and Low Platelets (HELLP) syndrome are risk factors for maternal cardiac events. Surveillance on cardiac arrest and severe HDP during delivery is critical to informing evidence-based strategies to reduce pregnancy-related death. Methods: Using pooled data from the National Inpatient Sample from 2017-2019, we identified delivery hospitalizations among women aged 12-55 years. Delivery hospitalizations, cardiac arrest, and maternal medical conditions were identified using ICD-10-CM codes. Survival to hospital discharge was based on patient discharge disposition. Prevalence of cardiac arrest, severe HDP, and survival following cardiac arrest were calculated. We estimated the prevalence of severe HDP among delivery hospitalizations with cardiac arrest, cardiac arrest frequency among delivery hospitalizations with severe HDP, and survival to hospital discharge with co-occurring cardiac arrest and severe HDP. All estimates were weighted to account for complex sampling. Results: During 2017-2019, an estimated 10,921,784 delivery hospitalizations among which 1,465 cardiac arrests were identified. Overall cardiac arrest prevalence was 13.4 per 100,000 delivery hospitalizations (95% CI, 11.9-14.9). Of these, 1,005 (68.6% [95% CI, 63.2-74.0]) survived to hospital discharge. Overall prevalence of severe HDP was 2.7% (95% CI, 2.6-2.7) compared with 15.4% (95% CI 11.2-19.5) of delivery hospitalizations with cardiac arrest. Frequency of cardiac arrest per 100,000 delivery hospitalizations with severe HDP was 76.9 (95% CI, 54.6-99.2). Survival to hospital discharge with co-occurring cardiac arrest and severe HDP was 77.8% (95% CI, 65.6-89.9). Conclusion: Delivery hospitalizations affected by cardiac arrest are rare, and over two thirds survived to hospital discharge. Cardiac arrest disproportionately affected delivery hospitalizations among patients who had severe HDP.

Prevalence, Outcomes, and Risk Factors for Cardiorespiratory Arrest in the Intensive Care Unit: An Observational Study.

BackgroundCardiorespiratory arrest is defined as an abrupt halt in the cardiac mechanical activity that is accompanied by the loss of a detectable pulse, the cessation of breathing, and the loss of consciousness. The aim of this study is to create a clinical–epidemiological profile of patients who experienced cardiorespiratory arrest and were admitted to the intensive care unit to evaluate the associated factors and their impact on the prognosis of these patients.Patients and methodsFrom January to December 2019, the medical records of 135 patients who received cardiopulmonary resuscitation were reviewed for this cross-sectional observational study. The information was collected according to the Utstein model.ResultsA low return of spontaneous circulation of 22.2% was observed, with a predominance of females (53.3%) and older patients (68.9%), multiple comorbidities at admission (68.4%), and asystole as the predominant rhythm. Female sex and age >60 years were statistically significant (p = 0.017), as was the association between sex and comorbidities (p = 0.036), with heart disease being the most prevalent in females (p = 0.036).ConclusionIn this study, even though the resuscitation maneuver time (start of resuscitation following arrest) was very short and the defibrillation was performed promptly, there was a high prevalence of cardiac arrest and low survival rates after cardiopulmonary resuscitation.How to cite this articleMenezes da Silva A, Braga AL, Cruvinel de Souza V. Prevalence, Outcomes, and Risk Factors for Cardiorespiratory Arrest in the Intensive Care Unit: An Observational Study. Indian J Crit Care Med 2022;26(6):704–709.

Cardiopulmonary Resuscitation in Obstetric Patient: Special Considerations.

The prevalence of cardiac arrest in pregnant women varies from 1/20,000 to 1/50,000 pregnancies and is associated with high fetomaternal mortality. The pregnant mother is more susceptible to cardiac arrest as hypoxia is poorly tolerated. Hemorrhage, eclampsia, sepsis, and embolism are common causes of arrest. Cardiac arrest is preventable if a predisposing clinical problem is detected in time by an early warning score and treated immediately. Resuscitation in obstetricpatient is challenging and special as it involves the lives of two patients, the mother and the fetus. Physiological and anatomical changes during pregnancy need special considerations during cardiopulmonary resuscitation. Chest compressions, defibrillation, and drug administration guidelines are similar to those in non-pregnant women. Early endotracheal intubation by an expert is desirable but bag-mask ventilation with oxygen supplementation should be initiated immediately by the first responder to prevent hypoxia. Hyperventilation should be avoided. An intravenous line should be established above the level of the diaphragm. Manual left lateral uterine displacement is necessary to relieve aortocaval compression when uterine height is more than 20weeks. Perimortem cesarean delivery at the site is a part of resuscitation if spontaneous circulation is not established within 4min, after detection of the arrest. Echocardiography and ultrasonography can help to find out the etiology of the arrest. Targeted temperature management and extracorporeal cardiopulmonary resuscitation should be considered as needed. The newborn will be taken care of by a neonatologist. Following emergency protocols, early warning scores, training and updating resuscitation guidelines, simulations, collecting a national database of pregnant mothers along with the teamwork of obstetrician, anesthesiologist, neonatologist, and emergency physician can reduce fetomaternal mortality.

Resuscitation After Cardiac Surgery Awareness an Egyptian Multicentre Survey

Abstract Introduction There has been an increasing recognition that cardiac surgery patients have different resuscitative needs than other medical and surgical patients who experience in-hospital cardiac arrest. This was addressed in the 2010 European Resuscitation Council Guidelines and the 2010 American Heart Association Guidelines. However, it’s unknown how widely the guidelines are practiced, or a training protocol is followed in different units in Egypt. Objectives This national survey aims to identify the views and common practice of Egyptian cardiac teams regarding resuscitation after cardiac surgery. Methods A 21-question survey is created based on a prior survey used by the EACTS guidelines committee. Questions included the following topics: Participants demographics, Prevalence of cardiac arrest in the intensive care unit, Cardiac arrest with ventricular fibrillation or non-shockable rhythm, Emergency resternotomy technique, Training and arrest protocols. Survey dissemination was through social media platforms, mobile messaging applications and emails during the time period between November 2020 and January 2021. Results Of 126 responses, 95 were suitable for inclusion. Responses were from 11 centres across Egypt. 68.5% of the respondents were surgeons while cardiac anaesthetists and intensivists formed 12.6% and 18.9% respectively. 76.8% of participants were middle-grade doctors, consultant participation was 23.2%. The median annual number of cases performed in the units was 480 and this ranged from 10 to 3000. The average percentage of cardiac arrests was 7%, Median survival to hospital discharge of all arrests was 33% For patients who go into VF after cardiac surgery, respondents would attempt a mean of 5 shocks with only 24.2% commencing defibrillation shocks before external cardiac massage, while the majority initiating CPR immediately. They would perform emergency resternotomy in a mean time of 12 mins and in 15 mins if the rhythm was not shockable. 56.8% would give 1 mg of adrenaline as soon the cardiac arrest was established, only 6.3% thought that it should be given rarely or not at all. If a surgeon was not immediately available 36.8% of respondents would be happy for any trained personnel to perform the emergency resternotomy while 58.9% expect only the surgeon to perform the resternotomy. 49.4% of the participants have not practised any training to perform an emergency sternotomy. 41% of the respondents state they occasionally practice or talk with the staff about it. Only 9.5% practice regularly on emergency sternotomies. 25% assume current training is enough and does not need modification, while 75% think tailored training is important and staff should be oriented about it in the future. Conclusion An action plan is required to improve the awareness of the junior surgeons with the Cardiac Advanced Life Support Protocol. Proper training of the intensive care staff to implement the protocol in a timely organised manner is needed. Assessment of the rhythm before starting external chest compressions is the corner stone in cardiac patients undergoing cardiac arrest. VF/pVT rhythm, 3 defibrillation shocks are given first; for the non- shockable rhythm, the emergency pacing switched on, this is followed by compressions till resternomtomy. Emergency resternotomy under 5 minutes is the only effective way to save patients with tamponade and extreme hypovolemia.

Abnormal Microarray, Clinical Outcomes, and Surgical Risk Scores in Young Children with Cardiac Disease.

The clinical implications of abnormal chromosomal microarray (CMA) remain unclear for children less than 1year of age with critical heart disease. Our objective was to determine whether abnormal CMA was related to surgical severity scores or to pre-determined clinical outcomes, including cardiac arrest. Retrospective review of children under 1year of age admitted to a pediatric cardiac intensive care unit from December, 2014 to September, 2017. Associations between CMA result and cardiac arrest, syndromic abnormalities, and extracardiac anomalies were evaluated. A simple and multivariable logistic regression model was used to analyze associations between STAT mortality category and CMA result. The overall prevalence of abnormal microarray was 48/168 (29%), with peak prevalence in AV septal defects and left-sided obstructive lesions. There was no statistical association between surgical severity scores and abnormal CMA (STAT 1/2 vs. 3+, odds ratio 0.56, p = 0.196). Abnormal CMA was associated with a higher prevalence of cardiac arrest (5/48 abnormal CMA vs. 2/120 normal CMA, p = 0.02). Abnormal CMA was associated with a higher frequency of syndromic abnormalities (18/48 abnormal CMA vs. 13/120 normal CMA, p < 0.001). There was a high prevalence of abnormal CMA findings in the pediatric cardiac population less than 1year of age (29%), associated with cardiac arrest, but not associated with surgical risk score. The absence of a standardized protocol for ordering a CMA in the setting of congenital heart disease results in a highly variable prevalence data.

Cardiac sarcoidosis and ventricular arrhythmias. A rare association of a rare disease. A retrospective cohort study from the National Inpatient Sample and current evidence for management.

Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis is associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data is available regarding the disease and associated ventricular arrhythmias. Data from the National Inpatient Sample (NIS) database 2012-2014, were reviewed. Dis-charges associated with sarcoidosis were identified as the target population using relevant ICD-9-CM codes. Primary outcome was a diagnosis of ventricular tachycardia (VT) in the sarcoidosis population. Secondary outcomes include rate of ventricular fibrillation (VF) and cardiac arrest. Subgroup analyses were performed to examine the association of VT with multiple potential confounding clinical variables. Of 18,013,878 health encounters, 46,289 (0.26%) subjects had a diagnosis of sarcoidosis. VT and VF were more prevalent among patients with sarcoidosis compared to those without a diagnosis of sarcoidosis (2.29% vs. 1.22%; p < 0.001 and 0.25% vs. 0.21%; p < 0.001, respectively). Sarcoidosis was also associated with a higher prevalence of cardiac arrest (0.72% vs. 0.6%; p < 0.001). In unadjusted analyses, all examined comorbidities were significantly more common in those with sar-coidosis, including diabetes mellitus (31.6% vs. 21.25%; p < 0.001), hypertension (65.2% vs. 51.74%; p < 0.001), chronic kidney disease (21.09% vs. 14.02%; p < 0.001), heart failure (24.87% vs. 15%; p < 0.001) and acute coronary syndrome (4.32% vs. 3.35%; p < 0.001). The present study showed that sarcoidosis was associated with increased rates of ven-tricular tachyarrhythmia, which can affect the overall disease morbidity and mortality.

105 Cardiac Arrest Masquerading as Seizure: Dispatch for Agonal Breathing

Sudden unexpected death account for 17% of deaths in epileptic patients and seizures can trigger cardiac arrest, respiratory arrest, or be the initial clinical manifestation of a cardiac arrest. Given these relationships, bystanders may report a patient is having a seizure when in fact they are displaying agonal breathing and are in early cardiac arrest. The objective of this study is to evaluate the prevalence of cardiac arrest among calls dispatched as seizures in a large, urban 911 dispatch system. This is a retrospective review of all electronic medical records for Los Angeles Fire Department (LAFD) attended 911-incidents dispatched as active seizure from December 2014-November 2018. Cases were included if the patient was greater than or equal to 18 years old, an LAFD 911-telecommunicator selected a dispatch code for active seizure, and an electronic patient care report was completed. All calls were managed by nationally certified 911-telecommunicators who are cross-trained as LAFD firefighter-EMTs. The primary outcome was the prevalence of cardiac arrest in LAFD 911-dispatches for active seizure using the Los Angeles-Tiered Dispatch System (LA-TDS). Secondary outcomes included description of the characteristics of patients in cardiac arrest. During the study period, a total of 19,908 911 calls met inclusion criteria. The mean age was 44.3 years, and 12,170 patients (62.1%) were male. In 135 cases (0.68%), the patient was found on scene to be in nontraumatic cardiac arrest. Of those in cardiac arrest, the mean age was 50.6 years; 96 patients (71.1%) were male; and the initial cardiac rhythm on scene was ventricular fibrillation or ventricular tachycardia in 49 (36.3%) cases, asystole in 44 (32.6%) cases, pulseless electrical activity in 36 (26.7%) cases, and 6 (4.4%) cases had an unknown rhythm. Among patients dispatched as active seizure and found to be in cardiac arrest, 14 (10.4%) had a known history of seizure disorder versus 9,783 (49.5%) in the group who did not have a cardiac arrest. Using logistic regression, males were found to be more likely to be in cardiac arrest (OR 1.59, p=0.016) as were those with increasing age (OR 1.01, P=0.001.) Patients with a history of seizure disorder were less likely to be in cardiac arrest (OR 0.12, p<0.001). Cardiac arrest in 911-calls dispatched as active seizure using LA-TDS is a rare event. Patients who were found in cardiac arrest tend to be older, male, without a history of seizure disorder and most commonly present with a shockable rhythm.

Diagnosis of Out-of-Hospital Cardiac Arrest by Emergency Medical Dispatchers: A Diagnostic Accuracy Study

Introduction This study was conducted to assess the diagnostic accuracy of out-of-hospital cardiac arrest (OHCA) made by emergency medical dispatchers (EMDs) in Tehran, Iran. Methods Patients more than 18 years of age who were suspected of having an OHCA by EMDs or emergency medical service (EMS) technicians at the patient's bedside were eligible for inclusion in the study. The initial diagnosis, results of primary assessment and monitoring, and the final outcome of the mission (gold standard) were all recorded. Related archived audios were extracted from the system and listened to by the researcher (MM). Other required data were extracted from EMS mission forms and recorded in a pre-prepared checklist. After statistical analysis the accuracy was calculated. Results A total of 4732 patients were included (mean age 68.1 ± 19.7 years) of which 2830 (59.8%) were men. These cases reported by 173 EMDs that the EMDs mean age was 27.7±3.7 years, and they were all women. Cardiac arrest prevalence based on final diagnosis (gold standard) was 37.4% (95% CI: 36.0–38.8). Sensitivity and specificity of OHCA diagnosis by EMDs was 78.6% and 92.4%, respectively. Positive predictive value, negative predictive value and accuracy were 86.1% (95% CI: 84.5–87.6), 87.8% (95% CI: 86.8–88.8) and 87.3% (95% CI: 86.3–88.2), respectively. The sensitivity of diagnosis increased with increasing EMD's work experience and also increasing the number of reported OHCA cases. Conclusion Based on the results, accuracy of OHCA diagnosis by EMDs was almost 87%. It is likely that more experienced EMDs or those with more experience diagnosing OHCA are better at recognising OHCA.

Characteristics, course and outcomes of children admitted to a paediatric intensive care unit after cardiac arrest

Background. Cardiac arrest is a potentially devastating event, associated with death or severe neurological complications in survivors. There is little evidence on paediatric cardiac arrest prevalence, characteristics and outcomes in South Africa (SA). Objective. To describe the characteristics, course and outcomes of children admitted to an SA paediatric intensive care unit (PICU) following cardiac arrest. Methods. Retrospective descriptive study of routinely collected data (January 2010 - December 2011). Results. Of 2 501 PICU admissions, 110 (4.4%) had preceding cardiac arrest. The median (interquartile range (IQR)) age of children was 7.2 (2.5 - 21.6) months. In-hospital arrests accounted for 80.6% of the events. The most common primary diagnostic categories were respiratory (29.1%), cardiovascular (21.4%) and gastrointestinal (21.4%). Twenty-four patients (23.3%) arrested during endotracheal intubation. Cardiopulmonary resuscitation (CPR) was applied for a median (IQR) of 10 (5 - 20) minutes. Duration of CPR for non-survivors and survivors was 17.5 (10 - 30) v. 10 (5 - 15) minutes ( p =0.006). PICU mortality was 38.8%, with half of the deaths occurring within 24 hours of admission. The standardised mortality ratio was 0.7. The median (IQR) length of stay in the PICU and hospital was 3 (1 - 8) and 27 (9 -52) days, respectively. No independent predictors of mortality were identified. Thirty-nine surviving patients (76.5%) had normal neurological function or mild disability at follow-up after hospital discharge. Six (11.8%) survived with severe disability. Conclusion. Mortality was lower than predicted in children admitted to the PICU following cardiac arrest. The majority of survivors had good neurological outcomes.

Cardiac Arrest and Mortality Related to Intubation Procedure in Critically Ill Adult Patients: A Multicenter Cohort Study.

To determine the prevalence of and risk factors for cardiac arrest during intubation in ICU, as well as the association of ICU intubation-related cardiac arrest with 28-day mortality. Retrospective analysis of prospectively collected data. Sixty-four French ICUs. Critically ill patients requiring intubation in the ICU. None. During the 1,847 intubation procedures included, 49 cardiac arrests (2.7%) occurred, including 14 without return of spontaneous circulation (28.6%) and 35 with return of spontaneous circulation (71.4%). In multivariate analysis, the main predictors of intubation-related cardiac arrest were arterial hypotension (systolic blood pressure < 90 mm Hg) prior to intubation (odds ratio = 3.406 [1.797-6.454]; p = 0.0002), hypoxemia prior to intubation (odds ratio = 3.991 [2.101-7.583]; p < 0.0001), absence of preoxygenation (odds ratio = 3.584 [1.287-9.985]; p = 0.0146), overweight/obesity (body mass index > 25 kg/m; odds ratio = 2.005 [1.017-3.951]; p = 0.0445), and age more than 75 years old (odds ratio = 2.251 [1.080-4.678]; p = 0.0297). Overall 28-day mortality rate was 31.2% (577/1,847) and was significantly higher in patients who experienced intubation-related cardiac arrest than in noncardiac arrest patients (73.5% vs 30.1%; p < 0.001). After multivariate analysis, intubation-related cardiac arrest was an independent risk factor for 28-day mortality (hazard ratio = 3.9 [2.4-6.3]; p < 0.0001). ICU intubation-related cardiac arrest occurs in one of 40 procedures with high immediate and 28-day mortality. We identified five independent risk factors for cardiac arrest, three of which are modifiable, possibly to decrease intubation-related cardiac arrest prevalence and 28-day ICU mortality.

Abstract TP166: Frequency of Brain Death in Acute Cerebrovascular Disease Related Mortality

Background: Despite the frequent occurrence of brain death in intensive care unit, the prevalence rate of brain death in ischemic stroke (IS), intracranial hemorrhage (ICH) and subarachnoid hemorrhage (SAH) is not known at national level. In addition the prevalence of cardiac arrest in these patients is not established. Methods: From 2012, ICD-9-CM includes a specific code for brain death (348.82). Brain death patients were identified from the nationwide in-patient sample database for the years 2012 to 2014. Associated in-hospital cardiac arrest patients were also identified under each category. Demographics, medical comorbidities, in-hospital complications, procedures, length of stay and hospital charges were compared. Results: Rate of brain death was highest in SAH related mortality (22%, 3255 brain deaths/ 14620 in-hospital mortality), followed by ICH, (12.5%, 5760 brain deaths/ 45945 in-hospital mortality) and ischemic stroke (3%, 1840 brain death/62285 in-hospital mortality). Majority of the patients had brain death secondary to neurological insult (ICH n=5260, 91.3%; SAH n= 2625 (80.6%) and IS n=1640, 89.1%) without any secondary diagnosis of in-hospital cardiac arrest. Length of stay was shorter in patients with SAH and ICH (mean 2.92±4.13 days and 2.53±3.56 days respectively) compared to IS patients (mean 4.93 ± 10.2 days, p &lt; 0.001) suggesting brain death is an early event in hemorrhagic stroke. Conclusion: Brain death in the majority of cerebrovascular patients occurs as a result of primary neurological insult without associated cardiac arrest. It occurs much earlier in hemorrhagic stroke compared to ischemic stroke.

Epidemiology and Outcomes of Cardiac Arrest in Pediatric Cardiac ICUs.

In-hospital cardiac arrest occurs in 2.6-6% of children with cardiac disease and is associated with significant morbidity and mortality. Much remains unknown about cardiac arrest in pediatric cardiac ICUs; therefore, we aimed to describe cardiac arrest epidemiology in a contemporary multicenter cardiac ICU cohort. Retrospective analysis within the Pediatric Cardiac Critical Care Consortium clinical registry. Cardiac ICUs within 23 North American hospitals. All cardiac medical and surgical patients admitted from August 2014 to July 2016. None. There were 15,908 cardiac ICU encounters (6,498 medical, 9,410 surgical). 3.1% had cardiac arrest; rate was 4.8 cardiac arrest per 1,000 cardiac ICU days. Medical encounters had 50% higher rate of cardiac arrest compared with surgical encounters. Observed (unadjusted) cardiac ICU cardiac arrest prevalence varied from 1% to 5.5% among the 23 centers; cardiac arrest per 1,000 cardiac ICU days varied from 1.1 to 10.4. Over half cardiac arrest occur within 48 hours of admission. On multivariable analysis, prematurity, neonatal age, any Society of Thoracic Surgeons preoperative risk factor, and Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery mortality category 4, 5 had strongest association with surgical encounter cardiac arrest. In medical encounters, independent cardiac arrest risk factors were acute heart failure, prematurity, lactic acidosis greater than 3 mmol/dL, and invasive ventilation 1 hour after admission. Median cardiopulmonary resuscitation duration was 10 minutes, return of spontaneous circulation occurred in 64.5%, extracorporeal cardiopulmonary resuscitation in 27.2%. Unadjusted survival was 53.2% in encounters with cardiac arrest versus 98.2% without. Medical encounters had lower survival after cardiac arrest (37.7%) versus surgical encounters (62.5%); Norwood patients had less than half the survival after cardiac arrest (35.6%) compared with all others. Unadjusted survival after cardiac arrest varied greatly among 23 centers. We provide contemporary epidemiologic and outcome data for cardiac arrest occurring in the cardiac ICU from a multicenter clinical registry. As detailed above, we highlight high-risk patient cohorts and periods of time that may serve as targets for research and quality improvement initiatives aimed at cardiac arrest prevention.

Relationship of Hospital Costs With Mortality in Pediatric Critical Care: A Multi-Institutional Analysis.

With increasing emphasis on high "value" care, we designed this study to evaluate the relationship between hospital costs and patient outcomes in pediatric critical care. Post hoc analysis of data from an existing administrative national database, Pediatric Health Information Systems. Multivariable mixed effects logistic regression models were fitted to evaluate association of hospital cost tertiles with odds of mortality after adjusting for patient and center characteristics. Forty-seven children's hospitals across the United States. Patients 18 years old or younger admitted to a PICU at a Pediatric Health Information Systems participating hospital were included (2004-2015). None. A total of 917,663 patients from 47 hospitals were included. Median cost per patient was $42,181 in the low-cost hospitals (341,689 patients, 16 hospitals), $56,806 in the middle-cost hospitals (310,293 patients, 16 hospitals), and $82,588 in the high-cost hospitals (265,681 patients, 15 hospitals). In unadjusted analysis, patients cared for in the high-cost tertile hospitals were younger in age, associated with more comorbidities, had higher resource utilization (including extracorporeal membrane oxygenation and nitric oxide), had higher prevalence of cardiac arrest, and were associated with worse outcomes (including mortality). In adjusted analysis, high-cost tertile hospitals were not associated with improved mortality, when compared with low- and medium-cost tertile hospitals (low cost vs high cost: odds ratio, 0.99; 95% CI, 0.79-1.25 and middle cost vs high cost: odds ratio, 1.10; 95% CI, 0.86-1.41). When stratified by diagnoses category, we noted similar trends among cardiac and noncardiac patients. This large observational study did not demonstrate any relationship between hospital costs and patient outcomes in children with critical illness. Further efforts are needed to evaluate quality-cost relationship and high value care in critically ill children across centers of varying volume by linking data from clinical and administrative databases.

Student paramedic rapid sequence intubation in Johannesburg, South Africa: A case series.

IntroductionPre-hospital rapid sequence intubation was introduced within paramedic scope of practice in South Africa seven years ago. Since then, little data has been published on this high-risk intervention as practiced operationally or by students learning rapid sequence intubation in the pre-hospital environment. The objective of this study was to describe a series of pre-hospital rapid sequence intubation cases, including those that South African University paramedic students had participated in.MethodsA University clinical learning database was searched for all endotracheal intubation cases involving the use of neuromuscular blockers between 1 January 2011 and 31 December 2015. Data from selected cases were extracted and analysed descriptively.ResultsData indicated that most patients were young adult trauma victims with a dominant injury mechanism of vehicle-related accidents. The majority of cases utilised ketamine and suxamethonium, with a low rate of additional paralytic medication administration. 63% and 72% of patients received post-intubation sedation and analgesia, respectively. The overall intubation success rate from complete records was 99.6%, with a first pass success rate of 87.9%. Students were successful in 92.4% of attempts with a first-pass success rate of 85.2%. Five percent of patients experienced cardiac arrest between rapid sequence intubation and hospital arrival.DiscussionStudents demonstrated a good intubation success and first pass-success rate. However, newly qualified paramedics require strict protocols, clinical governance, and support to gain experience and perform pre-hospital rapid sequence intubation at an acceptable level in operational practice. More research is needed to understand the low rate of post-intubation paralysis, along with non-uniform administration of post-intubation sedation and analgesia, and the 5% prevalence of cardiac arrest.

Cardiac Arrest in Pediatric Patients Receiving Azithromycin

To compare outcomes of pediatric patients treated with azithromycin compared with penicillin or cephalosporin. We hypothesized that azithromycin use would not be associated with increased cardiac mortality in the pediatric population. Retrospective cohort study from the Pediatric Health Information System database between 2008 and 2012. Patients <19 years of age with a principal diagnosis of community-acquired pneumonia who received an antibiotic were included. Primary outcomes were cardiopulmonary resuscitation (CPR) and mortality. Secondary outcomes were ventricular arrhythmias incidences and readmission for ventricular arrhythmia. Statistical analysis was performed with the χ2 test. Multivariable analysis was performed to control for potential confounders among patient, event, and treatment characteristics. A total of 82 982 patients (54.3% males) met study criteria. Median age was 2.6 years (IQR 1.2-5.9 years) and median length of stay was 2 days (IQR 2-4 days). Azithromycin was used in 5039 (6.1%); penicillin or cephalosporin was used in 77 943 (93.9%). Overall prevalence of antibiotic-associated CPR was 0.14%. Patients receiving a macrolide antibiotic had a lower prevalence of CPR compared with patients receiving a penicillin or cephalosporin (0.04% vs 0.14%, P = .04), and there was no difference in mortality. Multivariable analysis did not find an association between macrolide use and CPR. In contrast to recent adult studies, among children hospitalized for community-acquired pneumonia, azithromycin use was not associated with a greater prevalence of cardiac arrest compared with penicillin or cephalosporin use.