Abstract 18883: Inflammatory Bowel Disease is Not Significantly Associated With Cardiac Arrest in STEMI Patients

Abstract

Introduction: Systemic inflammatory diseases, such as psoriasis, lupus, and rheumatoid arthritis, have exhibited a strong association with an increased incidence of cardiovascular events over a patient’s lifetime. However, there is limited information regarding outcomes, particularly cardiac arrest, in STEMI patients with concurrent IBD. Thus, our study aims to assess potential outcomes, including cardiac arrest, in STEMI patients with IBD, utilizing a nationally representative sample of adult individuals in the United States, with a specific focus on MACE and associated risk factors. Our study provides valuable insights into the cardiovascular implications and associated risk factors in this unique patient population. Methods: The US-based National Inpatient Sample was queried between 2015 and 2020 using ICD-10 codes for adults ≥ 18 years with STEMI with and without IBD. The adjusted odds ratio of index hospitalization outcomes was calculated using a multivariate logistic regression analysis. Results: Overall, 3,960 out of 898,525 (0.44%) STEMI patients reported a history of IBD. Patients with IBD were predominantly middle aged, white, and female compared to non-IBD patients. STEMI patients with IBD had similar CVD risk factors (specifically hypertension and obesity) than non-IBD patients (P > 0.05), however the prevalence of smoking and diabetes were lower in IBD patients (P < 0.001). Notably, STEMI patients with IBD had a lower prevalence of cardiac arrest compared to their non-IBD counterparts (P < 0.001). However on adjustment for baseline CVD risk factors and hospital characteristics, no significant difference was appreciated (P = 0.25) (Table 1). Conclusions: In a nationally representative adult US population IBD was not shown to confer an increased risk of cardiac arrest in patients with a history of STEMI. These findings underscore the need for further investigation to elucidate the complex relationship between IBD and cardiovascular outcomes.