Background: Burnout is defined as a long-term work stress. The prevalence of burnout syndrome among nurses is 42% of nurses in England. Many countries have conducted studies to measure the level of burnout among health care providers. There is a lack of research on burnout among healthcare providers in the Arabic countries. Aims: This study aimed to assess the burnout level among healthcare providers in Saudi Arabia and United Arab Emirates and to predict the burnout factors of healthcare providers working in tertiary private hospitals. Methods: A descriptive cross-sectional survey was used to evaluate the burnout among healthcare providers. A total of 900 healthcare providers working in the clinical areas of six private hospitals in the Arabia Gulf Region were recruited for the study. A total of 892 healthcare providers were included in the study. A total of eight surveys were excluded due to major missing data. Results: A total of 892 healthcare providers were included in the study. The average age was 32 years ± 7 years for male and female healthcare providers. A high burnout level was found in the results. The participating female healthcare providers had a higher level of emotional exhaustion as compared with their male counterparts. Nurses had more emotional exhaustion as compared with physicians, respiratory therapists, and other colleagues. Conclusions: High burnout levels among healthcare providers can reflect negatively on the healthcare providers well-being, job satisfaction, and mental health. Burnout has been linked with medical errors and physician–patient relationships. We believe that it is important to deal with this issue of public health in Saudi Arabia and UAE. This study aimed to explore burnout levels among healthcare providers in Saudi Arabia and UAE. Results showed a high level of burnout among the healthcare.