Prevalence Of Breast Cancer Research Articles

Overview of Early Detection for Breast Cancer: Current Status and Future Perspectives

Cancer remains a formidable challenge in our modern society, and breast cancer has emerged as the most prevalent form of cancer among women worldwide. Timely detection of breast cancer holds immense potential for improving the lives of countless women globally. In this comprehensive review, we delve into the multifaceted factors that contribute to the prevalence of breast cancer among women from diverse socioeconomic backgrounds. We explored the intricate interplay of genetics, lifestyle choices, and environmental influences that contribute to breast cancer susceptibility. Additionally, we discussed the well-established screening methods, particularly mammography, which has revolutionized the early detection of breast cancer. Moreover, we highlight the advancements in the development of biomarkers that offer a simple and convenient alternative to overcome the limitations of mammography. Furthermore, we examine the pivotal role that artificial intelligence plays in enhancing breast cancer detection, presenting its potential to revolutionize diagnostic approaches and improve overall outcomes. Through this review, we aim to provide valuable insights into the various aspects of breast cancer detection, facilitating informed decision-making and advancing the fight against this formidable disease.

Aktivitas Tabir Surya Pada Formulasi GEL Mengandung Ekstrak Etanol Daun Kersen (Muntingia Calabura Linn) Secara In Vitro

The prevalence of breast cancer in the city of Surakarta was the second highest cancer prevalence in the province of Central Java in 2013, namely 678 cases, while in the city of Semarang as the first place there were 832 cases and the city of Magelang as the third place there were 348 cases. Kersen leaves (Muntingia Calabura L) have a high total flavonoid and phenol content so they can be used as a basic ingredient for making sunscreen gel. The aim of this research was to determine the sunscreen activity of a gel formulation containing ethanol extract of cherry leaves (Muntingia calabura L), the effective dosage, and the good quality of the preparation. This type of research uses quantitative analytical experimental methods. Kersen leaf ethanol extract sunscreen gel was made using Carbopol 940 base. Three formulas were made with a Carbopol base concentration of 1% and varying doses of cherry leaf extract 4%, 6%, 9%. The total flavonoid content of cherry leaves was 21.55 mg QE/g. The result of physical characteristics of FI (pH 4,82 ; Viscosity 250 dpas ; Spreadability 6,05 cm ; Adhesion 3,57cm), FII (pH 5,41 Viscosity 330 dpas ; Spreadability 5,79 cm ; Adhesion 4,43 cm), FIII (pH 5,84 Viscosity 360 dpas ; Spreadability 5,21 cm ; Adhesion 4,64 cm) and FIV (pH 4,63 ; Viscosity 170 dpas ; Spreadability 6,14 cm ; Adhesion 4,88 cm). The SPF values ??produced at extract concentrations of 4% (FI), 6% (FII), 9% (FIII) were 17.02; 34.74, and 40.09. The highest SPF value is found in FIII, namely 40.09, which is included in the ultra protection category with a cherry leaf extract concentration of 9%.

Reply to "Increased Prevalence of Breast and All-cause Cancer in Female Orthopedic Surgeons": Alcohol Consumption as a Possible Contributing Factor.

Reply to "Increased Prevalence of Breast and All-cause Cancer in Female Orthopedic Surgeons": Alcohol Consumption as a Possible Contributing Factor.

Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model.

The prevalence of breast cancer (BC) continues to increase and is the leading cause of cancer deaths in many countries. Numerous in vitro and in vivo studies have demonstrated that 2-methoxyestradiol (2-ME) has antiproliferative and antiangiogenic effects in BC, thereby inhibiting tumour growth and metastasis. We compared the effect of 2-ME in early- and late-stage BC using a transgenic mouse model-FVB/N-Tg(MMTV-PyVT)-of spontaneously development of aggressive mammary carcinoma with lung metastasis. Mice received 100 mg/kg 2-ME treatment immediately when palpable mammary tumours were identified (early-stage BC; Experimental group 1) and 28 days after palpable mammary tumours were detected (late-stage BC; Experimental group 2). 2-ME was administered via oral gavage three times a week for 28 days after initiation of treatment, whereas control mice received the vehicle containing 10% dimethyl sulfoxide and 90% sunflower oil for the same duration as the treatment group. Mammary tumours were measured weekly over the 28 days and at termination, blood, mammary and lung tissue were collected for analysis. Mice with a tumour volume threshold of 4000 mm3 were killed before the treatment regime was completed. 2-ME treatment of early-stage BC led to lower levels of mammary tumour necrosis, whereas tumour mass and volume were increased. Additionally, necrotic lesions and anti-inflammatory CD163-expressing cells were more frequent in pulmonary metastatic tumours in this group. In contrast, 2-ME treatment of late-stage BC inhibited tumour growth over the 28-day period and resulted in increased CD3+ cell number and tumour necrosis. Furthermore, 2-ME treatment slowed down pulmonary metastasis but did not increase survival of late-stage BC mice. Besides late-stage tumour necrosis, none of the other results were statistically significant. This study demonstrates that 2-ME treatment has an antitumour effect on late-stage BC, however, with no increase in survival rate, whereas the treatment failed to demonstrate any benefit in early-stage BC.

Economic burden of breast cancer: a case of Southern Iran

BackgroundBreast cancer is one of the main causes of death from cancer around the world, imposing a significant economic burden on the families and healthcare system. The present study aimed at determining the economic burden of breast cancer in the patients referred to the medical centers in Fars province in southern Iran in 2021.MethodsThis cross-sectional study is a partial economic evaluation and a cost-of-illness study with a bottom-up and prevalence-based approach, conducted in Fars province in southern Iran in 2021 from the societal perspective. A total of 230 patients were randomly included in the study, and a researcher-made data collection form was used to collect the required data. The data on direct medical costs were collected using the information on patients’ medical and financial records. On the other hand, the data on direct non-medical and indirect costs were obtained using self-reports by the patients or their companions. The Excel 2016 software was used to analyze the collected data.ResultsThe results showed that the annual cost of each breast cancer patient in the studied sample was 11,979.09 USD in 2021. Direct medical costs accounted for the largest share of costs (70.69%, among which the cost of radiotherapy was the highest one. The economic burden of the disease in the country was estimated at 193,090,952 USD.ConclusionsIn general, due to the high prevalence of breast cancer and the chronicity of this disease, its medical costs can impose a heavy economic burden on society, the health system, the insurance system, and patients. Thus, in order to reduce the costs, the following suggestions can be offered: the use of advanced radiotherapy techniques, increasing the insurance coverage of required services, establishing low-cost accommodation centers near medical centers for the patients and their companions, providing specialized medical services for the patients in towns, using the Internet and virtual space to follow up the treatment of the patients, and carrying out free screening programs and tests for faster diagnosis of the infected patients and susceptible or exposed people.

Screening of Oral Tamoxifen Ocular Toxicity in Breast Cancer Patients

Background Breast cancer is one of the leading cancer types among females worldwide. Prevalence of breast cancer is reported to be the second most common among women. Several treatment lines were prescribed in treatment of breast cancer besides surgical, radiological interventions. Tamoxifen is one of the medical treatments used in postsurgical prophylaxis of breast cancer. Various visual problems were reported with tamoxifen therapy. These include posterior subcapsular cataracts, color vision changes, optic neuritis, and intra-retinal crystals. Aim of the Work The aim of the work was to screen for ocular toxicity of tamoxifen used for treatment of breast cancer patients having no ophthalmic complains and treated with tamoxifen for at least 2 years with dose (20mg per day). Patients and Methods We included 50 female patients with breast cancer treated with Tamoxifen therapy for at least 2 years then we divided them into two groups regarding duration of tamoxifen intake from (2-4) years group and from (5-8) years group, all subjects underwent complete careful history taking and full ophthalmological examination, BCVA was measured using Snellen chart with conversion to log. MAR notation for statistical analysis. Results There was significant correlation between duration of tamoxifen intake and RPE mottling, no other significant correlations were detected, there was no significant difference in mean of BCVA, IOP, cup values, disc parameters, GCC thickness, RNFL zones between the two groups except for (inferior quadrant), macular thickness except in (superior quadrant), OCT layers thinning shows RNFL affection in (34%) of cases, GCC affection in (48%) of cases and macula affection in (64%) of cases, color vision defects was found in (12%) and electrophysiological test changes found in few cases. Conclusion Tamoxifen therapy causes minimal affection on the ocular structure and function, OCT layers thinning (34-64% of cases) preceed the clinical changes this highlights the importance of OCT examination in those patients to evaluate tamoxifen toxicity and further studies will be needed to evaluate reversibility of these changes after stoppage of therapy, main ocular complications associated with tamoxifen therapy were correlated to duration of treatment.

Breast cancer classification using deep learned features boosted with handcrafted features

Breast cancer is one of the leading causes of death among women across the globe. It is difficult to treat if detected at advanced stages. However, early detection can significantly increase chances of survival and improves the lives of millions of women. Given the widespread prevalence of breast cancer, it is of utmost importance for the research community to provide comprehensive framework encompassing early detection, classification, and diagnosis. The artificial intelligence research community, in coordination with medical practitioners, is developing such frameworks to automate the task of detection. With the surge in research activities coupled with the availability of large datasets and enhanced computational powers, it is expected that AI framework results will help even more clinicians in making correct predictions. In this article, a novel framework for the classification of breast cancer using mammograms is proposed. The proposed framework not only uses features extracted from Convolutional Neural Network (CNN) but also combines these features with handcrafted features (Histogram of Oriented Gradients (HOG) and Local Binary Pattern (LBP)) which helps in embedding domain expert knowledge, a step towards making proposed framework transparent. Experimental results conducted on the CBIS-DDSM dataset demonstrate that the proposed framework outperforms the current state-of-the-art methods in breast cancer classification.

Implementation of Health Education Counseling on Breast Self Examination (BSE) with Android Media on Breast Cancer Prevention Behavior in Balikpapan

Background: Breast cancer is a frightening disease for women. The prevalence of breast cancer in Indonesia is 109 per 100,000 population. The most cancer in EastKalimantan in 2014 was breast cancer with 179 people and in 2015 it rose to 424 people, this case experienced an increase of 56.28%. Aims: The aim of the researchers was to implement breast self-examination health education counseling (BSE) with Android media on breast cancer prevention behavior in Balikpapan. Method: This research method is a quasi-experimental study with a one-group pre-test and post-test design. The sample in this study was 2 groups of cadres totaling 50 people, each 25 people in the control group and 25 in the intervention group with ages 18-55 years. Results: The results of the study showed an increase in knowledge (good 48%, enough 40%, less 12%) and increased behavior about BSE (good 44%, enough 48%, less 8%), there was a difference in knowledge before and after being given BSE counseling using android media (p-value = 0.362). There are differences in behavior before and after being given the BSE counseling treatment using Android media (p-value = 0.607). Conclusion: Providing counseling using Android media provides better benefits.

A case-control study on the association between adherence to a Mediterranean-style diet and breast cancer.

Previous studies on the association between diet and breast cancer are mostly from Western populations, and data from Middle East countries are scarce, where the prevalence of breast cancer is high; therefore, it ranks first among other cancers. This population-based case-control study aimed to investigate the relationship between a Mediterranean-style diet and breast cancer among Iranian women. In the current study, 350 new cases of breast cancer and 700 age- and socioeconomic status-matched controls were enrolled. We evaluated the dietary intakes of participants by using a 106-item Willett-format semi-quantitative dish-based food frequency questionnaire (SQ-FFQ). We calculated the Mediterranean diet score according to the dietary intakes of participants. In addition, using pre-tested questionnaires, we collected information on potential confounding variables. In this study, we found a significant inverse association between the Mediterranean diet and breast cancer so that after controlling for potential confounders, individuals in the highest tertile of the Mediterranean diet score compared with those in the lowest tertile were 57% less likely to have breast cancer [odds ratio (OR): 0.43, 95% confidence interval (CI): 0.28-0.67]. Such an inverse association was also observed for postmenopausal women. Similarly, after controlling for potential confounding variables, high adherence to the Mediterranean dietary pattern was associated with lower odds of breast cancer (OR: 0.37, 95% CI: 0.23-0.60). However, this relationship was not significant among premenopausal women. We found that adherence to Mediterranean dietary pattern was associated with reduced odds of breast cancer. Studies with prospective design are needed to further examine this association.

Relationship between polymorphisms in the CD40 gene with the prevalence of breast cancer: A case-control study

Background. Breast cancer with a complex inheritance pattern is a major cause of cancer death among women worldwide. Single nucleotide polymorphisms (SNPs), the most common genetic variations, influence interindividual predisposition to disease and treatment outcomes with drugs. Evidence suggests that CD40 polymorphism contributes to pathogenesis of cancer. The co-stimulatory molecule CD40 plays a prominent role in immune regulation. This study aimed to test the association between polymorphisms in the CD40 gene and breast carcinogenesis in Arak, Iran. Methods. In this case-control study, three SNPs (rs1883832, rs4810485, rs3765459) were genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. We included 80 patients with breast cancer and 80 healthy controls. Statistical analysis was performed by SPSS (version 26) using Chi-Squared test at P˂ 0.05. Results. Our data showed a statistically significant association between the two CD40 SNPs (1s1883832 and rs4810485) and breast cancer risk (P=0.038 and P=0.000, respectively). There was no significant association between rs3765459 and breast cancer risk (P=0.190). Conclusion. We witnessed that CD40 gene polymorphisms (rs1883832 and rs4810485) contributed to breast cancer. So, they are associated with breast cancer risk. Practical Implications. The obtained data revealed a significant relationship between the rs1883832 and rs4810485 polymorphisms and the risk of breast cancer. Thus, these polymorphisms could be used as biomarkers to predict breast cancer.

The Efficacy of Mindfulness-Based Cognitive Therapy on Disease Perception, Body Image, and Fear of Cancer Recurrence in Women with Breast Cancer

Background: Currently, the prevalence of breast cancer and its debilitating consequences are increasing, causing adverse personal, family, and social effects in patients. Therefore, patients with breast cancer should try to reduce the injuries described above through various treatment methods. Objectives: This study aimed to assess the efficacy of mindfulness-based cognitive therapy (MBCT) on disease perception, body image, and fear of cancer recurrence in women with breast cancer. Methods: This applied study was designed based on a pre-test and post-test. The study included 30 participants, 15 test groups (15 people), and 15 control groups (15 people). A test group was used for MBCT, while the other was not exposed to the intervention. Eight 90-minute sessions were held weekly for the test group for two months. The research tools included the Broadbent Illness Perception Questionnaire (BIPQ), Multidimensional Body-Self Relations Questionnaire (MBSRQ), and Fear of Cancer Recurrence Inventory Questionnaire (FCRIQ). Finally, the resulting data were analyzed by SPSS software Version 25. Results: The statistical test of covariance analysis showed that the MBCT method significantly affects disease perception, body image, and fear of disease recurrence in women with breast cancer (P < 0.05). Conclusions: Based on the results, the MBCT method can help manage breast cancer in women. Therefore, breast cancer patients can improve their quality of life and life expectancy by learning this treatment method.

Temporal Variation of Treatment Patterns and Survival Outcomes of Triple-Negative Breast Cancer Patients: A Real-World Experience From 2000 to 2014

BackgroundPrevious studies have reported a higher prevalence of triple-negative breast cancer (TNBC) in US Hispanic/Latina populations. However, survival outcomes and treatment approaches over time in Latin American females are scarcely reported. We aimed to evaluate the temporal variation in treatment patterns and overall survival (OS) outcomes of females with TNBC according to cancer stage. Materials and MethodsWe performed a single-center retrospective cohort study on 1840 females from 2000 to 2014. Patients were classified in 3 calendar periods (2000-2004, 2005-2009, and 2010-2014). The Kaplan-Meier method and multivariable regression analyses were employed. ResultsStage III cancer was identified in half of the population. Five-year OS estimates for cancer stages I, II, and IV remained unchanged across all calendar periods. However, we found worsening 5-year OS estimates in stage III females (49% in 2000-2004 and 31% in 2010-2014; P < .001). Despite increased uptake of overall use of neoadjuvant therapy in stage III females, the time from diagnosis to treatment initiation (P = .013) and time to complete the planned cycles (P < .001) increased over time. Fifty-sex percent of stage IV patients were untreated. Females aged ≥70 years were less likely to receive treatment. ConclusionsSurvival estimates were lower than those reported in high-income countries. Most females were diagnosed with advanced disease, and the OS for stage III females worsened over time. Our outcomes show difficulties in delivering timely neoadjuvant therapy in an overwhelmed healthcare system. Public health authorities should improve screening practices, develop regional clinical guidelines, and expand trial enrollment.

Distinct cardiovascular and cancer burdens associated with social position, work environment and unemployment: a cross-sectional and retrospective study in a large population-based French cohort

ObjectivesDistinguish the respective effects of social position, work environment and unemployment on cardiovascular and cancer risks.DesignA cross-sectional and retrospective observational study.SettingA population-based French cohort (CONSTANCES).Participants130 197 adults enrolled between 2012...

Bra Usage Duration and Breast Cancer Risk: A Case-Control Study

Introduction: Breast cancer is a disease feared by most women, with 2.3 million women worldwide being diagnosed with this disease. In 2024, Indonesia will relocate its capital to East Kalimantan Province, which currently has the second-highest (1%) prevalence of breast cancer cases in Indonesia. Objective: Given the increasing prevalence of breast cancer, it is worthwhile to scientifically examine the relationship between the duration of bra usage, age at first bra usage, bra size suitability, and types of bras used in relation to the occurrence of breast cancer. Method: The study design used was a case-control study with a 1:1 ratio of 48 respondents (24 cases and 24 controls) selected through purposive sampling. The analysis employed chi-square and odds ratio tests. Results: The study revealed that the average age of the respondents was 45.25 years. Furthermore, the variables of bra usage duration (OR=2.333), age at first bra usage, bra size suitability, and bra type (OR=0.639) showed no association with the occurrence of breast cancer (α&gt;0.05). Conclusion: This research concludes that there is no association between bra usage and the occurrence of breast cancer in women in East Kalimantan Province. Recommendation: It is suggested to reduce the duration of bra usage to less than 24 hours to minimize the risk factors for breast cancer.

Ayurveda treatment strategy in management of advanced breast cancer in elderly female- A case report with review of literature

Breast cancer is the most common malignancy among women globally and in India. The higher prevalence of advanced breast cancer (ABC) in elderly women is attributable to delayed diagnosis, lack of sufficient health care resources and high costs for conventional treatment). Also, the modern treatment very extensive for ABC cases with surgery, chemotherapy and radiotherapy with little compliance for elderly patients and mortality is mostly linked to the side-effects of these advanced treatments. We report a case of advanced breast cancer (locally advanced to axillary nodes and skeletal muscles) in 76 year-old-female patient who presented with initially with in right subscapular region and insomnia after conventional chemotherapy. She opted for complete Ayurvedic treatment over 8 months which led to complete regression of cancer and local sites. The aim of the case report is present the symptoms, treatment regimens, and dietary modifications of such a case with basic literature review on Ayurveda treatment of breast cancers.

The Association Between Meningioma and Breast Cancer

A potential relationship between meningioma and breast cancer was suggested 70 years ago. However, to date, no conclusive evidence is available on this topic. To provide a comprehensive review of the literature on the association of meningioma with breast cancer, supported by a meta-analysis. A systematic PubMed search was performed up to April 2023 to identify articles on the association of meningioma with breast cancer. The following key words were used strategically: meningioma, breast cancer, breast carcinoma, association, relation. All studies reporting women diagnosed with meningioma and breast cancer were identified. The search strategy was not limited by study design or publication date but only included articles in English. Additional articles were identified via citation searching. Studies reporting a complete population of meningiomas or breast cancer patients throughout a specific study period and a proportion of patients with a second pathology could be used for the meta-analysis. Data extraction was performed by 2 authors in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. Meta-analyses regarding both populations were performed using a random-effects model. Risk of bias was assessed. The main measures were whether there was an increased prevalence of breast cancer in female patients with meningioma and whether there was an increased prevalence of meningioma in female patients with breast cancer. A total of 51 retrospective studies (case reports, case series, and cancer registry reports) describing 2238 patients with both diseases were identified; 18 studies qualified for prevalence analyses and meta-analysis. The random-effects meta-analysis (13 studies) revealed a significantly greater prevalence of breast cancer in female patients with meningioma than in the overall population (odds ratio [OR], 9.87; 95% CI, 7.31-13.32). Meningioma incidence in patients with breast cancer (11 studies) was greater than that in the baseline population; however, the difference according to the random-effects model was not statistically significant (OR, 1.41; 95% CI, 0.99-2.02). This large systematic review and the meta-analysis on the association between meningioma and breast cancer found nearly 10-fold higher odds of breast cancer in female patients with meningioma compared with the general female population. These findings suggest that female patients with meningioma should be screened more intensively for breast cancer. Further research is required to identify the factors causing this association.

Effect of air pollution on the prevalence of breast and cervical cancer in China: a panel data regression analysis.

The association between the prevalence of breast and cervical cancer in Chinese women and air pollution is obscure. The study aims to analyze the correlation between air pollution and the prevalence of breast and cervical cancer, and whether the gross domestic product (GDP) has a modifying effect on the impact of air pollution on the prevalence of breast and cervical cancer. Extracting panel data from 31 provinces and cities between 2006 and 2020, we evaluated the association between breast and cervical cancer prevalence and pollutant emissions from 2006 to 2015 with two-way fixed-effect models. We also analyzed the interaction between GDP and pollutant emissions and further check the robustness of the moderating effect results using group regression from 2016 to 2020. Cluster robust standard errors were used to correct for the heteroskedasticity and autocorrelation. The coefficients of models show that the coefficients of logarithmic soot and dust emissions are estimated to be significantly positive, and the coefficients of their square terms are significantly negative. The robust results suggest that the relationship between soot and dust emissions and breast or cervical cancer prevalence is non-linear, from 2006 to 2015. In the analysis of particulate matter (PM) data in 2016-2020, the PM-GDP interaction term was also significantly negative, indicating that GDP growth weakened the effect of PM on the prevalence of breast cancer and cervical cancer. In provinces with higher GDP, the indirect effect of PM emissions concerning breast cancer is -0.396 while in provinces with lower GDP, it is about -0.215. The corresponding coefficient concerning cervical cancer is about -0.209 in provinces with higher GDP but not significant in provinces with lower GDP. Our results suggest that there is an inverted U-shaped relationship between the prevalence of breast cancer and cervical cancer and air pollutants from 2006 to 2015. GDP growth has a significant negative moderating effect on the impact of air pollutants on the prevalence of breast cancer and cervical cancer. PM emissions have a higher effect on the prevalence of breast and cervical cancer in provinces with higher GDP and a lower impact in provinces with lower GDP.

Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow's Health cohort.

Chronic exposure to arsenic through drinking water has been linked to several cancers. The metabolism of arsenic is thought to play a key role in arsenic-related carcinogenesis as metabolites of varying toxicity are produced and either stored in or excreted from the body. Atlantic Canada has the highest age-standardized incidence rates of all cancers in the country. This may be due to its high levels of environmental arsenic and the prevalence of unregulated private wells for water consumption. Here, we aimed to characterize the profiles of arsenic species and metallome in the toenails of four cancer groups, compare them to healthy participants (N = 338), and assess potential associations between the profiles with cancer prevalence. This study employed a case-control design. Toenail samples and questionnaire data from cases (breast, cervical, prostate, and skin cancers) and controls were sourced from the Atlantic Partnership for Tomorrow's Health (PATH) cohort study. The levels of arsenic species were measured using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) paired with High Performance Liquid Chromatography (HPLC) and total concentrations of metallome (23 metals) were determined by ICP-MS separately. Multivariate analyses were conducted to compare cases with controls within each cancer group. Arsenic speciation profiles varied by cancer type and were significantly different between cases and controls in the breast (p = 0.0330), cervical (p = 0.0228), and skin (p = 0.0228) cancer groups. In addition, the profiles of metallome (nine metals) were significantly differentiated in the prostate (p = 0.0244) and skin (p = 0.0321) cancer groups, with higher zinc concentrations among cases compared to controls. History of cancer diagnosis was associated with specific profiles of arsenic species and metallome. Our results indicate that arsenic methylation and zinc levels, as measured in toenails, may be an important biomarker for cancer prevalence. Further research is needed to use toenails as a prognostic measure of arsenic-and other metal-induced cancer.

Dispelling Myths Regarding Cisgender Sexual Minority Women and Breast Cancer

Lesbian and bisexual cisgender women have higher rates of breast cancer and breast cancer mortality than their heterosexual counterparts (Committee on Lesbian, Gay, Bisexual, and Transgender Health Issues and Research Gaps and Opportunities, 2014). There is not much known about why this is the case, although most researchers revert to the common hypotheses that the increased prevalence of obesity, substance abuse, and nulliparity (not having given birth) among lesbian and bisexual women contributes to incidences of breast cancer (Committee on Lesbian, Gay, Bisexual, and Transgender Health Issues and Research Gaps and Opportunities, 2014). These hypotheses place individual responsibility on sexual minority women with breast cancer as opposed to identifying complicated, underlying structural problems. This literature review argues that homophobia and bisexual invisibility, in conjunction with fatphobia and inaccurate research methodology, have prevented clinicians and scientists from thoroughly examining the ways in which increased rates alcohol abuse, the physiological effects of stress due to discrimination, and a lower rate of receiving mammograms caused by perceived negative judgment from healthcare providers contribute to the higher prevalence of breast cancer among lesbian and bisexual women.

Women cancer early detection and linkage to care (navigation) in Rwandan community.

e18740 Background: Whilst early detection and treatment of breast and cervical cancers are increasing, a large number of cancer patients in low and middle income countries lack access to prompt, high-quality diagnosis and care.This study’s primary objective was to demonstrate real time prevalence of breast and cervical cancer from Rwandan district community and establish a link to care for timely diagnosis and treatment in order to curb the health system delays. Methods: From June 2022 January 2023, the Women's Cancer Early Detection Program (WCED) was initiated in Kicukiro district health facilities. The community health workers were Identified, training was given, centers were chosen for integrated screening then clinical breast exams /ultrasound for suspected lesions and cervical cancer screening ((HPV DNA /VIA) done. Precancerous lesions treated by thermal ablation in the community. Patient suspected for cancer were navigated to Rwanda military hospital for biopsy and treatment. Results: A total number of 4,991 were screened. 372 with abnormal findings on clinical breast exam then through ultrasound, 16 women were selected for biopsies. From the highly suspected, 13 (0.3%) confirmed positive for breast cancer. All confirmed cancer cases were staged according to AJCC 8th edition (TNM) at Rwanda cancer center. TNM staging revealed that 7 (54%) women out of those 13 were of T1-T2N0M0(early stage).They were sent to the multidisciplinary team for treatment planning and treatment with curative intent initiated. Conclusions: Rwanda biomedical center indicates that 65% of our patients arrive at treatment centers with T3-T4N1-3M0-1 (locally advanced and metastatic). The above data shows that through the integrated navigation program, there is a shift from presentation t late stage to early stage. This model is simple and easy for low and middle income countries because it ensures a proper referral process, efficient delivery of optimal care, and patient support to overcome challenges mainly due to health system delay.