Video-based teaching has become rapidly popular during the coronavirus disease 2019 (COVID-19) pandemic. The current study aimed to assess the efficacy of a hybrid video-based teaching module of oxygen therapy and critical care troubleshooting in nursing professionals managing COVID-19 patients in our institute. A retrospective analytical study (pretest and posttest design) was conducted in our medical education department in March 2022 using the data from a workshop conducted on oxygen therapy and critical care area troubleshooting during COVID-19 patient management for 296 nursing professionals. A hybrid video-based teaching module was used. Pretest and posttest data were compared along with subgroup analysis. P value <0.05 was considered significant. Posttest scores were significantly higher than the baseline scores in the overall group as well as in all subgroups (P < 0.001). Subgroup comparisons revealed no significant difference in mean baseline pretest and posttest scores in male versus female participants. Baseline pretest scores (P = 0.02) and posttest scores (P = 0.08) were lower in the nurses of the noncritical areas compared to critical area nurses. Mean improvement in posttest score compared to baseline score was similar between all groups. Hybrid technique involving both video aspects and in-person teacher presence for demonstration or troubleshooting improves perceived knowledge in nursing professionals with some prior formal training and may be superior to the conventional only didactic/lecture-based demonstrations, especially in the context of imparting rapid training during pandemics or similar urgent situations.