Pressure Rise Research Articles

Inhibition effect of inert gas jet on gas and hybrid explosions caused by thermal runaway of lithium-ion battery

When lithium-ion batteries undergo thermal runaway in a confined space, the released gases and/or vapors or dust particles can lead to an explosion. An 8L cylindrical experimental vessel was constructed to study the inert effect of inert gases on battery-vented gas (BVG) in a confined vessel. Firstly, the inhibition effect and inert mechanism of CO2 and N2 on BVG explosion were analyzed by experiments and simulation software. The results show that the inert effect of CO2 on the BVG is significantly better than that of N2. This is because CO2 is not only better than N2 in physical explosion inhibition, but also participates in the chemical reaction. Secondly, the effect of the release of high-pressure CO2 gas on the explosion of the BVG in a closed container was simulated, showing that when the BVG is near the lower explosive limit, the CO2 jet will significantly increase the rate of explosion pressure rise of the BVG. This suggests that the inhibition effect of the CO2 jet is not as good as in premixed conditions. Finally, it is found that the inhibition effect of CO2 on the hybrid explosion is better than that of CO2 jet on the BVG. Since CO2 makes oxygen insufficient, leading to a reduction in the amount of graphite dust burned. The graphite dust and CO2 have a synergistic inhibition effect on the hybrid explosion. The above findings can provide a reference for the lithium-ion battery explosion inhibition method in the process industry.

Novel Insights in the Hypertension Treatment & Type 2 Diabetics Induced by Angiotensin Receptor Blockers: MD Simulation Studies & Molecular Docking of Some Promising Natural Therapies.

Angiotensin receptor blockers (ARBs) are commonly used to treat hypertension that target the hormonal system (renin-angiotensin system (RAS)), which regulates various physiological functions in the body. ARBs work by blocking the binding of angiotensin II to its receptor, thereby preventing a rise in blood pressure. These drugs not only normalize the overactivation of RAS but also provide protective effects against cardiovascular, renal, and type 2 diabetic patients. Inappropriate RAS activity has been linked to insulin resistance of type 2 diabetes. Olmesartan, as an ARB, was found to have a beneficial role in reducing postprandial glucose levels in type 2 diabetes. However, ARBs can cause side effects, prompting a search for new compounds that have fewer adverse effects. This study explores the potential of natural metabolites, specifically eugenol, gallic acid, myricetin, p-cymene, quercetin, and kaempferol, as ARB inhibitors compared to the current standard, olmesartan. Using in silico studies, the binding affinity of these natural substances to the ARB receptor was evaluated. The results showed that myricetin and kaempferol had affinities higher than those of olmesartan, suggesting that they could serve as promising ARB inhibitors for hypertension treatment. These natural compounds could provide an alternative approach to conventional antihypertensive drugs, which may have fewer side effects. However, more research is needed to validate the efficacy and safety of these natural compounds as antihypertensive drugs. Further in vitro and in vivo studies are needed to confirm their effectiveness and safety. This study provides a promising starting point for future investigations into the potential of natural metabolites as alternative treatments for hypertension. The findings also highlight the importance of exploring natural alternative treatments for hypertension and the protective effects of ARBs on early stage type-2 diabetics.

Laser induced spark ignition of a gaseous methane–oxygen model rocket combustor

The spatio-temporal evolution of laser induced spark ignition of non-premixed gaseous methane and oxygen is investigated. The reactants are injected into an optically accessible combustion chamber from an oxidizer centered shear-coaxial injector. High-speed schlieren imaging and measurements of laser energy deposited are used to characterize ignition behavior at various spark locations throughout the chamber. A spatial map of ignition probability is generated from tests at multiple axial and radial locations from the point of propellant injection. The rate of pressure rise from successful tests reveals two modes of ignition dependent on the location of the laser-induced breakdown, direct and indirect, based on laser-induced breakdown occurring within reactant jet or in the recirculation region, respectively. Physical processes occurring over multiple timescales throughout the direct ignition method are first discussed. Ignition outcomes associated with the indirect method are determined by the hydrodynamic ejection protruding from the laser spark, the behavior of which is explored in detail using flow statistics extracted from images taken at a single spark location. The spatial–temporal progression of this jet is found to be dependent on deposited laser energy, leading to a relationship between the amount of energy added to the flow and ignition outcome. General bounds for spark location, deposited laser energy, and ejection behavior are identified to predict ignition outcomes. Cases that are an exception from these bounds are investigated in detail to understand the cause of unique behavior. These cases lie within regions of the variable space that are susceptible to stochastic elements of the flow.Novelty and Significance Statement: This work investigates laser induced spark ignition of O2 and CH4 issuing from a shear-coaxial injector in a model rocket combustor. Probability of ignition as a function of deposited energy and spatial location is studied with high-speed schlieren imaging and pressure measurements. Two distinct ignition modes that have previously not been identified, direct and indirect, are dependent on the laser deposition location with respect to the reactant jet. For indirect cases, where laser deposition is at a distance from the reactants, the hydrodynamic jet ejection generated from the breakdown of the plasma plays a critical role on ignition probability. The behavior of the ejection jet is characterized to provide a phenomenological description of the ignition process. The results of this research show the important interaction between chemical, fluid dynamic, and thermodynamic processes and their impact on laser ignition.

Investigation of convective peristaltic flow of non-Newtonian fluids through a non-uniform tapered porous conduit with Ohmic heating and viscous dissipation

ABSTRACT The study of convective magnetohydrodynamic (MHD) biofluid transport through a non-uniform duct is of interest due to its applications to biomedical devices and equipment. Because of this, a comparative study of free convective peristaltic flow of non-Newtonian (Casson and Jeffrey) fluids in a tapered porous symmetric duct with Hall current and viscous dissipation effects is carried out. The proposed dimensional governing equations are converted into a system of non-dimensional partial differential equations by invoking adequate non-dimensional parameters. Furthermore, a long-wavelength approximation is used to reduce the complexity of the system. Then the reduced system of partial differential equations is solved analytically using the regular perturbation method. The fascinating features of the influential parameters on the flow characteristics are demonstrated and analyzed in depth through graphs and tables. The results demonstrate that the velocity and temperature in the Jeffrey fluid flow are larger compared to those in the Casson fluid flow. The thermal Grashof number and the Hall current parameter enhanced the pressure rise profile. This research has significant implications in biomedical devices (MRI, vitamins A and D injections, heart-lung machines, etc.) and pharmaceutical fluid preparation in biomedical sciences.

Stimuli factor of muscular receptors, extraocular muscles and oculocardiac reflex (OCR)

Introduction: The oculocardiac reflex (OCR) was first described in 1908 as a reduction in heart rate secondary to direct pressure on the eyeball. OCR has been described during ophthalmologic procedures. This is also a standard test for peripherical autonomic and vagal system with the diving reflex and overtraining. The aim studied the specificities of stimuli of stretch receptors wich can be the traction at the extraocular muscles. Materials: 7 rabbits were included on the study. The anesthesia was done by an Intraperitoneal administration of ethyl carbamate. During all the study the rabbit is immobilized with a gripping frame for the head. Heart rate and RR were measured with EKG was recorded online. Methods: Bilateral pressure is applied using a mechanical pressure compression device, ranging from 100 to 800 mmHg, either instantaneously or in 15 or 30 seconds. For each pression we studied the variations of the RRspace (RRmax and RRt function of time) compared with the RRcontrol. If no variation, RRmax/RRcontrol and RRt/RRcontrol =1 Results: Response to abrupt compression RRmax varied linearly and significantly with pression. Response to progressive compression did not show any significant variation either during rise of pressure or when pressure was reached. Time-based response was studied from 56RR intervals. With abrut compression, the increase was effective from the first or second RR intervals. Depending on the pressure, it increased up to the 20th, presented a peak and decreased even with maintained pressure. The RR interval reverted to the control (RR/tRR = 1) around the 40th interval. With progressive stimulation, the maximum elongation value is lower, with an identical decay. Discussion: Our work showed the characteristics of stimulating factor: we used pressure on eyeballs, as in a sports medicine test (cardiac parasympathetic analysis) and in emergencies for the reduction of arrhythmias. This principal factor is tension in function of time, with an elongation of the periorbital muscles and the neuromuscular spindle. This is a proprioceptive sensory mecano-receptor sensitive to elongation. It is made up of primary neuromuscular fibers known as nuclear sac fibers and secondary neuromuscular fibers known as nuclear chain fibers. The former are 'phasic' (i.e. reacting to a variation in tension) and the latter 'tonic' (i.e. reacting directly to tension). Our work showed that the neuromuscular fibers of the nuclear sac type are stimulated by variations in tension as a function of time. Platen (1961) in ocular surgery introduced the notion of traction on the oculomotor muscles. In ‘OpenAnesthesia 2023’ Dennath Chatterjee did a synthesis work in the traction and anesthesia factors. In sports medicine, the dive reflex has been shown to be responsable of arythmia and paroxysmal supraventricular tachycardia. To trigger this reflex, several tests have beeen proposed. A recommandation during clinical examination is the OCR or Carotid glomus massage, with record of EKG and cardiac frequency. Conclusion: The OCR is defined by a reduction in heart rate from direct pressure on the eyeball. Afferent and efferent pathways are known and studied. But the stimulating factor must be studied. We have demontred that is the elongation of neuro-muscular fibers according to the time that excites the phasic fibers. This notion must be integrated both in eye surgery and in tests to highlight the cardiac parasympathetic balance, especially in sports physiology. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

The Arterial Baroreflex Buffers Muscle Metaboreflex-Induced Coronary Vasoconstriction

The ability to increase cardiac output and thereby skeletal muscle blood flow during dynamic exercise is paramount to maintaining exercise workload. Increases in cardiac output are driven via increases in heart rate, ventricular function, and central blood volume mobilization which raises arterial blood pressure, in part, due to activation of the muscle metaboreflex. The increase in cardiac sympathetic tone also activates coronary vascular alpha-adrenergic receptors which restrains increases in coronary blood flow which limits increases in ventricular function. During submaximal dynamic exercise, the muscle metaboreflex acts primarily to raise cardiac output with little net peripheral vasoconstriction. However, after sinoaortic baroreceptor denervation (SAD), the muscle metaboreflex causes increases in both cardiac output and total peripheral resistance indicating that the baroreflex buffers the muscle metaboreflex mainly via restraint of peripheral vasoconstriction. To what degree the arterial baroreflex restrains muscle metaboreflex-induced coronary vasoconstriction is unknown. Therefore, we utilized our chronically instrumented canine model to evaluate if SAD would significantly impact muscle metaboreflex-induced coronary vasoconstriction. Canines were chronically instrumented to measure cardiac output, left circumflex coronary artery blood flow, hindlimb blood flow and arterial blood pressure. During steady-state mild treadmill exercise (3.2 kph, 0% grade) the muscle metaboreflex was activated via partial inflation of vascular occluders placed distal to the hindlimb blood flow probe. Metaboreflex activation caused substantial increases in cardiac output, heart rate, cardiac power, coronary blood flow, and arterial blood pressure. Assessment of coronary vasodilation was performed via linear regression of the relationship between coronary vascular conductance (CVC; coronary blood flow/mean arterial pressure) vs. cardiac power (CP, an index of O2 demand). Experiments were performed at least 2 weeks after chronic bilateral SAD. Muscle metaboreflex activation after SAD caused a significantly greater pressor response driven by increases in both cardiac output and total peripheral resistance. Furthermore, after SAD the slope of the CVC-CP relationship was significantly lower during muscle metaboreflex activation (0.072 ml/min/mmHg/Watt, control vs 0.033 ml/min/mmHg/Watt, SAD; p<0.05) We conclude that the arterial baroreflex buffers the muscle metaboreflex and restrains the reflex coronary vasoconstriction. This baroreflex-induced restraint of metaboreflex mediated coronary vasoconstriction potentially limits metaboreflex-induced reductions myocardial oxygen delivery. Augmented coronary vasoconstriction with metaboreflex activation after SAD likely contributes to the smaller role of cardiac output in mediating the rise in arterial blood pressure after SAD, and provides further evidence that baroreflex buffering of metaboreflex responses improves cardiac function. Thus, reduced baroreflex function in heart failure may contribute to the accentuated metaboreflex coronary vasoconstriction which impairs ventricular performance during exercise in heart failure. This work was supported by the National Heart, Lung and, Blood Institute grants HL-055473, HL-126706. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Deletion of dipeptidyl peptidase 4 attenuates angiotensin II-induced blood pressure rise and enhances NHE3 phosphorylation at serine 552 in the kidneys of male and female mice

Dipeptidyl peptidase 4 (DPP4) physically associates with the Na+/H+ exchanger isoform3 (NHE3), and DPP4 inhibitors reduce NHE3-dependent sodium reabsorption in the renal proximal tubule. Angiotensin II (Ang II) is a key mediator of sodium and water retention by the kidneys, partly through the activation of proximal tubule NHE3. Recent studies from our group reveled that Ang II activates DPP4 by, both in vivo and in vitro, and that inhibition of several canonical and non-canonical pathways can suppress this activation. However, the impact of this interaction on renal sodium handling and blood pressure remains unclear. This study aimed to test the hypothesis that DPP4 deletion mitigates the blood pressure elevation induced by Ang II in male and female mice, at least partly due to the downregulation of NHE3 in the renal proximal tubule. Male and female mice with global DPP4 deletion or wild-type controls were acutely administered either a pressor dose of Ang II (1000 ng/kg/minute) or saline. Blood pressure was measured before and one hour after the administration of Ang II or saline by tail-cuff plethysmography. Kidneys were subsequently collected for protein homogenate preparation. Increased DPP4 activity was observed in response to acute Ang II stimulation in both male and female wild-type mice, with female mice exhibiting higher basal DPP4 activity. As expected, DPP4 knockout mice exhibited minimal DPP4 activity. Baseline blood pressure did not differ significantly between male wild-type and DPP4 knockout mice or between females. In line with our hypothesis, both male and female DPP4 knockout mice displayed a reduced increase in blood pressure in response to acute Ang II administration compared to their wild-type counterparts. Furthermore, the phosphorylation of NHE3 at serine 552 (pS552-NHE3), a surrogate marker of NHE3 inhibition, was higher in wild-type females than males. Interestingly, pS552-NHE3 was fivefold higher in male DPP4 knockout mice and threefold higher in female DPP4 knockout mice compared to their wild-type counterparts. Additionally, the increase in pS552-NHE3 one hour after Ang II administration was higher in males (1208 ± 119 vs. 544 ± 54 %, P < 0.01) and females (385 ± 18 vs. 271 ± 27%, P < 0.01) DPP4 knockout mice compared to wild-type animals. Moreover, ERK, a well-known effector of the AT1R signaling cascade, was phosphorylated in a similar manner as NHE3 in response to Ang II in males but not in females. In conclusion, our data demonstrate that the absence of DPP4 reduces the rise in blood pressure induced by acute Ang II stimulation, possibly through Ang II/AT1R signaling pathways influencing phosphorylation of downstream effectors such as NHE3. Furthermore, we observe significant sex differences in Ang II effects on DPP4 activity, and AT1R signaling cascades. FAPESP 2021/14524-3 NIDDKD - K08DK115886. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

AN EXPLANATION FOR UNDERESTIMATION OF SYSTOLIC PRESSURE IN CUFF-BASED MEASUREMENT

Objective: Auscultatory blood pressure measurement is the gold standard used to calibrate other measurement devices. However, auscultatory tests systematically underestimate systolic blood pressure (SBP) and overestimate diastolic blood pressure (DBP). While there is some literature explaining overestimation, there is no physical understanding of the underestimated SBP. Our objective is to understand why auscultatory measurement results in the underestimation of SBP. The SBP is recorded when the artery first begins to reopen, during cuff deflation. Prior to this, the cuff cuts off the blood supply and the pressure in the distal part of the artery drops to the venous pressure. We propose this low pressure as a cause of underestimation and investigate this through a controlled variation of the downstream pressure in an experimental rig. Design and method: Figure 1 shows a schematic of the rig. The tube representing the artery is compressed under an inflatable cuff. The downstream pressure is varied between tests. The upstream pressure is fixed with a header tank for simplicity. Therefore, the ‘blood pressure’ measured in the rig is constant rather than oscillatory, resulting in only a single opening of the artery as the cuff is deflated, rather than repeated opening and closing. This single opening is equivalent to the first opening of the artery in the body and so represents the systolic measurement. Figure 2 depicts an example test run. The cuff around the artery is gradually deflated, and the reopening of the artery is indicated by the rise of the downstream pressure (point a). The cuff pressure at this timestamp is recorded (point b), representing the measured SBP. Results: Figure 3 shows that the recorded cuff pressure is a function of downstream pressure, with the cuff reading giving greater underestimation of SBP when the downstream pressure is lowered. Conclusions: The delay in artery reopening which results from lowering the downstream pressure provides an explanation for the systematic underestimation of SBP. This information may lead to recommendations for new measurement protocol which avoid a drop in the pressure distal to the cuff, and the resulting underestimation of SBP.

Neuro-inflammatory interactions as a mediator of the Exaggerated Exercise Pressor Reflex (EPR) in a mouse model of Peripheral Artery Disease

Introduction and rationale: The Exercise pressor reflex (EPR) is a physiological mechanism in which the contraction of skeletal muscle results in a rise in heart rate (HR) and mean arterial pressure (MAP). In patients with Peripheral Artery Disease (PAD), this reflex is exaggerated, leading to abnormally high elevations in blood pressure during exercise. These cardiovascular responses in patients with PAD have been linked to increased morbidity and mortality, thus limiting the prescription of exercise for these patients. Using a novel murine model of the EPR, our laboratory has demonstrated that mice with femoral artery ligation (a well-established model of PAD), exhibit augmented increases in MAP which is mediated by PIEZO2 positive, mechanosensitive afferent neurons. We have demonstrated that inhibition of PIEZO2 expressing channels normalizes the MAP response to exercise. Patients with PAD also display increased macrophage infiltration in their ischemia-injured limbs, indicating a pro-inflammatory environment. Sensory neurons have been reported to detect various signals produced by immune cells including IL-1β and TNFα. The immune-derived signals can sensitize the peripheral terminals of the sensory neurons, thereby reducing their firing threshold and increasing their responsiveness. Previous studies have also reported the enhancement of Piezo2-mediated mechanosensitive currents in the presence of inflammatory signals. Hypothesis: We, therefore, hypothesize that in mice with femoral artery ligation, muscle inflammation increases the expression and activation of resident ion channels (e.g., Piezo2) in mechanosensitive afferent neurons to mediate the exaggerated EPR in PAD.Study objective: To mechanistically investigate the interaction between muscle inflammation and Piezo2 in mechanosensitive afferent neurons.Methods: We performed sham surgery or ligation of the femoral artery ipsilaterally in C57BL/6 mice. After 72 hours, we harvested the gastrocnemius muscle for histological and molecular analyses.Data and summary and results: Our preliminary findings reveal that there is significantly increased expression of pro-inflammatory genes and infiltrating immune cells in the ischemic muscle when compared to non-ischemic muscle.Specifically, H&E staining revealed the presence and accumulation of inflammatory cells, including macrophages, in the ischemic muscle compared to control, along with observed necrosis. Transcript analysis of the ischemic gastrocnemius muscle showed significantly increased IL-1β and TNFα, two pan-proinflammatory genes that encode cytokines released by macrophages. TNFα is known to induce the synthesis of adhesion molecules (E-selectin and ICAM-1) on endothelial cells, allowing leukocytes to adhere and cross the endothelial wall into the injured tissue. Indeed, we observed significantly increased ICAM-1 and E-selectin transcripts in the ischemic muscle compared to controls. MCP1, a well-established chemokine, was also significantly increased, further emphasizing the recruitment of leukocytes to the ischemic muscle. In addition, inducible NOS ( iNOS), which is known to be expressed in IL-1β- and TNFα-rich proinflammatory environment was also significantly increased in our FAL model compared to Sham. These data establish that the ischemic muscle of a femoral-artery ligated mouse has a high proinflammatory phenotype. We are currently exploring the impact of proinflammatory mediators on Piezo2 channel expression and activity, as well as the effect of macrophage depletion on Piezo2 in afferent neurons. The data from these studies will provide novel insights regarding the influence of neuroimmune interactions on cardiovascular responses to exercise in PAD. These data hold the potential to reveal innovative therapies enabling safe prescription of exercise, thus alleviating the burden of PAD, and improving the quality of life for those affected by this condition. Internal sources. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Long-Term Blood Pressure Control After Hypertensive Pregnancy Following Physician-Optimized Self-Management: The POP-HT Randomized Clinical Trial

(Abstracted from JAMA 2023;330:1991–1999 Worldwide, about 10% of pregnancies are affected by an abnormal rise in maternal blood pressure (BP). Individuals whose BP remains high 6 weeks after birth are more likely to have higher BP 5 to 10 years later.

RAPID ENDOGENOUS PRODUCTION OF ENDOTHELIN-1 REVEALED BY AN ENDOTHELIN NEUTRALIZING ANTIBODY IN A SERIES OF EXPERIMENTAL AND MODELING STUDIES

Objective: The endothelin pathway is implicated in driving pathophysiological changes leading to pulmonary and systemic hypertension, chronic kidney disease and heart failure. Small molecule antagonists that selectively blocked endothelin A receptors (ETA) as well as non-selective ETA and endothelin B receptor (ETB) antagonists were successfully developed for the treatment of these vascular diseases. However, the treatment-related adverse events, such as fluid retention and edema, significantly limit the utility of this class of therapeutics, especially in the heart failure patients. Design and method: A monoclonal antibody that selectively neutralizes endothelin-1 (ET-1) may offer an attractive alternative therapeutic approach that remedies ETA-mediated vasoconstriction without impacting desirable ET-3/ETB mediated fluid regulation. A selective ET-1/2 neutralizing antibody, S69glC21 was discovered and optimized through protein engineering to 80 pM and 30 pM binding affinities to ET-1 and ET-2, respectively. Results: When administered into rats exogenously infused with ET-1, S69glC21 prevented blood pressure increase. In a hypoxia-induced pulmonary hypertension rat model, S69glC21 reduced pulmonary pressure. Compared to atrasentan, a selective small molecule ETA antagonist, S69glC21 had a distinct pharmacodynamic (PD) effect characterized by initial complete inhibition followed by a delayed rise of pulmonary pressure as the hypoxia condition persisted. To further dissect these findings, S69glC21 pharmacokinetics (PK) and circulating ET-1 target engagement (TE) analysis were performed. In the S69glC21 treated rats, antibody bound ET-1 was shown to accumulate relative to baseline plasma levels at all dose levels. In the 30 mpk group, the antibody bound ET-1 accumulated nearly 40,000-fold above the baseline plasma level of 2.25 ± 0.87 pg/mL indicating a rapid production rate of ET-1. Conclusions: Thus, PK/PD modeling reveals significant druggability challenges for the development of a highly effective, commercially viable ET-1 selective neutralizing antibody for the treatment of cardiovascular, pulmonary, and/or renal diseases.

Numerical Analysis of a Novel Casing Treatment in an Axial Flow Fan

The present paper reports the use of a slotted casing treatment of trapezoidal shape to enhance the stall margin of an axial flow fan. The Taguchi method was used to optimize the rectangular slotted casing treatment based on that which the trapezoidal slots were designed. The unsteady numerical simulations were carried out using the shear-stress-transport turbulence model. The rotor with trapezoidal slots led to the stall margin improvement of 23.4% and mild pressure rise of 0.54%. Without the casing treatment, the tip leakage trajectory was directed from the suction surface of the blade toward the pressure surface of the adjacent blade. After incorporating the trapezoidal slots, the tip leakage trajectory was significantly shifted toward the suction surface of the same blade. This alteration in flow characteristics near the blade-tip region may be attributed to the exchange of momentum due to the simultaneous suction and blowing through the trapezoidal slots. It was also found that the trapezoidal slots improved the axial flow velocity and reduced the diffusion factor in the blade-tip region as compared to the baseline case.

Effect of water injector location on combustion and performance of an HCCI engine - A CFD analysis

A homogeneous charge compression ignition (HCCI) engine is capable of producing high thermal efficiency with very low emissions. However, because of the limited upper load level constrained by knocking, the HCCI engine is not yet commercialized. Water injection can tackle this issue, enhancing the upper load limit without excessive heat release rate. However, the effectiveness of water injection depends on in-cylinder water evaporation, which in turn depends on water injection parameters. Therefore, this study is conducted to study the effect of water injector location on the combustion and performance characteristics of an HCCI engine by a computational fluid dynamic (CFD) analysis. The engine specifications and boundary conditions are taken from the literature. A three-dimensional computational fluid dynamics (3D CFD) model was developed using CONVERGE CFD coupled with detailed chemical kinetics to gain a better understanding of the phenomena of water injection in an HCCI engine. The CFD models used are validated from the available experimental data in the literature for the engine considered. Here, the water injector location is optimized based on the Water vapor distribution within the cylinder, nitric oxide (NOx) emissions, and maximum rate of pressure rise (MRPR). The results show that the water injector at 37 mm from the center of the cylinder gives better results than in other cases considered. With the optimum water injector location, the indicated mean effective pressure is increased by about 35.91% than without the water injection case. This study will be helpful in the development of HCCI engines.

Neonatal blood pressure by birth weight, gestational age, and postnatal age: a systematic review.

Blood pressure is a vital hemodynamic marker during the neonatal period. However, normative values are often derived from small observational studies. Understanding the normative range would help to identify ideal thresholds for intervention to treat hypotension or hypertension. Therefore, the aim of this study was to assess observed blood pressure values in neonates who have not received any blood-pressure modifying treatments from birth to three months postnatal age and whether these vary according to birth weight, gestational age and postnatal age. This was a systematic review. A literature search was conducted in MEDLINE, PubMed, Embase, Cochrane Library, and CINAHL from 1946 to 2017 on blood pressure in neonates from birth to 3months of age (PROSPERO ID CRD42018092886). Unpublished data were included where appropriate. Of 3,587 non-duplicate publications identified, 30 were included (one unpublished study). Twelve studies contained data grouped by birth weight, while 23 contained data grouped by gestational age. Study and clinical heterogeneity precluded meta-analyses thus results are presented by subgroup. A consistent blood pressure rise was associated with increasing birth weight, gestational age, and postnatal age. In addition, blood pressure seemed to rise more rapidly in the most preterm and low birth weight neonates. Despite blood pressure increasing with birth weight, gestational age, and postnatal age, there was marked blood pressure variability observed throughout. To better define hypotension and hypertension, future studies should develop consistent approaches for factors related to blood pressure variability, including the method and timing of measurement as well as statistical control of relevant patient characteristics.

Numerical study on altitude-compensating mechanism of a permeable nozzle

A conceptual adaptive altitude compensation nozzle with a permeable wall (permeable nozzle for short) is proposed in the present study. The typical operating states of the nozzle are demonstrated using numerical methods and the underlying mechanism of its altitude compensation is interpreted. The numerical results show that, at low nozzle pressure ratios, the external atmosphere enters the nozzle through its permeable wall section, which inhibits the backflow at the nozzle wall, weakens the strength of the separated oblique shock, thus improves the low-altitude thrust performance of the nozzle. However, at high nozzle pressure ratios, the exhaust gas leaves the nozzle through its permeable wall, which weakens the expansion of the exhaust gas and reduces the thrust performance. The permeable nozzle is considered to possess altitude compensation ability when the enhancement in its low-altitude thrust performance surpasses the deterioration in high-altitude thrust performance. The thrust composition analysis of the permeable nozzle reveals that its altitude compensation ability derives from the internal pressure rise due to the atmospheric air penetration into the nozzle at low nozzle pressure ratios.

An experimental study on in-cylinder soot formation and flame oscillation of renewable fuel blends in an optical engine

Methanol has been widely recognized as a promising alternative fuel for mitigating greenhouse gas emissions. However, its application in internal combustion engines often necessitates blending with a high-reactivity fuel to address challenges related to ignitability and combustion stability. In this study, a two-color method was employed in a single-cylinder optical engine to investigate the characteristics of soot formation and flame oscillation of methanol blended with a high-reactivity fuel, hydrogenated catalytic biodiesel (HCB), under partially premixed combustion (PPC) modes. The blended fuels include M15 (15% methanol, 60% HCB, and 25% n-octanol) and M25 (25% methanol, 60% HCB, and 25% n-octanol), with pure hydrogenated catalytic biodiesel M0 (100% HCB) serving as the reference fuel. N-octanol was utilized as the co-solvent to enhance the stability of the mixture. The results indicate that, employing double-injection strategies, as the methanol content increases in the blended composition, leading to a postponed peak cylinder pressure and heat release rate during combustion. Thanks to the high-level premixed combustion and higher oxygen content, the increases of alcohol blending significantly reduced in-cylinder soot formation. Double-injection strategies reduced soot production effectively and resulted in a more uniform soot distribution compared to single-injection strategies. In terms of flame oscillation, its amplitude primarily correlates with the rate of cylinder pressure rise, while the methanol content within the blends exerts a minor impact on flame oscillation. Double-injection strategies contributes to a more uniform fuel distribution, ensuring a smoother heat release process and significantly reducing flame oscillation amplitudes compared to single-injection strategies.

Modeling and simulation of xenon storage and supply system for electric propulsion system based on fundamental equation of state

The electric propulsion system (EPS) xenon storage and supply system (SSS) is a complex pipeline network system, which involves the multi-physics coupled fields of transcritical flow, heat transfer, rigid body motion, electromagnetics, and control. Based on the fundamental equation of state, a one-dimensional finite volume model system is proposed for compressible transcritical transient pipe flow. Six typical components of the SSS are modularization modeled by using an object-oriented programming method in Fortran 2018. To evaluate the performance of the algorithm, a simulation model consisting of 77 components is developed for a proportional controlled EPS xenon SSS, and a system-level simulation is performed. Compared with the standard case constructed on the Amesim platform, the model has a pressure rise time error lower than 6%, and the restrictors mass-flow-rate errors of the anode, cathode, and neutralizer are less than 2.8% of the rated flow rate after stabilization. Moreover, the proposed model yields more accurate results at certain operating points. The model system provides an efficient reference for the design and optimization of EPS SSSs, and offers a new approach to simulate complex cryogenic pipe flow systems.

Experimental investigation on the effect of diesel-ethanol blends for a constant-speed diesel engine

ABSTRACT Keeping the need for energy security and the world’s transition to a thriving low-carbon economy in mind, the research, on the feasibility of diesel ethanol blends, has gained momentum. The present work is related to comparing the performance and emission characteristics of pure diesel [D100] with 4 diesel-ethanol blends [D90E10, D85E15, D80E20 and D75E25]. The single-cylinder 4-stroke un-modified diesel engine running at constant 1500 rpm was used for experimentation which ran at different loads. Experimental results showed that with the addition of ethanol in blends, the brake thermal efficiency (BTE) and exhaust gas temperature (EGT) reduced while brake-specific fuel consumption (BSFC) increased. The addition of ethanol shortened the combustion duration. Hence, D75E25 showed a rapid rise in combustion pressure and heat release rate (HRR). As the concentration of ethanol increases in blends, the oxide of nitrogen (NOx) is reduced and carbon monoxide and hydrocarbon (HC) are increased. Thus, D75E5 was good blend producing less NOx with the penalty of fuel consumption on an unmodified diesel engine. In the long run, the effect of blends on the engine should be checked to make ethanol a feasible fuel for diesel engines. Abbreviations: CA: Crank Angle; ATDC: After Top Dead Centre; BMEP: Brake Mean Effective Pressure; BSFC: Brake Specific Fuel Consumption; BTE: Brake Thermal Efficiency; BTDC: Before Top Dead Centre; CO: Carbon Monoxide; COV: Coefficient of Variation; D100: 100% Diesel + 0% Ethanol, Pure petroleum diesel; D90E10: 90% Diesel + 10% Ethanol; D85E15: 85% Diesel + 15% Ethanol; D80E20: 80% Diesel + 20% Ethanol; D75E25: 75% Diesel + 25% Ethanol; HC: Hydrocarbon; IMEP: Indicated Mean Effective Pressure; LHV: Lower Heating Value; NOx: Nitric Oxide.

Explosion characteristics of lithium-ion batteries vent gases containing dimethyl carbonate at elevated temperatures

Dimethyl carbonate (DMC) is a common component of lithium-ion batteries (LIBs) electrolyte, which is vented into the environment along with LIBs thermal runaway vent gases (BVG). This study used different ratios of DMC/BVG mixtures to simulate the combustible components vented from LIBs thermal runaway process. The explosion characteristic parameters of the DMC/BVG mixtures, such as the peak overpressure (Pex), the peak rate of pressure rise ((dp/dt)ex), lower flammability limits (LFL) and limiting oxygen concentrations (LOC), were investigated in an 8-L stainless steel cylindrical explosion vessel. The results indicated that as the percentage of DMC increased, maximum Pex, maximum (dp/dt)ex and LOC of the mixtures increased, while LFL showed a decrease trend. In addition, LFL decreased approximately linearly as increasing the initial temperature. The Britton correlation method can estimate LFL at varying initial temperatures. The research results are helpful to better understand the risk of the mixtures vent from LIBs and provide a reference for the explosion-proof design of LIBs’ transport containers and LIB energy storage stations.

Effects of the vent burst pressure on the duct-vented explosion of hydrogen-methane-air mixtures

The effects of the vent burst pressure (Pv) on the vented explosion of hydrogen-methane-air mixtures are investigated in a cylindrical vessel connected with a duct. The results demonstrate that Pv significantly affects the flame behaviors and overpressure inside and outside the venting configuration. The flame front velocity at the vent increases with Pv. Two pressure peaks, Pac, caused by the acoustically enhanced combustion, and Pse, caused by the secondary explosion, dominate within the vessel at Pv ＜ 132 kPa and Pv ≥ 132 kPa, respectively. The maximum overpressure (Pmax) inside the duct increases with Pv. The maximum pressure rise (dP/dt) of the duct is always higher than that of the vessel. As Pv increases, increased turbulence of unburned gases within the duct results in higher dP/dt. Exit flame speed increases with Pv. When Pv ≥ 153 kPa, “Mach disk” appears outside the relief duct. Three pressure peaks, Pa, Pb, and Pext, due to vent failure, the secondary explosion, and the external explosion, respectively, occur in the external pressure curve. Pb dominates outside the configuration except for Pv = 153 kPa.