The electric superchargers driven by a high-speed motor instead of exhaust gas to operate the compressor have excellent transient characteristics and can effectively reduce the turbo lag of diesel engines. To develop an optimal control strategy for the electric superchargers, it is necessary to explore the combined effects of the electric supercharger and turbocharger under transient processes. Therefore, this study investigated the influence of different intervention speed and time of the electric supercharger on the transient performances of a turbocharged diesel engine. The combined effects of the electric supercharger and turbocharger were analyzed to optimize control strategy through simulations. Effects of the optimization in control strategies were tested through engine experiments. According to the results, the optimized control strategy (slope control strategy) was able to effectively balance transient responsiveness and stability since the rise time of intake pressure were reduced by 52.5 % compared to the base engine and the fluctuations in intake pressure and engine torque were significantly eliminated. Besides, the slope control strategy achieved the lowest PM and NOx emissions during the transient loading process.