In order to predict a product’s durability in the early phases of development it is necessary to know the stress–strain behaviour of the material, its resistance to fatigue and the loading states in the material. These parameters, however, tend to exhibit a considerable degree of uncertainty. Due to a lack of knowledge of the actual circumstances in which the product is used, during the early development phase, simulations based on statistical methods are used. The results of the experiments show that the cyclic stress–strain curves demonstrate not only a large amount of scatter, but also a dependence on the temperature, the size of the cross-section, the content of alloying elements, the loading rate, etc. This article presents a method for modelling cyclic stress–strain curve scatter using a hybrid neural network for an arbitrary selection of the influencing factors. In an example of the measured data for a high pressure die-cast aluminium alloy it is clear that the suggested method is suitable for describing cyclic stress–strain curves. The main advantage of a hybrid neural network in comparison with a conventional method is the neural network’s ability to precisely describe the influence of various factors, and their combinations, based on the form and scatter of the cyclic stress–strain curve families. Defining the model parameters, i.e., training the neural network, is a procedure that does not require any additional user interventions; however, it enables us to gather knowledge that would otherwise require a lot of research. Thus, the trained neural network is a robust tool that can be used to predict cyclic stress–strain curves for random values of influencing factors. The capabilities of the presented method are only limited by the quantity of the measured data used for the neural-network training.