Pressure Amplitude Research Articles

Effect of ultrasonic frequency on mass transfer of acoustic cavitation bubble

Mass transfer of acoustic cavitation bubble is numerically investigated focusing on ultrasonic frequency. In the present simulation, transport of chemical specie from an acoustic cavitation bubble after rapid bubble compression is modeled. The simulation results indicate that the bubble oscillation is more nonlinear, and the oscillation amplitude becomes larger with sound pressure amplitude, ultrasonic frequency, and bubble size. Under the condition of strong nonlinear bubble oscillations, the bubble shape becomes non-spherical. The mass transfer of chemical specie becomes smaller with sound pressure amplitude at 20 kHz ultrasound due to shell effect and area effect, although it becomes larger with pressure amplitude at higher ultrasonic frequency because the concentration of chemical specie in the bubble becomes high near the periphery of bubble due to hysteresis effect, which becomes remarkable especially at higher ultrasonic frequency because time for the bubble compression becomes too short for chemical specie to diffuse at higher ultrasonic frequency.

A methodology for evaluating damage in thin-walled cylindrical shells using bounded ultrasonic beam scattering

This paper introduces an ultrasonic detection methodology specifically designed to assess damage in thin-walled cylindrical shells, which crucially relies on the interaction between a bounded ultrasonic beam and a thin-walled cylindrical shell immersed in fluid, considering both water-filled and air-filled cavities. Initially, we derive the scattered sound field expression for a bounded ultrasonic beam obliquely striking the shell. Subsequently, through finite element simulations and experimental verification, we observe that when the incident bounded beam is emitted at the critical angles defined in this study, early damage significantly enhances the received sound pressure amplitude detected by a symmetrically positioned receiver. Notably, a mere 5 % decrease in the shell's elastic modulus leads to a notable 233.69 % increase in the area under the amplitude-frequency curve of the received sound pressure for water-filled cavities and a remarkable 642.85 % surge in area for air-filled cavities. Experimental data further validates the sensitivity of this method towards varying corrosion damage states. This approach combines the reliability of linear ultrasonic methods with the enhanced sensitivity of nonlinear ultrasonic techniques, offering a significant advancement over traditional ultrasonic detection methods for inspecting cylindrical shells. The proposed assessment method holds immense potential in providing novel insights for inspecting cylindrical shells in practical applications.

Experimental investigation on the mode transition characteristics of a phase-change thermofluidic oscillator with external loads

Phase-change thermofluidic oscillator has drawn significant attention thanks to its low operating temperature, which is beneficial for recovering low-grade heat. The vapor–liquid coupling oscillation in the thermofluidic oscillator leads to complex non-linear mode transition phenomenon that affects the steady operation. In this work, the mode transition characteristics of a thermofluidic oscillator with external loads (i.e., a needle valve and a load reservoir) are experimentally investigated through bifurcation analysis. A low-order van der Pol model is employed to examine the effect of acoustic resistance on mode transition. Experimental results demonstrate that modifying the valve opening and load volume under a constant temperature difference can trigger bifurcation, resulting in high-frequency limit cycle, low-frequency limit cycle and quasi-periodic modes. The non-linear features of each mode are revealed through phase space and Poincaré section, with Neimark-Sacker bifurcation, second bifurcation and inverse Neimark-Sacker bifurcation observed. Steady-state performance of oscillator is then characterized under different oscillation modes. The maximum pressure amplitudes measured are 11.54 kPa during the high-frequency oscillation and 1.35 kPa during the low-frequency oscillation, while the maximum displacement amplitudes obtained are 45.5 mm during the high-frequency oscillation and 91.4 mm during the low-frequency oscillation. The oscillation modes can be adjusted by external load to maximize output performance. This study offers comprehensive guidelines for constructing phase-change thermofluidic oscillators.

Explaining the correlation between subharmonic amplitude and ambient pressure for subharmonic-aided pressure estimation (SHAPE)

BackgroundSubharmonic aided pressure estimation (SHAPE) is an innovative non-invasive technique that leverages ultrasound subharmonic imaging to estimate pressure. This method exploits the “negative correlation between subharmonic amplitude and ambient pressure” observed in experimental settings. Despite extensive experimental validation and some promising results in clinical studies, the underlying mechanism of SHAPE remains incompletely understood. Although some studies have attempted to provide theoretical explanations, definitive conclusions have yet to be reached. In addition, theoretical investigations have mainly focused on the steady oscillation of bubbles under long pulse excitation, which contrasts with the short pulse excitation required for clinical SHAPE applications. An understanding of the SHAPE principle under short pulse excitation is needed. MethodsThe exponential elasticity model (EEM) was used to simulate Sonazoid bubbles, and a probe-to-probe acoustic propagation model was introduced to mimic a practical SHAPE scenario. The simulated acoustic signals in response to three-cycle sinusoidal pulse excitations were analyzed for spectral composition. The relationship between microbubble oscillation patterns and subharmonic characteristics was identified through detailed investigation. ResultsFor the excitation pulse of 2.5 MHz frequency and 350 kPa magnitude, bubbles larger than the resonance radius (2.29 μm) exhibited significant subharmonics in the magnitude spectrum, while bubbles smaller than the subharmonic resonance radius (3.85 μm) showed the activity of scattering subharmonic energy and the sensitivity to ambient pressure. The emergence of subharmonics when increasing excitation power was related to the increasing amplification of the bubble self-oscillation and the period-doubling features in the acoustically forced oscillation. The negative correlation between subharmonic amplitude and ambient pressure was attributed to the reduced self-oscillation caused by increasing ambient pressure and hence bubble size reduction. Microbubbles falling between 2 and 3 μm showed the desired subharmonic sensitivity to ambient pressure under the specified excitation conditions. ConclusionThe transient oscillatory behavior of microbubbles in response to short pulse excitation, characterized by a ringing down self-oscillation after the acoustic forcing effect has ceased, is crucial for understanding the subharmonic emergence and the observed negative correlation between subharmonic amplitude and ambient pressure. The proposed concepts of subharmonic resonance radius, subharmonic-significant bubbles, and subharmonic-active bubbles provide valuable insights into the diverse subharmonic behavior of microbubbles. The theoretical explanation of this negative correlation highlights the importance of using subharmonic-significant-and-active bubbles for SHAPE applications.

Stress Analysis of a Concrete Pipeline in a Semi-Infinite Seabed under the Action of Elliptical Cosine Waves Based on the Seepage Equation

This study aims to investigate the mechanical response of a submarine concrete pipeline under wave action in shallow waters, taking into account factors such as the compressibility of pores and the permeability of the seabed. The control equation of the elliptical cosine wave theory is adopted to simulate the action of waves. In order to simulate the interaction between the solid skeleton and pore fluid, the concept of a “porous medium” is used to establish the transient seepage control equation. Utilizing the stress and displacement conditions at the interface of the ideal fluid media, porous media, and concrete pipeline, the numerical solutions for the internal force and pore pressure of the concrete pipeline buried in a semi-infinite thickness seabed were obtained; meanwhile, the effects of changes in the gas content in pore water and changes in the seabed permeability coefficient on a concrete pipeline were analyzed. The numerical calculation results show that, with the increase in the gas content in the pore water, the amplitude of the pore pressure on the pipeline surface decreases, and both the horizontal and vertical forces acting on the pipeline decrease; the amplitude of the pore pressure on the pipeline surface increases with the increase in seabed permeability and decreases with the enhancement of seabed permeability anisotropy; the improvement of the seabed permeability or enhancement of the permeability anisotropy can increase the horizontal force acting on the pipeline. This study provides a reference for the stability evaluation of submarine concrete pipelines under wave action in shallow water areas.

Extending the operational range of Francis turbines: A case study of a 200 MW prototype

Francis turbines are now widely used to support the integration of renewable and intermittent energy sources such as solar and wind power. Consequently, these turbines often operate away from their best efficiency point (BEP). Such operations cause detrimental pressure fluctuations in the runner and draft tube, leading to early fatigue failures. To address these harmful flow conditions and extend the operating range of Francis turbines, a mitigation system was developed and tested on a large-scale, high-head 200 MW Francis turbine. The system consists of four circular rods placed in the draft tube with variable radial protrusion lengths, adjustable using linear actuators. Pressure, accelerometer, and vibration sensors installed on the turbine allowed quantification of the rod system performance. The results demonstrate the system’s capability to reduce pressure pulsations by up to 80 % in terms of maximum pressure amplitude and 100 % in terms of fatigue cycle in both low and high-frequency ranges, up to ten times the runner frequency, based on pressure analysis. The optimal rod protrusion ranges from 5 to 20 % of the runner outlet diameter function of the operating load. The impact of the rods’ protrusion on the turbine structure appears negligible from the accelerometer measurements performed on the draft tube and spiral casing. The hydraulic efficiency is reduced by up to 1 %. These findings are significant across a wide range of part-load operations, from 40 % to 60 % load, indicating the potential to extend the operational range of existing Francis turbines. The research presented here is a novel attempt to enhance the existing Francis turbines with a new degree of freedom using protruding rods.

Numerical analysis of ultrasound-mediated microbubble interactions in vascular systems: Effects on shear stress and vessel mechanics

The present study concerns the numerical modeling of microbubble oscillation within an elastic microvessel, aiming to enhance the safety and efficacy of ultrasound-mediated drug delivery and diagnostic imaging. The success of such applications depends on a thorough understanding of microbubble–vessel interactions. Despite some progress, the critical impact of the stabilizing shell around gas core has remained underexplored. To address this, we developed a novel numerical approach that models the stabilizing shell. Additionally, there is novelty in modeling consequent vascular deformation in response to complicated spatiotemporal microbubble oscillations. The novel approach was implemented for shear stress evaluation as a critical factor in vascular permeability. Finally, our unique approach offered novel insights into microbubble–vessel interactions under diverse acoustic conditions. Results indicated substantial impact of shell properties and acoustic parameters on induced shear stress. With a fourfold increase in acoustic pressure amplitude, 15.6-fold and sixfold increases were observed in maximum shear stress at 1 and 3 MHz, respectively. Also, the peak shear stress could reach up to 15.6 kPa for a shell elasticity of 0.2 N/m at 2.5 MHz. Furthermore, decreasing microvessel/bubble size ratio from 3 to 1.5 increased maximum shear stress from 5.1 to 24.3 kPa. These findings are crucial for optimizing ultrasound parameters in clinical applications, potentially improving treatment outcomes while minimizing risk of vessel damage. However, while our model demonstrated high fidelity in reproducing experimental observations, it is limited by assumptions of vessel geometry and homogeneity of vessel properties. Future work can improve our findings through in vitro experimental measurements.

Impact of acoustic wave propagation characteristics on aerodynamic damping of rotor blades in a transonic axial compressor

The aeroelastic stability associated with the acoustic wave propagation characteristics of transonic rotor blades was numerically investigated in this study. The influence of the vibration frequency on the aerodynamic damping of the first bending mode was primarily considered at different speeds, including both work and stall points. We found that the state of acoustic wave propagation associated with aeroelastic instability is closely related to rotational speed. At low speeds near stall points, the risk of aeroelastic instability is confined to the upstream cut-off state. However, at high speeds near stall points, aeroelastic instability may occur in both the downstream cut-off state and the acoustic wave propagation state of the upstream cut-off frequency, further expanding the range of the acoustic wave propagation state in which aeroelastic instability can arise. The research findings show that for suction surfaces, aerodynamic work is affected not only by acoustic wave propagation characteristics, but also by shock waves, radial flow, and reflux in the flow field. However, for pressure surfaces, the acoustic wave propagation characteristics play a significant role. When aeroelastic instability occurs, negative damping predominantly arises from the pressure surface. To investigate why lower-order modes are more prone to aeroelastic instability, specific simulations were conducted for the first bending and twisting modes under different operating conditions in the downstream cut-on state. When the vibration frequency significantly exceeds the downstream cut-off frequency, the blade phase is minimally influenced by acoustic wave propagation characteristics, and the rotor is aeroelastically stable in these phases. Simultaneously, there is an approximately linear increase in the unsteady pressure amplitude with increasing vibration frequency, and the aerodynamic work is predominantly influenced by the unsteady pressure amplitude.

Airway mechanics alters generation of cough motor pattern.

Effects of sequential increase in airway resistance: no, low (5 kPa.s/l), high (24 kPa.s/l), and complete block in the inspiratory or expiratory phase of mechanically induced cough on the cough motor pattern were studied in 16 anesthetized (pentobarbital) spontaneously breathing cats (3.70±0.15 kg, 11♂, 5♀). Esophageal pressure and electromyographic activities of the diaphragm during inspiration and abdominal muscles during expiration were analyzed. No significant changes in the number of coughs occurred. Inspiratory occlusion caused a prolongation of cough inspiratory phase, cough inspiratory diaphragm activity, and all cough-related activity. Inspiratory occlusion along with high resistance increased inspiratory esophageal pressure amplitude, total cough cycle duration and the time between maximum activity of the diaphragm and abdominal muscles. High expiratory resistance and occlusion resulted in increased cough expiratory esophageal pressure amplitude, a longer active portion of cough expiration, and cough abdominal activity. Expiratory occlusion also prolonged cough expiratory phase, all cough activity, and total cough cycle. Significantly increased airway resistance and occlusion induce secondary, in addition to mechanical, changes in cough by significantly modulating the generated cough motor pattern. A certain level of resistance appears to be successfully compensated, resulting in minimal changes in coughing characteristics, including expiratory airflow and the rising time of the airflow. Afferent feedback from the respiratory tract, particularly volume feedback, represents a significant factor in modulating cough, mainly under various pathological conditions in the respiratory system.

Analysis of CFRP inter‐laminar cracking location under laser impacts

AbstractIn this study, a combination of theoretical analysis and experimental verification was used to investigate the effects of laser parameters and shock wave shape on the location of layer cracks in carbon fiber‐reinforced plastics specimens. Firstly, the propagation coupling process of trapezoidal, rectangular, and triangular pulses in the material was investigated based on the one‐dimensional stress wave propagation theory. The study analyzed the effects of shock wave pressure amplitude, pulse width, and other factors on the location of layer cracks in the material. Subsequently, laser impact experiments with varying energies and pulse widths were conducted on specimens of different thicknesses to investigate the impact of shock wave pressure amplitude and laser pulse width on the location of layer cracking. The results show that the theoretical analysis of triangular shock waves has broader applicability and can serve as a representative analytical model to describe single‐layer crack damage.Highlights Laser impact experiments with various specimen thicknesses. Laser pulse width determines the initial location of inter‐laminar cracking. The applicability of the triangular pulsed layer cracking formula. The effect of laser energy on pulse amplitude.

Relationship between oscillatory volume and oscillatory pressure in neonatal high-frequency oscillatory ventilators: an in vitro study

ObjectiveWe analysed the relationship between oscillatory volume (VOSC) and pressure amplitude (ΔP) in six neonatal high-frequency oscillatory (HFO) ventilators and related it to (1) the accuracy of VOSC and ΔP...

Research on the mechanism of severe unsteadiness of PAT braking condition during the power failure

The Pump-As-Turbine (PAT) technology has become popular in micro hydropower stations due to its simple installation and cost-effectiveness. Nevertheless, power failures present a substantial risk to the secure and steady functioning of PAT’s braking system. The commercial CFD code (ANSYSCFX) is improved by incorporating a secondary development to model the power-off transition using Fortran accurately. This enhancement allows for real-time iterative calculations of angular momentum equations for mixed-flow PAT at different speeds. Meanwhile, the time–frequency domain analysis is utilized to analyze pressure pulsation signals and the evolution of the internal flow field in mixed-flow PAT. An investigation was conducted to have a deeper understanding of braking circumstances. The results revealed that the main frequency of the pressure pulsation aligns with the blade frequency at various flow rates, and there is a sudden change in pressure amplitude during the braking phase. The impeller experienced the majority of energy losses, with the draft tube being the subsequent area of concern. In addition, a thorough examination and comparison of the changes in the internal flow field during braking were carried out. This analysis revealed a distinct double helix structure within the draft tube, with a slower inner helix and a faster outer helix. Furthermore, it was observed that there is a strong correlation between wall shear stresses and hydraulic losses on the blade surface. This research enhanced understanding of the flow characteristics of mixed-flow PAT can help improve system safety and provide valuable guidance for future optimization efforts.

Numerical Investigation on the Influence of Continuous Rotating Backpropagation Pressure Wave on Turbine Performance

Abstract Researches have shown that the use of a continuous detonation afterburner can improve the propulsion performance of aero engine. However, backpropagation pressure waves (BPW) generated by the pressure gain of detonation will affect the internal flow and performance of turbine. This article simulates BPW through a custom function, and investigates the effects of BPW amplitude, rotation frequency, and propagation mode on turbine performance through three-dimensional simulation. The results show that as the pressure amplitude of the BPW increases, the pressure oscillation at each section of the turbine increases and a local subcritical flow state will appear, leading to the decrease of turbine flowrate and turbine power, as well as an intensification of instantaneous turbine power fluctuations. As the rotation frequency of the BPW increases, the pressure oscillation at each section of the turbine gradually decreases. The flowrate and power of the turbine do not change much, but turbine efficiency gradually decreases. Compared to the aligned mode, the turbine performs better under the influence of BPW in misaligned mode. Compared to the single-wave mode, the fluctuation of transient turbine power is lower under the influence of BPW in the multiwave mode excluding collision mode. Finally, the constraints of equal flowrate region and equal turbine power line on the peak-to-peak value of the BPW were analyzed when the joint operation of the turbine and compressor was not affected. The rotation frequency and mode of BPW will affect the flowrate region and power line.

Modelling ultrasonic cavitation onset in spiral-wound reverse osmosis modules

A model was developed to predict the onset of inertial cavitation within a spiral-wound reverse osmosis module sonicated along its axis from within its pressure vessel. The aim was to investigate the scalability of ultrasonic antifouling for reverse osmosis applications. The model employs a one-dimensional discretization to represent the module feed channel, calculating each element's pressure, flow rate, permeate flux, and sonication intensity. The Blake threshold assesses whether the pressure amplitude at each element is sufficient to produce inertial cavitation. When applied with parameters from a typical small-scale reverse osmosis module, the model identified a linear relationship between inlet pressure and inertial cavitation onset location, with a constant inlet flow rate and sonication power. With a sonication power of 120 W and a flow rate of 8.796 × 10−5 m3 s−1, the model predicted that inertial cavitation could be induced throughout the reverse osmosis module with inlet pressures ranging from 335 kPa to 355 kPa. While these pressures may be inefficient from a permeate production standpoint compared to standard operating pressure, they could be produced temporarily as part of a regular membrane cleaning operation. The model estimates the system's power consumption during cleaning to be 134.8 W, approximately equal to the estimated system energy requirements under recommended operating conditions of 134.3 W. This suggests that this technology could integrate effectively with existing reverse osmosis systems.

Cyclic inelastic behaviour of a bonded patch repair system used for pipes with through-wall corrosion damage

Repairs of through-wall corrosion damage in pipes conveying liquids using bonded metallic patches are becoming common in the oil and gas industry. Usually, this kind of patch is used in association with a composite sleeve, and it is essential to assure that the repair wońt leak. The use of bonded metallic patches associated with the composite sleeve is not forbidden in the standards for the design of composite repair systems (such as ASME PCC-2 and ISO 24817). However, they do not address this very frequent practice adopted in industry. Since the patch is responsible for sustaining most of the pressure of the repair, it becomes necessary to further understand its behaviour. This paper investigates the cyclic inelastic behaviour of a metal patch/adhesive system and its effect on the failure pressure. Hydrostatic tests were performed regarding how pressure variations can generate cyclic inelastic strains in the adhesive layer that bonds the metal patch to the pipe, and how this cyclic loading–unloading process ultimately affects the failure pressure. The failure pressure in monotonic burst tests can be reasonably modelled using basic concepts of linear elastic fracture mechanics. Although the assumption of a brittle-elastic behaviour of the repair system seems adequate in the case of monotonic loading, it is not in the case of cyclic tests with high pressure amplitudes. Repairs in steel pipes under pressure with a 25 mm diameter hole failed after a very small number of cycles with pressure amplitude of 80% of the average failure pressure obtained in monotonic burst tests. To help understanding the behaviour of the system, single lap joints were studied. The patch and pipe are not subjected to significant permanent deformations, while the adhesive layer has an inelastic behaviour. Results show that the lap joints present a rate-dependent behaviour in tensile tests and may present highly different cyclic responses which are quite sensitive to very small perturbations in the manufacturing process.

Could the anterior cruciate ligament reconstruction and pronated feet affect the plantar pressure variables and muscular activity during running? A comparative study

The unilateral anterior cruciate ligament reconstruction can create asymmetry in vertical ground reaction force and muscle activities, which could be amplified by pronated feet. The study compared plantar pressure variables, amplitude, and muscular frequency in individuals with pronated feet and anterior cruciate ligament reconstruction (PF/ACLR) versus control during running. As part of a cross-sectional study, 15 individuals with PF/ACLR (aged 23.2 ± 4.5 years) and 15 healthy control participants (aged 22.9 ± 4.1 years) ran barefoot at a speed of 3.3 m/s±5% on an 18-m runway. During running, a foot scan and electromyography systems were used to record the peak plantar pressure variables and electromyography activity of the main lower limb muscles, respectively. Results demonstrated lower peak plantar pressure values at the Toe 1 region (p < 0.001, d = 1.83) for the PF/ACLR group. The PF/ACLR group had larger peak plantar pressure values at toes second to fifth (p = 0.013, d = 1.15), fourth (p = 0.026, d = 0.97), fifth (p < 0.001, d = 1.74) metatarsal, and medial (p = 0.002, d = 1.41), and lateral (p = 0.001, d = 1.51) heel regions. The PF/ACLR group presented larger tibialis anterior (p = 0.003, d = 1.15), vastus lateralis (p = 0.001, d = 1.27), and gluteus medius (p = 0.009, d = 0.60) amplitude at the loading phase. At the mid-stance phase, larger tibialis anterior (p = 0.039, d = 0.99) and vastus lateralis (p = 0.00.024, d = 1.52) amplitudes were observed. For the push-off phase, the PF/ACLR group presented larger vastus medialis (p = 0.037, d = 0.82), biceps femoris (p = 0.004, d = 1.14), and semitendinosus (p = 0.001, d = 0.96) amplitudes. Our results demonstrated that pronated feet and anterior cruciate ligament reconstruction significantly impact plantar pressure variables and muscular amplitude in the lower limb during running.

Propagation Characteristics of Initial Compression Wave Induced by 400 km/h High-Speed Trains Passing through Very Long Tunnels

When high-speed trains enter tunnels, an initial compression wave is generated. As the compression wave propagates at the local speed of sound to the tunnel exit, it radiates into the surrounding environment, forming micro-pressure waves (MPWs). MPWs create sonic booms, resulting in significant environmental issues. The magnitude of the micro-pressure waves is directly proportional to the pressure gradient of the compression wave at the tunnel exit. The nonlinear effects of the initial compression wave during propagation lead to a significant increase in pressure gradient. Therefore, the propagation characteristics of the initial compression wave during the tunnel are the crucial factor affecting the amplitude of MPWs. Based on the one-dimensional compressible unsteady non-isentropic flow model and the improved generalized Riemann variable characteristic method, this paper researched the propagation and evolution characteristics of an initial compression wave generated when 400 km/h high-speed trains enter tunnels with three portal shapes: (no tunnel entrance hood (no hood), an oblique, enlarged tunnel entrance hood (type A), an enlarged equal-section non-uniform opening hole tunnel entrance hood (type B)). The results show that when the initial compression wave propagates inside very long tunnels, the pressure gradient of the compression wave exhibits a trend of initially increasing and then decreasing with the increase in propagation distance. When the pressure gradient of the compression wave reaches its maximum value, the corresponding propagation distance is the steepening critical distance. For no tunnel entrance hoods, type A tunnel entrance hoods, and type B tunnel entrance hoods, the steepening critical distances are 5 km, 6 km, and 16 km, respectively. The steepening critical distance shortens with increasing train speed. Steady friction and unsteady friction effects mainly affect the pressure amplitude and pressure gradient during compression wave propagation, respectively. At lower ambient temperatures, the nonlinear effects in compression wave propagation are significantly enhanced. The mitigation effects of type A tunnel entrance hoods and type B tunnel entrance hoods on pressure gradient reduction are mainly concentrated within 4 km and 12 km, respectively. It is necessary to determine the optimal matching relationship between the tunnel entrance hood and tunnel length based on the characteristics of compression wave propagation to ensure their mitigating performance is maximized.

A Flexural Ultrasonic Transducer for Inducing Acoustic Cavitation on Material Surfaces

Abstract Purpose This paper proposes a flexural ultrasonic transducer specifically designed for surface treatment of materials with delicate surfaces such as skin by acoustic cavitation at low frequencies. The goal of this preliminary study is to assess the resonance frequencies and the output sound pressure of the proposed transducer and confirm generation of acoustic cavitation on the surface of an artificial skin phantom. Methods A transducer prototype was designed based on structural-acoustic simulation and fabricated. The proposed design employs a concave-shaped acoustic resonator with a spherical cavity, which is driven by flexural vibration of a piezoelectric ceramic disk actuator. The transducer prototype has compact dimensions of 15 mm in diameter and 8 mm in axial length, working at frequencies around flexural vibration modes of the piezoelectric disk with a thickness of 1 mm. Results The maximum sound pressure amplitude reached 125 kPa with an input voltage amplitude of 10 V at the second resonance frequency of 167 kHz, where the third axisymmetric eigenmode was excited. Despite enhancing the maximum pressure, the sound pressure outside the resonator attenuates because the near-field distance of the irradiated sound wave is smaller than the height of the resonator. This implies that the proposed method provides the cavitation effect on material surfaces, possibly minimizing the side effect of ultrasound irradiation on the underlying structure. Cavitation generation on a urethane gel surface was directly observed by using a high-speed video camera. Conclusion We confirmed that acoustic cavitation was generated and propelled to the target surface. It concludes that ultrasound irradiation using the proposed ultrasonic transducer could be a promising alternative for effective and safe ultrasound treatment of material surfaces.

Association of Aortic Stiffness and Pressure Pulsatility With Noninvasive Estimates of Hepatic Steatosis and Fibrosis: The Framingham Heart Study.

Arterial stiffening may contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease. We aimed to assess relations of vascular hemodynamic measures with measures of hepatic steatosis and fibrosis in the community. Our sample was drawn from the Framingham Offspring, New Offspring Spouse, Third Generation, Omni-1, and Omni-2 cohorts (N=3875; mean age, 56 years; 54% women). We used vibration-controlled transient elastography to assess controlled attenuation parameter and liver stiffness measurements as measures of liver steatosis and liver fibrosis, respectively. We assessed noninvasive vascular hemodynamics using arterial tonometry. We assessed cross-sectional relations of vascular hemodynamic measures with continuous and dichotomous measures of hepatic steatosis and fibrosis using multivariable linear and logistic regression. In multivariable models adjusting for cardiometabolic risk factors, higher carotid-femoral pulse wave velocity (estimated β per SD, 0.05 [95% CI, 0.01-0.09]; P=0.003), but not forward pressure wave amplitude and central pulse pressure, was associated with more liver steatosis (higher controlled attenuation parameter). Additionally, higher carotid-femoral pulse wave velocity (β=0.11 [95% CI, 0.07-0.15]; P<0.001), forward pressure wave amplitude (β=0.05 [95% CI, 0.01-0.09]; P=0.01), and central pulse pressure (β=0.05 [95% CI, 0.01-0.09]; P=0.01) were associated with more hepatic fibrosis (higher liver stiffness measurement). Associations were more prominent among men and among participants with obesity, diabetes, and metabolic syndrome (interaction P values, <0.001-0.04). Higher carotid-femoral pulse wave velocity, but not forward pressure wave amplitude and central pulse pressure, was associated with higher odds of hepatic steatosis (odds ratio, 1.16 [95% CI, 1.02-1.31]; P=0.02) and fibrosis (odds ratio, 1.40 [95% CI, 1.19-1.64]; P<0.001). Elevated aortic stiffness and pressure pulsatility may contribute to hepatic steatosis and fibrosis.

Characteristic Pressure Waveforms Can Distinguish Airway Collapse Patterns in Sleep Apnea Patients: A Pilot Study.

To use pharyngeal pressure recordings to distinguish different upper airway collapse patterns in obstructive sleep apnea (OSA) patients, and to assess whether these pressure recordings correlate with candidacy assessment for hypoglossal nerve stimulator (HGNS) implantation. Prospective case series. Single tertiary-quaternary care academic center. Subjects with OSA prospectively underwent simultaneous drug-induced sleep endoscopy (DISE) and transnasal pharyngeal pressure recording with a pressure-transducing catheter. Pressure was recorded in the nasopharynx and oropharynx, and endoscopic collapse patterns were classified based on site, extent, and direction of collapse. Pressure recordings were classified categorically by waveform shape as well as numerically by inspiratory and expiratory amplitudes and slopes. Waveform shape, amplitude, and slope were then compared with the endoscopic findings. Twenty-five subjects with OSA were included. Nasopharyngeal waveform shape was associated with the extent of collapse at the level of the palate (P = .001). Oropharyngeal waveform shape was associated with anatomical site of collapse (P < .001) and direction of collapse (P = .019) below the level of the palate. Pressure amplitudes and slopes were also associated with the extent of collapse at various sites. Waveform shape was also associated with favorable collapse pattern on endoscopy for HGNS implantation (P = .043), as well as surgical candidacy for HGNS (P = .004). Characteristic pharyngeal pressure waveforms are associated with different airway collapse patterns. Pharyngeal pressure is a promising adjunct to DISE in the sleep surgery candidacy evaluation.