Background: Sjogren syndrome (SS) is a chronic autoimmune disorder of the exocrine glands, accompanied by lymphocyte infiltration of these glands, that manifests clinically with dryness of the eyes (lacrimal glands involvement) and of the mouth (salivary glands involvement). SS can develop extraglandular manifestations and complications such as hematologic malignant transformation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus discovered in 2019, causing a world pandemic by developing an acute respiratory disease ‘coronavirus disease 2019’ (COVID-19). We are presenting a case with pSS, complicated with Non Hodgkin Lymphoma (NHL), after infection with SARS-CoV-2. Case presentation: The patient is a 52 year old female, who presented in the clinic complaining of dryness of the eyes and mouth, swollen nodule in the neck region. According to European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR) criteria, the patient is diagnosed with SS and starts treatment with Plaquenil 200mg/day, Medrol 4mg/day, Calcium, D3 vitamin, Proton-pump inhibitor (PPI). After infection with SARS-CoV-2, the patients has aggravation of her symptoms related to SS and in a time frame of 8 months she manifests weakness, tiredness and weight loss and generalized lymphadenopathy. Biopsy is performed confirming the diagnosis of Non Hodgkin Lymphoma. Conclusions: This clinical case presentation tries to explain a possible relation between COVID-19 and hematologic malignant transformation in predisposed patients, like patients with pSS.