Present Research Research Articles

Potential Impacts of Diversification of Food Retail Working Hours on Consumer Behaviour and the Benefits for Local Producers in Latvia

The capability of large food retail chains to respond quickly to changes in consumer behaviour and their dominant market position affects all food market players and often conflicts with the interests of national food producers, which can reduce the presence of locally sourced products in the food product mix in the country. Accordingly, the present research aims to identify the impacts of the diversification of opening hours of food supermarkets on consumer shopping habits and the implications for creating an advantage for small and medium agri-food producers in selling their products. The research applied a quantitative approach to identify the main trends in society (n = 2738), with a survey including 31 variables to quantify consumer behaviour, values, and opinions and seven socio-demographic variables. If a decision was made in Latvia to close grocery shops on Sundays or reduce their opening hours on weekends, 85% of consumers indicated that they would be unlikely to change their usual shopping location and would plan to shop at a supermarket on other days. The choice between farmers’ markets and local food shops on Sundays would be made by 45% of consumers, with more than half (53%) of them shopping at local food shops at least a few times a month. The research uniquely investigated the impact of reducing supermarket opening hours on the competitive advantage of small and medium-sized agri-food producers. The findings revealed that reducing supermarket opening hours does not confer a competitive advantage to the producers or significantly shift consumer preferences towards their products.

Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment.

Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive women worldwide, contributing greatly on the incidence of female infertility and gynecological cancers. It is a complex health condition combining of multiple symptoms like androgen excess, uncontrolled weight gain, alopecia, hirsutism, etc. Conventionally PCOS was associated with obesity while it is often found among lean women nowadays, making the disease more critical to diagnose as well treatment. The disorder has an impact on several signal transduction pathways, including steroidogenesis, steroid hormone activity, gonadotrophin regulation, insulin secretion, energy balance, and chronic inflammation. Understanding the aetiology and pathophysiology of PCOS is difficult due to its multiple causes, which include environmental factors, intricate genetic predisposition, and epigenetic modifications. Despite research supporting the role of familial aggregations in PCOS outcomes, the inheritance pattern remains unknown. Henceforth, to reduce the burden of PCOS, it is inevitably important to diagnose at early ages as well as intervene through personalized medicine. With this brief background, it was imperative to elucidate the genetic architecture of PCOS considering BMI as an controlling factor. This study aims to investigate the genetic basis behind obesity-mediated PCOS, focusing on both obese and lean individuals. It uses a comprehensive bioinformatics methodology to depict pathways and functionality enrichment, allowing for cost-effective risk prediction and management. In the present research, the representative study participants (N = 2) were chosen from a cross-sectional epidemiological survey, based on their anthropometric parameters and confirmation of PCOS. Upon voluntary participation and written consent, biological fluids (whole blood and buccal swab) were taken from where DNA was extracted. The clinical-exome sequencing was performed by the Next-generation Illumina platform using the Twist Human Comprehensive Exome Kit. A comprehensive bioinformatics methodology was employed to identify the most important, unique, and common genes. A total of 26,550 variants were identified in clinically important exomes from two samples, with 5170 common and 2232 and 2322 unique among PCOS lean and obese phenotypes, respectively. Only 262 and 94 variants were PCOS-specific in lean and obese PCOS. Three filters were applied to shortlist the most potent variants, with 4 unique variants in lean PCOS, 2 unique variants in obese PCOS, and 5 common variants in both. The study found that leptin signalling impairment and insulin resistance, as well as mutations in CYP1A1, CYP19A1, ESR1, AR, AMH, AdipoR1, NAMPT, NPY, PTEN, EGFR, and Akt, all play significant roles in PCOS in the studied group. Young women in West Bengal, India, are more likely to have co-occurring PCOS, which includes estrogen resistance, leptin receptor insufficiency, folate deficiency, T2DM, and acanthosis nigricans, with obesity being a common phenotypic expression.

Intermittent Preventive Treatment of Malaria in Pregnancy and the Impact on Neonates in African Countries as Assessed by Entropy Weight and TOPSIS Methods.

Background/Objectives: In regions of Africa with a high prevalence of malaria, pregnant women in their first or second trimester should be administered intermittent preventive treatment in pregnancy (IPTp). However, infants may contract malaria despite the IPTp therapy that their mothers have received. The objective of the present investigation was to assess the symptoms and various treatments for neonatal malaria. Methods: Entropy weight and TOPSIS were used to achieve the study goal. The TOPSIS multi-attribute decision-making system was used to assess newborn malaria symptoms and select the optimal treatment, even for mothers receiving IPTp medication during pregnancy. The entropy weight approach calculated TOPSIS attribute weights. The present research used UNICEF data for 14 African nations in 2023. Results: The results indicated that neonates whose mothers received IPTp therapy ultimately contracted malaria, with diarrhea being the primary symptom. It is important to note that health providers administer a combination of zinc and oral rehydration solution (ORS) to infants as the most effective treatment for malaria symptoms, thereby abandoning the first-line treatment for malaria, artemisinin-based combination therapy (ACT). Conclusions: The most effective treatment for neonatal malaria is a combination of zinc and ORS, although less than half of children in Africa have access to ORS. Therefore, the findings of this study may encourage African countries to prioritize co-pack therapy in their procurement and supply, healthcare provider training, and expenditures. This therapy will also help alleviate the symptoms of malaria in neonates.

Growth and Yield Performance of Different Mustard Varieties Grown in Barind Tract Soils of Bangladesh

The present research was conducted to investigate the growth and yield performance of thirteen mustard varieties grown in Chapai Nawabganj district, Bangladesh. Thirteen mustard varieties, viz. “BINA Sarisha-4”, “BINA Sarisha-7”, “BINA Sarisha-9”, “BINA Sarisha-10”, “BARI Sarisha-14”, “BARI Sarisha-15”, “BARI Sarisha-16”, “BARI Sarisha-17”, “BARI Sarisha-18”, an “Indian tall” variety, “Indian short” variety, a Japanese variety “Sarisha” and a local variety were cultivated during “Rabi” (rainy) season 2021-2022. The preparation of land with recommended fertilizer doses, the experiment was arranged in a randomized complete block design consisting of three replications. All the growth, yield, and yield attributes significantly differed among the mustard varieties. In growth attributes, the highest value in plant height (149.97 cm), number of leaves per plant (16.77), leaf length (12.33 cm), number of branches per plant (11.40), and tap root length (22.53 cm) for “Indian tall” variety, “Indian short” variety , “BARI Sarisha-18”, “BINA Sarisha-7”, and “Japanese Sarisha”, respectively. In terms of yield and yield attributes, number of siliqua per plant (102.00), siliqua length (6.37 cm), number of grains per siliqua (39.50), grain yield per plot (576.33), 1000-seeds weight (3.75 g), biological yield (5.06 ton.ha-1), and harvest index (35.23%) was highest in the “Indian tall” variety , “BARI Sarisha-14”, “BARI Sarisha-14”, “BINA Sarisha-9”, and “Indian short” variety , respectively. The maximum benefit cost ratio (BCR) was 2.21, observed in “BINA Sarisha-9”. Besides, BCR 1.71 and 1.66 were for “BARI Sarisha-14” and “Japanese Sarisha”, respectively. The findings of the study suggested that “BINA Sarisha-9”, “BARI Sarisha-14”, and “Japanese Sarisha” would be suitable for better productivity and recommended for cultivation in the medium highland of Chapai Nawabganj district of Bangladesh.

Self-compassion improves barrier self-efficacy and subsequently physical activity: A test of longitudinal mediation using a representative sample of the United Kingdom.

Self-compassion, which directs the awareness of suffering, sympathetic concerns and caring motives towards oneself, is an important psychological quality and resource for health and well-being. In the context of physical activity, self-compassion can help individuals overcome obstacles, recuperate from a setback or a lapse and engage in regular physical activity. The present research was the first to examine the longitudinal effects of self-compassion on physical activity and the mediation role of barrier self-efficacy of such effects. We recruited a national representative sample of 654 UK adults and followed them over three timepoints across 9 months. At each time point, participants completed an online survey assessing levels of state self-compassion, barrier self-efficacy and physical activity behaviours. We examined the longitudinal effects of self-compassion on physical activity and the mediation role of barrier self-efficacy. Baseline state self-compassion consistently correlated with physical activity levels at Times 2 and 3. Barrier self-efficacy at Time 2 mediated the longitudinal effect of baseline state self-compassion on Time 3 physical activity, after controlling for within- (e.g., Time 1 on Time 2 self-compassion) and between-person variations (e.g., covariance of self-compassion and physical activity within a timepoint). Adopting a self-compassionate mind facilitates engagement and maintenance of physical activity. Future studies could consider accelerometer-based physical activity measures and develop and validate a more context-specific state self-compassion measure tailored for physical activity contexts. Researchers and practitioners should consider incorporating self-compassion to future interventions and education programmes for promoting physical activity.

A study on analytical solutions of one of the important shallow water wave equations and its stability analysis

Abstract The present research uses the modified w/g-expansion technique to give analytical solutions for the nonlinear time fractional integro-differential Kadomtsev Petviashvili (KP) hierarchy equation with beta fractional derivative. The modified w/g-expansion technique is an important method for finding analytical solutions to nonlinear equations. The suggested approach produces three sorts of solutions trigonometric, hyperbolic, and rational. These answers have been discovered with the aid of a software tool. Additionally, stability analysis of observed governing model solutions is used to validate scientific calculations. Furthermore, the 3-dimensional, contour, and 2-dimensional images are provided for a better understanding of the behavior of the solutions.

Preparation of Polyvinyl Alcohol–Chitosan Nanocellulose–Biochar Nanosilver Composite Hydrogel and Its Antibacterial Property and Dye Removal Capacity

In this research, silver-loaded biochar (C-Ag) was acquired from a waste fish scale, and nanocellulose (CNF) was prepared from the waste wheat stalk. Then C-Ag was loaded into chitosan-polyvinyl alcohol hydrogel (CTS-PVA) with CNC as a reinforcement agent, and a novel nanocomposite material was acquired, which could be efficiently applied for antibacterial and dye removal. By plate diffusion analysis, the inhibition areas of C-Ag-CTS-PVA-CNF (C/CTS/PVA/CNF) hydrogel against E. coli ATCC25922, S. aureus ATCC6538, and P. aeruginosa ATCC9027 could reach 22.5 mm, 22.0 mm, and 24.0 mm, respectively. It was found that the antibacterial rate was 100% in the water antibacterial experiment for 2 h, and the antibacterial activity was more than 90% within 35 days after preparation, and the antibacterial rate was more than 90% after repeated antibacterial tests for five times. Through swelling, water adsorption, water loss rate, and water content tests, the hydrogel manifested good moisturizing properties and could effectually block the loss of water and improve the stability of the C/CTS/PVA/CNF hydrogel. The pseudo-first-order and pseudo-second-order models were built, and the adsorption capacity of hydrogel to dye was analyzed, and the dye removal was more consistent with the pseudo-first-order kinetic model. The best removal effect for Congo red was 96.3 mg/g. The C/CTS/PVA/CNF hydrogel had a remarkable removal efficacy on Malachite green, Methyl orange, Congo red, and Methylene blue. As a result, the C/CTS/PVA/CNF hydrogels had robust antibacterial properties and reusability. In addition, the present research developed a facile strategy for effectual dyes removal from the aqueous medium.

Folic acid-targeted redox responsive polylactic acid-based nanoparticles co-delivering pirarubicin and salinomycin suppress breast cancer tumor growth in vivo.

Targeted cancer therapy using nanocarriers has emerged as a promising solution to the majority of drawbacks associated with conventional chemotherapy. The present research work describes the development of folic acid (FA)-targeted redox responsive [S-(PLA-b-PEG-CONH)]2 polymeric nanoparticles for the co-delivery of pirarubicin (Pira) and salinomycin (Sal). The nanoparticles' redox responsiveness arises from embedded disulfide bonds within the polymer, which gradually break in response to high GSH levels in tumors, enabling sustained drug release. The nanoparticles exhibited a hydrodynamic size of ∼104 nm and a surface charge density of -15.5 mV with low PDI values. Blank nanoparticles (w/o drug) showed negligible toxicity towards both non-malignant human and murine cells and exhibited excellent stability under different environmental conditions for up to 3 weeks. A cellular internalization study conducted using Rho B/C6 dual-dye-encapsulated nanoparticles showed efficient uptake of the nanoparticles after just 1 hour of incubation with SUM-149 2D adherent cells and 3D spheroids. The release of Pira and Sal from Pira/Sal dual-loaded nanoparticles increased significantly in a reducing environment. The % cumulative release of Pira increased from 20.5% ± 1.0 in PBS (pH 7.4) to 40.1% ± 0.4 in dithiothreitol (DTT) after 20 days; similarly, the % cumulative release of Sal increased from 36.2% ± 1.7 in PBS (pH 7.4) to 51.5% ± 1.7 in DTT. The cytotoxicity studies of FA-targeted Pira/Sal dual-loaded nanoparticles with varying Pira : Sal ratios (1 : 1, 3 : 1 and 1 : 3) revealed that the nanoparticles displayed 8-10 fold lower IC50 values than the respective free drug formulations across multiple breast cancer cell lines including SUM-149, MDA-MB-231 and EAC as well as in 3D mammospheres. Balb/c syngeneic mice bearing EAC tumors experienced ∼100% tumor regression upon treatment with FA-targeted Pira/Sal (3 : 1) dual-loaded nanoparticles, indicating synergistic anti-tumor potency. In vivo survival and histopathological studies indicated no significant toxicity in vital organs of the body as compared to free drugs. Based on the performance, the currently investigated FA-targeted Pira/Sal dual-loaded nano-formulation is recommended to be further explored in other cancer types as well as in higher animals for cancer therapy.

Salinity influence on Mytilus galloprovincialis exposed to antineoplastic agents: a transcriptomic, biochemical, and histopathological approach

Nowadays, aquatic species face a variety of environmental risks associated with pharmaceutical consumption. More specifically, the increased number of cancer patients has been accompanied by an increased consumption of antineoplastic drugs, such as ifosfamide (IF) and cyclophosphamide (CP). These drugs have been found in aquatic ecosystems, raising concerns about their impact, especially on estuarine species, as marine waters are the final recipients of continental effluents. Simultaneously, predicted climatic changes, such as salinity shifts, may threaten organisms. Considering this, the present research aims to investigate the combined effects of IF and CP, and salinity shifts. For this, a transcriptomic, biochemical, and histopathological assessment was made using the bivalve species Mytilus galloprovincialis exposed for 28 days to IF and CP (500 ng/L), individually, at different salinity levels (20, 30, and 40). IF and CP up-regulated metabolism-related gene cyp3a1, with CP also affecting abcc gene, showing minimal salinity impact and highlighting the importance of these metabolic routes in mussels. Salinity shifts affected the transcription of genes related to apoptosis and cell cycle growth, such as p53, as well as the aerobic metabolism, the antioxidant and biotransformation mechanisms. These findings indicate mussels' high metabolic adaptability to osmotic stress. Under CP exposure and low salinity, mussels exhibited increased cellular damage and histopathological effects in digestive gland tubules, revealing detrimental effects towards M. galloprovincialis, and suggesting that a metabolic slowdown and activation of antioxidant mechanisms helped prevent oxidative damage at the control and high salinities. Overall, results reinforce the need for antineoplastics ecotoxicological risk assessment, especially under foreseen climate change scenarios.

Fluconazole-loaded Hyaluronic Acid-modified Transfersomal Hydrogels Containing D-panthenol for Ocular Delivery in Fungal Keratitis Management.

Fungal keratitis (mycotic keratitis) is an eye infection in which the cornea is infected by fungi and such fungal keratitis management can be effectively possible by ocular administration of antifungal drugs. The main objectives of the present research were to develop and evaluate fluconazoleloaded transfersomal hydrogels for ocular delivery in the effective management of fungal keratitis. A 23 factorial design-based approach was used for statistical optimization, where (A) the ratio of lipid to edge activators, (B) the amount of hyaluronic acid (% HA), and (C) the ratio of edge activators (sodium deoxycholate to Span 80) were taken as three factors. The average vesicle diameter (Z, nm) of transfersomes was taken as a response. Further, fluconazole-loaded transfersomes (FTO) were incorporated into 1% Carbopol 940-based hydrogel (OF1) and 2% HMPC K4M-based hydrogel (OF2) containing D-panthenol (5% w/w). The optimal variable setting for the optimized formulations of FTO was (A) = 9.15, (B) = 0.30%, and (C) = 3.00. FTO exhibited 66.39 nm Z, 0.247 polydispersity index, - 33.10 mV zeta potential, and 65.38 ± 1.77 % DEE, and desirable elasticity. TEM image of FTO demonstrated a unilamellar vesicular structure. The ex vivo ocular permeation of fluconazole from transfersomal hydrogels was sustained over 24 h. All the transfersomal hydrogels showed good bioadhesion and excellent antifungal activity with respect to the zone of inhibition against Candida albicans than Aspergillus fumigates, in vitro. HET-CAM study results demonstrated that both the hydrogels were nonirritant and safe for ocular. Short-term physical stability study suggested the stability of the developed formulation. The current research demonstrated a new way to enhance the ocular penetration of fluconazole via transfersomal hydrogel formulations for ocular delivery in the effective management of fungal keratitis.

Devising a Breast Cancer Diagnosis Protocol through Machine Learning

AbstractBreast cancer is a life-threatening disease and has serious health implications. It is categorized based on receptors, including the estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2), which are the focus of the present research We analyzed gene expression from data obtained from a functional genomics repository called Array Express. The accession numbers are E-GEOD-52194, E-GEOD-75367, and E-GEOD-58135, and the molecular details of these subsets of cancer receptors. Upon following a predefined computational pipeline, we identified 369 genes that had distinct patterns of gene expression profiles in cases of ER-positive (ER + ) and HER2-negative (HER2-) breast cancer. The support vector machine (SVM) and decision tree models of machine learning were used to evaluate the prognostic and diagnostic significance. Accuracy, sensitivity, and specificity were examined to gauge the effectiveness of these models. Then, a network analysis was performed to assess the significant biological process and signaling pathways of HER2- and ER+ breast cancer development. The present study facilitates an enhanced approach to these subcategories of breast cancer so that precise diagnoses can be made, and better and more focused treatment plans can be provided. The current research provides valuable information on the molecular and genetic basis of ER+ and HER2- breast cancer and has great potential for improving patients' treatment.

Socioeconomic status differences in agentic and communal self-concepts: Insights from 6 million people across 133 nations.

Do people of different socioeconomic status (SES) differ in how they see themselves on the Big Two self-concept dimensions of agency and communion? Existent research relevant to this theoretically and socially important question has generally been indirect: It has relied on distant proxies for agentic and communal self-concepts, narrow operationalizations of SES, comparatively small samples, and data from few nations/world regions. By contrast, the present research directly examines the associations between SES and agentic and communal self-concepts, relies on well-validated measures of agency and communion, examines three complementary measures of SES, and uses data from 6 million people (years of age: M = 26.12, SD = 11.50) across 133 nations. Overall, people of higher status saw themselves as somewhat more agentic and as slightly less (or negligibly less) communal. Crucially, those associations varied considerably across nations. We sought to explain that variation with 11 national characteristics and found only three of them to be robustly relevant: National religiosity and pathogen load curbed status differences in agentic self-concepts, and income inequality amplified status differences in communal self-concepts. Our discussion develops theory to explain the importance of national religiosity, pathogen load, and income inequality for socioeconomic status differences in agentic and communal self-concepts and it also describes the substantial societal implications of those differences. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Geo-Hydrobiology and Geoinformatics Mapping of Ethnobotany in the Gandhamardan Hills, Odisha, India

Objective: The Gandhamardan Hills (GMH)range is a group of small mountains in Peninsular India in Balangir district in Odisha state in India. There is uniqueness in geology, geography, geomorphology, climatology, Hydrology, petrology, and lithology. The lithology, soil, water, geomorphology, and traditional use of plants in Ayurveda (India) have holistic medicinal/surgery. origin. Geo-hydro-biological amalgamation through Geological Information Systems (GIS) and chemical analysis is still being explored, and the present research emphasises such studies. Methods: Data about geo-hydro-biology through grapy, geology, geomorphology, hydrology, and traditional medicinal practices are implored from literature sources, using TOPO and Q-GIS maps and ERDAS software; their analytical interpretations were reported. The chemical analysis was conducted using X-ray fluorescence spectrometric studies of the water and soil of GMH, and the exuberance of ethnobotanical species in GMH was correlated. Results Laboratory analysis, literature studies, and interaction with Ayurvedic and Kaviraj practitioners, 154 popular species databases with their pharmacological applications reported for ordinary people. Many species have multidimensional applications that can transform Ayurveda into Materia medica. Conclusion: This ethnobotanical study documented the use of plants by the local community. The natural medicinal plants are cheap for the rural communities. The information gathered can be used for further scientific investigation to develop new commercial plant-based medicines as they will be safer than synthetic drugs. SDGs 1 to 3 and 12, 13, and 15 will be satisfied if we can conserve and adequately manage the hub of medicinal plants in GMH.

A Scale to Measure Social Media Jealousy

As social media continues to grow rapidly throughout the world, researchers and mental health professionals have been keenly observing and recording some of its detrimental effects on the mental and emotional health of its users. In this regard, one of the constructs that has been gaining interest is social media jealousy. However, there is a paucity of standardised tools that accurately measure this construct. To fill this gap, the present research was undertaken as a part of a larger study examining the possible negative effects of social media. The present research has resulted in the development of the 15-item Social Media Jealousy Scale (SMJS-15). It is a single-dimensional scale that has shown strong reliability, convergent validity, as well as evidence of construct validity. The scale has been developed using both exploratory and confirmatory factor analyses and can be used to test social media jealousy experienced by users across multiple social media platforms.

DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis.

D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor (NMDAR)-related physiological and pathological processes. D-aminoacyl-tRNA deacylase 1 (DTD1) may biochemically contribute to D-serine or D-aspartate production. However, it is unclear thus far whether DTD1 regulates D-serine or D-aspartate content in neurobiological processes. In the present research, we found that DTD1 was essential to maintain the D-serine or D-aspartate homeostasis, which was consistent with the phenomenon that DTD1-deficiency resulted in changes in the quantity changes of functional NMDAR subunits in postsynaptic compartments. Moreover, DTD1 played a considerable role in regulating dendritic morphology and synaptic structure. As a consequence, DTD1 affected neurobiological events, including the synaptic strength of the CA3-to-CA1 circuit, dendritic spine density of hippocampal pyramidal neurons, and behavioral performance of mice in the Morris water maze. These findings highlight the important role of DTD1 in synaptic transmission, neuronal morphology, and spatial learning and memory and suggest an undisclosed mechanism of DTD1 that participates the regulation of D-serine or D-aspartate homeostasis in hippocampal neurons.

Qualitative phytochemical analysis of bioactive constituents in acetone extract of seeds of Hydnocarpus pentandra

Ethnoveterinary medicine focuses on the practical use of community or area based traditional and indigenous knowledge including the collection, preparation and administration of medicinal plants or plant parts for curing diseases of animals. Hydnocarpus pentandra is a plant endemic to South India which is traditionally known for the antileprotic activity of its seed oil. Diverse pharmacological activities of the plant extracts depend on the presence of its secondary metabolites. The present research was conducted to explore the phytochemical constituents present in the acetone solvent extract of the seeds of H. pentandra. Preliminary phytochemical screening of the extract using colorimetric reactions revealed the presence of steroids, triterpenes, diterpenes, flavonoids, alkaloids and carbohydrates. Gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of different compounds which included paromomycin, D-streptamine, carnegine, 4-propyl acridine and R-limonene. The acetone extract could be considered as a potent source of new molecules with different pharmacological actions. Keywords: Hydnocarpus pentandra, phytochemical screening, secondary metabolites

Effect of rare earth ions on the optical and electronic properties of defect chalcopyrite: Experimental and theoretical investigation

The present research is a systematic experimental and computational study focused on structural, electronic, and optical properties of ZnGa2S4 doped with neodymium rare earth ions for the first time. High-intensity, narrow-band luminescence peaks are observed in the visible and infrared regions by doping the matrix with Nd ions. These peaks in the background of the broadband spectrum are due to intercenter 4f-4f transitions of Nd3+ ions. The fact that the Raman peaks of the alloy crystal are more intense than that of the pure crystal confirms that the neodymium does not move freely in the lattice and occupies the place of defects. This confirms the results from our X-ray structural analysis. The crystal lattice parameters of the studied materials were determined as follows: a = 5.496 Å, c = 10.99 Å, c/a = 2. To explain the electronic, optical and magnetic properties, using ATK-DFT method, electronic energy band structure, density of states and optical spectrum for pure and doped with ZnGa2S4:Nd compound are computed and discussed. DFT result shows that impurity Nd leads to a decreased bandgap of ZnGa2S4 due to the hybridization of Nd-4d with S-3p orbital in the forbidden gap. The peaks in the optical spectrum are shifted toward the lower energy range for doped supercell.

Playing the Publish or Perish Game: Guidance for Doctoral Students and Early Career Faculty

“Publish or perish,” or the idea that one must consistently publish to succeed in an academic career is a well-known adage within higher education (Schaberg, 2016). Specifically, Bond (2023) shares that publications are promoted as a path to career success. The scholarly output of professors simultaneously affects the reputations of the professors and their institutions. Similarly, doctoral programs often require students to publish before they graduate. When applying for academic positions, having publications beyond the dissertation is seen as a strength by prospective employers. Although publications are viewed as a strength, Huang (2021) discusses some challenges doctoral students have with publishing, including a lack of understanding of the publication process. Many students who are in master’s degree programs may complete a thesis. However, the thesis process diverges from journal articles because the publication procedures differ. Huang (2021) further notes that the pressure to publish in high-quality, well-known journals is another challenge. These journals are identified as the best because of the rigor involved in their peer review process, and they typically accept fewer papers per year. Finally, journal publications are a competitive process, and the inability to complete a publication on time can cause anxiety among students. Researchers have called for an evaluation of publishing practices in academia. For example, Saxena, Godfrey, and Yannessa (2023) explain that publishing expectations can lead to the production of low-quality publications and an increase in unethical behaviors such as plagiarism. Moreover, inexperienced writers may seek to validate their research by relying on the willing acceptance of predatory journals (Mertkan, Aliusta, & Bayrakli, 2022). These journals flood the internet with low-quality papers that do not adhere to rigorous peer-review standards. Consequently, inferior research that has not been vetted is often repetitively cited. Since navigating the publication process is a skill that must be gained, Dyke (2019) suggests that it is necessary to teach early-career academics how to manage the rigors of publication expectations. Dyke asserts that learning to manage stress and time is essential for successfully publishing. Also, new scholars must be taught how to explain their research’s benefits and potential impact. Dyke further argues that publishers can play a crucial role in teaching publication skills. Instead of relying solely on universities, publishers can develop courses to clarify the process of writing publications. These courses can include content about basic writing and editing skills and submitting revisions. The panel recognizes that publishing is indeed not a game. However, it is a necessary component of career progression at many universities. Therefore, in response to library and information science doctoral and early career professionals’ scholarly publishing professional development needs, this panel seeks to advise about strengthening writing skills and clarifying the peer review publishing process. This panel will include expert editors and editorial board members with over a century of combined scholarly publishing experience. Attendees will participate in a discussion of the peer review process and receive suggestions for efficiently writing and submitting journal articles. The panelists are Drs. John Budd and Denice Adkins (co-editors of JELIS), Yunfei Du (editorial board member of JELIS), Maria Cahill (co-editor of School Library Research), and Vanessa Reyes (co-editor of The International Journal of Information, Diversity, & Inclusion). The moderator will be Dr. Daniella Smith (editorial board member of Public Library Quarterly). Program Format This interactive program will include polls to increase audience engagement and an online whiteboard to collect questions for the discussion after the presentation. The program format will be as follows: Session introduction: The moderator will introduce the session by sharing the presentation objectives and research about publishing in academia.. Panel introduction: Each panelist will introduce themselves and their experience with scholarly publications. Topic Discussion: The panelists will answer questions related to the following topics. Understanding the peer review process: The presenters will share the peer-reviewed process used by the journals and the pros and cons of the peer-review process. Implementing strategies for publishing quicker: Panelists will provide suggestions for streamlining the publication process. Submitting revisions and options for addressing comments: Our experts will discuss their expectations for article revisions and the do’s and don’ts of getting an article published after revisions have been requested. Preparing content for peer-reviewed journals: There is a difference between casual and scholarly writing. The panelists will discuss the differences and provide examples of their expectations regarding the content of peer-reviewed publications. Identifying appropriate journals: The panel will suggest how to determine the best journals for their research areas and how to avoid predatory journals. Identifying publication tools and resources: Authors curate tools and acquire skills that help them navigate the publication process. The presenters will share their favorite tools and resources. Making writing enjoyable: The panelists will discuss embracing writing and making publishing fun. Final words of advice and questions: The session will conclude with audience questions and final panelist thoughts.

Substance P a potent prognostic indicator for canine mammary tumours- a comparative study

Substance P, a neurotransmitter in the central and peripheral nervous system, is considered as a biomarker of pain due to its key role in nociception. But recent researches have proved the increased expression of Substance P and its receptors in human breast cancers and their role in its progression. Canine mammary glands and spontaneously occurring neoplasms in them are considered best models for human breast cancers. Hence as a preliminary study, the present research work was undertaken to assess the level of Substance P in dogs with mammary tumours in comparison to healthy dogs. From the dogs brought for ovariohysterectomy and mammary tumour resection, 20 female dogs were selected for the study. Signalment and detailed history regarding each dog were recorded. All the dogs were subjected to thorough preanaesthetic evaluation and were grouped into Group I (mammary tumour) and II (control group) with 10 dogs each. Blood was collected from all the dogs and serum was separated and stored at -20ºC for estimation of substance P. The same was performed using sandwich ELISA technique with canine specific Substance P ELISA kit. The values obtained for Group I and II were statistically analysed using independent t- test. The level of substance P was significantly higher in the dogs of Group I when compared to Group II Keywords: Substance P, mammary tumour, dogs

Mechanical‐performance deterioration of RC segment of shield tunnel under high corrosion degree and the transformation of eccentric‐failure mode

AbstractReinforcement corrosion in shield tunnel segments has an important impact on the structure's bearing capacity and failure mode. Generally, a shield tunnel structure is under small eccentric compression, but if the reinforcement corrosion develops sufficiently, then a transition occurs from small to large eccentric load state, thereby lowering the structural bearing capacity and endangering the safety of tunnel operation. In the study reported here, based on the compressive bending load characteristics of the shield lining structure, corrosion test columns with small eccentric loading were designed to simulate the actual force state of the tunnel lining, and the whole evolution process of their mid‐span strain, ultimate bearing capacity, and cracks under different corrosion degrees was analyzed. With increasing corrosion, the bearing capacity, concrete strain, and depth of the compressive zone of a test column decrease more and more rapidly, and at the maximum corrosion degree of 68.32%, the maximum reduction of bearing capacity is 53.23%. The tests show that the failure mode of a test column with high corrosion degree (≥46.25%) is transformed from small to large eccentric failure. Based on theoretical analysis of the normal section bearing capacity of reinforced concrete flexural members, a theoretical method is proposed for calculating the critical corrosion degree for the tunnel lining structure to transform from small to large eccentric failure. The theoretical calculation method is verified against finite‐element calculations, and the present research results offer theoretical support for the durability design and safety evaluation of shield tunnel lining structures.