Present Research Research Articles

Investigating the relationship between students’ executive functions, emotion regulation, and academic achievement

Our research aimed to identify interrelationships between performance in the Stroop test and emotion regulation and academic achievement of students. The present research method was descriptive of correlation type. The statistical population in this study included all students of Mashhad in Iran. Using the cluster sampling method and within each cluster using random sampling method, 120 students were recruited from three different educational levels. In this study, the Stroop test, Cognitive Emotion Regulation Questionnaire (CERQ-P), and GPA of the students were used to measure the research variables. To analyze the data, a multivariate regression statistical model was used to determine the relationship between the desired variables. The analysis shows that there is a significant relationship between academic achievement and performance on the Stroop test and emotion regulation (p < 0.05). It is included that training based on improving executive functions and emotion regulation can be used to improve students’ academic status.

The Analysis of Learning Performance Satisfaction for Physical and Online Learning: A Case Study from Taiwan

Management education, continuously evolving since the 1990s, recognizes the need to develop proficient management professional’s adept at strategic decision-making. The present research delves into the effectiveness of a management course for first-year students at a chosen School of Management, underlining its paramount importance in ensuring student retention and bolstering departmental stability. The purpose of this research is to evaluate the effectiveness of traditional physical and online learning methods in a management course for first-year students at a university in Taiwan, focusing on students' satisfaction with their learning performance. The study aims to compare the educational efficacy of these two instructional modes and analyze the variations in student performance and satisfaction. The methodology involved a longitudinal design with data collection from first-year students in 2022 (online learning) and 2023 (physical learning). The research employed pre-test and post-test evaluations, regression analysis, and Importance-Performance Analysis (IPA) to assess the impact of course units on students' learning satisfaction. This study employed regression analysis to determine the influence of enhancing "Management Basis" and "Management Operations" on satisfaction. The results revealed that online learning outperformed physical learning in terms of overall student satisfaction, particularly in understanding "Management Basis" and "Management Operations." However, physical learning demonstrated higher improvements in student scores and satisfaction, particularly in areas requiring detailed explanations and hands-on engagement, such as "Control Tools.". The novelty of this research lies in its comparative approach to evaluating two distinct learning environments during a critical period marked by the COVID-19 pandemic. The findings offer valuable insights into how different teaching modalities impact student satisfaction and learning outcomes, providing guidance for educators to refine instructional strategies to enhance student learning efficacy across different formats. The study underscores the importance of adapting teaching methods to suit the specific demands of online and physical learning environments.

A matter of trust? Analyzing the relationship between attitudes toward COVID‐19 countermeasures and right‐wing ideology in Germany

AbstractThe COVID‐19 pandemic has divided societies, especially regarding vaccine mandates. While research suggests that political ideology plays a crucial role in whether people support or oppose COVID‐19 countermeasures, the relationship between these attitudes and political ideology remains unclear, with varying results across different countries. The present research focuses on right‐wing authoritarianism (RWA) in Germany, examining its role as a predictor. Prior studies highlight that, conservatives and right‐wing authoritarians, particularly in the USA, tend to hold more negative attitudes toward COVID‐19 countermeasures despite RWA's usual association with unwavering support for state authorities. Therefore, the present survey study (N = 1063) investigated whether trust in politics and science moderates this relationship. Contrary to expectations, the findings revealed that RWA consistently predicted support for vaccine mandates independent of trust levels. Results are discussed about the specifics of the German case and more general relationships between political ideology and the support of state authorities.

Collaborative AI-enhanced digital mind-mapping as a tool for stimulating creative thinking in inclusive education for students with neurodevelopmental disorders

BackgroundNowadays, inclusive education is becoming an increasingly important method in the education of people with various types of disabilities. This study is aimed at investigating the effectiveness of utilizing collaborative digital mind-mapping techniques in the practical work of students in inclusive educational groups, as well as examining how the use of AI-provided prompts influences the development of creative skills.MethodsThe study involved 163 participants, among whom 28 had neurodevelopmental disorders. The application of the proposed methodology resulted in an improvement in the indicators of creative thinking as measured by the Torrance Figural Creativity Test, specifically in terms of Fluency, Originality, Elaboration, and overall creativity score; the observed increase was statistically significant according to the Wilcoxon signed-rank test (p = 0.05).ResultsThis increase in indicators was observed both in students with neurodevelopmental disorders and in students without developmental disorders, with a notably stronger impact observed on students with neurodevelopmental disorders. Furthermore, a slightly higher effectiveness of the applied methodology was recorded when AI prompts were used for both categories of students. Students with neurodevelopmental disorders largely perceived the usefulness of the prompts they received subjectively.ConclusionsThe present research may contribute to further study of various creativity development methodologies in inclusive education, as well as regarding the influence of AI utilization on creative skills. The obtained results can be utilized in the development of educational programs for students in higher education institutions that support inclusive forms of learning.

The role of transitional probabilities in word holistic processing.

In recent years, increased attention has been devoted to visual word recognition under a perceptual expertise framework. Because the information required to identify words is distributed across the word, a holistic attentional strategy is optimal and develops with experience. It is, however, an open question the extent to which other information embedded in a word may contribute to word holistic processing, namely sublexical word properties. In the present research, we therefore explore the role of sublexical properties-specifically bigram transition probabilities-in this processing strategy. We used a common task in the holistic processing literature (i.e., composite task) and four-letter disyllabic words, where two of the bigrams reinforce the cohesiveness of each syllable and one of the bigrams reinforces the cohesiveness between the syllables. We found preliminary evidence of a role of these sublexical properties in word holistic processing.

Impact of the COVID-19 pandemic on Canadian performing and creative artists: An interpretive descriptive study using the social-ecological model.

Public health restrictions during the Coronavirus-2019 (COVID-19) pandemic in Canada have substantially reduced the work and income of performing and creative artists. We aimed to understand how factors at the public policy, community, organizational, interpersonal and individual levels affected Canadian performing and creative artists' health and livelihood during the pandemic. We interviewed 14 creative and performing artists from an academic hospital-based healthcare center in Toronto, Canada. In addition, we conducted secondary data analysis on an existing set of 17 transcribed interviews from a quality improvement study that included relevant information to answer the present study's research question. We applied an interpretive descriptive approach to our qualitative inquiry and used the social-ecological model (SEM) as our analytic framework. We identified factors at all levels of the SEM that tended to synergistically affect the health and livelihood of artists during the COVID-19 pandemic. Public health restrictions and government financial assistance programs have downstream effects on other levels. During the pandemic, many artists sensed an overwhelming loss of community, financial instability, and limited access to healthcare; which in turn affected their health. For those who accessed financial assistance programs, the stability of income afforded time for rest without the stress of food insecurity or housing instability. Use of the SEM as an analytic framework reflects the multidirectional intricacy and dynamic interplay among factors operating within and across all five levels, bringing to light potential areas of improvement at various levels to strengthen resilience and reduce risk factors associated with artists' health and healthcare access. Findings also accentuated the fragility of precarious work that inundates the performing arts industry, which emphasizes the need for interventions and policies to address this issue. Such interventions might include financial support programs for artists, access to affordable healthcare services, and efforts to strengthen social support networks within the arts community.

Entrepreneurial Competency of Single-Mother Entrepreneurs

Today, the business world has embraced increasing uncertainty and abrupt changes. The concern for business owners is business sustainability, which is crucial for their business to remain relevant and flexible in unpredictable business environments. The process of change forces business owners to be ready for any consequences that affect their business. Due to overwhelming tasks and responsibilities, single mothers may need help to succeed in business. The present research offers a comprehensive review of business continuity from the perspective of single mothers. Within the scope of this research is an exhaustive and methodical investigation of the business acumen of single mothers as entrepreneurs. A literature review was conducted, and the findings may offer a comprehensive discussion of several dimensions of entrepreneurial competency. The findings contribute new information to the existing body of knowledge regarding entrepreneurial competency, which has been a recurrent topic of discussion among earlier academics who have explored the subject matter to investigate. At the end of this paper, practising entrepreneurial competency with single-mother entrepreneurs has several implications. These findings can be applied and utilized by single-mother entrepreneurs, as well as by the government, industry, and the community.

Associations between motivational factors and burnout syndrome among elite skiers

The present research investigated the association between a series of motivational factors and burnout syndrome among elite skiers at the contextual level within the Hierarchical Model of Intrinsic and Extrinsic Motivation (HMIEM). There are 352 subjects (258 males, 94 females, aged 18 to 25 years) across five skiing events from three sport universities in this study. Four psychological scales related to motivational factors and burnout syndrome were completed by subjects. Overall, the result showed that a task-involving climate had a positive relationship with basic psychological needs, eliciting a positive pathway to autonomous motivation, and thus negatively affecting burnout syndromes. On the other hand, an ego-involving climate had a negative relationship with basic psychological needs, eliciting a negative pathway to amotivation, and then positively affecting burnout syndromes. The results underscore the intricate associations between a variety of motivational factors and athletes’ burnout syndrome, supporting the need to incorporate burnout syndrome elements into the outcomes of HMIEM sequence.

Effectiveness of Exploratory activities Based on Engineering and Science Practices of Next Generation Science Standards in Developing Exploratory Thinking among Elementary Students

The present research paper aimed to identify the effectiveness of exploratory activities based on engineering and science practices of Next Generation Science Standards (NGSS) in developing exploratory thinking among elementary students in Mecca, Saudi Arabia. The author utilized the quasi-experimental method based on the control and experimental groups. Moreover, the sample consisted of (64) 4th grade elementary female students. The "Unit of Energy" was restructured based on engineering and science practices of NGSS among the 4th grade elementary students. A teacher guide and a student notebook concerning the activities of the "Unit of Energy" were prepared. Moreover, an exploratory thinking test was developed and applied to the participants over 6 weeks. The results showed statically significant differences at the level of ≤0.01 between the mean scores of the experimental and control groups at exploratory thinking post-test and in each domain. The study recommends the need for teacher preparation programs at Colleges of Education on preparing the pre-service teachers according to NGSS that should be involved in teaching practices to evaluate pre-service teachers’ performance in practicum.

Effects of short-term oral letrozole on fresh semen parameters, endocrine balance, and prostate gland dimensions in domestic dogs

BackgroundAromatase inhibitors improve male fertility by modifying the hormonal control of spermatogenesis. The present study aimed to investigate the effects of oral administration of letrozole on testosterone and estradiol concentrations and their ratios in blood serum, seminal plasma, prostatic fluid, sperm quality in fresh semen, and prostate gland dimensions. Seven adult male intact mixed-breed dogs were selected. The animals received letrozole (72 µg/kg, PO) daily for four weeks. Blood samplings and semen collections were carried out on days 0 (control), 14 (treatment), 28 (treatment), and 42 (post-treatment).ResultsOur results showed that letrozole administration resulted in a 4.3 fold significant increase in serum, seminal plasma, and prostatic fluid testosterone levels after 14 days. This remained high until the end of the study. Serum and prostatic fluid estradiol levels did not change significantly over the study period. However, the seminal plasma estradiol level showed a significant increase on day 14. The estradiol: testosterone ratio was significantly reduced on day 14 in serum, seminal plasma, and prostatic fluid samples. Letrozole significantly improved the ejaculated spermatozoa viability and concentration after 28 days of oral administration. However, the sperm plasma membrane functional integrity and kinematic parameters were not significantly affected by the treatment. Transabdominal ultrasound examination revealed a significant increase in the height, width, and volume of the prostate gland after 28 days of treatment.ConclusionsAccording to the present research, oral administration of letrozole for 28 days affects local and systemic sex hormone balance leading to an improvement of the ejaculated canine spermatozoa viability and concentration concurrent with an increase in the prostate gland dimensions.

Empowered by representation: How plus‐size models create brand evangelists

AbstractTraditional beauty standards are evolving as brands embrace diversity and equity through inclusive communication strategies. This paradigm shift is evident in the transition from stereotypical slender models to the inclusion of more diverse plus‐size models in brand communication. However, an important question arises: Does the presence of a plus‐size model in an advertisement enhance consumer support for a brand? The present research encompasses six studies, including one field study and five experimental studies, that delve into the relationship between models' body size and brand evangelism. The findings demonstrate that featuring a plus‐size model in an advertisement enhances brand evangelism among consumers. Further, consumer empowerment is the underlying mechanism driving this effect. Finally, this research identifies the moderating role of empathy such that consumers with higher levels of empathy experience a heightened sense of empowerment through inclusive brand communication. By illuminating these dynamics, this research contributes to the growing literature of diversity, equity, and inclusion in brand communication.

A spiking neuron model of moral judgment in trolley dilemmas

People will make different moral judgments in similar moral dilemmas where one can act to sacrifice some number of lives to save several more. Research has shown that although people can reason that an action would save more lives, automatic processes can overwrite deliberate reasoning. Having participants imagine hypothetical moral dilemmas, researchers have discovered that factors such as action/omission, means/side-effect, and personal/impersonal can affect judgment. Joshua Greene suggests that these features do not affect people’s judgment because they are morally relevant but are instead a result of the myopic nature of the automatic moral process. Greene hypothesizes that there is some myopic module or domain-general process that attaches a negative emotional response to an action when one is contemplating violent actions. In the present research a model of this myopic automatic process is paired with an analytic system to replicate deontological and utilitarian responses to moral dilemmas. Our system, MERDJ, models this in simulated spiking neurons. The system takes in representations of specific moral dilemmas as inputs and outputs judgments of appropriate or inappropriate.

Jewish Americans’ identity salience and effects on attitudes toward diversity

Although Jewish people in the US are often racialized (i.e., perceived by others) as White, Jewish Americans vary in the extent to which they consider themselves White, and in how strongly they identify with being Jewish. Based on prior findings that identifying with a White ethnic subgroup (e.g., Irish, Italian) can reduce prejudice toward racial and ethnic minorities, we predicted that strongly identified Jewish Americans would exhibit less intergroup bias than weakly identified Jewish Americans. For the present research, we recruited participants whose religious affiliation was Jewish but who self-identified as racially White. In a preregistered correlational study, Jewish identification was associated with lower bias, whereas White identification was associated with greater bias, toward Whites relative to racial/ethnic minorities. The relationship between Jewish identification and intergroup bias was accounted for by high Jewish identifiers’ perceptions that they could personally contribute to diversity in groups and organizations. Across three meta-analyzed experiments, participants whose religious minority (Jewish) identity was made salient exhibited less intergroup bias than did control participants, and in one preregistered experiment, perceived personal contributions to diversity mediated the effect of condition on intergroup bias. Implications for the forms of ethnic identity that predict more versus less intergroup bias in an increasingly multicultural society are discussed.

Exopolysaccharides from the Green Microalga Strain Coelastrella sp. BGV—Isolation, Characterization, and Assessment of Anticancer Potential

Algal metabolites have been extensively studied as potential anticancer therapeutics. Among them, polysaccharides have attracted much attention because of their beneficial biological effects and safety. In the present research, the chemical characteristics, antitumor, and proapoptotic activities of extracellular polysaccharides (EPS) isolated from a new Bulgarian strain of the green microalga Coelastrella sp. BGV were investigated. A fast and convenient method of precipitation with cold ethanol was used to isolate EPS from the culture medium. The chemical characteristics of the isolated EPS were examined by colorimetric and spectrophotometric analyses, HPSEC-RID and HPLC-UV chromatography, and FT-IR spectroscopy. The results showed that the isolated EPS sample consists of three carbohydrate fractions with different molecular weights (11.5 × 104 Da, 30.7 × 104 Da, and 72.4 × 104 Da, respectively) and contains 7.14 (w/w%) protein. HPLC-UV analysis revealed the presence of galactose and fucose. The total uronic acid content in the sample was 4.5 (w/w%). The IR-FT spectrum of EPS revealed the presence of various functional groups typical of a polysaccharide (or proteoglycan) composed primarily of neutral sugars. The anticancer potential of the obtained EPS was assessed using cell lines with cancerous and non-cancerous origins as in vitro experimental models. The results of the performed MTT assay showed that EPS reduced the viability of the cervical and mammary carcinoma cell lines HeLa and MCF-7, while the control non-cancer cell lines BALB/3T3 and HaCaT were less affected. The HeLa cell line showed the highest sensitivity to the effects of EPS and was therefore used for further studies of its anticancer potential. The ability of EPS to inhibit cancer cell migration was demonstrated by wound-healing (scratch) assay. The cell cycle FACS analysis indicated that the EPS treatment induced significant increases in the sub G1 cell population and decreases of the percentages of cells in the G1, S, and G2-M phases, compared to the control. The fluorescent microscopy studies performed using three different staining methods in combination with Annexin V-FITC flow cytometric analysis clearly demonstrate the ability of EPS to induce cancer cell death via the apoptosis pathway. Moreover, an altered pattern and intensity of the immunocytochemical staining for the apoptosis- and proliferation-related proteins p53, bcl2, and Ki67 was detected in EPS-treated HeLa cancer cells as compared to the untreated controls. The obtained results characterize the new local strain of green microalgae Coelastrella sp. BGV as a producer of EPS with selective antitumor activity and provide an opportunity for further studies of its pharmacological and biotechnological potential.

Crotalaria quinquefolia L. Revealed as a Potential Source of Neuropharmacophore in Both Experimental and Computational Studies.

Herbal remedies have shown great promise for improving human health. The plant Crotalaria quinquefolia is used in folk medicine to cure different diseases, including scabies, fever, discomfort, and lung infections. The present research was designed to explore bioactive compounds and evaluate the neuropharmacological effects of C. quinquefolia through in vivo and in silico approaches. Different secondary metabolites as well as the antioxidant activity were measured. Furthermore, chemical compounds were identified by HPLC and GCMS analysis. The neuropharmacological activity was examined by hole cross, hole board, open field, Y-maze, elevated plus maze, and thiopental sodium induced sleeping time tests in mice at doses of 100 mg/kg and 200 mg/kg body weight. Besides, an in-silico study was performed on proteins related to Alzheimer disease. The extract showed a significant content of secondary metabolites and antioxidant potential. The in-silico analysis showed that myricetin, quercetin, rutin, and kaempferol have good binding affinity with studied proteins, and QSAR studies revealed potential benefits for treating dementia, age-related macular degeneration, and more. The findings of the present neurological activity collectively imply that the extract has strong CNS depressant and anxiolytic activity. Therefore, C. quinquefolia can be a potential source of secondary metabolites to treat Alzheimer disease.

Development and comprehensive analyses of a hybrid solar–geothermal driven polygeneration system: Thermodynamic, exergoeconomic, and emergoenvironmental aspects

The present research proposed an innovative polygeneration system that uses solar, geothermal, and natural gas energy to produce power, heat, steam, and freshwater. The system consists of a proton exchange membrane fuel cell, an organic Rankine cycle, and a multi-effect thermal desalination system. The study included thermodynamic, exergy, exergoeconomic, exergoenvironmental, emergy-based exergoeconomic, and emergy-based exergoenvironmental factors in its comprehensive evaluation of the system. Results underscored the financial aspect of the organic Rankine cycle and cogeneration system, incurring costs of 0.4518 $/s and 1.054 $/s respectively, while also highlighting the system's capability to produce 6 kg/s of freshwater. The environmental impact rates were quantified for the organic Rankine cycle and cogeneration system at 0.1417 and 0.4814 pts/s respectively, situating the system within its ecological context. Further, the study detailed the total efficiency and net power output of the organic Rankine cycle and cogeneration system, ranging between 32.45–33.51% and 43.25–45.83% for efficiency, and 56956–56322 kW and 50174–51898 kW for net power output r espectively, showcasing the system's operational capacity. A parametric analysis was also integral to the study, examining the impact of key parameters on the functionality of the proposed system, thereby providing a nuanced understanding of the system's performance under varying operational scenarios.

Outcome of Levofloxacin in the Treatment of Lower Respiratory Tract Infection

Background: Levofloxacin, a broad-spectrum fluoroquinolone antibiotic, is commonly used in treating lower respiratory tract infections (LRTIs) like pneumonia and chronic bronchitis. Its effectiveness lies in its ability to inhibit bacterial DNA gyrase, leading to bacterial cell death. Clinical outcomes of levofloxacin in LRTI treatment have generally been positive, with high rates of bacterial eradication and symptom resolution. Objective: The present research aimed to determine whether levofloxacin is an effective and safe option for treating lower respiratory tract infections. Method: From January 2022 to January 2023, researchers analyzed data from 120 patients with a lower respiratory tract infection at a tertiary hospital. Sixty patients were split evenly between a control group and an observation group. Levofloxacin was administered at the standard dosage to the control group and at a significantly higher dose to the observation group. Both the clinical efficacy and adverse reaction rates were compared and contrasted between the two groups statistically. Results: The cure rate in the observation group was 53.33 percent, which was substantially greater than the cure rate in the control group, which was 36.67 percent. There is a statistically significant difference between them (P 0.05). The overall efficacy rate of the observation group was 93.33%, significantly higher than that of the control group (73.33%). There is a statistically significant difference between them (P 0.05). There was no statistically significant difference (P&gt;0.05) between the two groups due to the low incidence of adverse responses in both the observation and control groups. Conclusion: This research demonstrates that large dosages of levofloxacin have a stronger clinical curative impact on treating lower respiratory infections than lesser doses. It is worthwhile to promote the widespread adoption of this technique since it has the potential to greatly enhance the quality of patient care

Consent to voluntary antipsychotic drug treatment-Is it free and informed?

The present research investigates the dynamics of consent in the context of antipsychotic drug therapy, with a particular emphasis on the essential attributes that constitute free and informed consent within medical treatment scenarios. Twenty individuals treated with antipsychotic drugs with consent underwent semistructured interviews. The following major themes were identified: (a) lack or total absence of information regarding the treatment, emphasizing side effects, risks, chances of success, and treatment alternatives. (b) A subjective experience of the lack of free choice that was sometimes also accompanied by the conditioning of psychiatric rehabilitation services or receiving treatment in an open ward by taking antipsychotic medication. The research findings may indicate a problem in obtaining informed consent for antipsychotic treatment that should be addressed. The themes highlight the need to examine the interface between rehabilitation services and psychiatric treatment from the legal and ethical perspective of the autonomy of individuals receiving care. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Impact of Nutrition and Exercise on Kidney Health: How to Prevent Kidney Stones?

IntroductionKidney stone disease, characterized by the formation of calculi in the kidneys, is becoming an increasingly common urinary tract disorder in developed countries. Although kidney stone disease may be caused by metabolic disorders, anatomical, functional, and genetic factors, diet plays a crucial role in its formation. Changing dietary habits has become a primary tool in the treatment and prevention of kidney stone disease. ObjectiveThe aim of this study is to present research on the impact of diet and its individual components on the risk of kidney stone formation. Special attention is given to the role of vitamins, minerals, and dietary habits in the pathogenesis and prevention of this condition. Materials and MethodsThe study involves a review of the scientific literature, considering research published in reputable medical and scientific journals regarding the impact of diet on the risk of kidney stones, focusing on key dietary components such as calcium, magnesium, sodium, vitamins C and D, as well as the role of physical activity and proper hydration. ConclusionsA balanced diet, proper hydration and maintaining a healthy body weight are fundamental elements in preventing of kidney stone disease. Adequate hydration is crucial; high fluid intake, especially water, dilutes urine and reduces the concentration of lithogenic substances.Calcium and magnesium intake are particularly important as they influence the absorption and excretion of oxalates, and excessive supplementation with vitamins C and D should be avoided. A diet rich in fruits and vegetables, and the limitation of animal protein and salt, can significantly reduce the risk of kidney stone formation. Ultimately, dietary changes and lifestyle modifications, including weight control and physical activity, play a crucial role in preventing kidney stone disease. However, further research is needed to develop effective dietary guidelines tailored to the individual needs of patients.

Green formulation of Menadione-loaded niosome as a skin-lightening preparation: In vitro/In vivo safety evaluation on Wistar rat

Purpose: In the present research, a green technique (an ultrasonic method) was used to synthesize menadione sodium bisulfite (MSB) niosome (Menasome) which is used to improve dermal delivery and increase anti-melanogenesis activities. Methods: Various cholesterol: surfactant (Chol: Sur) ratios were investigated to optimize the Menasomes. Photon correlation spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) were employed to characterize the solid state of MSB in nanoparticle form. Additionally, the optimized formulation was used to investigate ex-vivo skin absorption, in vivo skin irritation, in vitro cell survival, and anti-melanogenesis activity. Results: The results exhibited that increasing cholesterol (Chol) declined the average size of the Menasomes from 653.766±25.171 nm to 298.133±8.823 nm and increased entrapment efficiency 30.237±3.4204% to 83.616±2.550 %. The rat skin permeation study indicated that Menasome gel administered more MSB in dermal layers (439.000±36.190μg/cm2 or 23.827±1.964%) than MSB plain gel (286.200± 22.6μg/cm2 or 15.53±1.227%). In both the in vivo skin irritation test and the in vitro cytotoxicity experiment, the extended-release behavior of the enhanced Menasome demonstrated a minimal side effect profile. Furthermore, optimum Menasome inhibited melanin formation (37.426± 1.644% at 15μM) greater than free MSB (57.383±1.654%) considerably (p &lt;0.05). Furthermore, Menasome 7 prevented L-dopa auto-oxidation in higher levels (95.140±2.439%) than pure MSB solution (83.953±1.629%). Conclusion: According to the study's findings, the prepared Menasome could be employed as a viable nanovehicle for MSB dermal delivery, a promising solution for the management of human hyperpigmentation disorders.