The present numerical Bernoulli wavelet technique aims at investigating the heat transfer of Casson nanofluid flow squeezed between parallel plates with the influence of an internal heat source. The fundamental governing equations describing the proposed flow problem is expressed in terms of highly nonlinear coupled ordinary differential equations via appropriate similarity transformations. The numerical Bernoulli wavelet method (BWM) is used to solve these nonlinear equations. Numerical outcomes of the BWM are compared with the different numerical results. Comparison between calculated results showed that the BWM is more suitable and correct than the any numerical method. The effects of each parameters, such as the Casson parameter, internal heat generation/absorption parameter, squeezing number, and nanoparticle volume fraction on the velocity and temperature are presented graphically and discussed. Overall, this research provides novel insights into the heat transfer characteristics of Casson nanofluids in squeezing flows with internal heating, which are highly relevant to several industrial processes and biomedical applications.