In the aircraft industry, the use of fiber reinforced materials for primary structural components over metallic parts has increased up to more than 50% in the recent years, because of their high strength and high modulus to weight ratios, high fatigue and corrosion resistance. Currently, the need of lowering weight and fuel consumption is pushing the world’s largest aircraft manufacturers in the design and building of structures entirely made of composites.Fuselage structure plays an important role in absorbing the kinetic energy during a crash. Through the deformation, crushing and damage of fuselage sub-floor structure, a survivable space inside the cabin area should be preserved during and after a crash impact in order to minimize the risk of passengers’ injuries.In this work, a Finite Element (FE) model of a full-scale 95% composites made fuselage section of a regional aircraft under vertical drop test is presented. The experiment, conducted by the Italian Aerospace Research Centre (CIRA) with an actual impact velocity of 9.14 m/s in according to the FAR/CS 25, has been numerically simulated. Two ATDs (Anthropomorphic Test Dummies), both 50th percentile, seats and belts have been modelled to reproduce the experimental setup. The results of the simulation, performed by using LS-DYNA® explicit FE code, have been validated by correlation with the experimental ones. Such comparisons highlight that a good agreement has been achieved.The presented FE model allows verifying the structural behavior under a dynamic load condition and also estimating the passive safety capabilities of the designed structure. Since the experiment is expensive and non-repeatable, a FE model can be used for Certification by Analysis purposes since, if established, it is able to virtually demonstrate the compliance to the airworthiness rules.