Present Analysis Research Articles

Hydrodynamics of an underwater vehicle near the sea surface

The primary goal of this study is to evaluate the hydrodynamic characteristics and the wave exciting forces on a shallowly submerged vehicle. A thin, rigid plate, which is completely submerged beneath the free surface in waters of finite depth is considered herein. The examined body is similar to an unmanned vehicle which is developed in Cyprus Marine and Maritime Institute for ocean science applications. From the present analysis the phenomenon of negative added mass and rapid variations of the added mass and damping coefficients is verified due to the free surface effect which is explained in terms of near-resonant standing waves above the submerged body.

DIABETES TYPE 2 AND OBESITY

Diabetes mellitus type 2 is a socially significant disease, which etiologically and pathogenetically is to the greatest extent influenced by body weight. Obesity has become a pandemic of our time. It is most often caused by the imbalance between energy intake and energy expenditure. Excess calories accumulate as fat. In patients with DM type 2, obesity further increases the risk of atherosclerosis, ischemic heart disease, cerebrovascular disease, arterial hypertension, hepatic steatosis, chronic kidney disease, increased mortality. The aim of the present analysis is to determine the frequency of patients with type 2 DM 170 patients with DM type-2 were studied. Of them, 77 with a relative share of 45.% are men, 93 are women, who make up 54.7%. The method of calculating the body mass index, which serves to assess the physical condition of the patients, was applied. After processing the data, it was found that 4.4% of the patients had a normal body weight, 26.5% were overweight, 1st degree obesity - 34.7%, 2nd degree obesity - 20.3% and with obesity of the 3rd degree are 14.1% of the studied patients. Obesity is a serious metabolic disorder that harbors multiple health risk factors that may reduce quality and life expectancy among patients with type-2 DM.

Impact of the Stefan gusting on a bioconvective nanofluid with the various slips over a rotating disc and a substance-responsive species

This paper presents thorough computational and theoretical analyses of steady forced convective flow over a rotating disc submerged in a water-based nanofluid containing microorganisms. It delves into the examination of boundary layer flow characteristics of a viscous nanofluid, considering Stefan blowing effects and multiple slip conditions influenced by a magnetic field. Notably, the study accounts for novel aspects such as thermal radiation and both constructive and destructive chemical reactions. The movement of nanoparticles is elucidated based on thermophoresis and microscopic behaviors, while changes in volume fraction do not affect the thermo-physical properties of the nanofluid. To address the altered nonlinear set of differential equations, an effective numerical approach, the Keller-Box method, is implemented for critical and efficient solutions. These appropriate transformations are defined and applied. When compared to blowing suction, it shows a better enhancement in the rate of heat transfer, mass, and microorganisms. Some of the main observations are there is a decrease in wall skin friction in the directions of radial and tangential as magnetic field strength is increased. The evaluation of thermal boundary layer thickness and temperature is noted for the radiation parameter (Rd) improvement. The present analysis has applications in electromagnetic micro-pumps and nanomechanics. As to the applications in the science and engineering fields, technologies such as micro-electromechanical systems-based microfluidic devices and microfluidic-related technologies will be accepted.

Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.

Enhancement of malignant cell immunogenicity to relieve immunosuppression of lung cancer microenvironment is essential in lung cancer treatment. In previous study, we have demonstrated that dihydroartemisinin (DHA), a kind of phytopharmaceutical, is effective in inhibiting lung cancer cells and boosting their immunogenicity, while the initial target of DHA's intracellular action is poorly understood. The present in-depth analysis aims to reveal the influence of DHA on the highly expressed TOM70 in the mitochondrial membrane of lung cancer. The affinity of DHA and TOM70 was analyzed by microscale thermophoresis (MST), pronase stability, and thermal stability. The functions and underlying mechanism were investigated using western blots, qRT-PCR, flow cytometry, and rescue experiments. TOM70 inhibition resulted in mtDNA damage and translocation to the cytoplasm from mitochondria due to the disruption of mitochondrial homeostasis. Further ex and in vivo findings also showed that the cGAS/STING/NLRP3 signaling pathway was activated by mtDNA and thereby malignant cells underwent pyroptosis, leading to enhanced immunogenicity of lung cancer cells in the presence of DHA. Nevertheless, DHA-induced mtDNA translocation and cGAS/STING/NLRP3 mobilization were synchronously attenuated when TOM70 was replenished. Finally, DHA was demonstrated to possess potent anti-lung cancer efficacy in vitro and in vivo. Taken together, these data confirm that TOM70 is an important target for DHA to disturb mitochondria homeostasis, which further activates STING and arouses pyroptosis to strengthen immunogenicity against lung cancer thereupon. The present study provides vital clues for phytomedicine-mediated anti-tumor therapy.

Predictors of bleeding and thrombotic events among patients admitted to the hospital with COVID-19 and elevated D-dimer: insights from the ACTION randomized clinical trial.

Therapeutic anticoagulation showed inconsistent results in hospitalized patients with COVID-19 and selection of the best patients to use this strategy still a challenge balancing the risk of thrombotic and hemorrhagic outcomes. The present post-hoc analysis of the ACTION trial evaluated the variables independently associated with both bleeding events (major bleeding or clinically relevant non-major bleeding) and the composite outcomes thrombotic events (venous thromboembolism, myocardial infarction, stroke, systemic embolism, or major adverse limb events). Variables were assessed one by one with independent logistic regressions and final models were chosen based on Akaike information criteria. The model for bleeding events showed an area under the curve of 0.63 (95% confidence interval [CI] 0.53 to 0.73), while the model for thrombotic events had an area under the curve of 0.72 (95% CI 0.65 to 0.79). Non-invasive respiratory support was associated with thrombotic but not bleeding events, while invasive ventilation was associated with both outcomes (Odds Ratio of 7.03 [95 CI% 1.95 to 25.18] for thrombotic and 3.14 [95% CI 1.11 to 8.84] for bleeding events). Beyond respiratory support, creatinine level (Odds Ratio [OR] 1.01 95% CI 1.00 to 1.02 for every 1.0mg/dL) and history of coronary disease (OR 3.67; 95% CI 1.32 to 10.29) were also independently associated to the risk of thrombotic events. Non-invasive respiratory support, history of coronary disease, and creatinine level may help to identify hospitalized COVID-19 patients at higher risk of thrombotic complications.ClinicalTrials.gov: NCT04394377.

Effectiveness, safety and discontinuation rates of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in people with HIV using real-world data: a systematic review and meta-analysis.

The use of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) is based on the results of robust clinical trials. To assess the effectiveness and safety of BIC/FTC/TAF in treatment-naïve (TN) and treatment-experienced (TE) people with HIV using available real-world cohort studies. Systematic review and meta-analysis of publications and communications identified via Boolean search in Medline, PubMed and Embase, and conference abstracts reporting retrospective real-world use of BIC/FTC/TAF, published until 31 January 2024. The primary endpoint was the proportion of TN and TE people with HIV with viral load (VL) < 50 copies/mL at 48 weeks while on treatment. Of the 38 identified publications and conference abstracts, for the present analysis we included 12 publications (comprising 792 TN and 6732 TE individuals). For the three publications including 507 TN participants reporting the primary outcome, VL suppression was 97% [95% confidence intervals (CI): 89-100]. For the nine publications including 4946 TE participants reporting the primary outcome, VL suppression was 95% (95% CI: 94-96), with suppression >93% in all studies. Total discontinuations at 48 weeks in TE individuals were 3% (95% CI: 2-5), 1% (95% CI: 0-2) due to side effects. A total of four publications with 151 TE individuals with previous presence of M184V substitution were identified, reporting a suppression rate at 48 weeks of 95% (95% CI: 88-100). Real-world studies demonstrate low discontinuation rates and high rates of virologic suppression in individuals treated with BIC/FTC/TAF, both TN and TE with and without previous detection of M184V substitution.

Inclined magnetic field and joule heat on unsteady ternary nanofluidic flow impinging over a convectively heated cylinder

The present analysis considered the condition of unsteady stagnation point flow on ternary nanofluid [Formula: see text] through the regularly affecting and convective heated stretchable cylinder by the effect on inclining Lorentz force. This influence on thermal radiation, velocity slip, viscous dissipation, and Joule dissipation were again integrated by the analysis. The suitable thermo-physical relationship in the hybrid nanofluid is cultivated into followed Xue form. With the help of appropriate comparison alterations, the controlling dimensional numerical equations were transformed by the dimensionless models. The governing equations are transformed through comparison transformation and mathematically tackled in MATLAB with a boundary value problem algorithm. These mathematical solutions were validated with the presented material. Tabular and graphical descriptions of mathematical information were utilized to analyze the physical effect on different relevant parameters in the ternary nanofluid temperature and velocity. This thermal buoyancy force hikes the fluid flow although the opposite direction was noted in magnetic parameters and velocity slips. This heat transport rate in the surface was enhanced by an improvement in thermal radiation, Biot number, and solid fraction of nanoparticles. Moreover, a 44.9754% enhanced decreased skin friction is observed by triple nanoparticle nanofluid it signifies its best behavior as related to both other nanofluids.

Перераспределение полномочий по решению вопросов местного значения в материалах правоприменительной практики

This research featured norms that provide an opportunity to redistribute matters of local significance from local government bodies to state authorities. The Federal Law on Organization of Local Governance (2014) provides an algorithm for this procedure. However, it has received poor scientific attention, as has the current law enforcement practice in the corresponding category of cases. The present analysis of the regional and court decisions shows that the state authorities tend to act chaotically in exercising their discretionary powers. Reauthorization has received no criteria of expediency and effectiveness so far. The examples from law enforcement practice are not in favor of local government and violate the constitutional principle of trust in the government (Constitution of the Russian Federation, Article 75.1). Reauthorization prevents local governments from long-term development strategizing of their municipalities. Both the laws of the subjects of the Russian Federation and the law enforcement practice show that reauthorization in its current form contradicts the constitutional principles of maintaining trust in the government, thus reducing the power of local governments.

Effect of Double Stratification on MHD Williamson Boundary Layer Flow and Heat Transfer across a Shrinking/Stretching Sheet Immersed in a Porous Medium

The present study aims to provide a mathematical model of the Williamson fluid flow via a permeable stretching/shrinking sheet in the MHD boundary layer in the presence of a heat source, chemical reaction, and suction. This study is novel because it investigates the physical effects of thermal and solutal stratification on convective heat and mass transport using thermal radiation. The flow’s PDEs are numerically solved using the BVP4c approach and the pertinent similarity variables until a stable solution is found. Through visual analysis, the effects of dimensionless factors on temperature, velocity, and concentration profiles are examined. This encompasses the mass transfer rate, the heat transfer rate, and the coefficient of friction. The results of the present analysis are found to be consistent with those of previously published studies. The findings demonstrate that enhanced temperature and concentration profiles cause the Williamson, magnetic, and permeability parameters to rise in conjunction with a drop in the dimensionless velocity. In relation to temperature, the thermal stratification parameter exhibits the opposite tendency. Regarding the solutal stratification parameter, concentration profiles are seen to show the opposite trend. Lastly, the current work will have important implications for the removal of dust and viruses from viscoelastic fluid in bioengineering, the medical sciences, and medical equipment.

King Oscar II of Sweden and his connections with the Romanian freemasonry

The present analysis represents a novel approach to the issue of Romanian-Swedish bilateral relations in the second half of the 19th century. This time, the focus is on the dimension of contacts between Romanian and Swedish Freemasonry. This was conducted in the second half of the 19th century by King Oscar II himself. In 1885 he made an official visit to Bucharest with Queen Sofia. On this occasion, he was made an honorary member of the Grand National Lodge of Romania (M.L.N.R.). Far from being merely a protocol award, it held a special significance. This visit underlined the desire of Constantin Moroiu, Grand Master of the Grand National Lodge of Romania, to gain international recognition for this Romanian Masonic powerIt was a very turbulent period in the history of Romanian Freemasonry, marked by a series of interventions by the Grand Orient of Italy in its internal affairs. With the award of this distinction, Romanian Freemasons sought to strengthen their internal unity through external recognition from all Masonic powers. To this end, the help of the Grand Lodge of Sweden was essential. The desire to consolidate the unity of Romanian Freemasonry was a natural reality, given the fact that Romania was proclaimed a Kingdom in 1881 and became a base of stability in this part of the continent.

Dietary supplement intake in women with breast cancer before and after diagnosis: results from the SUCCESS C trial

BackgroundThere is little evidence that dietary supplements are beneficial for patients with breast cancer; therefore, they are usually not recommended by treatment guidelines. The aim of the present analysis was to assess the prevalence of dietary supplement (DS) intake among women before and after a breast cancer diagnosis.MethodsParticipants in the SUCCESS C lifestyle intervention study, a randomized controlled trial in women with newly diagnosed intermediate- to high-risk breast cancer, completed two questionnaires on dietary supplement intake 24 months (QS1) and 48 months (QS2) after beginning the lifestyle intervention. The study was registered on 12.17.2008 under the EU Clinical Trials Register https://www.clinicaltrialsregister.eu/, trial registration number: 2008-005453-38. The questionnaires collected data on DS intake during the 5-year period prediagnosis (QS1) and in the period postdiagnosis (QS2). Multivariate logistic regression models were fitted to examine differences in DS intake between the two intervention groups. The groups were then pooled to examine differences in DS use between the prediagnostic and postdiagnostic period.ResultsA total of 320 questionnaires from 58.5% of intervention group completers and 416 questionnaires from 46.6% of low-level intervention group completers were included in the analysis. Overall, 20.2% of all respondents reported taking DS prior to their diagnosis. After a cancer diagnosis, the percentage of women taking DS significantly increased to 56.4% (p for time effect < 0.0001). No differences in DS intake between the intervention groups were observed. Single or combined preparations of vitamins and minerals/trace elements were the most frequently reported supplements. Notably, a 9-fold increase in vitamin D intake was reported postdiagnosis, where the proportion of women increased from 3.8 to 34.5%.ConclusionA 3-fold increase in the reported intake of dietary supplements was seen in women after a breast cancer diagnosis. These observations underscore the need to incorporate patient education surrounding the use of dietary supplements in a treatment care plan, particularly addressing the negligible benefits as well as the potential risks and treatment interactions.

Quantum entropic exchange at avoided crossings due to laser–atom interaction

In the present study, we detail the entropic characteristics of a dressed atom, wherein the atom undergoes an interaction with a monochromatic laser beam. Our investigation of the laser–atom interplay employs a well-established non-perturbative quasi-energy methodology, allowing us to discern the dressed wavefunctions and quasi-energies of the laser-dressed atom. Utilizing these dressed wavefunctions as a foundation, we systematically examine various entropic measures, observing their behaviour for laser frequency and intensity. The selection of levels within the system adheres to the criteria dictated by the selection rules governing transitions between these levels. Our exploration focuses on the interplay between Shannon entropy and other entropic metrics, with their fluctuations intricately tied to the phenomenon of avoided crossings. As the laser amplitude intensifies, the AC Stark effect takes centre stage, exerting influence over the sharp or smooth variations in Shannon entropy at these avoided crossings. Furthermore, we delineate the correlation between the number of levels considered and the identification of avoided crossings. Our present analysis sheds light on the intricate dynamics in the dressed atom system, enhancing our understanding of the interplay between laser-induced dressing and entropic measures.

Examining the Influence of Cognitive Load and Environmental Conditions on Autonomic Nervous System Response in Military Aircrew: A Hypoxia-Normoxia Study.

Executing flight operations demand that military personnel continuously perform tasks that utilize low- and high-order cognitive functions. The autonomic nervous system (ANS) is crucial for regulating the supply of oxygen (O2) to the brain, but it is unclear how sustained cognitive loads of different complexities may affect this regulation. Therefore, in the current study, ANS responses to low and high cognitive loads in hypoxic and normoxic conditions were evaluated. The present analysis used data from a previously conducted, two-factor experimental design. Healthy subjects (n = 24) aged 19 to 45 years and located near Fort Novosel, AL, participated in the parent study. Over two, 2-h trials, subjects were exposed to hypoxic (14.0% O2) and normoxic (21.0% O2) air while simultaneously performing one, 15-min and one, 10-min simulation incorporating low- and high-cognitive aviation-related tasks, respectively. The tests were alternated across five, 27-min epochs; however, only epochs 2 through 4 were used in the analyses. Heart rate (HR), HR variability (HRV), and arterial O2 saturation were continuously measured using the Warfighter MonitorTM (Tiger Tech Solutions, Inc., Miami, FL, USA), a previously validated armband device equipped with electrocardiographic and pulse oximetry capabilities. Analysis of variance (ANOVA) regression models were performed to compare ANS responses between the low- and high-cognitive-load assessments under hypoxic and normoxic conditions. Pairwise comparisons corrected for familywise error were performed using Tukey's test within and between high and low cognitive loads under each environmental condition. Across epochs 2 through 4, in both the hypoxic condition and the normoxic condition, the high-cognitive-load assessment (MATB-II) elicited heightened ANS activity, reflected by increased HR (+2.4 ± 6.9 bpm) and decreased HRV (-rMSSD: -0.4 ± 2.7 ms and SDNN: -13.6 ± 14.6 ms). Conversely, low cognitive load (ADVT) induced an improvement in ANS activity, with reduced HR (-2.6 ± 6.3 bpm) and increased HRV (rMSSD: +1.8 ± 6.0 ms and SDNN: vs. +0.7 ± 6.3 ms). Similar observations were found for the normoxic condition, albeit to a lower degree. These within-group ANS responses were significantly different between high and low cognitive loads (HR: +5.0 bpm, 95% CI: 2.1, 7.9, p < 0.0001; rMSSD: -2.2 ms, 95% CI: -4.2, -0.2, p = 0.03; SDNN: -14.3 ms, 95% CI: -18.4, -10.1, p < 0.0001) under the hypoxic condition. For normoxia, significant differences in ANS response were only observed for HR (+4.3 bpm, 95% CI: 1.2, 7.4, p = 0.002). Lastly, only high cognitive loads elicited significant differences between hypoxic and normoxic conditions but just for SDNN (-13.3 ms, 95% CI, -17.5, -8.9, p < 0.0001). Our study observations suggest that compared to low cognitive loads, performing high-cognitive-load tasks significantly alters ANS activity, especially under hypoxic conditions. Accounting for this response is critical, as military personnel during flight operations sustain exposure to high cognitive loads of unpredictable duration and frequency. Additionally, this is likely compounded by the increased ANS activity consequent to pre-flight activities and anticipation of combat-related outcomes.

Analysis of interventional treatment options of the common femoral artery - a retrospective single center experience.

Background: Due to the rapid development of treatment techniques of peripheral arterial disease (PAD) treatment is nowadays predominantly interventional. An exception are lesions of the common femoral artery (CFA), which should be treated surgically according to vascular guidelines. However, recent evidence has shown that endovascular techniques, e.g. stenting, have comparable clinical outcomes while causing fewer complications. The aim of the present analysis was to evaluate the therapeutic success of endovascular therapy of CFA lesions in a single center, all - comers registry. Patients and methods: All patients who were treated for a CFA lesion at the Department of Internal Medicine I of the University Hospital Jena in the period from 01/2017 to 12/2020 were included. Treatment success was determined by evaluating the ankle-brachial-index (ABI) pre- and post-interventional as well as after follow-up (FU), measuring walking distance (WD) and by target revascularization rate (TLR) and primary patency rate (PPR). Results: The analysis included 109 patients with a mean age of 73.4 years, with 67% (73) of those being men. 72 patients received interventional treatment, whereas 33 were treated surgically and 4 conservatively. Resting ABI in the overall cohort showed an increase from 0.5 to 0.7 post intervention (p=<0.05; mean FU-time: 6.5 months). In the interventional cohort ABI increases from 0.6 to 0.8 (p=<0.05; mean FU-time: 5,8 months) at FU and from 0.3 to 0.6 (p=<0.05; mean FU-time: 8,8 month) in the surgically treated group. The WD improved in the whole collective from 116.5 meter (m) to 152.5 m (p=<0.05). The TLR showed no significant difference with 8.1% after interventional treatment and 6.1% after vascular surgery in the present analysis (p=0.72) as well as PPR with 89.8% after EVT and 90.9% after surgical approach (p=0.87). The intra-/postinterventional complication rate was 5.5% in the intervention group, compared to postoperative complication rate of 15.2% in the surgically treated group. Conclusions: The present analysis demonstrates that even in a real-world, all-comers collective, interventional therapy for CFA lesions was safe and equally effective as the surgically treated patient cohort. Continuing to generate registry data is important to eventually initiate a paradigm shift.

Role of Artificial Intellengence in the Recruitment Process with Special Reference to Selected it Companies

Artificial Intelligence playing an important role in IT recruitment. In recent days most of the IT companies giving importance to AI to ensure and effective recruitment process to select an efficient and qualified people. The present paper analyses the role of AI i.e., Artificial Intelligence in IT companies. The present analysis selected three top IT companies in India and examined the role of AI in their recruitment process. The papers examined the different factors which are linking to both recruitment process and IT industry. The present paper collected the opinions of employees working in three different companies and evaluated the importance of AI in recruitment process in IT industry.

Synthesis, Biological and Molecular Docking Studies of Thiazole-Thiadiazole derivatives as potential Anti-Tuberculosis Agents.

Tuberculosis remains a global health threat, with increasing infection rates and mortality despite existing anti-TB drugs. The present work focuses on the research findings regarding the development and evaluation of thiadiazole-linked thiazole derivatives as potential anti-tuberculosis agents. We present the synthesis data and confirm the compound structures using spectroscopic techniques. The current study reports twelve thiazole-thiadiazole compounds (5 a-5 l) for their anti-tuberculosis and related bioactivities. This paper emphasizes compounds 5 g, 5 i, and 5 l, which exhibited promising MIC values, leading to further in silico and interaction analysis. Pharmacophore mapping data included in the present analysis identified tubercular ThyX as potential drug targets. The compounds were evaluated for anti-tubercular activity using standard methods, revealing significant MIC values, particularly compound 5 l, with the best MIC value of 7.1285 μg/ml. Compounds 5 g and 5 i also demonstrated moderate to good MIC values against M. tuberculosis (H37Ra). Structural inspection of the docked poses revealed interactions such as hydrogen bonds, halogen bonds, and interactions containing Pi electron cloud, shedding light on conserved interactions with residues like Arg 95, Cys 43, His 69, and Arg 87 from the tubercular ThyX enzyme.

AirCore Observations at Northern Tibetan Plateau During the Asian Summer Monsoon

AbstractWe present data and analysis of a set of balloon‐borne sounding profiles, which includes co‐located O3, CO, CH4, and particles, over the northern Tibetan Plateau during an Asian summer monsoon (ASM) season. These novel measurements shed light on the ASM transport behavior near the northern edge of the anticyclone. Joint analyses of these species with the temperature and wind profiles and supported by back trajectory modeling identify three distinct transport processes that dominate the vertical chemical structure in the middle troposphere, upper troposphere (UT), and the tropopause region. The correlated changes in profile structures in the middle troposphere highlight the influence of the strong westerly jet. Elevated constituent concentrations in the UT identify the main level of convective transport at the upstream source regions. Observed higher altitude maxima for CH4 characterize the airmasses' continued ascent following convection. These data complement constituent observations from other parts of the ASM anticyclone.

Magnetohydrodynamic Casson SWCNT-MWCNT/EG hybrid nanofluid flow over a stretching cylinder with Cattaneo-Christov double diffusion model

The present problem examines the flow features of a two-dimensional time-independent Casson hybrid nanofluid on a stretching cylinder with dual stratification and MHD effects. Heat and mass transfer effects are analyzed by utilizing the Cattaneo-Christov double diffusion scheme with entropy generation. Further, the energy losses due to viscous and Joulian dissipation are also considered in the problem. Due to the high thermal conductivity nature of the carbon nanotubes, which plays a crucial role in cooling systems, material sciences, electrical components and treatment of cancer cells, single and multi-walled carbon nanotube particles (SWCNT, MWCNT) are considered in the hybrid nanofluid. The carbon nanotubes are mixed with base fluid ethylene glycol (EG) to form the required hybrid nanofluid. Suitable transformations are adopted for transforming the non-linear PDEs to non-linear ODEs of the mathematical model. Then, the system of ODEs are resolved by utilizing bvp4c numerical approach in MATLAB software. The impact of the various flow pertinent parameters on the flow model are disclosed through graphs and tables and then explained elaborately. The important findings of the study reveal a reduction in the absolute value of coefficient of surface friction with the Casson and velocity slip parameters. The entropy generation rate (NG ) is diminished due to slip parameters, whereas the opposite effect is observed due to the SWCNT nanoparticle volume fraction. The thermal and mass relaxation parameters induce a significant amplification in the rates of heat and mass transport, respectively. Furthermore, it is observed that the heat and mass transfer rates of EG-based SWCNT – MWCNT hybrid nanofluid perform better than those of EG-based SWCNT nanofluid. The outcomes of the investigation exhibit an excellent agreement with the previously published results. The present analysis has applications in cancer therapy, microelectronics cooling, industrial heat generators, nuclear reactor maintenance, electrolytic condensers, and many more.

Time‑dependent ROC curve analysis to determine the predictive capacity of seven clinical scales for mortality in patients with COVID‑19: Study of a hospital cohort with very high mortality.

Clinical data from hospital admissions are typically utilized to determine the prognostic capacity of Coronavirus disease 2019 (COVID-19) indices. However, as disease status and severity markers evolve over time, time-dependent receiver operating characteristic (ROC) curve analysis becomes more appropriate. The present analysis assessed predictive power for death at various time points throughout patient hospitalization. In a cohort study involving 515 hospitalized patients (General Hospital Number 1 of Mexican Social Security Institute, Colima, Mexico from February 2021 to December 2022) with COVID-19, seven severity indices [Pneumonia Severity Index (PSI) PaO2/FiO2 arterial oxygen pressure/fraction of inspired oxygen (Kirby index), the Critical Illness Risk Score (COVID-GRAM), the National Early Warning Score 2 (NEWS-2), the quick Sequential Organ Failure Assessment score (qSOFA), the Fibrosis-4 index (FIB-4) and the Viral Pneumonia Mortality Score (MuLBSTA were evaluated using time-dependent ROC curves. Clinical data were collected at admission and at 2, 4, 6 and 8 days into hospitalization. The study calculated the area under the curve (AUC), sensitivity, specificity, and predictive values for each index at these time points. Mortality was 43.9%. Throughout all time points, NEWS-2 demonstrated the highest predictive power for mortality, as indicated by its AUC values. PSI and COVID-GRAM followed, with predictive power increasing as hospitalization duration progressed. Additionally, NEWS-2 exhibited the highest sensitivity (>96% in all periods) but showed low specificity, which increased from 22.9% at admission to 58.1% by day 8. PSI displayed good predictive capacity from admission to day 6 and excellent predictive power at day 8 and its sensitivity remained >80% throughout all periods, with moderate specificity (70.6-77.3%). COVID-GRAM demonstrated good predictive capacity across all periods, with high sensitivity (84.2-87.3%) but low-to-moderate specificity (61.5-67.6%). The qSOFA index initially had poor predictive power upon admission but improved after 4 days. FIB-4 had a statistically significant predictive capacity in all periods (P=0.001), but with limited clinical value (AUC, 0.639-0.698), and with low sensitivity and specificity. MuLBSTA and IKIRBY exhibited low predictive power at admission and no power after 6 days. In conclusion, in COVID-19 patients with high mortality rates, NEWS-2 and PSI consistently exhibited predictive power for death during hospital stay, with PSI demonstrating the best balance between sensitivity and specificity.

Acute kidney injury in acute decompensated heart failure related cardiogenic shock: data from the Alt-Shock2 registry

Abstract Funding Acknowledgements None. Background Acute kidney injury (AKI) is one of the most common complications in patients with cardiogenic shock (CS), proving the strict relationship between heart and kidney (the so-called cardio-renal syndrome). AKI is a marker of shock severity, but also independently associated with worse outcomes. Purpose Many data are available on the prevalence of AKI in acute heart failure, but very few studies assessed the role of AKI in CS and they were mainly focused on acute myocardial infarction (AMI)-related CS. Aim of our study was to analyze the impact of AKI on acute decompensated heart failure (ADHF)-CS. Methods Between March 2020 and August 2022, we prospectively enrolled 375 CS patients from a Cardiac Intensive Care Units Network of 12 centers. Among these patients 121 (33.9% of the whole cohort) with ADHF-CS were included for the present analysis. AKI was defined according to KDIGO 2012 criteria as serum creatinine increase ≥ 0.3 mg/dl or 1.5 times compared to admission value, or urinary output &amp;lt; 0.5 ml/kg/h. Results Table 1 shows the baseline characteristics of the cohort. Patients with AKI were older (70 years old [55.5; 76] vs 61 [54; 69], p&amp;lt;0.05), had more comorbidities and a worse CS profile on admission. On multivariable analysis, SCAI stage D-E on admission was independently associated with a higher risk of AKI 24 hours after admission (OR 5.54 and p = 0.01). Treatment with mechanical circulatory support did not prevent AKI (OR 0.84 and p = 0.8). Notably, patients with a greater reduction in central venous pressure (CVP) 24 hours after admission had a lower risk of AKI (deltaCVP in AKI group 0 [-3;0] versus deltaCVP in no-AKI group -3 [-6;0], p = 0.025). Kaplan-Meier curves showed significantly worse survival in patients with AKI (Figure 1A). Cox regression analysis confirmed an association between AKI and increased risk of death (HR 2.14, CI 95% 1.16-3.96, p = 0.01). Notably, this association was even more pronounced in patients with SCAI stages A-B-C (HR 2.81, CI 95% 1.30-6.09, p = 0.01). Finally, in patients treated with renal replacement therapy (RRT) there was no association with lower survival at 180-days follow up (Figure 1B). Conclusions Our study confirms that AKI is a predictor of adverse outcomes in patients with ADHF-CS. Effective decongestion 24 hours after admission was associated with a lower risk of AKI. Considering that AKI had a negative impact even at lower SCAI stages, our findings underscore the importance of early identification of renal injury to promptly target decongestion with pharmacologic therapy and, ultimately, early use of RRT.