In this paper, magnetohydrodynamics of a Casson fluid flow is inspected with the presence of thermal radiation and chemical reaction. Employing the perturbation procedure, the modeling equations are tenacious; the graphs are acquired to illustrate the results. The Casson fluid velocity increases as the perturbation parameter increases. Grashof values for heat and mass transport enhanced Casson fluid velocity. Increasing Casson, magnetic, heat source, and radiation parameters reduce the flow velocity. Prandtl number, heat source, and radiation parameter all reduced the temperature profiles. Chemical reaction parameters lowered the concentration profiles. The skin friction enhances with Casson parameter impact. However, the skin-friction coefficient, Sherwood and Nusselt numbers reduce with an increment in the perturbation parameter. In certain cases, this study’s answers agreed well with the previous literature. Casson liquid with a magnetic region using mixed convection by an exponential vertical boundary layer is the novelty of the work.