ABSTRACT This article analyses the influence of gender stereotypes in entrepreneurship by jointly studying the effect of gender-role orientation (GRO) and sex (women vs. men) on the entrepreneurial intentions (EI) and actions of individuals. Entrepreneurship is associated with the typical male stereotype in most societies, leading to a lower rate of women entrepreneurs. Our model builds on social role theory (SRT) to identify how descriptive and prescriptive gender stereotypes exert this influence. It integrates SRT and the theory of planned behaviour (TPB) to analyse the differential effect of sex and GRO on entrepreneurial motivations, intentions, and new venture creation behaviours. We test our model on a sample of highly educated adults in Spain using a longitudinal research design. Our results indicate that descriptive gender stereotypes influence individuals’ entrepreneurial motivations and intentions depending on their GRO. Androgynous people (women and men alike) exhibit the most favourable perceptions regarding entrepreneurship, and, through them, a higher EI (compared to masculine, feminine, and undifferentiated GRO individuals). In turn, prescriptive gender stereotypes affect individuals’ actual venture creation depending on their biological sex. Men are significantly more likely to act on their EIs and launch their venture than are women.