Premature Destruction Research Articles

Protocolo diagnóstico de las anemias hemolíticas

Hemolytic anemias are defined by the premature destruction of circulating red blood cells. They can be classified as congenital or acquired and most are of immune origin. Diagnosis requires a comprehensive medical history, including a personal and family history; use of drugs or toxins; and a series of laboratory tests. Test findings predominantly show a marked decrease in hemoglobin; an increase in reticulocytes, bilirubin (indirect fraction), and lactate dehydrogenase; and a decrease in haptoglobin. Finally, a direct antiglobulin test (direct Coombs test) and a peripheral blood smear can be very useful in indicating the possible cause of hemolytic anemia.

Correlation Crossmatching Test with Effectiveness of Transfusion in Hemolytic Anemia Patients

Hemolytic anemia is anemia caused by the premature destruction of red blood cells. Transfusion with hemolytic anemia is a dilemmatic indication and is still based on clinical decisions. Several studies assessed the effectiveness of transfusions in hemolytic anemia patients with incompatible crossmatching showed effectiveness. This study aimed to analyze crossmatching with transfusion effectiveness in hemolytic anemia patients. Retrospective cohort observational study with medical record data from January 2019 to May 2022 of hemolytic anemia patients who got transfusion therapy. The variables included age, gender, hemoglobin levels before and after transfusion, crossmatching test, and transfusion effectiveness based on increased hemoglobin after transfusion 1 g/dL of 1 Pack Red Cell (PRC) unit. One hundred three (103) patients with hemolytic anemia 45 received PRC, 12 males (26.7%) and 33 females (73.3%). Ages 19 - < 45 years subjects had the most transfusions. Hemoglobin levels before and after transfusion showed significant differences (p-value =0.000) in the patients with a diagnosis of hereditary, unspecified, and autoimmune hemolytic anemias. The correlation between the effectiveness of transfusions with gender and age was not found (p=0.521, p=0.240). The correlation between crossmatching with the effectiveness of transfusion was not found (p=0.089). Hemolytic anemia patients with transfusion showed an increase in hemoglobin levels between before and after transfusion even with incompatible crossmatching. The correlation between the results of crossmatching with transfusion effectiveness in patients with hemolytic anemia was not found. Good premedication treatment can provide effective transfusion.

РОЛЬ САСО3 У ФОРМУВАННІ МІЦНІСНИХ І ДЕКОРАТИВНИХ ВЛАСТИВОСТЕЙ ПОРОШКОВОГО ЛУЖНО-АКТИВОВАНОГО ШЛАКОПОРТЛАНДЦЕМЕНТНОГО БЕТОНУ

The article discusses approaches to the formation of compositions of alkali-activated decorative Portland slag cements containing Portland cement type CEM1 5...45% with high performance and decorative properties. The optimization of the compositions of decorative alkali-activated Portland slag cements was carried out using statistical methods for designing experiments. Finely dispersed TiO2 and CaCO3 additives with a whiteness of 90% were used as bleaching components. The alkaline component is sodium metasilicate in the form of a non-hygroscopic powder. The research carried out made it possible to obtain decorative Portland slag cements with a whiteness of 45...77%, which allows them to be used to produce colored cements with a wide range of colors from white to black. It has been established that alkali-active decorative Portland slag cements have an activity of 37...59 MPa at the age of 28 days. All compositions have good hardening dynamics and, based on the strength at the age of 2 days  22...36.6 MPa, they can be classified as fast-hardening. Based on them, it is possible to produce dry construction mixtures. All mortar compositions based on alkali-active decorative Portland slag cements demonstrate fairly high frost resistance  F200. This allows them to be used for the manufacture of products and solutions both for indoor use and when exposed to atmospheric influences without loss of design characteristics and decorative appeal. The inherent shrinkage strains of decorative alkali-activated Portland slag cements are 0.51...0.61 mm/m, which eliminates cracking and premature destruction of products. The use of the CaCO3 additive is especially effective for controlling the shrinkage deformations. Thus, the CaCO3 additive performs the functions of not only a decorative component, but also a structure-forming component. Concrete and mortar mixtures can be used to produce decorative products using the traditional method, extrusion, 3D printing on construction printers, etc. And not too long setting times and a rapid increase in strength make it possible to produce products without thermal treatment or with minimal consumption of thermal energy.

SCIENTIFICLY BASED CALCULATION METHODS AND EXPERIMENTAL DATA BASES FOR THE PREVENTION OF PREMIUM FIRE EXPLOSIONS AND UNSAFE EXPLOSIONS OF PYROTECHNIC MULTICOMPONENT NITRATE-METALLIZED MIXTURES UNDER EXTERNAL THERMAL

Problem statement. Methods of preventing the occurrence of forced fire-hazardous destruction of products in the event of exposure to external thermal actions are of great practical importance. At the same time, they should be based on scientifically based methods for determining the critical values of parameters of thermal effects on products and technological parameters of mixture charges, the excess of which leads to premature fire-hazardous destruction of products. To develop such methods, it is necessary to have the results of theoretical and experimental studies of the processes of heating the shells of mixture charges for various external heat flows and their thermoreaction times, as well as the processes of ignition and development of their combustion under different external conditions. Purpose of the article. To form the results of theoretical studies in the form of scientifically based methods that allow preventing and controlling the premature ignition of mixture charges, the explosive development of their combustion process and the fire-hazardous destruction of products under conditions of external thermal effects, as well as the compilation of the results of experimental studies into a single database with determination of the influence of the technological parameters of the mixtures on the characteristics of their ignition processes and the development of combustion, the use of which allows reducing the number of fire-explosive destruction of products in conditions of elevated heating temperatures and external pressures. Conclusion. Scientifically based methods of determining the critical values of the parameters of external thermal actions for the quantitative assessment of the level of fire safety of pyrotechnic products based on multi-component nitrate-metallized mixtures have been developed. A scientific and technical base of experimental data was created to determine the regularities of the influence of a wide class of technological parameters of mixtures on the main characteristics of the processes of ignition and development of combustion of mixtures (ignition temperature, induction time, speed of combustion development) under conditions of external thermal actions (elevated heating temperatures, external pressures, etc.), which makes it possible to determine the probability of fires occurring at facilities where products are stored.

Analysis of Application of Cement-Sand Solutions During the Renovation of Road Water-Draining Structures Using Metal Corrugated Structures

Abstract. Problem. Today, the restoration of road culverts using metal corrugated structures is relevant and necessary, as they are in difficult operating conditions, which is the reason for their premature destruction. Goal. Сonducting an analysis of the dynamic viscosity of cement-sand solutions during the restoration of road culverts using metal corrugated constructions. Methodology. The hydraulic resistance analysis of the cement-sand solution during fogging of the inter-pipe gap and the dynamic viscosity analysis of the cement-sand solution were carried out. Results. Based on the conducted research, the need to improve the existing cement-sand solutions for inter-pipe clogging was established. Originality. The work considers the most common approaches to determining the hydraulic resistance to the movement of cement-sand mortar. The dynamic viscosity analysis of the cement-sand solution was performed. Practical value. The work considers the most common models describing the flow of an ordinary cementconcrete mixture (cement-sand mortar). An approach to determining the pressure loss when filling the inter-pipe gap is presented. The paper provides an analysis of the use of cement-sand mortars during the restoration of road culverts using metal corrugated structures. Based on the conducted analysis, the dependence of dynamic viscosity on the composition of the mixture and the water-cement ratio was established. The paper proposes general provisions for the restoration of road culverts using metal corrugated structures with the establishment of requirements for cement-sand mortar.

Unraveling the complexity: Case reports of drug-induced hemolytic anemia due to ceftriaxone

Abstract: Drug-induced hemolytic anemia (DIHA) is a rare but significant condition characterized by the premature destruction of red blood cells (RBCs) triggered by certain medications. Ceftriaxone, a commonly used antibiotic, has been linked to DIHA, presenting diagnostic challenges due to its diverse clinical manifestations. This study examines three cases of DIHA caused by ceftriaxone therapy at our center. The patients presented with symptoms such as fatigue, jaundice, and dark urine following ceftriaxone therapy. Laboratory tests indicated hemolytic anemia with decreased hemoglobin, elevated lactate dehydrogenase, and positive direct antiglobulin tests. Immunohematological workups confirmed ceftriaxone-induced antibodies targeting RBCs and guided management strategies, including discontinuation of ceftriaxone, supportive therapy, and corticosteroids. Timely diagnosis and collaboration between clinicians and laboratory specialists are crucial for optimal patient outcomes.

Effect of temperature-deformation regimes of equal channel angular pressing in core-shell mode on the structure and properties of near-equiatomic titanium nickelide shape memory alloy

Near-equiatomic titanium nickelide (TiNi) shape memory alloy is subjected to thermomechanical treatment by quasi-continuous equal channel angular pressing (ECAP) in core-shell mode at temperatures of 250, 300, and 400°С at the highest possible accumulated true strain. TiNi bulk samples are successfully deformed for the first time at 300°С – the temperature threshold for dynamic polygonization – at an accumulated true strain e of 2.4. Deformation at low temperatures leads to the premature destruction of TiNi samples in the second pass (e = 1.6), providing high deformation hardening and corresponding strength characteristics. An increase in the deformation temperature to 400°С allows an accumulated true strain of 5.6, while the mechanical and functional properties are inferior to those that occur after deformation at low temperatures. The most balanced combination of properties is achieved after quasi-continuous ECAP in core-shell mode at 300°С and subsequent post-deformation annealing at 400°С for 1 h: dislocation yield stress σy = 1040 MPa, ultimate tensile strength σв = 1166 MPa, and total recoverable strain Ɛrt = 10.3 %.

Scientific-Practical Enhancement Principles for the Long-Term Stability of Cultural Heritage Objects through a Multi-Component Underground Space Analysis

This article presents approaches for enhancing engineering-geological and geotechnical research for the restoration and reconstruction projects of cultural heritage objects in St. Petersburg’s historical center. According to the Venice Charter, an interdisciplinary approach is recommended for developing a preservation program for cultural heritage objects. The authors consider the underground space as a multi-component system, where soils are a host medium for underground water with specific composition, complex physicochemical and biochemical conditions, the presence and vigorous activity of microorganisms, gases of various origins, and underground bearing and enclosing structures. The last of these components is crucial for the long-term stability of historical and cultural objects, as they interact in complex with water-saturated soils and microorganisms. This approach is not to be found in Russian cultural heritage preservation regulations. In engineering-geological and geotechnical research, multi-component underground space should be studied at the regional, local, and object levels. Assessing redox conditions in the underground environment is crucial for understanding the state of its components. Moreover, this can trigger hazardous processes such as changes in the stress–strain state and unconsolidation of the soil layer due to the generation of low-solubility gases and biocorrosion of ancient and modern building materials, causing premature destruction. Recommendations are provided for carrying out engineering-geological and geotechnical research based on cultural heritage objects, considering the multi-component underground space and features of its geoenvironmental state due to the long-term contamination and transformation of its components.

Current Management of Warm Autoimmune Haemolytic Anaemia and Recent Advancements in Research: Interview with a Key Opinion Leader

Warm autoimmune haemolytic anaemia (wAIHA) is a rare, life-threatening disorder caused by autoantibodies that lead to the premature destruction of erythrocytes (haemolysis). There is currently no licensed targeted therapy for wAIHA. Until recently, there has been little research attention on autoimmune haemolytic anaemias (AIHA), with few developments in the field over the past 20 years. The last 3 years have seen a surge in research interest in wAIHA, with the development of potential new therapies for this rare disorder. For this article, the EMJ conducted an interview in June 2024 with key opinion leader, Bruno Fattizzo, from the University of Milan, and Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, to raise awareness of wAIHA, and explore recent advancements in research on this disease. Fattizzo, who has a wealth of experience and expertise in the clinical management of wAIHA, provided valuable insights into topics such as the clinical and quality of life (QoL) impact of wAIHA on the patient; current management of wAIHA, including steroids, rituximab, immunosuppressants, splenectomy, anticoagulant prophylaxis, and recombinant erythropoietin; and remaining unmet needs in the disease area. Also discussed were potential future therapies for this autoimmune disorder, including tyrosine kinase inhibitors, neonatal fragment crystallisable receptor (FcRn) inhibitors, and B cell activating factor receptor (BAFF-R) antagonists, and the challenges involved in managing patients with wAIHA. Finally, Fattizzo described the patient experience of living with wAIHA, proposed how best to raise awareness of wAIHA among healthcare professionals, the scientific community, patients, and the public, and outlined what the future of the management of patients with wAIHA might look like.

Optimized laser production of thermonuclear neutrons from plasma of submicron-sized clusters

The concept of maximizing the D-D fusion neutron yield from the laser-heated large volume of cluster medium by matching the focal spot size and cluster plasma structural scales to the laser pulse intensity was confirmed. For this purpose, the three-dimensional particle-in-cell GEANT4 simulations have been performed by zoning of the large interaction domain. While considering a small domain of the entire interaction volume, which is partitioned into successive zones along laser propagation direction, a special algorithm was proposed allowing to reconstruct the integral spectrum of deuterons and D-D neutron yield. We demonstrate that it makes possible to specify high-performance laser–cluster neutron source following this concept. For example, for the submicron heavy water droplets heated by femtosecond laser pulse of the intensity 3×1019 W/cm2 a D-D neutron yield may reach 107 neutrons per 1 J of deposited laser energy if the intensity contrast ratio prevents premature cluster destruction. Such yield is considerably higher than achieved to date for microstructured targets.

Umbilical cord clamping: Midwife's perspective at one of the regional general Hospitals of Gorontalo Province

The incidence of iron deficiency anemia in infants is a problem that often occurs in all countries, especially in developing countries, which is caused by visible dan invisible blood loss, decreased red blood cell production, premature cell destruction, premature birth, LBW, small gestational age, maternal anemia dan time of umbilical cord clamping. Delaying cord clamping by 1-3 minutes allows blood flow between the placenta dan neonate to continue, which can improve iron status in the baby for up to six months after birth. In Indonesia, 62.7% of births are attended by midwives, so the midwife's perception plays an important role in deciding when to clamp the umbilical cord during childbirth care. Objectives: To determine the perception of midwives in one of the regional general hospitals of Gorontalo province regarding delays in clamping the umbilical cord. Methods: This research uses a qualitative method with a phenomenological approach. Data collection was carried out on 7 informants using in-depth interviews dan the results of the interviews were analyzed using thematic analysis. Results: There is a difference between the informant's perception dan the practice carried out by the informant regarding the delay in clamping the umbilical cord. Conclusion: This difference in perception is caused by the informant's education which is dominated by DIII level, less than optimal training, experience during work, dan the work environment.

IMPRОVЕD FINЕ-GRAINЕD CОNCRЕTЕ FОR PAVING SLABS WITH ОRGANОMINЕRAL ADDITIVES

Currently, putty concrete is widely used in mad construction. But, as can be seen from thе experiments, there is a problem of premature destruction of facing concrete exposed to an aggressive environment. In addition, fine-grained concrete is characterized by a higher level of consumption of Portland cement compared to conventional heavy concrete. One of the possible ways to solve these problems is the introduction of a complex organomineral mixture that promotes binding. Crushed concrete was mainly considered as a local building material. Because at present, consumers are abandoning large fillers that require large funds. A large number and of great importance are works on the study of reinforced concrete. To date, approaches to concrete have not changed, and their research continues to develop.

INVESTIGATION OF SURFACE PROPERTIES OF MODIFIED BITUMEN COMPOSITIONS

One of the main reasons for premature destruction of road surfaces is the poor quality of road bitumen. An effective way to improve the quality of a bitumen binder is to modify it with polymer or surface-active additives. The goal is to determine the effect of the concentration of modifiers on surface tension in binary "bitumen-surfactant", "bitumen-polymer" and triple "bitumen-surfactant-polymer" systems. The methodology of the work included measuring the surface tension of modified bitumen systems depending on the quantitative content of additives in bitumen. Results and discussion: As follows from the analysis of the data obtained, in bitumen systems with a limited concentration of polymer AG-4I (C≤1 g/dm3), the effect of reducing surface energy at the interface with air is achieved by concentrating surfactants in the surface layer, which are part of the structure of the bitumen itself. The extreme nature of the change in surface tension was also recorded in AC-2 bitumen compositions. Conclusion: In the "bitumen-AG-4I-AS-2" triple systems, the change in the specific surface energy at the "liquid-gas" interface is not an additive value, taking into account the separate contribution of AG-4I and AS-2. The concentration threshold of additives to achieve a minimum surface tension varies in comparison with binary compositions. With the combined administration of AG-4I (C=1g/dm3) and AC-2 (C=1g/dm3), the surface tension decreased by 9.30 mN/m compared with unmodified bitumen.

Increased BNIP3 activity contributes to mitochondrial dysregulation: A hypothesis on the mechanism of ineffective erythropoiesis in β-thalassemia

Ineffective erythropoiesis (IE) and the premature destruction of erythroblasts play important roles in the pathophysiology of β-thalassemia. Accumulating evidence suggests that the pathology of IE is associated with multiple factors, including apoptosis and reactive oxygen species (ROS) generation. A previous study also indicated that dysregulation of mitochondrial homeostasis and autophagy contributes to IE in the bone marrow of β-thalassemia patients. However, the precise molecular mechanism underlying mitochondria-mediated IE remains poorly understood. Here, we propose that the increased activity of adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) promotes mitochondrial fragmentation, autophagy, and apoptosis of erythroid progenitors in β-thalassemia. The present hypothesis is based on the published literature showing that 1) BNIP3 is involved in mitochondrial dysfunction and autophagy, 2) BNIP3 expression is regulated by p53 and hypoxia-inducible factor-1α, and 3) BNIP3 expression can be attenuated by a number of approaches. Our hypothesis can be verified through both in vitro and in vivo experiments. BNIP3 could be a promising therapeutic target for minimizing the pathophysiology of IE and reducing ROS generation associated with mitochondrial dysfunction in patients with β-thalassemia.

Clinical Exome Sequencing Reveals Novel Mutations in SPTB Gene Associated with Hereditary Spherocytosis in Patients with Suspected Congenital Hemolytic Anemia

Congenital hemolytic anemia (CHA) is defined as the premature destruction of red blood cells (RBC) due to congenital or acquired defects. The hereditary form of hemolytic anemia can be divided into hemoglobinopathies, membranopathies, and enzymopathies. Hereditary spherocytosis (HS) is the most common inherited RBC membranopathy leading to congenital hemolytic anemia. To date; five genes have been associated with HS coding for cytoskeleton and transmembrane proteins, those genes are SPTB, SLC4A1, EPB42, ANK1, and SPTA1. Due to genetic heterogeneity, clinical exome sequencing (CES) was performed on four unrelated Moroccan patients referred for CHA investigation. Sanger sequencing and qPCR were performed to confirm CES results and to study the de novo character of identified variants. The molecular analysis revealed 3 novel mutations and one previously reported pathogenic variant of the SPTB gene confirming the diagnosis of HS in the four patients. Hereditary spherocytosis anemia is a genetically heterogenous disease which could be misdiagnosed clinically. The introduction of novel sequencing technologies can facilitate accurate genetic diagnosis, allowing an adapted care of the patient and his family.

ДОСВІД ЕКСПЛУАТАЦІЇ ТА ОСОБЛИВОСТІ РОБОТИ ВОДОПРОПУСКНИХ СПОРУД ІЗ МЕТАЛЕВИХ ГОФРОВАНИХ КОНСТРУКЦІЙ НА АВТОМОБІЛЬНИХ ДОРОГАХ

Introduction. Road culverts made of metal corrugated structures despite of more than a hundred years of application history, in Ukraine they are a fairly new type of construction and are widely used in transport construction as an alternative to traditional steel or concrete bridge structures. The well-known advantages that justify the choice of such a solution are mainly a short term and relatively low cost of construction, construction provided that the appropriate technological regime is followed and does not cause any particular problems. However, the modern process of design and construction of road culverts from metal corrugated structures is imperfect and is constantly being improved. Therefore, there is a need to conduct an analysis conditions of operation and features of the operation of road culverts from the metal corrugated structures with the determination of approaches to improving design and construction to further increase the durability of the structure as a whole. Problems. From the literature analysis, it was established that road culverts are in difficult operating conditions, which causes their premature destruction. Goal. It consists in the analysis of operating experience and features of the operation of culverts made of metal corrugated structures on highways with the installation of measures to increase durability.

ПЕРСПЕКТИВНІ РОЗРАХУНКОВІ НАВАНТАЖЕННЯ ДЛЯ МОСТІВ НА АВТОМОБІЛЬНИХ ДОРОГАХ

Introduction. The article deals with the analysis and coverage of statistical data related to the development and application of temporary loads and the relevant norms for the design of bridge structures. Problem Statement. Over the past 5-7 years, the highway bridges of Ukraine have undergone significant changes in the intensity and composition of traffic flows. At the same time, the load, which is established by the current regulations, does not take into account the tendency to increase the weight of cars. At the same time, a significant part of the building's life cycle takes place under conditions of overload, which leads to premature destruction and overspending on repairs. In this regard, it is not always possible to unambiguously assign the type of calculated load, which can cause significant errors in the assessment of the strength and serviceability of bridge structures. Materials and methods. Comparison of estimated vehicle loads of models H-10, H-13, H-18, NK-80, Н-30, NK-100, NG-60, A11, A15, AB-51, AB-74, AB-151 (from 1931 to 2023) with the LM1 model of Eurocode EN 1991-2 shows that there is some balance between the two. The estimated load according to Ukrainian standards is intermediate between the standards of Europe and the USA. However, the level of characteristic loads is almost twice as low as in the Eurocode. This is a significant shortcoming of state building regulations, as it reduces the level of reliability of calculations.

Theoretical substantiation of system for organising preventive treatment of asphalt concrete road pavements

Introduction. Over the past 20 years, the fleet of vehicles in the Republic of Belarus has increased significantly, and, consequently, the intensity of traffic on roads with a proportional increase in wear and tear of their surfaces. The need to protect asphalt concrete pavements from premature destruction dictates the search for new technological solutions. To effectively protect asphalt concrete pavements from the complex effects of water and traffic loads in the autumn-winter and spring-winter periods, the author has developed and implemented one of the options for protecting asphalt concrete pavements of a highway – treating them with a hydrophobic preventive Protekt- 01composition.Materials and methods. The research used theoretical and practical results from the implementation of the developed hydrophobic prophylactic composition.Results. The article presents an overview of the state of the problem of preventing destruction of asphalt concrete pavements abroad and in the Republic of Belarus, an analysis of the measures taken to implement the developed hydrophobic preventive Protekt-01composition at transport infrastructure facilities, and also, based on the data obtained from production testing a ‘System for organizing preventive treatment’ has been proposed, which will be aimed at preventing the beginning and future destruction of the asphalt concrete pavement of highways and will be based on monitoring the technical condition of the control object, planning, organizing, implementing and managing preventive and repair measures using navigation equipment and software that makes it possible to optimize the balance of costs and road surface defects.Originality. Thus, based on the theoretical substantiation and the results of practical implementation of the developed composition, the following are proposed:- method for ensuring the operation of a control system for liquid road-building materials which enables to eliminate overconsumption of the distributed substance;- ‘System for organizing preventive treatment’, which enables to increase the service life of asphalt concrete pavement by 1.2–1.5 times.

Thermally stressed state of asphalt concrete layer on a metal base

The results of a finite element study of the thermally stressed and deformed states of a fragment of a two-layer bridge structure, consisting of a bearing metal orthotropic slab with a layer of asphalt concrete applied on it, are presented. It is believed that the materials of the layers are characterized by different thermomechanical parameters, which determine the inhomogeneity of the stress and strain fields. An analogue of these phenomena can be the effect of transformation in electric thermal relays of thermal action on a bimetallic plate with different coefficients of thermal linear expansion into its mechanical displacements, which are used to actuate the switch and switches. Using the method of computer modeling, it was found that these factors lead to the concentration of stresses and strains and changes in the stress-strain state in all elements of the bridge structure end are not taken into account in the modern practice of designing and operating bridges, as well as are one of the reasons for the premature destruction of asphalt concrete pavements. To eliminate these shortcomings, on the basis of finite element algorithms, a theoretical analysis of the thermally stressed state of a metal bridge slab with an asphalt concrete pavement at various ratios of their thicknesses is carried out. It is shown that an increase in the thickness of the upper layer can lead to an increase in shear and normal tensile stresses initiated in it. Therefore, when designing bridge structures, these features should be additionally taken into account.

Belt conveyor starting mode optimization

The work is aimed at increasing the efficiency of belt conveyors by choosing the drive mechanism movement mode. During the operation of belt conveyors, significant energy and dynamic loads occur in the elements of the drive mechanism and traction body. The available loads significantly affect the energy losses and the reliability of the drive mechanism and the traction body. Energy and dynamic loads during transient processes (starting, braking, changing speed or performance and emergency stop) are especially dangerous. At this moment, high-frequency oscillations of both the traction body and the drive elements arise. With such fluctuations in the traction body (belt) of the conveyor, significant breaking forces arise, which create additional unwanted stresses in it and, as a result, contribute to premature destruction. In addition, the stator and rotor windings of the electric motor are heated, which accelerates their wear and failure. In order to reduce dynamic loads, it is proposed to optimize the movement mode of the drive mechanism. For this purpose, the conveyor is presented in the form of a three-mass dynamic model, based on which a mathematical model was created. From the conducted dynamic analysis of the belt conveyor, it was established that during the start-up process, significant power and energy overloads occur in the elements of the drive and the traction body, which depend on the driving force of the drive. In addition, high-frequency oscillations of the tape are observed. Since the undesirable properties of the belt conveyor largely depend on the magnitude of the driving force of the drive, it should form the basis of the optimization criterion. In addition, the driving force of the drive must be reflected in the optimization criterion during the entire movement process, that is, the optimization criterion must be presented in an integral form. To eliminate the possible compensation of negative and positive values of the driving force on the conveyor, the latter should be represented in the integral criterion in quadratic form. Therefore, the rms value of the driving force of the drive during the start-up time was chosen as the criterion for optimizing the motion mode of the belt conveyor. Optimization of the conveyor movement mode was carried out by minimizing the integral dynamic criterion. As a result of the optimization, the start-up mode of the belt conveyor was determined, which minimizes the effect of dynamic loads. This start-up mode makes it possible to increase the reliability of the conveyor and reduce the energy consumption of the drive.