Pre Group Research Articles

E-28 | Temporal Trends in Radiation and Contrast Dose After the Introduction of New X-Ray Systems

The effect of technological improvements on radiation dose and contrast volume during cardiac catheterization has received limited study. We compared the cumulative air kerma, fluoroscopy time, and contrast dose before and after installation of new X-ray systems in 14,051 procedures performed between 2018 and 2021 at a tertiary US center. Cumulative air kerma (AK) increased after new X-ray system installation by 94 mGy (95% CI [55, 133], p < 0.001). After adjusting for baseline characteristics, (age, body mass index, bifurcation lesion, complexity) the estimated increase was 61 mGy (30, 92), p < 0.001. Adjusting for fluoroscopy time, the estimated increase was 45 mGy (24, 66), p < 0.001. The estimated increase compared with 2018 was 40 mGy (11, 69), p = 0.007. Fluoroscopy time also by 1.0 min (95% CI 0.54, 1.5, p < 0.001). Adjusting for baseline characteristics, the estimated increase was 0.54 (95% CI 0.15, 0.93, p = 0.006). Fluoroscopy time was similar between 2018 and 2021 (0.07 min, 95% CI -0.44, 0.58, p = 0.8). Contrast volume was similar in the pre and post group (difference 0.00 mL, 95% CI -3.2, 3.2, p > 0.9). After adjusting for baseline characteristics, contrast volume did not significantly decrease (mean difference 2.9 mL, 95% CI-0.07, 5.9, p = 0.056). Fluoroscopy time and radiation dose increased from 2018-2021 after the introduction of new technologies. More research is needed to understand the underlying reasons and improve radiation safety in the cardiac catheterization laboratory.

Myofascial Pain Syndrome Of The Upper Trapezius Muscle: Different Effects Of Myofascial Release And Stretching On Pain

Background: The increasing demand of works from day to day and unergonomic posture habits and static positions at works for a longer period of time can cause physical symptoms such as muscle spasm and pain especially on the neck area or known as myofascial pain upper trapezius muscle. The pain can limit daily functional activities so that invidivual with this problem usually seek for treatment to reduce it. Physiotherapy intervention that can be used in this case among others are myofascial release and stretching. Objective: To know the difference between the effect of myofascial release with stretching on myofascial pain upper trapezius muscle. Research Methods and Result: This research is an experimental study with two group with pre and post test design. The sampling technique was purposive sampling. The subject is 30 workers in Fitasoma Clinic who fulfill inclusion criteria and divided into two groups namely group I (n=15) with myofascial release treatment and group II (n=15) with stretching. Each group received treatment 6 times for 2 weeks. The assessment of pain in this research used quadruple visual analogue scale (QVAS). During pre and post-test group I and II used paired t test and each group got the score of p=0,000. Meanwhile, in post-test group I and II used unpaired t test and got the score of p=0,009. Conclusion: This research shows that myofascial release and stretching is effective to reduce pain on myofascial pain upper trapezius muscle. However, myofascial release is more effective than stretching to decrease pain on myofascial pain upper trapezius muscle.

Spiritual Benson Relaxation in Reducing Stress in Patients Undergoing Hemodialysis

Background: Patients with chronic kidney failure experience various changes in their lives, starting from their diet, exercise, blood sugar control, urea, creatinine and renal function replacement therapy that must be carried out throughout their lives, causing long stress for the patient. Purpose: The purpose of this study was to analyze the effect of Spiritual Benson Relaxation on reducing stress in patients undergoing hemodialysis. Methods: This research design uses quasi-experimental approach with a pre and post control group design. The population of all patients with chronic kidney failure who underwent dialysis in the Hemodialysis unit of the Surabaya Islamic Hospital A. Yani was 70 people. The sample size is 32 respondents. The sampling technique is purposive sampling. The intervention group was given Spiritual Benson Relaxation and the control group were given intervention according to hospital standards. The analysis used the Wilcoxon with a significant value of . &lt; 0.05. Results: The results showed that the stress level p value 0.001 in the intervention group and the control group p value 0.035 which means that there is an effect of Spiritual Benson Relaxation on reducing stress in patients undergoing hemodialysis. Conclusion: Spiritual Benson Relaxation is effective in reducing stress in patients undergoing hemodialysis and the technique is easy to do.

The Effect of Electronic Tindak Lanjut Tensiku (e-Titenku) Model to Knowledge of Coronary Heart Disease Prevention

Background: Cardiovascular disease is still a major global health problem. Hypertension is the most risk factor for the incidence of cardiovascular disease and increases the risk of death. Primary and secondary prevention efforts are needed by increasing patient awareness of identifying risk factors and carrying out preventive management. “Electronic-Tindak lanjut Tensiku”, known as e-TITENKU, is a web and smartphone-based application designed to manage coronary heart disease prevention in patients with hypertension. Purpose: The purpose of this study was to determine the effect of the e-TITENKU intervention model on knowledge of coronary heart disease prevention. Methods: This research design is true experiment pre and post control group design. The sample size is 120 respondents with primary hypertension in Banyumas Regency, Indonesia. The sampling technique used is simple random sampling. The inclusion criteria included respondents with primary hypertension, adults aged 40-65 years, cooperative and willing to be respondents, while the exclusion criteria were respondents experienced complications of other diseases due to hypertension. Results: The results of the study were that the age of the respondents in the intervention group was 64.91 years old, the systolic blood pressure was 169 mmHg and the diastolic blood pressure was 97 mmHg. The characteristics of the respondents in the control group were the mean age of 65.98, the mean systolic blood pressure of 172 mmHg and the diastolic of 93 mmHg. Conclusion: The e-TITENKU intervention model was able to increase the knowledge score of coronary heart disease prevention. This model can be used by nurses in hospital and community services.

Exclusive Breast Milk Education with Android-Based Application Program Towards Breastfeeding Patterns

During the Covid-19 pandemic, education, which so far has been carried out directly, has switched to education through various online media, but the effectiveness of education through these applications needs to be evaluated. The aim of the study was to increase pregnant women's knowledge about exclusive breastfeeding and to find out the effect of android-based application programs on breastfeeding patterns. The research design was quasi-experimental with a pre and post-test control group design, subjects were grouped into intervention groups and control groups, selected by purposive sampling with a total of 30 people in each group. This research was conducted in 2022 in the Sindang Barang and Cipaku Health Centers, Bogor City. The independent variable is the Android-based ASI application program with the dependent variable being the pattern of breastfeeding. The statistical test uses the Wilcoxon and Mann Whitney tests. The results of the study showed that there was a significant increase in the average knowledge and attitude after exclusive breastfeeding education was carried out with Android-based application program, as well as a significant change in the pattern of breastfeeding after participating in the breastfeeding education program. The conclusion of the study is that there is a significant relationship between breastfeeding education and Android-based application program on increasing knowledge, attitudes of mothers and patterns of breastfeeding.

Utilizing social media in socioscientific issues discussion to improve argumentative skills and microbial literacy

Microbial literacy plays an essential role in understanding microbiology issues. Discussion of socioscientific issues is one way to improve microbial literacy and argumentative skills. Socioscientific issues discussion takes a long time if applied in an inadequate classroom. Thus, social media is used as a tool to discuss socioscientific issues. This study aims to utilize social media Facebook' in discussing socioscientific issues. The research method used is quasi-experimental. The pre-post one group design was used to know the effect of socioscientific discussion on argumentation skills, and the pre and post-control group design was used to know the differences in microbiological literacy of students who discuss socioscientific issues and did not discuss socioscientific issues. Discussion of socioscientific issues is carried out through four steps: polemic, exploration, conclusion, and action. The results showed increased individual argumentation skills before and after discussing socioscientific issues via Facebook. Before the discussion there are 34.38% of students reached argumentation levels 4 to 5, after which 56.25% reached argumentation levels 4-5. Discussion of socioscientific issues through social media has made group argumentation skills reach higher performance (level 5). Microbiological literacy between groups discussing socioscientific issues and not discussing socioscientific issues showed no significant difference except for questions directly related to the topic of discussion, namely changes in perceptions of microbes. Online discussions of socioscientific issues with pro and con arguments were very effective through social media “Facebook.”

ROLE OF SEX HORMONE BINDING GLOBULIN AS AN INDICATOR OF INSULIN RESISTANCE

Objective: To determine the role of Sex Hormone Binding Globulin (SHBG) in cases of hyperinsulinemia and insulin resistance among our population. Material and Methods: It was a cross-sectional analytical study conducted at Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from Jun 2022 – Dec 2022. Study is comprised of total 90 samples consisting of both males and females. Study individuals were categorized as Pre-Diabetic and Diabetic according to their fasting plasma glucose levels. Fasting plasma insulin levels were done on Advia Centaur XPT Chemiluminescence Immunoassay analyser. Serum SHBG was done on Immulite 2000 by chemiluminescent immunometric assay. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was calculated from fasting glucose and insulin levels. Cut off value of 2.2 was used for labelling insulin resistance. Data was analyzed on SPSS version 23. Mean and standard deviation (SD) was calculated for glucose, insulin and SHBG. T test was used to compare means of pre diabetic and diabetic groups. Pearson’s correlation was used to establish correlation between SHBG and HOMA-IR. Results: Our study included 57 males and 33 females with mean age of 47±11 years and 47±12 years, respectively. SHBG levels were significantly higher in pre-diabetics as compared to diabetics. The Pearson’s correlation between SHBG and Fasting serum insulin is weak negative (r = 0.3, p = -0.23), same is between SHBG and HOMA-IR (r = 0.25, p = -0.86), showing no significant association between SHBG and HOMA-IR among our population. However, two tailed t-test showed marked difference between means of serum SHBG, fasting serum insulin and HOMA-IR among diabetic and pre-diabetic groups with 95% confidence Interval. Conclusion: The negative association of SHBG with insulin resistance is not marked in our population. Various epidemiological, external and metabolic factors could affect and should be excluded before establishing this negative correlation between SHBG and Insulin resistance for predicting the development of diabetes mellitus (DM) Key Words: SHBG, Hyperinsulinemia, HOMA-IR, Correlation

Kombinasi Isometric Quadriceps Exercises dan Edukasi Treatment Terhadap Perubahan Nyeri Lutut Pada Penderita Osteoarthritis Genu

Objective: to find out whats effects give isometric quadriceps exercises and education treatment intervention can reduce knee pain in patient osteoarthritis genu. Methods: This study used the Quasi-Experimental of one group design pre and post group, respondents numbered 20 men and women with purposive sampling techniques, data cellection techniques using NRS test. Normality test using Shapiro-Wilk and continued with data analisis using WilcoxonResults: in the NRS measurement of isometric quadriceps exercises and education treatment intervention post-test there is a change in decrease of genu pain, and the results of the hypothesis test with normality data distribution show significance value of &lt;0,000Conclusion: Isometric Quadriceps exercises and education treatment have been show to effect reduce knee pain in patient osteoarthritis genu

EDUKASI HOLISTIK PADA IBU POSTPARTUM TERHADAP PEMBERIAN ASI

Introduction : Breast milk is the best food for infants because it contains many substances and protective factors that are impotant for the growth and development of infants so as to reduce infant morbidity and mortality. This contens is very complete and complex, there are hunderds of bioactive molecules that can protect babies from infectione and help in the formation of a strong immune system. Objective : This study aimsto determine whether there is an effect of holistic education on post partum mother on the success of breastfeeding at the Watampone Health Center. Research Methods : Based on the results of the research that researchers have done, the average value of knowledge in the interventioan group before being given education was 4,88, the lowest score was 3 and the highest score was 7 (total score 10), while the average score in the intervention group after education was 9.00. while the average value of knowledge in the pre test control group was 4,82, while the average value of knowledge in the post test control group was 6,29. This shows that there is an effect of providing education on changes in knowledge of post partum mothers in exclusive breastfeeding. Conclution : This study concludes that there is an increase in post pratum mother’s knowledge of exclusive breastfeeding at UPT Puskesmas Watampone after education.&#x0D;

Polishing the bonding surface, before or after crystallization, does not alter the fatigue behavior of bonded CAD-CAM lithium disilicate

The aim of this study was to assess if the finishing/polishing of the bonding surface of lithium disilicate ceramic, prior to or after crystallization, would affect the fatigue behavior of a bonded restorations. For this, lithium disilicate ceramic (IPS e.max CAD) discs (n = 15) were milled and randomly divided into 3 groups: CAD-CAM group which remained untouched; PRE group which received a finishing/polishing protocol (OptraFine system) prior to its crystallization; and POST group, which received the treatment after its crystallization. After surface treatments, ceramic and glass-fiber reinforced epoxy resin discs were paired and bonded using a resin cement (Multilink N). A cyclical fatigue test was conducted (frequency 20 Hz, initial load 200 N for 5000 cycles, step-size of 100 N for 10,000 cycles/step) until failure occurrence. Surface roughness and topography were analyzed. An initial descriptive analysis of surface roughness, FFL and CFF was performed to obtain the mean, standard deviation and confidence interval values (SPSS v. 21, SPSS Inc.) for statistical analysis. Roughness data was using one-way ANOVA with Tukey's post hoc test (α = 0.05), while the fatigue data was submitted to survival analysis with Kaplan-Meier test (α = 0.05) and Weibull modulus (Weibull++, Reliasoft). Neither the finishing/polishing procedure of the bonding surface, nor the moment (prior to or after crystallization), affected the fatigue behavior of bonded milled lithium disilicate. There were also no differences for mechanical reliability among conditions. Despite this, finishing/polishing reduced surface roughness and led to smoother topography. Finishing/polishing the bonding surface of milled lithium disilicate, before or after crystallization, does not alter the fatigue behavior of the bonded restorative set, although there is some influence on roughness and topography.

Curcumin reduce creatine kinase (CK) levels without decreasing malondialdehyde (MDA) levels after 24 hours of high-intensity physical exercise

This study aims to analyze the effect of curcumin on serum levels of creatine kinase (CK) and malondialdehyde (MDA) after 24 hours of high-intensity physical exercise. This experimental study used a pre and post-control group design. A total of 18 healthy men with an average age of 23 years participated in this study. Subjects were selected using a random sampling technique and then the subjects were divided into 2 groups, namely the group given a placebo and the group given curcumin at a dose of 400 mg. On the first day, all subjects took data on the characteristics of the research subjects, and then the subjects did the high-intensity physical exercise in the form of squad and leg press exercises with an intensity of 80-90% of maximum ability. On the second day, after 24 hours, all subjects took pre-test data samples to measure serum CK and MDA levels, then the intervention was given based on their respective groups. On the third day, after 24 hours, all subjects took post-test blood samples to measure CK and MDA serum levels. Blood samples were analyzed in the laboratory using the ELISA method. The results of this study reported that the group given a placebo did not significantly reduce serum CK levels, while the group with curcumin at a dose of 400 mg could significantly reduce CK levels (p&lt;0.05). Furthermore, there was no significant decrease in serum MDA levels in the placebo group or the curcumin group (p&gt;0.05). It can be concluded that the administration of curcumin after 24 hours after high-intensity weight training was able to reduce serum CK levels without a decrease in MDA serum levels. Since the decrease in serum CK levels is an essential part of recovery during muscle damage. Therefore, curcumin is recommended to be taken after 24 hours after exercise to speed up recovery. Keywords: Curcumin; creatine kinase; malondialdehyde; muscle damage; free radicals; physical training

Combination method imagination guidance listening to music through audio with art therapy in reduce adolescent anxiety with thalasemia major

Introduction: Thalasemia mayor is a congenital disorder characterized by a lock of production of hemoglobin chain, thus requiring blood transfusion for the rest of his life, where side effect will be changes in the state of the body with facial cooley, enlargement of the liver so that the abdomen looks distended, growth that does not match its age. These changes occur in adolescent who will experience fear of death and anxiety about the future. The research objective was to determine the effect of a combination of listening to audio music therapy with art therapy on adolescent anxiety. The method is the pre test and post test control group design approach. The number of respondents was 28 in the control grou[ and in the intervention group. The results of statistical tests in the pre and post control groups had no effect (p=0.13) and in the intervension group there was a significant effect with a value of p=0.00. it can be concluded that there is an effect of giving a combination method of listening to music through audio with art therapy on the anxiety of adolescent withthalsemia mayor.

HOMA-IR level in obese type 2 diabetic rat model treated by Sleeve gastrectomy and pancreatic omentoplasty

Obesity is a health problem that occurs due to the wrong lifestyle, such as lack of physical activity and the wrong diet. Accumulation of adipose tissue in obesity may increases pro-inflammatory cytokines, particularly in pancreatic beta cells leading to type 2 diabetes mellitus (T2DM). Sleeve gastrectomy (SG) is an alternative therapy for T2DM in obese patients by losing about 40-60% of body weight and increasing GLP-1 secretion which stimulates increased insulin secretion. However, the SG procedure cannot reduce pro-inflammatory cytokines which promote damaged pancreatic cells. Pancreatic omentoplasty can suppress pro-inflammatory cytokines and promote the regeneration of damaged pancreatic cells. The goal of this study is to investigate HOMA-IR in obese rats with diabetes mellitus who underwent SG and pancreatic omentoplasty procedures. An experimental using pre and post-test control group design were done in this study. Eighteen Diabetes Mellitus rats were divided into 3 groups: K1 (SG), K2 (SG + Omentoplasty), and K3 (control). Blood glucose and insulin level were measured using a glucoDR Glucometer Bio-sensor kit and ELISA, respectively before and 10 days after the procedure. HOMA-IR measurement was calculated based on insulin and blood glucose level. A significant decrease of fasting blood gluocese levels were shown in all treatment groups of this study after day 10th. There was a significant increase in the insulin levels after day 10th. Highest decrease of the blood glucose levels and increase of the insulin levels were shown in group K2. Furthermore, a significant decrease of HOMA-IR was shown in the K2 on day 10th. From this study, we may conclude that SG and Pancreas Omentoplasty may significantly reduce the HOMA-IR value in obese rats with T2DM.

Evaluation Of Oxidative Stress On Dogs With Demodicosis

Aim: In this study, it was aimed to investigate the effects of demodicosis on oxidative stress in dogs.&#x0D; Materials and Methods: The material of the study is based on a total of 32 dogs, 21 of which are diagnosed with demodicosis and 11 of which are healthy, with different ages, genders and breeds. Examination for diagnostic evaluation of demodex is performed by examining the samples under the microscope which are taken by trichogram and deep skin scraping methods. In order to evaluate the oxidative stress on dogs with demodicosis at pre and post treatment groups and the control group without demodex diagnosis, the values of SOD (Superoxide dismutase), GPX (Glutation Peroxidase), GSH (Glutation) as antioxidant and MDA (Malondialdehyde) as oxidant are investigated.&#x0D; Results ?: In clinical examinations, manifestations such as alopecia, erythema, generalized pruritus, hyperpigmentation, lichenification, pododermatitis, interdigital pruritus, lymphadenopathy are observed on dogs with demodicosis on pre and post treatment stages. In the analyzes performed in order to evaluate the oxidative stress, MDA 20.30 nmol/ml, GSH 4.9 nmol/ml, GPx 0.42 U/l, SOD 4.1 U/l are measured in dogs with clinical demodicosis. At the post treatment stage, the average values on the same dogs are measured as MDA 6.08 nmol/ml, GSH 8.11 nmol/ml, GPx 0.83 U/l, SOD 6.67 U/l, whilst in the control group they were measured as MDA 4.94 nmol/ml, GSH 9.73 nmol/ml, GPx 0.97 U/l, SOD 7.20 U/l. It is obtained that, GSH, GPx and SOD values in the control and post treatment groups are significantly higher (p˂0.001) and MDA value is lower (p˂0.001) than the clinical demodicosis group.&#x0D; Conslusion: In dogs with clinical demodicosis, compared to control and post-treatment, higher level of MDA which is oxidant and lower level of GSA, GPx and SOD which are antioxidants showed that demodex is caused oxidative stress.

Promoting development of entrepreneurial skills of youth in Ghana through a structured sport intervention program

IntroductionThe purpose of this brief report is to describe how a structured sport-based positive life skills program can be used in promoting the development of entrepreneurial skills of youth in Ghana.MethodsA total of 29 youth participated in the study with 11 as the control group and the remaining 18 as the intervention group. The students in the intervention together with 5 parents participated in a weekend mapping camp. Data for the study was collected with the Youth Experience Survey for Sport to measure the Life skills and entrepreneurship skills using a quasi experimental pre and post test control group design.ResultsThe youth in the intervention group reported important physical and personal benefits and entrepreneurial skills such as cooperation (teamwork), risk taking, creativity, leadership, cognitive development, and positive engagement in physical activity which they did not previously have. The results are similar to existing published papers giving this report a commendable validity and reliability.DiscussionSimilar to the previously published papers, the perceived gains in this report also show that exposing youth to a structured sport-based positive life skills program produce both physical benefits and development of lifelong skills necessary to develop skills necessary for entrepreneurial endeavors. When this intervention is upscaled in Ghana the country could offset high youth unemployment with its associated challenges.

The impact of an organizational-level mindfulness-based intervention on workplace social capital and psychological safety: A qualitative content analysis.

Through the past decades, the mental health of the European population has been continuously declining. Social relations in various spheres of life, including workplace settings, have been shown to impact mental health. Mindfulness-based stress reduction (MBSR) has been found effective in enhancing well-being, and reducing perceived stress, and symptoms of depression and anxiety. Research into mindfulness-based interventions (MBIs) in workplace settings has shown that these interventions may positively affect workplace outcomes, such as interpersonal relations. However, research regarding the organizational impacts of MBIs is still nascent. The objective of this study was to investigate how an organizational-level mindfulness-based intervention (MBI) including a workplace-adapted MBSR programme may impact workplace social capital and psychological safety. Four small and medium-sized private companies were included in this study, representing 368 employees and managers. The intervention consisted of three steps: 1. Mandatory participation in introductory sessions on mental health and mindfulness, 2. Voluntary participation in a 10-week workplace-adapted MBSR programme, and 3. A workshop for selected employee representatives and managers on further implementation of mindfulness. Data was collected using pre and post-intervention focus group interviews. In total, 27 interviews including 76 respondents were conducted. Verbatim transcription was performed. Data was analyzed using deductive content analysis with theoretical frameworks for social capital and psychological safety. The analysis resulted in three main categories: 1. Social capital (1.1. bonding social capital, 1.2. bridging social capital, 1.3. linking social capital), 2. Psychological safety, and 3. Emergent theme: The role of lockdown on the perceived organizational impact of a workplace MBI. The greatest impact was found relating to the bridging social capital, i.e., social capital between departments, and psychological safety among colleagues at the same level of employment. The results indicate that company participation in this organizational-level MBI including a workplace-adapted MBSR programme may positively impact social relations at work, especially the bridging social capital and psychological safety between colleagues at the same level of employment. These results may have been influenced by lockdowns due to the COVID-19 pandemic.

Abstract P2-14-19: Targeted Axillary Lymph Node Dissections Using Radar Reflector Localization Can Reduce Unnecessary Axillary Lymph Node Dissections in Node Positive Patients Treated with Neoadjuvant Chemotherapy

Abstract Background Targeted axillary dissection (TAD) is a surgical strategy that involves staging the axilla through sentinel lymph node biopsy (SLNB) combined with the removal of a biopsy-proven positive lymph node identified by a clip. TAD reduces the false negative rate of SLNB alone in patients with clinically detected nodal metastasis who receive neoadjuvant chemotherapy (NAC) while avoiding axillary lymph node dissections (ALND). Radar reflector-localization (RRL) can be used to identify previously positive nodes and safely and effectively guide dissection. Methods We performed an institutional retrospective chart review of breast cancer patients with clinical stage T1-3 and N1-3 disease treated with NAC from 2015 to 2020 who had a biopsy proven positive node and underwent TAD using RRL. The primary outcome was the retrieval of clipped node as documented by gross visualization or specimen radiography. Secondary outcomes included pathologic complete response rates and completion axillary lymph node dissections (cALND). Results 79 patients were identified who fulfilled inclusion criteria. 32 (40.5%) had RRL markers placed prior to chemotherapy (mean 187 days prior to surgery) and 47 (59.5%) had RRL markers placed following the completion of chemotherapy (mean 7 days prior to surgery). The clipped node was retrieved in 77 patients (97.5%). 32 of the 34 ypN0 (i+) patients avoided an ALND; 1 patient had a cALND for failure to localize the RRL and 1 patient had a cALND for a false-positive on frozen section. There was no significant difference in clip recovery rates in the pre vs post NAC RRL groups (p=1.00). Conclusion RRL systems are an effective way to guide TAD with a high success rate in identifying and removing previously biopsied nodes. These markers can be placed prior to NAC without migration or deactivation. This strategy allows surgeons to avoid unnecessary cALND. Citation Format: Lilia Lunt, Alison Coogan, Andrea Madrigrano, Cristina O’Donoghue. Targeted Axillary Lymph Node Dissections Using Radar Reflector Localization Can Reduce Unnecessary Axillary Lymph Node Dissections in Node Positive Patients Treated with Neoadjuvant Chemotherapy [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-14-19.

Zinc Content, Suppleness and Favorability Test on Anchovy Flour Fortified Cob Meatballs

Stunting in Jember Regency is the eighth most common condition in East Java, affecting up to 30% of the 180,000 children under the age of five. The creation of meatballs made from tuna fortified anchovy, which are increasingly rich in nutrients like zinc, will help to overcome nutritional issues. The aim of this research was to look at zinc levels, elasticity, and organoleptic properties. The aim of this study was to look at the zinc levels, elasticity, and organoleptic consistency of tuna fish balls after fortification with anchovy flour and chewers, which could help stunted toddlers improve their nutritional status. This is a true experimental study with a pre and post control group configuration. The sample size was set at 27 (eight samples from the treatment group and one sample from the control group). Zinc levels, elasticity, and organoleptic consistency are all measured in the lab through observation. On zinc levels, ANOVA Two Way was used to analyze data presentation. Zinc levels of 0.001 mg/100 gr and elasticity of 707.38 4.13 gf were found in tuna fish balls until they were reinforced with anchovy flour and chewers. The interaction of zinc content, elasticity, and organoleptic quality of anchovy meal fortification (0, 18%, and 35%) and thickener (carrageenan and STTP) has a major effect on zinc content, elasticity, and organoleptic quality (physical and preferences include taste, aroma, color and texture). The best tuna meatballs in terms of general nutritional content and chewiness are tuna fish balls fortified by 35% anchovy and with carrageenan as thickener. His general favorite is tuna fish balls which are not fortified with anchovy flour and without chewing. Future research is expected to find alternatives to other highly nutritious fish with good acceptance

The Effectiveness of Giving Crystal Guava Juice (Psidium guajava L. “Crystal”) on Haemoglobin Levels in Female Adolescents with Anaemia

Anaemia is one of the health problems in female adolescents with haemoglobin levels in the blood circulation is below normal, which is &lt;12 g/dl at the adolescent threshold. Crystal guava is a fruit that is rich in iron and vitamin C, which helps increase haemoglobin levels in the blood. This study aims to analyse the effectiveness of giving crystal guava juice (Psidium guajava L.“Crystal”) on haemoglobin levels in female adolescents with anaemia. The design of this study was a quasi-experiment with pre and post-test control group design with 36 subjects divided into 3 group. This study was tested using SPSS version 25 with a significant level of 0.05. The result showed that there was an effect of giving crystal guava juice on haemoglobin levels in female adolescents with anaemia by p=0.018 (p&lt;0.05). Giving crystal guava juice with iron tablets is effective to increase haemoglobin levels in female adolescents with anaemia.International Journal of Human and Health Sciences Vol. 07 No. 02 April’23 Page: 176-182

Real-world treatment patterns and sequencing in patients with locally advanced or metastatic urothelial cancer (la/mUC) in the US.

572 Background: Platinum-based chemotherapy (PBC) is standard first-line (1L) treatment (tx) for patients (pts) with la/mUC. On June 30, 2020, avelumab was approved in the US as 1L maintenance (1LM) for pts without disease progression following PBC. Other novel agents such as enfortumab vedotin were recently approved for second-line (2L) or later tx. Little is known about how to incorporate these agents into the optimal tx sequencing approach. This real-world (RW) study describes the characteristics and tx patterns of pts with la/mUC. Methods: A retrospective cohort of de-identified records of pts with la/mUC was obtained from the Tempus Database. Eligible pts were diagnosed with la/mUC between January 1, 2016 and February 23, 2022. Pts who completed 1L PBC were categorized as 1LM or 2L-treated. 1LM was differentiated from 2L tx based on stated clinical intent of 1LM or initiation of immunotherapy (IO) within 180 days of 1L PBC completion without disease progression. These patients were split into pre and post groups based on when they completed their 1L PBC in relation to avelumab 1LM US approval on June 30, 2020. Results: A total of 821 pts were included from community centers (21%), academic centers (27%), and ASCO CancerLinQ network sites (52%). The median age at diagnosis was 68 years (IQR, 61-75), 73% male, and 63% White. 634 (77%) pts received 1L systemic tx; of those, 62% (395/634) received PBC, 24% (155/634) received IO monotherapy, 7% (45/634) received non-PBC, and 6% (39/634) received other regimens. Tx sequencing for a subgroup of pts who discontinued 1L PBC pre- and post-avelumab 1LM approval is shown (Table). Of those receiving IO (n=84) as subsequent tx post-avelumab approval, 80% (67/84) received IO as 1LM, out of which, 84% (56/67) received avelumab as 1LM. Of the 25 pts who received 2L tx after progression on IO 1LM post-avelumab approval, enfortumab vedotin was the most commonly integrated 2L agent (n=20; 80%). Conclusions: This RW study offers valuable insight into the characteristics of pts with la/mUC treated in routine clinical practice in the US. These tx pattern data are consistent with known and evolving tx paradigms in la/mUC. In subsequent RW studies, clinical data with longer follow-up could provide further insight into the optimal tx sequencing and associated clinical outcomes. [Table: see text]