Event Abstract Back to Event The neural substrates of mindfulness interventions in major depressive disorder: a systematic review and meta-analysis of EEG and MRI studies Valentina Lorenzetti1*, Cat A. Whitehouse2, Deirdre B. Birtles2, Tim Lomas2 and Cynthia H. Fu2, 3 1 University of Liverpool, Psychological Sciences, Institute of Health Psychology and Society, United Kingdom 2 University of East London, Psychology, United Kingdom 3 King's College London, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, United Kingdom Mindfulness meditation has been adapted as a form of psychological therapy which has been found to reduce the rate of relapse in depression. Understanding the neural correlates of the therapy could aid in optimizing the aspect of the treatment which contributes to relapse prevention. However, there have been mixed findings with reports of the presence as well as absence of prefrontal asymmetry following mindfulness treatment. We performed a systematic review of the neural correlates of mindfulness treatment in depression from EEG and functional MRI studies. Nine studies met our inclusion and exclusion criteria, consisting of 427 patients with depression and 24 healthy controls (age range: 18 to 50 years). The findings revealed increases in alpha and gamma activity in prefrontal as well as parietal regions following a course of mindfulness as compared to control interventions. Alpha asymmetry and alpha and theta oscillatory dynamics were also associated with improvements in depressive symptoms. Mindfulness may reorganize dysfunctional neural networks in depression, though there was much heterogeneity in the experimental paradigms. Keywords: mindfulness, mindfulness-based cognitive therapy, intervention, Major Depressive Disorder, Depression, electroencephalogrpahy, EEG, fMRI, prefrontal, parietal, alpha, gamma Conference: ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future, London, United Kingdom, 6 Jul - 7 Jul, 2017. Presentation Type: Poster Topic: Psychological treatments Citation: Lorenzetti V, Whitehouse CA, Birtles DB, Lomas T and Fu CH (2019). The neural substrates of mindfulness interventions in major depressive disorder: a systematic review and meta-analysis of EEG and MRI studies. Front. Psychiatry. Conference Abstract: ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future. doi: 10.3389/conf.fpsyt.2017.48.00004 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 May 2017; Published Online: 25 Jan 2019. * Correspondence: Dr. Valentina Lorenzetti, University of Liverpool, Psychological Sciences, Institute of Health Psychology and Society, Liverpool, United Kingdom, valentina.lorenzetti@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Valentina Lorenzetti Cat A Whitehouse Deirdre B Birtles Tim Lomas Cynthia H Fu Google Valentina Lorenzetti Cat A Whitehouse Deirdre B Birtles Tim Lomas Cynthia H Fu Google Scholar Valentina Lorenzetti Cat A Whitehouse Deirdre B Birtles Tim Lomas Cynthia H Fu PubMed Valentina Lorenzetti Cat A Whitehouse Deirdre B Birtles Tim Lomas Cynthia H Fu Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.