As mobile device penetration increases, it has become pervasive for images to be associated with locations in the form of geotags. Geotags bridge the gap between the physical world and the cyberspace, giving rise to new opportunities to extract further insights into user preferences and behaviors. In this article, we aim to exploit geotagged photos from online photo-sharing sites for the purpose of personalized Point-of-Interest (POI) recommendation. Owing to the fact that most users have only very limited travel experiences, data sparseness poses a formidable challenge to personalized POI recommendation. To alleviate data sparseness, we propose to augment current collaborative filtering algorithms along from multiple perspectives. Specifically, hybrid preference cues comprising user-uploaded and user-favored photos are harvested to study users’ tastes. Moreover, heterogeneous high-order relationship information is jointly captured from user social networks and POI multimodal contents with hypergraph models. We also build upon the matrix factorization algorithm to integrate the disparate sources of preference and relationship information, and apply our approach to directly optimize user preference rankings. Extensive experiments on a large and publicly accessible dataset well verified the potential of our approach for addressing data sparseness and offering quality recommendations to users, especially for those who have only limited travel experiences.