Abstract
Object-place paired associate learning has been used to test hypotheses regarding the neurobiological basis of memory in rodents. Much of this work has focused on the role of limbic and hippocampal-parahippocampal regions, as well as the use of spatial information derived from allothetic visual stimuli to determine location in an environment. It has been suggested that idiothetic self-motion (vestibular) signals and internal representations of directional orientation might play an important role in disambiguating between spatial locations when forming object-place associations, but this hypothesis has not been explicitly tested. In the present study, we investigated the relationship between allothetic (i.e., distal and proximal cues) and vestibular stimuli on performance of an object-place paired-associate task. The paired-associate task was composed of learning to discriminate between an identical pair of objects presented in 180° opposite arms of a radial arm maze. Thus, animals were required to select a particular object on the basis of spatial location (i.e., maze arm). After the animals acquired the object-place rule, a series of probe tests determined that rats utilize self-generated vestibular cues to discriminate between the two maze arms. Further, when available, animals showed a strong preference for local proximal cues associated with the maze. Together, the work presented here supports the establishment of an object-place task that requires both idiothetic and allothetic stimulus sources to guide choice behavior, and which can be used to further investigate the dynamic interactions between neural systems involved in pairing sensory information with spatial locations.
Highlights
Recent theoretical and experimental work has argued that the recollection of previous experiences is composed of at least three fundamental elements: “what,” “when,” and “where” [1,2,3,4,5,6,7]
Animals showed marked improvement in selecting the reinforced object, and by Day 10 of training, animals demonstrated a high degree of discrimination between the two objects based on maze arm location. This observation was confirmed by an significant analysis of variance (ANOVA) yielding a training day effect for percent correct, F(9, 81) = 43.8, p < 0.001, η2 = 0.83
A repeated-measure ANOVA confirmed this observation with a significant day-by-strategy effect, F(9, 144) = 37.8, p < 0.001, η2 = 0.70
Summary
Recent theoretical and experimental work has argued that the recollection of previous experiences is composed of at least three fundamental elements: “what,” “when,” and “where” [1,2,3,4,5,6,7]. Cues and Object-Place Memory behavioral tasks in rats which pair specific items (what) and places (where) using a bi-conditional association rule [8, 9]. In this procedure, rats are rewarded when selecting object A only when it appears in location 1, but not in location 2. Object B is rewarded only when it is encountered in location 2, but not in location 1. Animals are required to select a particular object on the basis of where it is encountered in the environment, often referred to as an object-place paired associate
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