The work aimed at determining the optimal methods of using herbicides that ensures the control of gramineous and dicotyledonous weeds when growing oil flax in the conditions of unstable moistening of the south of Russia. A single treatment with a pre-emergence herbicide Dual Gold after sowing a crop against monocotyledonous gramineous or with a foliar Tifi at the stage of true leaves development of flax against dicotyledonous weeds contributed to the of 0.07-0.09 t/ha higher yield than in the control with manual weeding. However, the sequential introduction of these preparations led to a decrease in crop yield by 0.14 t/ha on one plot. We noted a slight increase in yield (+0.04 t/ha) under the separate application of Miura graminicide and anti-dicotyledonous herbicide Sekator Turbo, and a decrease in yield (-0.16 t/ha) and seed oil content (-0.8 %) under application of their tank mixture. The separate foliar herbicide treatments should be a priority in weed control of oil flax.