IntroductionSepsis is a highly prevalent pathology in the intensive care unit, with a significant incidence of complications, so the search for markers as predictors of mortality, with simple and easily available tools, is of the utmost importance. ObjectiveDetermine the shortening fraction in the first 48hours of admission to the Intensive Care Unit as a predictive factor for mortality at 21days in patients with sepsis. MethodologyA prospective, observational, longitudinal, comparative and descriptive study was carried out in patients from the Intensive Care Unit of the General Hospital of Ecatepec Las Américas, with septic shock. A transthoracic echocardiogram with shortening fraction and appreciable ejection fraction was performed on admission, 24 and 48hours later, after 21days. Mortality was evaluated. Results62 patients who met the selection criteria and to whom the design methodology was applied were analyzed, after which a correlation was observed between the shortening fraction and death at 21 days with a significant statistical value (P<.0001). ConclusionsFractional shortening is a predictor of mortality in patients with septic shock.