In this article, we study a new approach to predict failures in feedback control system and particularly in actuators. However, we use two-tank control system with a proportional–integral–derivative controller for controlling a process variable. In practice, the actuator is a dynamic operating component in a random environment. Moreover, its capacity decreases over time and becomes valuable information for reliability analysis. The loss of capacity which is related to degradation, either normally or in an accelerated manner, depends on different operational conditions of the feedback control system and environmental factors. For this reason, to improve its working condition, a service life time analysis is necessary. Obviously, one has to predict the trend of future system characteristics, such as the reliability, which is measured by the estimate value of remaining useful life. In this situation, we use the stochastic gamma process model to describe the degradation behavior of the actuator. Generally, the algorithm of extended Kalman filter is a widely used method to overcome the difficulties of estimating the state vector in a nonlinear model of two-tank control system. This algorithm gives an innovation vector or prediction residual which contains fault information, when the system is failed. The prediction residuals can be recursively computed for diagnosis by the generalized likelihood ratio test. However, we use the generalized likelihood ratio test algorithm to estimate the moment at which the prognostic started. Finally, a practical case study is given to show the effectiveness of the proposed approaches for failure detection. Obviously, the simulation results show that the degradation path of the actuator capacity is estimated and the reliability based on remaining useful life predicted is analyzed.