We formally introduce IsaVODEs (Isabelle verification with Ordinary Differential Equations), an open, compositional and extensible framework for the verification of cyber-physical systems. We extend a previous semantic approach with methods and techniques that increase its expressivity, proof automation, and scalability to the level of state-of-the-art deductive verification tools. Our contributions include a user-friendly specification language, a flexible hybrid store model, including vectors and matrices, and separation-logic-style rules for local reasoning with hybrid stores using a novel form of differentiation called framed Fréchet derivatives. The formalisation of correctness specifications with forward predicate transformers, the certification of flows as unique solutions to systems of ordinary differential equations, and invariant reasoning for such systems also contribute to the scalability and usability of our framework. In combination, these features make our framework flexible and adaptable to several verification workflows. A suite of examples and hybrid systems verification benchmarks validate our framework relative to other state-of-the-art approaches.
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