Abstract Personalized/precision cardiology is a great hope of our times. In daily practice, we apply personalized, but not precise, cardiology: we take individual patient histories and perform individual clinical examinations, but we treat using general rule, general evidence-based guidelines… We do hope, in the near future, to take individual examination and treat using individual rules. Genuine, meaningful precision cardiology will rely heavily on genetics and artificial intelligence, but lifestyle, individual risk factors, patient and family compliance to treatment, and genetic makeup can influence diagnostic accuracy and treatment effects and should not be neglected. Extensive data exists regarding applications of artificial intelligence in the practice of precision cardiology, but we lack the systems that would translate its potential into clinical outcomes for real patients.