The cable bracket is one of the most important components of high-speed EMUs, as it supports the cables of sensors. The fatigue failure of the bracket can severely affect the operation of the vehicle. In this study, the dynamic response of the cable bracket, including dynamic stress and acceleration, is obtained through field tests. The results show that the modal vibration of the bracket excited by high-frequency excitation in the wheel–rail system is an important cause of fatigue failure of the bracket. Rail welded joints in the track and polygonal wear of the wheelset further exacerbate the vibration and of the bracket. A model of the virtual vibration table is proposed to simulate the actual excitation experienced by the bracket. The effects of the cantilever beam length, steel plate thickness, and pre-tightening torque of the bolts on the dynamic stress of the bracket are studied using the virtual vibration table. Several vibration suppression methods are proposed. The results indicate that the dynamic stress of the bracket caused by the rail welded joints can be effectively reduced through the adjustment of the pre-tightening torque of the bolts or the appropriate reduction of the cantilever beam length. The findings of this study can serve as a reference for suppressing vibration and preventing fatigue failure of the bracket.