The teaching mode of art-industry integration talent cultivation is a project-driven design education mode based on the combination of art and skill constructed. The research in this paper explores the creative practice of cultural and creative product design, takes the effectiveness of the combination of art and craft and practice as the evaluation basis, and proposes a PCA point cloud alignment algorithm based on feature matching, so as to realize the innovation of teaching cultural and creative product design. The normalization of point cloud coordinates is achieved by PCA, and the current state prediction and covariance are obtained based on the normalized results. The results show that in the demand analysis of cultural and creative product design, the Kano value of students’ knowledge development demand reaches above 0.703. It shows that in the art-industry fusion talent cultivation mode, the effectiveness of practical teaching should be taken as the research acceptance standard, so as to explore a new mode and a new path about the cultivation of talents of cultural and creative design in colleges and universities.