Stability results for extremum seeking control in Rn have predominantly been restricted to local or, at best, semi-global practical stability. Extending semi-global stability results of extremum-seeking systems to unbounded sets of initial conditions often demands a stringent global Lipschitz condition on the cost function, which is rarely satisfied by practical applications. In this paper, we address this challenge by leveraging tools from higher-order averaging theory. In particular, we establish a novel second-order averaging result with global (practical) stability implications. By leveraging this result, we characterize sufficient conditions on cost functions under which uniform global (i.e., under any initialization) practical asymptotic stability can be established for a class of extremum-seeking systems acting on static maps. Our sufficient conditions include the case when the gradient of the cost function, rather than the cost function itself, satisfies a global Lipschitz condition, which covers quadratic cost functions. Our results are also applicable to vector fields that are not necessarily Lipschitz continuous at the origin, opening the door to non-smooth Lie-bracket ES dynamics. We illustrate all the results via different analytical and/or numerical examples.