The intensification of growing processes, concentrated feeding and other improvements in technological processes in poultry farms have led to the development of new metabolic pathologies for the industry, previously not widely recorded. The development of these diseases is directly related to excessive stress on the poultry body during intensive rearing. The central organ most susceptible to this type of stress is the liver. Currently, clear signs of hepatopathy are recorded even in poultry farming. As a result, an important offal – the liver – is discarded, the poultry lags behind in growth and development, and the quality of the meat decreases. Therefore, the development of hepatoprotective veterinary drugs for poultry farming is an urgent task. To determine the effectiveness of the new hepatoprotective drug Selephlan in the vivarium conditions of the Federal State Budgetary Scientific Institution “Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine”, an experiment was conducted on two groups of broiler chickens (experimental and control) of the Arbor Acres cross (n=100). The studied drug was given to the experimental group during the growth and finishing periods of rearing (15–40 days) at a dose of 1.0% per unit of feed. The poultry of the control group received complete feed (CF) without additives. In order to determine the state of the hepatobiliary system of poultyr in the end of the experimental period, intravital screening monitoring of the liver condition using ultrasound diagnostics was carried out in the experimental and control groups, followed by slaughter to clarify the identified changes in the liver parenchyma tissue. Based on ultrasound diagnostics and histological studies, it was determined that the drug Selephlan under conditions of intensive fattening allows maintaining the healthy structure and functional activity of the liver of broiler chickens at a physiologically normal level throughout the entire productive period of rearing, which has a beneficial effect on the growth characteristics of meat poultry and the quality of the resulting livestock products.