Background and objectives: Artificial intelligence (AI) is a cutting-edge technology affecting all eras of science and technology and medicine, which is not an exception. Medical writings play a significant role in improving health standard and patient outcomes owing to their global dissemination. AI has widely affected medical writings. This study aims to determine the knowledge, attitude, and practices among the doctors of Khyber Pakhtunkhwa (KPK) regarding the use of artificial intelligence (AI) in medical writings. Medial writings cover a broad horizon of writings ranging from simple medical reports and prescription and extending to impactful article writings and evidence-based research papers as well as figure and graph generation for these papers using the input data. Materials and methods: It is a questionnaire-based cross-sectional study involving convenience non-probability sampling. The questionnaire contained a total of 29 items with subsequent portions of knowledge assessment containing 11 items, the attitude assessment comprised 10 items, and the practice assessment involved eight items. Being the first study of its kind, a conservational approach was adopted for sample size determination, and initially, the calculated sample was 385 using an online sample size calculator. The final sample size adopted was 500 to avoid any discrepancies owing to small sample size. The study setting was KPK, a province of Pakistan, and the study population was the medical doctors practicing in KPK. SPSS 28 was used for data analysis. Frequency, percentage, correlation, and regression analysis were used. Results: Out of 500 respondents, 135 were females and 365 were males. The overall data suggest a high level of knowledge regarding AI in medicine (91.2%). The use of AI was about 30.6%, highlighting a gap that needs to be addressed. The majority of doctors agreed on the impact of AI in medical writing (92.5%), indicating a positive attitude toward promotion within the community. The Pearson coefficient showed statistically significant values. Regression analysis with P-value < 0.001 also supported the hypothesis. Conclusion: The study revealed a positive perception of AI in medical writing, recognizing its potential for efficiency and quality improvement. However, respondents expressed concerns about AI authorship, ethics, privacy, and bias, leading to low adoption. The findings underscore the necessity for education, training, and clear guidelines to responsibly integrate AI into medical writing, ensuring ethical use and advancing the field with informed practices.
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