Potential Matches Research Articles

DISCOURSE ON TABOOS IN ONLINE DATING: SEXUAL EXPRESSIONS OF JAKARTA OKCUPID USERS

The popularity of global dating platforms has affected the dating behavior of urban daters, including those who live in Jakarta. Compared to match-seeking via print media decades ago, there are some changes in the way people present themselves and express their sexuality on dating platforms. On one of the dating platforms, OKCupid, some Jakarta users boldly stated their intention of looking for a hookup or non-heterosexual partner. This creates a problem in Indonesia, where most societies consider sexual acts and expressions such as premarital sex and non-heterosexual relationship as taboos. In this research, we examine the practice of OKCupid use by adult online daters in Jakarta, specifically about how they present themselves to express their diverse sexualities through OKCupid unique features. We argue that OKCupid features help its users to disclose themselves in a more specific manner, and thus facilitate them to find people with a shared interest and preferred gender or sexual orientation. Furthermore, in our informants' self-presentations, we found some strategies they utilized to preserve their privacy, avoid the consequences of normativity that is perpetuated from offline context, or target certain users as their potential matches. These strategies are dependent upon sociocultural dynamics as well as facilities developed by OKCupid.

A simple retarding-potential time-of-flight mass spectrometer for electrospray propulsion diagnostics

The time-of-flight mass spectrometer (ToF-MS) is a useful tool for quantifying the performance of electrospray thrusters and characterizing their plumes. ToF-MS data can be used to calculate the mass-to-charge distribution in the plume, but the kinetic-energy-to-charge (i.e., the potential) distribution must be known first. Here we use a ToF-MS in tandem with a retarding potential (RP) analyzer. By sweeping the retarding potential through the range of potentials present in the plume, both the mass-to-charge distribution and the potential distribution can be measured independently. We demonstrate this technique in a case study using a capillary electrospray emitter and the ionic liquid propellant 1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, abbreviated EMI-Im. We report a linear correlation between retarding potential and mass-to-charge ratio that agrees with published data from more complex orthogonal RP/ToF-MS instruments. Calculated values for the jet velocity and jet breakup potential match within 2% and 12%, respectively. Using conventional ToF-MS, we estimated the propellant flow rate and compared those estimates to direct flow rate measurements. For flow rates between 233 pL/s and 565 pL/s, the error in ToF-based flow rate estimates ranged from -16% to -13% when the plume potential was assumed to be a function of mass-to-charge. Assuming a constant plume potential yielded mixed results. However, using the average stopping potential measured by a retarding potential analyzer resulted in higher errors, ranging from -26% to -30%. Data and MATLAB code are included as supplemental materials so that readers can easily apply the techniques described here.

MS2Query: reliable and scalable MS2 mass spectra-based analogue search

Metabolomics-driven discoveries of biological samples remain hampered by the grand challenge of metabolite annotation and identification. Only few metabolites have an annotated spectrum in spectral libraries; hence, searching only for exact library matches generally returns a few hits. An attractive alternative is searching for so-called analogues as a starting point for structural annotations; analogues are library molecules which are not exact matches but display a high chemical similarity. However, current analogue search implementations are not yet very reliable and relatively slow. Here, we present MS2Query, a machine learning-based tool that integrates mass spectral embedding-based chemical similarity predictors (Spec2Vec and MS2Deepscore) as well as detected precursor masses to rank potential analogues and exact matches. Benchmarking MS2Query on reference mass spectra and experimental case studies demonstrate improved reliability and scalability. Thereby, MS2Query offers exciting opportunities to further increase the annotation rate of metabolomics profiles of complex metabolite mixtures and to discover new biology.

Rules Of Attraction: Females Perception of Male Self-Representation in a Dating App

In the current study, we explore how women decide whether to accept or reject a potential match offered by a dating app (Tinder). Specifically, we were trying to identify overlying factors that influence the decision and understand how women make a judgment based on limited cues provided by a Tinder profile. Women largely base their decision on the perceived attractiveness and character of the potential match. The findings suggest that attractiveness is highly subjective, with no universal rules that can be quantified; thus, it is hard to predict acceptance of the potential match. There are however factors that contribute significantly to profile rejection, such as a big age difference and the inability to clearly see the face of the person

“I Thought It Would Have Been More about Only the Fun Stuff”—Exploring the Expectation–Reality Gap among the Novice Solo Self-Employed

Research on the career expectations of employees and the potential (mis)match with their lived reality is abundant, yet the research field has paid less attention to the expectation–reality gap of the self-employed. Self-employed people’s attitudes towards work are, however, important for determining business success and persistence. Therefore, research is needed to examine their expectations as well as how self-employed people’s expectations materialize in their experiences. By analyzing in-depth interviews with 19 self-employed workers without employees in Belgium, both desired and undesired career expectations were revealed. After becoming self-employed, these expectations sometimes materialized in reality, in both a positive (e.g., independence and doing what you love) and a negative (e.g., risk and insecurity) sense. Our results also imply that expectation–reality gaps going in two directions exist. We identified positive expectations being met by less-positive experiences (e.g., loneliness, increased responsibility, being unable to do what you like, overestimated financial success, and unavailable or expensive formal support), as well as negative expectations being met by better experiences (e.g., social support between self-employed colleagues). The study signals that the social environment of the solo self-employed (SSE) merits policy attention. Efforts need to be made to create self-employed networks, where professional and social ties can be formed.

Covalent Mechanochemistry and Contemporary Polymer Network Chemistry: A Marriage in the Making.

Over the past 20 years, the field of polymer mechanochemistry has amassed a toolbox of mechanophores that translate mechanical energy into a variety of functional responses ranging from color change to small-molecule release. These productive chemical changes typically occur at the length scale of a few covalent bonds (Å) but require large energy inputs and strains on the micro-to-macro scale in order to achieve even low levels of mechanophore activation. The minimal activation hinders the translation of the available chemical responses into materials and device applications. The mechanophore activation challenge inspires core questions at yet another length scale of chemical control, namely: What are the molecular-scale features of a polymeric material that determine the extent of mechanophore activation? Further, how do we marry advances in the chemistry of polymer networks with the chemistry of mechanophores to create stress-responsive materials that are well suited for an intended application? In this Perspective, we speculate as to the potential match between covalent polymer mechanochemistry and recent advances in polymer network chemistry, specifically, topologically controlled networks and the hierarchical material responses enabled by multi-network architectures and mechanically interlocked polymers. Both fundamental and applied opportunities unique to the union of these two fields are discussed.

Identifying effective criteria for author matching in bioinformatics

With the increasing development of information and scientific databases, scientific collaboration has expanded in health sciences. This study aims to prioritize the criteria that affect finding potential author matches in bioinformatics using fuzzy Multiple Criteria Decision Making (MCDM) methods such as Analytical Hierarchy Process (AHP), Fuzzy Delphi Method (FDM), and Triangular Fuzzy Numbers (TFN). To answer the research questions, a mix of documentary analysis and fuzzy methods is utilized. The documentary analysis stage involves collecting relevant documents and resources using the purposive sampling approach and ranking the effective criteria. The subsequent step involves experts determining the priorities of the effective criteria using pairwise comparisons and the Delphi questionnaire. The final weights are obtained based on the research purpose. The study shows that 79 criteria related to the research purpose can be grouped into three general categories: behavioral, topological, and content-based criteria. The most effective criteria in finding and recommending a potential author match are “journal titles”, “citations”, “paper titles”, “affiliations”, “keywords”, and “abstracts”. Among these criteria, citation and paper titles have a higher priority compared to others. The results indicate that content-based criteria have the most significant impact on finding potential author matches in static scholar networks and networks with text information. Furthermore, among the content-based criteria, the number of publications in common specialized journals and the number of common citations are the most sought-after criteria for finding a potential author match with the highest similarity.

Towards Robust Visual Object Tracking with Independent Target-Agnostic Detection and Effective Siamese Cross-Task Interaction.

Advanced Siamese visual object tracking architectures are jointly trained using pair-wise input images to perform target classification and bounding box regression. They have achieved promising results in recent benchmarks and competitions. However, the existing methods suffer from two limitations: First, though the Siamese structure can estimate the target state in an instance frame, provided the target appearance does not deviate too much from the template, the detection of the target in an image cannot be guaranteed in the presence of severe appearance variations. Second, despite the classification and regression tasks sharing the same output from the backbone network, their specific modules and loss functions are invariably designed independently, without promoting any interaction. Yet, in a general tracking task, the centre classification and bounding box regression tasks are collaboratively working to estimate the final target location. To address the above issues, it is essential to perform target-agnostic detection so as to promote cross-task interactions in a Siamese-based tracking framework. In this work, we endow a novel network with a target-agnostic object detection module to complement the direct target inference, and to avoid or minimise the misalignment of the key cues of potential template-instance matches. To unify the multi-task learning formulation, we develop a cross-task interaction module to ensure consistent supervision of the classification and regression branches, improving the synergy of different branches. To eliminate potential inconsistencies that may arise within a multi-task architecture, we assign adaptive labels, rather than fixed hard labels, to supervise the network training more effectively. The experimental results obtained on several benchmarks, i.e., OTB100, UAV123, VOT2018, VOT2019, and LaSOT, demonstrate the effectiveness of the advanced target detection module, as well as the cross-task interaction, exhibiting superior tracking performance as compared with the state-of-the-art tracking methods.

The Role of Marriage Brokers on Adolescent Girls’ Early Marriage: Qualitative Evidence-The Case of West Hararghe, Ethiopia

Marriages below the age of 18 are either forced or by own interest, influenced by different factors. The objective of this paper is to describe the role of marriage brokers in adolescent girls’ marriage in West Hararghe, Oromia region, Eastern Ethiopia. Qualitative data were drawn from a formative baseline (March to August 2016) and consecutive studies including the mid-term (May 2018 to August 2018) studies of Abdiboru, a Girls’ SRH and empowerment project. As findings demonstrate, adolescent girls below the legal age of marriage are forced to accept marriage proposals convinced by intermediaries/marriage brokers. Marriage brokers can be peers, relatives, elders or any skillful people in convincing and persuading girls. Marriage brokerage is commercialized and as a result, girls go through the burdens of early marriage and early child bearing. Marriage brokerage is a common act in the study area resulting in brokers to have a significant role on adolescent girls’ marriage. They play an inevitable role in arranging potential matches for adolescent girls. Programmers working on ending child marriage and related areas need to include these influential people in designing interventions.

Algorithmic Colonization of Love

Love is often seen as the most intimate aspect of our lives, but it is increasingly engineered by a few programmers with Artificial Intelligence (AI). Nowadays, numerous dating platforms are deploying so-called smart algorithms to identify a greater number of potential matches for a user. These AI-enabled matchmaking systems, driven by a rich trove of data, can not only predict what a user might prefer but also deeply shape how people choose their partners. This paper draws on Jürgen Habermas’s “colonization of the lifeworld” thesis to critically explore the insidious influence of delegating romantic decision-making to an algorithm. The love lifeworld is colonized inasmuch as online dating algorithms encroach into our romantic relations to the extent that communicative action within romance is replaced by the technocratic rules of an algorithm.

The structure and diversity of retinal ganglion cells in the masked greenling Hexagrammos octogrammus Pallas, 1814 (Pisces: Scorpaeniformes: Hexagrammidae).

The authors studied the structure and diversity of retinal ganglion cells (GC) in the masked greenling Hexagrammos octogrammus. In vivo labelling with horseradish peroxidase revealed GCs of various structures in retinal wholemounts. A total of 154 cells were camera lucida drawn, and their digital models were generated. Each cell was characterized by 17 structural and topological parameters. Using nine clustering algorithms, a variety of clusterings were obtained. The optimum clustering was found using silhouette analysis. It was based on a set of three variables associated with dendritic field size and dendrite stratification depth in the retina. A total of nine cell types were discovered. A number of non-parametric tests showed significant pair-wise between-cluster differences in at least four parameters with medium and large effect sizes. Three large-field types differed mainly in dendritic field size, total dendrite length, level of dendrite stratification in the retina and position of somata. Six medium- to small-field types differed mainly in the structural complexity of dendritic arbors and level of dendrite arborization. Cells similar and obviously homologous to types 1-4 were identified in many fish species, including teleosts. Potential homologues of type 5 cells were identified in fewer teleost species. Cells similar to types 6-9 in relative dendritic field size and dendrite arborization pattern were also described in several teleostean species. Nonetheless, their homology is more questionable as their stratification patterns do not match so well as they do in large types. Potential functional matches of the GC types were identified in a number of teleostean species. Type 1 and 2 cells probably match spontaneously active units with the large receptive field centre, so-called dimming and lightening detectors; type 4 may be a counterpart of changing contrast detectors with medium receptive field centre size preferring fast-moving stimuli. Type 3 (biplexiform) cells have no obvious functional matches. Probable functional matches of types 6, 8 and 9 belong to ON-centre elements with small receptive fields such as ON-type direction-selective cells, ON-type spot detectors or ON-type spontaneously active units. Type 5 and 7 cells may match ON-OFF type units, in particular, changing contrast detectors or orientation-selective units. Potential functional matches of GC types presently described are involved in a wide spectrum of visual reactions related to adaptation to gradual change in illumination, predator escape, prey detection and capture, habitat selection and social behaviour.

ODP365 The Psychological Impact of Adult-Onset Craniopharyngioma: The Experience of Patients and Clinicians

Abstract Introduction Individuals who experience social and emotional difficulties struggle to maintain successful social relationships and incur an increased risk of developing mood disorders. These, in turn, have been found to have a significant impact on both psychological and physical wellbeing. A small number of medical studies suggest that patients with adult-onset craniopharyngioma (AoC) report a poorer quality of life, however, no psychological research has been carried out. The present study aimed to capture, for the first time, a detailed description of AoC patients’ lives outside the clinic. Specifically, whether they experience a psychological impact from their diagnosis and whether psychological factors may contribute to a poorer quality of life. Methods Both patients with AoC and clinicians with experience of working with patients with AoC were invited to take part in a semi-structured interview. Clinicians were recruited with the view to providing an alternative viewpoint and the possibility to assess potential (mis)matches in perceptions of AoC patients’ social strengths and difficulties. Participants were recruited from three geographically disperse NHS units across the UK. Eight patients and 11 clinicians took part in the study. Interviews were analysed using inductive thematic analysis wherebycodes are identified which represent statements centring on a similar topic that are endorsed by multiple participants. Codes that are frequently used are compiled into larger themes, reflecting broader topics. Results The central theme of 'symptoms’ was consistent across patients and clinicians and consisted of three sub-themes: physical symptoms, psychological symptoms, and the tendency for patients to hide symptoms. Both cohorts stated that weight gain and fatigue were the most common physical symptoms, but these were also closely related to psychological symptoms, such as changing lifestyle patterns and a shrinking social network. Crucially, both cohorts stated that low mood, anxiety, and low self-esteem were common and significant experiences. Both cohorts discussed instances of specific mental health disorders. Conversely, some patients tried to hide symptoms with diminishing or contradictory statements or acknowledged that others had encouraged them to seek help, a theme that was also found with clinicians. In addition to these similarities there were also important differences in perceptions. Firstly, while clinicians believed they were open to or actively discussed a patient's psychological wellbeing during consultations, many patients felt they had never been asked about this. Secondly, while some clinicians were very clear on the extreme negative impact of the condition, patients also described more subtle social impacts. Finally, clinicians felt a sense of frustration regarding poor, unspecialised, under resourced psychological support, a feeling that was not common among patients. Conclusion In conclusion, both patients and clinicians recognised significant psychological impact as a result of AoC. Further research is planned to quantitively assess the topics raised in the present study. Presentation: No date and time listed

Necessary and sufficient conditions for the BRI success

AbstractThis paper presents a general theoretical framework for understanding the Belt‐and‐Road Initiative (BRI). We begin with an introduction to the connotations of the BRI and a review of the initiative's main achievements since its inception. From these achievements, we identify the existence of a potential match between supply and demand in jointly building the BRI to be the foremost necessary condition for win–win cooperation for participating countries. Several features of China's contemporary economic structure are shown to provide the huge potential of supply that matches the massive demand of many Belt‐and‐Road countries for infrastructure development. To unleash the full potential of the BRI, a series of sufficient conditions must be met so that supply and demand interact in a virtuous manner. In the first stage of jointly building the BRI, the key to turn the initiative's potential into reality is to develop the “Five Links” of policy coordination, infrastructure connectivity, unimpeded trade, financial integration, and people‐to‐people bond. Now that the BRI has entered the high‐quality development stage, we demonstrate that China has taken or needs to work on policy measures in 10 areas to ensure the continuing and sustainable success of the BRI construction.

Chemical Pressure-Derived Assembly Principles for Dodecagonal Quasicrystal Approximants and Other Complex Frank-Kasper Phases.

The structures of complex intermetallic compounds can often be interpreted in terms of assemblies of units from simpler parent phases. For example, dodecagonal quasicrystals appear, when viewed down their high-symmetry axes, as plane-filling arrangements of square and triangular tiles corresponding to the Cr3Si and Al3Zr4 structure types, respectively. The atomic arrangements and cell-dimensions at the (100) faces of the cells of these structures provide a close geometrical match, which underlies not only dodecagonal quasicrystals and their approximants but also the much more common σ-phase structure. In this article, we show that such intergrowth of parent structures can arise from more than just geometrical coincidences but can be driven by a complementary matching of atomic packing forces. DFT-chemical pressure (CP) analysis on elemental versions of the Cr3Si and Al3Zr4 types reveal that in both cases arrays of positive interatomic pressures inhibit the formation of optimal contacts elsewhere in the structures. When they are lined up at the potential Cr3Si/Al3Zr4 interfaces, however, positive pressures from the two structures interdigitate rather than coincide, providing the opportunity for the relaxation of strained interatomic contacts. That such relief is afforded by the interfaces is confirmed by CP analysis of the σ-phase (FeCr-type) structure. Building on this scheme, we introduce the CPinterface function to represent how the CP features of atoms within a structure impact planes or other surfaces that could serve as interfaces between different structures. Using this function, we then explore how the favorability of interfaces between Cr3Si- and Al3Zr4-type units is tuned by partial elemental substitution with Si, as well as their potential matches with Laves phase units. The emerging picture provides an account for features of the quasicrystal approximants Mn7VSi2 and Mn81.5Si18.5, as well as a framework for approaching intermetallic intergrowth structures more broadly.

Assessing the effectiveness of the NIST DART-MS Forensics Database and Data Interpretation Tool for designer drug screening with alternative instrumentation

The increasing prevalence of designer drugs has contributed towards the adoption of rapid screening techniques, such as direct analysis in real time-mass spectrometry (DART-MS). Recently, the National Institute of Standards and Technology (NIST) developed a DART-MS Forensics Database and Data Interpretation Tool (DIT) to assist practitioners with the interpretation of seized drug mixtures. However, this resource was only designed for DART ionization coupled with AccuTOF high-resolution mass spectrometers. This study assesses the effectiveness of the NIST DART-MS Forensics Database and DIT for mixture interpretation using other soft ionization sources, such as electrospray ionization (ESI), and coupling DART to an Agilent 6530 quadrupole time-of-flight (Q-TOF) mass spectrometer. As the seized drug community continues to shift towards the use of in-source collision-induced dissociation (IS-CID) with single-stage mass spectrometers coupled with soft ionization sources, it is imperative to understand the similarity of the generated IS-CID fragment ion spectra and the effectiveness of the DIT for seized drug screening using instrumentation other than the DART-AccuTOF.Pearson product-moment correlations (PPMCs) revealed a high degree of spectral similarity between the ESI-IS-CID and DART-IS-CID fragment ion spectra collected across a range of activation conditions. The 95% confidence interval for the average highest PPMC coefficient across the 12 designer drugs in this study was 0.9295 ± 0.0031. More importantly, nearly identical mixture interpretation results were obtained when the ESI-IS-CID and DART-IS-CID fragment ion spectra were analyzed with the DIT. In all cases, the DIT was able to identify a potential library match with at least two match types between the low and high IS-CID spectra for all compounds present in each mixture. Demonstrating the potential applicability of the NIST DART-MS Forensics Database and DIT for the screening of seized drug mixtures using instrumentation other than the DART-AccuTOF provides support for the expanded applicability of this freely available resource.

Registration of Building Scan with IFC-Based BIM Using the Corner Points

Progress monitoring is an essential part of large construction projects. As manual progress monitoring is time-consuming, the need for automation emerges, especially as, nowadays, BIM for the design of buildings and laser scanning for capturing the as-built situation have become well adopted. However, to be able to compare the as-built model obtained by laser scanning to the BIM design, both models need to use the same reference system, which often is not the case. Transforming the coordinate system of the as-built model into the BIM model is a specialist process that is pre-requisite in automated construction progress monitoring. The research described in this paper is aimed at the automation of this so-called registration process and is based on the dominant planar geometry of most buildings with evident corner points in their structures. After extracting these corner points from both the as-built and the design model, a RANSAC-based pairwise assessment of the points is performed to identify potential matching points in both models using different discriminative geometric invariants. Next, the transformation for the potential matches is evaluated to find all the matching points. In the end, the most accurate transformation parameter is determined from the individual transformation parameters of all the matching corner points. The proposed method was tested and validated with a range of both simulated and real-life datasets. In all the case studies including the simulated and real-life datasets, the registration was successful and accurate. Furthermore, the method allows for the registration of the as-built models of incomplete buildings, which is essential for effective construction progress monitoring. As the method uses the standard IFC schema for data exchange with the BIM, there is no loss of geometrical information caused by data conversions and it supports the complete automation of the progress-monitoring process.

The Development and Application of a HPTLC-Derived Database for the Identification of Phenolics in Honey.

This study reports on the development and validation of a HPTLC-derived database to identify phenolic compounds in honey. Two database sets are developed to contain the profiles of 107 standard compounds. Rich data in the form of Rf values, colour hues (H°) at 254 nm and 366 nm, at 366 nm after derivatising with natural product PEG reagent, and at 366 nm and white light after derivatising with vanillin–sulfuric acid reagent, λ max and λ min values in their fluorescence and λ max values in their UV-Vis spectra as well as λ max values in their fluorescence and UV-Vis spectra after derivatisation are used as filtering parameters to identify potential matches in a honey sample. A spectral overlay system is also developed to confirm these matches. The adopted filtering approach is used to validate the database application using positive and negative controls and also by comparing matches with those identified via HPLC-DAD. Manuka honey is used as the test honey and leptosperine, mandelic acid, kojic acid, lepteridine, gallic acid, epigallocatechin gallate, 2,3,4-trihydroxybenzoic acid, o-anisic acid and methyl syringate are identified in the honey using the HPTLC-derived database.

Astrometry of variable compact radio sources: a search for Galactic black hole X-ray binaries

ABSTRACT We use the Very Long Baseline Array to conduct high precision astrometry of a sample of 33 compact, flat spectrum, variable radio sources in the direction of the Galactic plane (Becker et al. 2010). Although Becker et al. (2010) ruled out a few potential scenarios for the origin of the radio emission, the study could not rule out that these sources were black hole X-ray binaries (BHXBs). Most known BHXBs are first detected by X-ray or optical emission when they go into an outburst, leaving the larger quiescent BHXB population undiscovered. In this paper, we attempt to identify any Galactic sources amongst the Becker et al. (2010) sample by measuring their proper motions as a first step to finding quiescent BHXB candidates. Amongst the 33 targets, we could measure the proper motion of six sources. We find that G32.7193-0.6477 is a Galactic source and are able to constrain the parallax of this source with a 3σ significance. We found three strong Galactic candidates, G32.5898-0.4468, G29.1075-0.1546, and G31.1494-0.1727, based purely on their proper motions, and suggest that G29.1075-0.1546 is also likely Galactic. We detected two resolved targets for multiple epochs (G30.1038+0.3984 and G29.7161-0.3178). We find six targets are only detected in one epoch and have an extended structure. We cross-match our VLBA detections with the currently available optical, infrared, and X-ray surveys, and did not find any potential matches. We did not detect 19 targets in any VLBA epochs and suggest that this could be due to limited uv-coverage, drastic radio variability, or faint, extended nature of the sources.

Incongruence between parental and adolescent educational aspirations hinders academic attainment.

Previous research has shown that parental educational aspirations for their children are an important predictor of children's academic attainment. However, recent studies have pointed to potential negative effects, in particular if there is a mismatch between parental educational aspirations and the aspirations of their children. This study examines (1) the role of socio-demographic and school achievement-related factors in shaping a potential (mis)match between parental educational aspirations and the aspirations of their children, and (2) whether incongruence between parental and their children's educational aspirations hinders academic attainment in times of social change. We use data collected for the 1970 British Birth Cohort Study (BCS70) and Next Steps (formerly known as the Longitudinal Study of Young People in England), a cohort of young people born in 1989/90. We find that in both cohorts socio-demographic and achievement-related characteristics are associated with incongruent aspirations, and that incongruent aspirations between parents and their children are associated with a decreased likelihood of participating in and completing higher education. The study contributes to current debates regarding the causes and correlates of discrepancies in educational aspirations and how such discrepancies affect later life chances.

384P Concordance of genomic alterations in tumour tissue and ctDNA in patients with colorectal cancer referred for early phase trials

Plasma-based circulating tumour DNA (ctDNA) provides a minimally invasive, contemporaneous assessment of genomic alterations (GAs) and captures tumour heterogeneity. We compare GAs identified in ctDNA and archival tissue in patients (pts) with metastatic colorectal cancer (CRC) recruited to the Tumour Characterisation to Guide Experimental Targeted Therapy (TARGET) trial, aiming to match pts to early-phase cancer clinical trials (EPCCT). Archival tumour tissue was analysed using next generation sequencing (NGS) panels (24 genes), and plasma-based ctDNA was analysed using a local research NGS panel (641 genes). Results were discussed in a molecular tumour board (MTB) to define actionability. Factors associated with the likelihood of having additional GAs in ctDNA were explored using logistic regression analysis and odds ratio (OR). 101 pts with CRC were recruited to TARGET. The median age was 56 years and 61% were male. Pts had NGS testing panels from primary (70%) or metastatic (30%) archival tumour tissue. The median age of archival tissue tested was 25 months (range 0-117 months) and 98% of pts received active treatment in the intervening time. Tissue and ctDNA NGS identified clinically relevant GAs in 90% and 79% of pts respectively, with a median of 2 GAs per pt. The most common GAs in ctDNA were TP53 (53%), KRAS (47%), APC (44%), and PIK3CA (12%). There was poor concordance of identified GAs between tissue and ctDNA (agreement=66.3%, Cohen's k<0, p=0.91). 23% of pts had clinically relevant GAs in ctDNA that were not identified in tissue, the commonest being KRAS (29%). There was no association between the presence of additional GAs in ctDNA with number of treatment lines (OR:1.23, p= 0.32), age of archival tissue (OR: 1.01, p= 0.91) or primary vs. metastatic archival tissue site (OR: 0.34, p= 0.11). The presence of liver metastases was associated with a higher likelihood of concordance between tissue and ctDNA NGS (OR: 3.5, p= 0.03). Overall, ctDNA-derived GAs were considered actionable in 51% of pts. Of those, 28% were a potential match for an EPCCT. Plasma-based ctDNA can be used as a contemporaneous tool to identify actionable GAs and guide treatment options for pts with metastatic CRC.