Coastal dynamics are governed by the interface of complex, multidimensional processes that result from the interaction between offshore wave climate and local geomorphology. Nearshore waves are usually the primary driver of sediment transport in the coastal zone. However, nearshore wave processes in sub-tropical to tropical regions are often poorly understood, since deep-water waves are often substantially transformed, via interaction with coral reefs, as they propagate towards the nearshore zone. Here, we produce a suite of nearshore wave conditions using a discrete set of representative deep-water wave parameters to determine the potential for large-scale, wave-driven longshore sediment transport along the sub-tropical to coral reef mediated tropical northeastern coast of Australia (15-28oS). Representative conditions at deep-water source points, determined using a Maximum Dissimilarity Algorithm (MDA), were used as boundary conditions for a coastal wave model. Potential longshore sediment transport is largely dependent on offshore wave direction and the presence (or lack thereof) of the Great Barrier Reef (GBR). There is a decrease in mean, wave-driven transport potential from >500,000 m3/year in southern Queensland to <50,000 m3/year north of Fraser Island and along the section of the coast regulated by wave transformation through the GBR. Seasonal changes in the deep-water wave regime control patterns of sediment transport along the entire coast, even in the low wave energy regions. We also show that there are complex sediment transport pathways on this tropical coast with large variability in both direction (up-coast vs. down-coast transport) and magnitude in the nearshore. Our results provide insights into the potential volumes, pathways, and complexity of sediment transport on tropical and sub-tropical coasts and a methodological approach that can be applied globally to efficiently construct wave-driven sediment flux estimates on tropical coastlines where coral reefs influence nearshore wave processes.