Potential Index Research Articles

Microplastic migration from landfill-mined soil through earth filling operations and ecological risk assessment: a case study in New Delhi, India.

Microplastics (MPs), plastic pieces smaller than 5 mm, are emerging as a critical ecological threat, potentially disrupting ecosystems and complicating waste management practices. Landfill-Mined Soil-Like Material (LMSLM), a byproduct of landfill reclamation, is gaining global traction for rehabilitating degraded land and repurposing it for geotechnical applications. While studies have examined contaminants like heavy metals and salts, MPs contamination has been largely overlooked, raising environmental concerns. The widespread use of LMSLM in earth-filling increases the risk of MP pollution. Additionally, significant gaps remain in understanding how MPs are distributed across different size fractions during sieving, which is critical for developing effective remediation strategies and informing future policies. This study aims to fill the existing knowledge gap by investigating the presence of microplastics in LMSLM collected from three aged waste dumpsites in New Delhi, India, and evaluating the ecological risks associated with its reuse. The results revealed the presence of MPs in all LMSLM samples with concentrations ranging from 25950 to 41110 items/kg. Fibers and fragments were the dominant shapes, with 60 % of particles measuring less than 425 µm. The color characteristics revealed the dominance of white, transparent, and black color. Polyethylene and polypropylene were the most common polymers, with smaller amounts of polyamide, polyethylene terephthalate, and polyester. SEM-EDX analysis revealed weathering effects and the presence of heavy metals, including Lead (Pb), Cadmium (Cd), and Arsenic (As), adsorbed on the MP surface. Ecological risk assessment using the Polymer Hazard Index and Pollution Load Index identified hazard levels of V and II, respectively, while the Potential Ecological Risk Index indicated a medium risk. Furthermore, the dimensional analysis demonstrates that MP width, particularly in fiber-shaped MPs, plays a crucial role in determining retention and migration during sieving, while MPs with uniform shapes, like spheres and fragments, exhibit limited movement. These findings underscore the need for protective measures when using LMSLM in geotechnical applications to prevent MP migration and contamination of surrounding environments. The study highlights the importance of further research on MP contamination in reclaimed landfill materials and its implications for sustainable land use and waste management.

Unlocking the adaptation mechanisms of the oleaginous microalga Scenedesmus sp. BHU1 under elevated salt stress: a physiochemical, lipidomics and transcriptomics approach.

Microalgae are vital for their photosynthetic abilities, contributing significantly to global oxygen production, serving as a key trophic level in aquatic ecosystems, aiding in biofuel production, assisting in wastewater treatment, and facilitating the synthesis of valuable biochemicals. Despite these advantages, photosynthetic microalgae are sensitive to salt stress, which alters their physiochemical and metabolic status, ultimately reducing microalgal growth. This sensitivity highlights the importance of understanding the impact of elevated salt content on the physiochemical, metabolic, and transcriptomic profiling of Scenedesmus sp., areas that are not yet fully understood. Our findings indicate that elevated salt stress decreases photosynthetic efficiency and increases non-regulated photochemical quenching of photosystem II (PSII). Moreover, PSII-driven linear electron flow (LEF) decreased, whereas photosystem I (PSI)-driven cyclic electron flow (CEF) increased in salt-stressed cells. To better understand the electron flow from PSII to PSI under elevated salt treatment, we analyzed the excitation energy flux per reaction center (RC), per cross-section (CS), energy flux ratios, and the potential index of PSII. Additionally, flow cytometry graphs depict the viability assay of Scenedesmus sp. BHU1. Our observations further revealed an increase in biochemical attributes, such as stress biomarkers, osmoprotectants, and enzymatic antioxidants, which help scavenge reactive oxygen species (ROS) under salt stress. Intracellular cations (Na + and Ca2+) were increased, while K+ levels decreased, indicating mechanisms of cellular homeostasis under salt stress. UHPLC-HRMS-based lipidome analysis confirmed that increasing salt stress induces the hyperaccumulation of several fatty acids involved in adaptation. Moreover, transcriptome analysis revealed the upregulation of genes associated with PSI, glycolysis, starch metabolism, sucrose metabolism, and lipid accumulation under salt stress. In contrast, genes related to PSII and C3 carbon fixation were downregulated to mitigate the adverse effects of salt stress.

Multimethod Analysis of Heavy Metal Pollution and Source Apportionment in a Southeastern Chinese Region

Excessive levels of heavy metals in soil can significantly impact human health and ecological safety. Evaluating heavy metal pollution and identifying its sources are crucial for environmental management. This study investigates the status of heavy metal pollution in a southeastern region of China and aims to identify its sources using data from the first national soil pollution survey, which includes 282 sampling points. Indicators such as the geoaccumulation index (Igeo), the potential ecological risk index (RI), the hazard index (HI), and the total lifetime cancer risk (TLCR) were utilized to assess contamination levels. Geographic information systems (GIS), positive matrix factorization (PMF) receptor modeling, cluster analysis (ClusA) and human health risk assessments were integrated to analyze the sources of heavy metals. The results indicate that agricultural pollution sources have a minor impact on overall heavy metal contamination, with low ecological risk levels in the eastern and western regions. In contrast, the central region exhibited moderate risk, with areas of extremely high risk distributed across the central-west and central-south regions. PMF analysis identified pollution sources including natural origins, coal combustion, industrial emissions, and traffic, with contributions of 17.62%, 18.50%, 28.35%, and 35.56%, respectively. Overall, the carcinogenic risk in the study area is not high. Targeted recommendations were made in response to the pollution situation in the study area. This research enhances our understanding of heavy metal pollution in the soil of the study area and provides a reference for pollution source delineation in other regions.

Comprehensive Assessment of the Correlation Between Ancient Tea Garden Soil Chemical Properties and Tea Quality

Understanding the correlation between soil chemical properties and tea quality is essential for the comprehensive management of ancient tea gardens. However, the specific links between these factors in ancient tea gardens remain underexplored. This study analyzes the soil chemical properties of four distinct research regions in Nanhua County to explore their effects on key chemical components in ancient tea garden teas, providing a scientific basis for improving the quality of ancient tea garden teas through soil management. Employing high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP-MS), the chemical components of tea and the chemical properties of the soil were meticulously quantified. Following these measurements, the integrated fertility index (IFI) and the potential ecological risk index (PERI) were evaluated and correlation analysis was conducted. The results revealed that ancient tea garden tea quality is closely linked to soil chemical properties. Soil’s total nitrogen (TN), total sulfur (TS), and available potassium (AK) negatively correlate with tea’s catechin gallate (CG) component and AK also with polyphenols. Most other soil properties show positive correlations with tea components. The research also evaluated soil heavy metals’ IFI and PERI. IFI varied significantly among regions. Hg’s high pollution index indicates ecological risks; Cd in Xiaochun (XC) region poses a moderate risk. PERI suggests moderate risk for XC and Banpo (BP), with other areas classified as low risk. Implementing reasonable fertilization and soil amelioration measures to enhance soil fertility and ensure adequate supply of key nutrients will improve the quality of ancient tea gardens. At the same time, soil management measures should effectively control heavy metal pollution to ensure the quality and safety of tea products. Insights from this study are crucial for optimizing soil management in ancient tea gardens, potentially improving tea quality and sustainability.

Heavy metal concentrations in soil and ecological risk assessment in the vicinity of Tianzhu Industrial Park, Qinghai-Tibet Plateau.

Industrial parks in China are centers of intensive chemical manufacturing and other industrial activities, often concentrated in relatively small areas. This concentration increases the risk of soil pollution both within the parks and in surrounding areas. The soils of the Tibetan Plateau, known for their high sensitivity to environmental changes, are particularly vulnerable to human activity. In this study, we examined the concentrations (mg/kg) of 10 metal elements (As, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Se, and Zn) in soils at depths of 0-10 cm, 10-20 cm, and 20-30 cm from the surface at three distances (500 m, 1000 m, and 1500 m from the park boundary) on the east, south, west, and north sides of the Tianzhu Industrial Park on the Qinghai-Tibet Plateau. The concentrations of As, Cr, Mn, and Pb were close to the standard reference values for the Qinghai-Tibet Plateau, while Cu, Ni, Se, and Zn levels were found to be 1.6-2.2 times higher than the reference values. Cd and Hg concentrations were particularly concerning, at 8.0 and 6.5 times higher than reference values, respectively. The potential ecological risk indexes indicated persistent risk levels for Cd and Se across various directions and distances. Variations in soil depth and direction were observed for the concentrations of As, Cd, Hg, Pb, Se, and Zn, underscoring the need for regular or long-term monitoring. Cd, in particular, presents a significant hazard due to its high concentration and its propensity for uptake by plants in the study area.

Integrated Assessment of Metal Contamination of Soils, Sediments, and Runoff Water in a Dry Riverbed from a Mining Area Under Torrential Rain Events

Dry riverbeds can transport mining waste during torrential rain events, disseminating pollutants from mining areas to natural ecosystems. This study evaluates the impact of these mine wastes on soils, sediments, and runoff/pore water in the La Carrasquilla dry riverbed (southeastern Spain). An integrated approach utilizing geochemical and mineralogical techniques was employed, analyzing water, soil, and sediment samples from both the headwater and mouth of the riverbed. Soil profiles and pore water were collected at 30 cm, 60 cm, and 90 cm deep, alongside sediment and runoff water samples. The assessment of metal(loid) contamination focused on arsenic, cadmium, chromium, copper, iron, nickel, manganese, zinc, and lead, utilizing sequential extraction to evaluate metal partitioning across soil phases. Various pollution indices, including the contamination factor (Cf), pollution load index (PLI), potential ecological risk index (RI), and metal(loid) evaluation index (MEI), were employed to classify contamination levels. The highest level of contamination was reported in the headwater, which suggested anthropogenic activities linked to the presence of mining residues as the major source of metal(loid)s. However, an active deposition of As, Cd, Cu, Fe, Mn, and Zn was reported in the topsoil at the mouth. In the headwater, a quartz and muscovite-rich zone exhibited the highest Cf for Pb (1022), primarily bound to the soil residual fraction (62.8%). At the headwater and mouth, pore water showed higher concentrations of sulfate, Ca, Na, Cl, Mg, and Mn and higher salinity than acceptable limits for drinking water or irrigation established by the World Health Organization. Runoff-water metal concentrations surpassed established guidelines, with MEI values indicating significant contamination by cadmium (36.1) and manganese (19.0). These findings highlight the considerable ecological risk of Pb and underscore the need for targeted remediation strategies to mitigate environmental impacts in the Mar Menor coastal lagoon.

Evaluation of solar distiller performance using steel wool pads, internal reflectors, and woven wire mesh: economic, environmental, and sustainability analysis

Abstract Different researches were performed by using thermal storage materials, solar concentrators, reflectors, and other technologies to increase the productivity of solar stills. The main objective of the present study is to enhance the basin solar still productivity by using ecomaterials from the wastes of workshops and factories. So, this study presents an experimental investigation of basin solar still performance using steel wool pads, internal reflectors, and woven wire mesh. The experimental setup was performed at Suez Canal University, Ismailia City, Egypt. Two solar stills were included: one represents the conventional design (CSS), and the second one is the modified with steel wool pads, internal reflectors, and woven wire mesh (MSS). Both solar stills were evaluated under identical climate conditions, considering water depths of 1, 2, 3, and 4 cm, and the required parameters were measured and tabulated during the working days. The results indicated that incorporating these modifications led to a notable increase in accumulative productivity and daily thermal efficiency with minimum cost per liter. The MSS enhanced the daily yield and thermal efficiency by 22.1% and 28.0%, respectively, versus CSS at a water depth of 1 cm. In addition, the energy production factor (EPF), energy payback time (EPT), and the average exergy waste were 1.2 years, 0.85, and 400.2 J, respectively, for MSS. The annual exergy output, environmental effect factor (EEF), improvement potential (IP), and sustainability index were 462.7 kWh, 10.4, 290.6 W, and 1.09, respectively, for MSS. Finally, the cost per liter and the annual CO2 reduction over a lifetime for CSS and MSS were 0.023 $/l, 17.4 tons, and 0.11 $/l, 20.4 tons, respectively. These results align with and reinforce previous publications on desalination, highlighting the potential of these modifications for addressing the pressing challenges of affordable and efficient water using solar energy.

Effects of Tide Dikes on the Distribution and Accumulation Risk of Trace Metals in the Coastal Wetlands of Laizhou Bay, China

Tide dikes play a key role in preventing seawater intrusion in coastal regions; however, their effects on trace metal distribution and accumulation remain unclear. This study explored the distribution and enrichment of trace metals (As, Cr, Cu, Ni, Pb, and Zn) inside and outside tide dikes in Laizhou Bay. The accumulative risk of these metals in the two habitats was analyzed by combining their sources. The results show that the average enrichment factor, geological accumulation index, and potential ecological risk index of As in the outside habitat are significantly higher than those in the inside habitat (p < 0.001), which indicates that the tide dike effectively reduces the migration of As from outside to inside habitats. For other trace metals, no statistical differences were found between the two habitats. Based on principal component analysis and redundancy analysis of trace metals and their correlations with soil physicochemical properties, we speculated that Cr and Zn may derive from soil parent material and rock weathering. Cu, Pb, and Ni may be related to atmospheric nitrogen deposition resulting from nearby agricultural activities, and As may come from industrial wastewater or transport through seagoing rivers. The findings suggest that tide dikes effectively block exogenous trace metals but not those from natural sources.

An Innovative TOPSIS–Mahalanobis Distance Approach to Comprehensive Spatial Prioritization Based on Multi-Dimensional Drought Indicators

This research explores a new methodological framework that blends the TOPSIS (technique for order of preference by similarity to ideal solution) and Mahalanobis Distance methods, allowing for the prioritization of nine major watersheds in China based on the integration of multi-dimensional drought indicators. This integrated approach offers a robust prioritization model by accounting for spatial dependencies between indices, a feature not commonly addressed in traditional multi-criteria decision-making applications in drought studies. This study utilized three drought indices—the Standardized Precipitation Evapotranspiration Index (SPEI), Vegetation Health Index (VHI), and Palmer Drought Severity Index (PDSI). Over years of significant drought prevalence, three types of droughts occurred simultaneously across various watersheds in multiple years, particularly in 2001, 2002, 2006, and 2009, with respective counts of 16, 17, 19, and 18 concurrent episodes. The weights derived from Shannon’s entropy emphasize the importance of the Potential Drought Severity Index (PDSI) in evaluating drought conditions, with PDSI-D (drought duration) assigned the highest weight of 0.267, closely followed by VHI-D (Vegetation Health Index under drought conditions) at 0.232 and SPEI-F (drought frequency) at 0.183. The results demonstrated considerable spatial variability in drought conditions across the watersheds, with Watersheds 1 and 4 exhibiting the highest drought vulnerability in terms of meteorological and agricultural droughts, while Watersheds 6 and 3 showed significant resilience to hydrological drought after 2012. In particular, the severe meteorological drought conditions at Watershed 1 highlight the urgent need for rainwater harvesting and strict water use policies, and in contrast, the conditions at Watershed 4 show the need for the modernization of irrigation to mitigate agricultural drought impacts. This integrated framework allows for targeted drought management solutions that directly relate to the specific contexts of the watersheds, while being more conducive to planning and prioritizing resource allocations for regions facing the highest drought vulnerability.

FORMULATION AND IN VITRO TESTS OF KETOPROFEN NANOSUSPENSION USING THE MILLING METHOD WITH POLYMER VARIATIONS

Objective: The aim of this research was to formulate ketoprofen nanosuspension with a variety of polymers and to compare the dissolution rate of the nanosuspensions with ketoprofen suspension. Methods: Ketoprofen nanosuspension was formulated by milling method using a different polymer such as Polyvinyl Pyrrolidone (PVP) K-30 (F1), Polyvinyl Alcohol (PVA) (F2) and Hydroxy Propyl Methyl Cellulose (HPMC) (F3). Nanosuspensions were prepared and characterized, including organoleptic, pH, particle size, zeta potential, Polydispersity Index (PI), specific gravity, crystalline state determination, physical stability at room temperature for 3 mo, and in vitro dissolution test compared with ketoprofen suspension. Results: The ketoprofen nanosuspensions with PVP K-30 and PVA showed stable preparations, while those with HPMC showed less stability, as indicated by sedimentation during storage. The particle size values of PVP K-30 and PVA were 10.004±0.03 nm; and 9.560±0.01 nm; zeta potential and polydispersity index values met the test requirements. The dissolution rate of the ketoprofen nanosuspensions was higher with a cumulative of F1, F2, and F3 were 83.35%; 85.00%, and 81.09% after 60 min, while the ketoprofen suspension was only 7.62%. Conclusion: The milling method of ketoprofen nanosuspensions with PVP and PVA has more stable physical characteristics than nanosuspension with HPMC. The ketoprofen nanosuspensions have a higher dissolution rate than the ketoprofen suspension.

Characterization and source apportionment of heavy metal pollution in soil around red mud disposal sites using absolute principal component scores-multiple linear regression and positive matrix factorization models.

In recent years, industrial waste and agrochemicals have reduced soil fertility and productivity, significantly impacting food security and ecosystems. In China, areas near red mud deposits from the aluminum industry show severe heavy metal contamination. This study examines agricultural soil near a red mud site in Shanxi Province, analyzing Cd, Cr, Hg, Ni, Pb, As, Cu, and Zn levels and distribution. Geostatistical methods and GIS are utilized to assess heavy metal pollution using the single factor index, the Nemerow integrated index, and the Hakanson potential ecological risk index. Absolute Principal Component Scores-Multiple Linear Regression (APCS-MLR) and Positive Matrix Factorization (PMF) models are used for quantitative analysis of pollution sources. Research indicates that the average concentrations of eight heavy metals exceed the natural background values of Shanxi, placing them at a severe pollution level with moderate ecological risk. Specifically, indices for As, Pb, and Cr are 3.79, 3.38, and 3.26, indicating severe pollution; Cd, Cu, and Hg at 2.36, 2.62, and 3.00 suggest moderate pollution; Ni at 1.87 shows mild pollution, while Zn at 0.97 is not polluted. Hg presents the highest ecological risk with a coefficient of 120.00, followed by Cd (70.69) and As (37.92). Spatial analysis shows significant correlations among Pb, Zn, Cu, and Ni, while Cr, Cd, Hg, and As show greater variability and weaker correlations. Both models identify five main sources: industrial activities, agricultural fertilizers, red mud leachate, energy combustion, and natural geological backgrounds, with respective contribution rates in the APCS-MLR model at 27.7%, 24.6%, 18.1%, 15.2%, and 14.4%, and in the PMF model at 29.2%, 21.5%, 16.9%, 16.7%, and 15.7%. This study offers a scientific basis for controlling soil pollution in the region, filling a literature gap.

Evaluating the continued significance of dam-induced vigorous downstream channel erosion in the context of projected climate change: a case study from Peninsular India

ABSTRACT Although erosion has naturally been driven by rainfall patterns, human activities have increasingly influenced erosion rates in recent times. However, as climate change alters precipitation, future erosion control may once again depend primarily on climate. The primary goal of this investigation was to ascertain whether the issue of escalated erosion, typically linked to downstream dam effects, could diminish in significance due to projected climatic shifts later in this century. An erosion potential index (Ep), formulated as the ratio of the mass of sediment influx from upstream to the frequency of the sediment-carrying flow events, was computed on a tributary of the Godavari River, located downstream of a dam. Using the Soil & Water Assessment Tool (SWAT), virtual experiments were conducted to distinguish the impacts of the dam from projected climate changes on river geomorphology. Two control scenarios were created using the current climate data and simulated regulated and unregulated states of the basin. Employing climate projections and various mitigation scenarios (SSPs) for the 2060s and 2090s, this study estimated Ep values exclusively under future climatic conditions in an unregulated state of the basin. Results indicate that, in the unregulated state without the existence of the upstream dam, future climate impacts on erosion outweigh the current effects of the dam, underscoring the growing influence of climate on geomorphology. It suggests that existing structural interventions may lose their geomorphic significance in the face of future climate conditions.

Pollution status of microplastics in the sediments of warm monomictic Dal lake, India: Abundance, composition, and risk assessment

This report presents the first investigation of microplastic (MP) contamination in the shoreline sediments of Dal Lake, Jammu and Kashmir, India. The MP concentrations ranged from 503 to 3154 MP/kg, with a notable seasonal variation. The highest concentrations of microplastics occurred in the Spring, ranging from 467 to 3445 MP/kg. Microplastics were identified using optical microscopy, Fourier Transform Infrared spectroscopy, and thermogravimetric analysis. Polymer analysis revealed that the Gagribal basin was contaminated with polyethylene (PE), polypropylene (PP), polystyrene (PS), polyvinyl chloride (PVC), polyamide (PA), and polyethylene terephthalate (PET). In contrast, the Nigeen basin mainly comprises PE, PP, and PS. The significantly elevated Polymer Hazard Index (PHI) values, exceeding 1000 in the Gagribal basin, were attributed to the presence of PVC. Sediment quality was assessed using Pollution Load Index (PLI), Potential Ecological Risk Index (PERI), and PHI. Health risk metrics, such as estimated daily intake (EDI) and microplastic carcinogenic risks (MPCR), were also evaluated. There is a positive correlation between microplastic abundance and total organic carbon (TOC), total phosphorus (TP), and total nitrogen (TN). The Nigeen basin, characterized by a higher proportion of less hazardous polymers like PP, exhibited greater TOC levels due to enhanced microbial degradation of microplastics. Conversely, the Gagribal basin, with its higher presence of toxic polymers like PVC, had lower TOC levels, likely due to these compounds' inhibition of microbial activity. This study provides crucial insight into the spatial distribution and ecological impact of MPs in Dal Lake, setting the stage for future research on their effects on aquatic ecosystems.

Characterization and ecological health risks of microplastics in the water and sediment of Xinyanggang River Estuary

ABSTRACT Microplastic (MP) pollution in aquatic environment has increased concerns. This study comprehensively examined properties and health risk to ecosystem of MPs in Xinyanggang River Estuary. Monthly sampling in 2023 detected MPs in water column (6.7 ± 0.55–11.6 ± 0.63 particles/L) and sediment (6.2 ± 0.78–10.2 ± 0.53 particles/g), with abundance peaking in summer, coinciding with the rainy season. The major features of the detected MPs included transparency and fiber, rayon, PVDF, PS, PE and PP composition. The dominant size fraction of detected MPs was 0.001–0.25 mm. Ecological risk assessment suggested relatively low load of MPs entering the Xinyanggang Estuary. However, polymer risk index (PRI) and potential ecological health risk index (PERI) suggested that MPs in Xinyanggang River are hazardous to ecosystem. This study firstly characterized MP contamination in Xinyangang River Estuary, and the provided results can guide the management of MPs in water environment more broadly.

Conversion of recovered phosphorus tailings into high-value lightweight ceramic materials and evaluation of environmental safety

In recent years, the substantial production and underutilization of phosphorus tailings have prompted an intensified search for innovative strategies to mitigate their accumulation and the associated hazards they present. This investigation the utilization of phosphorus tailings as a raw material for the cost-effective production of lightweight ceramic materials using the foaming-gel casting method. The impact of the stirring process on lightweight ceramic materials was investigated, encompassing mineral composition, pore structure, properties, and environmental safety assessment. The investigation utilized slurry volumetric foaming rate, XRD, SEM, ICP-MS, and potential ecological risk index (RI) for analysis. The findings suggested that the lightweight ceramic material, obtained by stirring at 1300 rpm for 15 min, exhibited the densest structure and excellent properties. It had a porosity of 79.19 %, a bulk density of 0.59 g/cm3, and a compressive strength of 6.08 MPa. Besides, the leaching concentration and RI of lightweight ceramic materials complied with national (GB 8978–1996) and US EPA standards. This study aimed to enhance the sustainable production capacity of lightweight ceramic materials and offered data support for the value-added application and performance optimization of phosphorus tailings in the production of lightweight ceramic materials.

Pollution assessment, ecological risk and source identification of heavy metals in paddy soils and rice grains from Salem, South India

The present study investigated concentrations of metals (Cu, Zn, Fe, Mn, Ni, Pb, and Cd) in paddy soils and rice tissues of nine different widely used indica rice varieties in Salem district, India. The order of DTPA soil available metal contents (mg kg-1) were Fe (33.50) > Mn (8.86) > Cu (2.58) > Pb (1.99) > Zn (1.67) > Ni (1.48) > Cd (0.13). Pollution load index (PLI) levels for Cd (1.28) were ‘moderately polluted’, contamination factor (CF) and enrichment factor (EF) values for all metals showed ‘medium contamination’ and ‘less enrichment’ except for Cu and Pb. Ecological risk factor (ERF) and potential ecological risk index (PRI) values of Cd (31.94 and 287.50) showed ‘moderate risk’ and ‘strong ecological risk’. Bio-accumulation factor (BAF) levels of Cd (48.12) and Pb (27.89) are classified as ‘high concentrators’. Translocation factor (TF) values of Pb (2.9), Cd (2.5) and Ni (1.7) were greater than one for roots to plants. Children had higher target hazard quotient (THQ) and hazard index (HI) values for Cd, Pb and Ni than adults. Principal component analysis (PCA) revealed with all parameters that they fell within the two primary factors 1 and 2, with an eigenvalue of 4.69 (33.52% variation) and 3.73 (26.66% variation), respectively. However, cluster analysis (CA) revealed three distinct groups between the metals studied. Although the soil metal contents were within the permissible levels, the grain Cd (6.07 mg kg-1), Pb (56.20 mg kg-1), and Fe (116.11 mg kg-1) contents in all the rice varieties exceeded the prescribed limits of 0.4, 0.2, and 15 mg kg-1, respectively. Our findings will provide important data for metal enrichment in soils to implement more effective measures to reduce the contamination of metals in paddy fields.

Predicting the impact of climate change on the potential geographical distribution and growth index of mirid predator, Nesidiocoris tenuis (reuter) (Heteroptera: Miridae) using CLIMEX

Predicting the impact of climate change on the potential geographical distribution and growth index of mirid predator, Nesidiocoris tenuis (reuter) (Heteroptera: Miridae) using CLIMEX

Association Between Different Insulin Resistance Indices and Heart Failure in US Adults With Diabetes Mellitus.

This study aims to scrutinize the association between various Insulin Resistance (IR) indices and heart failure (HF) risk in adult diabetics within the United States. The National Health and Nutrition Examination Survey (NHANES) (2005-2018) dataset was used in this study. Weighted logistic regression analysis and restricted cubic spline were employed to ascertain the correlation between IR indices and the incidence of HF in diabetic patients. The predictive capability of the IR indices was evaluated using the Receiver Operating Characteristic curve. This study included a total of 2574 diabetic patients, out of which 209 (8.1%) were diagnosed with HF. After the adjustment of potential confounders, TyG-BMI (OR: 1.005, 95% CI: 1.002-1.009), TG/HDL-C (OR: 1.138, 95% CI: 1.024-1.265), and METS-IR index (OR: 1.035, 95% CI: 1.015-1.057) were significantly associated with HF risk. RCS curves revealed nonlinear dose-response relationship between TyG, TyG-BMI, TG/HDL-C, and the occurrence of HF in diabetic patients. Subgroup analyses showed that four IR indices were positively associated with the risk of HF in the elderly diabetic population. Unfortunately, all IR indices failed to improve the predictive performance of the underlying risk model for HF in diabetic patients. Four IR markers may be important predictors of HF risk in diabetics.

Potential ecological risk assessment of microplastics in environmental compartments in Mexico: A meta-analysis.

Microplastic (MP) environmental contamination has been widely studied in Mexico. However, the evaluation of the associated risk to MPs in environmental compartments is scarce. Therefore, this study addresses this issue using diverse indicators such as the Pollution Load Index (PLI), the Polymer Risk Index (PRI), and the Potential Ecological Risk Index (PERI). The results of a meta-analysis revealed high MP contamination levels in most of the studied compartments, which included marine and estuarine waters, beach sand, freshwater, sediments, and biota. Regarding the risk assessment indicators, PLIs indicated low (56%), dangerous (22%), moderate (12%), and high (10%) levels across compartments. Meanwhile, PRIs displayed concerning values, with 36%, 35%, 20%, and 9% exhibiting dangerous, high, moderate, and low levels, respectively. Thus, high PRI values emphasized the significant rise in MP pollution, largely attributed to high-hazard polymer compositions. Otherwise, PERIs showed low (56%), very dangerous (29%), moderate (6%), high (5%), and dangerous (4%) levels. Thus, the ecological risk in Mexico is widespread and mainly linked to MP abundance, polymer type, environmental matrix, and characteristics of organisms. This study represents the first attempt at MP ecological risk assessment in Mexico, providing crucial insights for developing mitigation strategies to address concerns about MP contamination.

Optimization of invasomal gel of miconazole nitrate for the treatment of topical fungal infections

The treatment of deep topical fungal infections poses considerable obstacles. Miconazole nitrate which is used in the management of fungal infections has limited effectiveness owing to its poor aqueous solubility. The current study focuses on the improvement of solubility and permeability of miconazole nitrate through the skin by loading it into invasomes composed of soy lecithin and cilantro oil. The effects of varying amounts of soy lecithin and cilantro oil as independent variables was studied on entrapment efficiency and drug diffusion in-vitro by using the central composite design. An optimized formulation comprising of 104 mg of soy lecithin and 0.8 mL of cilantro oil was prepared and evaluated. Further, it was loaded into a gel base and evaluated for texture analysis, antifungal activity, in-vitro and ex-vivo drug diffusion. The entrapment efficiency and in-vitro drug diffusion for different formulations ranged from 84 ± 0.82 to 90 ± 0.74 % and 56.96 ± 1.51 to 86.3 ± 1.23 % respectively. Entrapment efficiency and in-vitro drug diffusion of optimized formulation were 85 ± 2.19 and 88.15 ± 1.57 % respectively. Particle size, zeta potential and polydispersity index of optimized formulation were 138.4 ± 2.25 nm, -45 ± 1.21 mV and 0.254 ± 0.12. The spherical shape of vesicles was confirmed by scanning electron microscopy. DSC thermogram revealed a partial conversion of crystalline to partial amorphous form of the drug due to encapsulation in a lipid matrix. The in-vitro and ex-vivo drug diffusion from invasomal gel was 88.15 ± 1.28 % and 77.9 ± 1.8 %, respectively. The in-vitro antifungal assay revealed that the invasomal gel exhibited a 1.5-fold increase in antifungal efficacy against Candida albicans compared to miconazole nitrate. This could be result of enhanced solubility, better drug diffusion and presence of cilantro oil. The results were conclusive of the enhanced effectiveness of miconazole nitrate in treating fungal infections by formulating it into invasomal gel formulation.