Potential Human Health Effects Research Articles

Environmental burden of disease related to pyrethroid-insecticide exposure and neurodevelopmental toxicity in Europe based on human biomonitoring

Abstract As indicated by human biomonitoring (HBM) studies, exposure to pyrethroids is widespread in Europe with significantly higher exposure observed in children compared to adults. Epidemiological, toxicological, and mechanistic studies raise concerns about potential health effects in humans and, particularly, behavioral disorders such as attention deficit hyperactivity disorder (ADHD) in children at low levels of exposure. Based on an exposure-response function from a single European study and on available quality-assured and harmonized HBM data collected in France, Germany, Iceland, Switzerland, and Israel, an initial estimate of the environmental burden of disease for ADHD associated with pyrethroid exposure (measured by the metabolite 3-phenoxybenzoic acid) was made for individuals aged 0-19 years. The estimated yearly number of prevalence-based disability-adjusted life years (DALYs) per million inhabitants due to ADHD were 34 DALYs for Israel, 26 DALYs for France, 14 DALYs for both Switzerland and Iceland, and 4 DALYs for Germany. Additionally, a substantial number of ADHD cases, averaging 18%, were associated with pyrethroid exposure. Yet, these figures should be interpreted with caution given the uncertainty of some input parameter. In addition to burden of disease estimates due to ADHD, the associated burden of autism-spectrum disorder (ASD) due to pyrethroid exposure and the health economic costs attributable to ADHD and ASD will also be investigated further. To ensure adequate follow-up of policy measures and more robust disease burden estimates, more HBM studies are recommended, along with increased efforts to harmonize the design of epidemiological studies to ensure more meaningful meta-analyses of exposure-response functions. This is particularly important for pyrethroids as more evidence on potential adverse health effects is continuously emerging.

A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring

Human biomonitoring (HBM) data indicate that exposure to pyrethroids is widespread in Europe, with significantly higher exposure observed in children compared to adults. Epidemiological, toxicological, and mechanistic studies raise concerns for potential human health effects, particularly, behavioral effects such as attention deficit hyperactivity disorder (ADHD) in children at low levels of exposure. Based on an exposure-response function from a single European study and on available quality-assured and harmonized HBM data collected in France, Germany, Iceland, Switzerland, and Israel, a preliminary estimate of the environmental burden of disease for ADHD associated with pyrethroid exposure was made for individuals aged 0–19 years. The estimated annual number of prevalence-based disability-adjusted life years (DALYs) per million inhabitants were 27 DALYs for Israel, 21 DALYs for France, 12 DALYs for both Switzerland and Iceland, and 3 DALYs for Germany; while the annual ADHD cases per million inhabitants attributable to pyrethroids were 2189 for Israel, 1710 for France, 969 for Iceland, 944 for Switzerland, and 209 for Germany. Direct health costs related to ADHD ranged between 0.3 and 2.5 million EUR yearly per million inhabitants for the five countries. Additionally, a substantial number of ADHD cases, on average 18%, were associated with pyrethroid exposure. Yet, these figures should be interpreted with caution given the uncertainty of the estimation. A sensitivity analysis showed that by applying a different exposure-response function from outside the EU, the population attributable fraction decreased from an average of 18 to 7%. To ensure more robust disease burden estimates and adequate follow-up of policy measures, more HBM studies are needed, along with increased efforts to harmonize the design of epidemiological studies upfront to guarantee meta-analysis of exposure-response functions. This is particularly important for pyrethroids as evidence of potential adverse health effects is continuously emerging.

A scoping review to determine if adverse human health effects are associated with use of organophosphates for mosquito control.

Organophosphate insecticides are widely used for adult mosquito control. Although proven effective in reducing mosquito populations and limiting arbovirus transmission, public concern exists regarding potential human health effects associated with organophosphate exposure. The aim of this scoping review was to describe any reported human health conditions associated with organophosphates during their use for adult mosquito control in the United States and Canada. Original peer-reviewed articles published in English language journals from 1 January 2000 to 22 May 2024, were obtained by searching from the databases MEDLINE, EMBASE, Agricultural & Environmental Science Collection, CAB Abstracts, and Scopus. The search identified 6,154 screened articles. Following an independent review, 10 studies were identified that described human health conditions associated with organophosphate exposure during adult mosquito control applications. Of the 10 included studies, only two articles were published within the last 11 years (2013 to 22 May 2024). Three types of study design were represented in the included studies: cohort (n = 5), case study (n = 1), and risk assessment (n = 4). The included studies could not determine causality between exposure to adulticides and development of illness or adverse impacts. Exposure to organophosphates did not contribute to an observed increase in metabolic toxicity, hospitalization rates, or self-reported symptoms and exposure. The available and limited evidence indicates that organophosphates can be used safely to control nuisance mosquitoes or mosquitoes that transmit arboviruses. Continued research regarding the human health effects associated with organophosphate applications for adult mosquito control could help evaluate the basis of the public's concerns and inform public health decision-making.

Impacts of oyster farms on sediment-associated mercury and methylmercury concentrations and health risks in an estuarine, mangrove forest, Zhanjiang Bay, China

Estuarine sediments serve as significant reservoirs for mercury (Hg) and methylmercury(MeHg), which can also interconvert in the external environment. The release of Hg in response to human activities raises concerns about its potential ecological and human health effects. Sediment samples were collected in December 2021 from four locations (sites), and Hg cycling by measuring the concentrations of, and controls on, the spatial distribution of total Hg (THg) and methylmercury (MeHg) in high-tidal zone (HTZ) and mid-tidal zone (MTZ) sediments of a mangrove forest (MF) and oyster farm (OF) was examined in northwestern Zhanjiang Bay, including simultaneous determination of sediment particle size, oxidation-reduction potential (Eh), pH, total organic carbon (TOC), sulfide concentration (S2-), and sulfate reducing bacteria (SRB). The research results indicated that concentrations of both THg and MeHg ranged between 20.0–104.0 ng/g and 0.011–0.277 ng/g in the sediments, respectively. The highest methylation potentials within the MF and OF were in sediments located approximately 10–15 cm below the surface. MeHg in the HTZ of the OF was likely derived from exogenous inputs as Hg methylation appears limited, and the formation of MeHg depended not only on the amount of inorganic mercury available for methylation in SRB, but also on the TOC, pH, Eh and S2- content in the sediment. A risk assessment of MeHg during the anthropogenic disturbance of this estuaries conducted on individuals eating oysters demonstrated that health risks are low.

Chemical characterization of pellet stove ashes: Elemental fractionation of ashes results in volatile particles with high concentrations of cadmium and lead

Use of wood-based biomass for home heating has increased as a more sustainable and economical alternative to fossil fuel heating sources. However, concerns remain regarding particulate emissions and potential human health effects. Pellet stoves are very efficient combustion sources but still emit high particle numbers of nanoparticles into the environment and generate ash within the stove that could be an exposure source during cleaning. In this study we chemically characterize pellet ash collected from zones (upper and lower) from three stoves and determine the chemical composition of room air during cleaning events. Ash was acid digested using reverse aqua regia and microwave digestion and analyzed by ICP-MS. Indoor air was sampled using impingers before and during stove cleaning to assess ultrafine particulate release and exposure. Within the pellet stove different fractions of ash could be identified by color and macro-scale morphology. Ash fractions collected lower in the stove were predominantly calcium-based, 25 % by weight, and high in refractory trace elements, Fe, Cr, Mn and Ni. In contrast, ash collected higher in the stove was predominantly K and S based (25 and 5 % respectively) and had high concentrations of volatile elements Zn (0.4 %), Cd and Pb. Maximum Cd and Pb ash concentrations were 274 mg/kg and 807 mg/kg respectively corresponding to enrichment factors of 1581 and 870 compared to the respective pellets. Electron microscopy of the particles suggested that ash particles were agglomerates of smaller primary particles and EDS identified areas of high K and S concentration on the particles. Impinger studies of room air during cleaning showed an increase in K, S, Zn, Cd and Pb suggesting a mobilization of upper ash particles into room air upon stove cleaning.

Computational analysis of electromagnetic field exposure in passengers near high- current contact wire environments.

The electromagnetic environment of a railway station is composed of electrical, magnetic, and electromagnetic fields, which are generated by various sources such as traction current, voltage, pantograph-catenary arc, locomotive braking, wheel-rail rolling arc, and communication systems. However, there is public growing concern among the public about the potential negative human health effects of this electromagnetic environment. To analyze the distribution of electromagnetic fields in human tissues, electromagnetic simulation software is used to create a model that includes six track contact wires and four waiting passengers on three platforms. This model is used to analyze the magnetic field environment created by high currents in the contact wires of a multi-track high-speed railway station. By varying the loads on different contact wires, the distribution of electric field and magnetic flux density within human tissues of waiting passengers on different platforms is studied using this model. When the track is unoccupied, the calculation results show that the maximum values of the electric field and magnetic flux density of the passenger's human body tissue at the blind way on the platform and 1m of the blind way are 17.6mVm-1 and 52.7 μT, respectively. These values increase by 9.28mVm-1 and 16.4 μT compared to when the track is occupied. When more contact wires are loaded with currents, the electric field mode and magnetic flux density mode of human tissues increase at the same position on the platform. Specifically, when the contact wires of six tracks are loaded with current at the same time, the maximum values of the electric field mode and magnetic flux density mode of the waiting passengers' human tissues at the blind way on different platforms are 29.6mVm-1 and 88.1 μT, respectively. These maximum values are lower than the public electromagnetic exposure limits that are designated by the International Commission on Non-Ionizing Radiation Protection guidelines. The research results demonstrate that the magnetic field environment generated by the current in the contact wires of a railway station with six tracks does not pose a health risk to human tissues of passengers waiting at the blind way and 1m of the blind way on the platform. These findings can provide valuable data reference for the formulation of relevant standards for the design of electrified rail transit, as well as the suppression of electromagnetic interference and protection of human bioelectromagnetism.

Occurrence and distribution of pesticides and transformation products in ambient air in two European agricultural areas

Pesticides present a significant risk for both humans and the environment. However, quantitative data for a broad range of airborne pesticides in agricultural areas are missing. During or after the application, pesticides can reach the atmosphere and partition between the particulate and gaseous phase. As part of the EU project SPRINT, weekly ambient air samples were collected from two agricultural areas in Portugal (vineyard) and the Netherlands (potatoes, onions, and sugarbeet) between April 2021 and June 2022 using high-volume air samplers. The samples were analysed for 329 pesticides, of which 99 were detected. The most frequently detected compounds included the fungicides folpet, fenpropidin and mandipropamid, the insecticide chlorpyrifos-methyl, the herbicide terbuthylazine, and the metabolite prothioconazole-desthio, which were found with detection frequencies between 40 and 57 %. Pesticide concentrations ranged between 0.003 ng/m3 and 10 ng/m3. Remarkably, 97 % of the samples contained at least one pesticide and in 95 % of the samples, pesticide mixtures were present. The calculated particle phase fractions correlated with the octanol-air partitioning coefficient for most of the investigated compounds. Furthermore, calculated daily inhalation rates for individual pesticides and pesticide mixtures were far below the Acceptable Daily Intake (ADI) with a margin of exposure (MOE) of >1000 for the highest calculated daily inhalation rate for a child. However, as this value only includes pesticide intake from food and drinking water and considering that 91 % of the detected pesticides are associated with potential adverse human health effects. These findings highlight the broad range of airborne pesticides in agricultural areas and the need for quantitative data to include the intake of mixtures of highly hazardous pesticides by inhalation in human risk assessment.

Microplastics in seafood: Consumer preferences and valuation for mitigation technologies

Microplastics, an emerging pollutant, have garnered widespread attention due to potential repercussions on human health and the environment. Given the critical role of seafood in food security, growing concerns about microplastics might be detrimental to meeting future global food demand. This study employed a discrete choice experiment to investigate Chilean consumers’ preferences for technology aimed at mitigating microplastic levels in mussels. Using a between-subjects design with information treatments, we examined the impact of informing consumers about potential human health and environmental effects linked to microplastics pollution on their valuation for the technology. We found that the information treatments increased consumers’ willingness to pay for mussels. Specifically, consumers were willing to pay a premium of around US$ 4 for 250 g of mussel meat with a 90 % depuration efficiency certification. The provision of health impact information increased the price premium by 56 %, while the provision of environmental information increased it by 21 %. Furthermore, combined health and environmental information significantly increased the probability of non-purchasing behavior by 22.8 % and the risk perception of microplastics for human health by 5.8 %. These results emphasized the critical role of information in shaping consumer preferences and provided evidence for validating investment in research and development related to microplastic pollution mitigation measures.

U-CAN-seq: A Universal Competition Assay by Nanopore Sequencing.

RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand the evolutionary fitness of novel viral variants relative to well-studied genotypes of epidemic viruses. Competition assays are an effective and rigorous system with which to assess the relative fitness of viral genotypes. However, it is challenging to quickly and cheaply distinguish and quantify fitness differences between very similar viral genotypes. Here, we describe a protocol for using reverse transcription PCR in combination with commercial nanopore sequencing services to perform competition assays on untagged RNA viruses. Our assay, called the Universal Competition Assay by Nanopore Sequencing (U-CAN-seq), is relatively cheap and highly sensitive. We used a well-studied N24A mutation in the chikungunya virus (CHIKV) nsp3 gene to confirm that we could detect a competitive disadvantage using U-CAN-seq. We also used this approach to show that mutations to the CHIKV 5' conserved sequence element that disrupt sequence but not structure did not affect the fitness of CHIKV. However, similar mutations to an adjacent CHIKV stem loop (SL3) did cause a fitness disadvantage compared to wild-type CHIKV, suggesting that structure-independent, primary sequence determinants in this loop play an important role in CHIKV biology. Our novel findings illustrate the utility of the U-CAN-seq competition assay.

A multi-marker assessment of sewage contamination in streams using human-associated indicator bacteria, human-specific viruses, and pharmaceuticals

Human sewage contaminates waterways, delivering excess nutrients, pathogens, chemicals, and other toxic contaminants. Contaminants and various sewage indicators are measured to monitor and assess water quality, but these analytes vary in their representation of sewage contamination and the inferences about water quality they support. We measured the occurrence and concentration of multiple microbiological (n = 21) and chemical (n = 106) markers at two urban stream locations in Milwaukee, Wisconsin, USA over two years. Five-day composite water samples (n = 98) were collected biweekly, and sewage influent samples (n = 25) were collected monthly at a Milwaukee, WI water reclamation facility. We found the vast majority of markers were not sensitive enough to detect sewage contamination. To compare analytes for monitoring applications, five consistently detected human sewage indicators were used to evaluate temporal patterns of sewage contamination, including microbiological (pepper mild mottle virus, human Bacteroides, human Lachnospiraceae) and chemical (acetaminophen, metformin) markers. The proportion of human sewage in each stream was estimated using the mean influent concentration from the water reclamation facility and the mean concentration of all stream samples for each sewage indicator marker. Estimates of instream sewage pollution varied by marker, differing by up to two orders of magnitude, but four of the five sewage markers characterized Underwood Creek (mean proportions of human sewage ranged 0.0025 % - 0.075 %) as less polluted than Menomonee River (proportions ranged 0.013 % - 0.14 %) by an order of magnitude more. Chemical markers correlated with each other and yielded higher estimates of sewage pollution than microbial markers, which exhibited greater temporal variability. Transport, attenuation, and degradation processes can influence chemical and microbial markers differently and cause variation in human sewage estimates. Given the range of potential human and ecological health effects of human sewage contamination, robust characterization of sewage contamination that uses multiple lines of evidence supports monitoring and research applications.

An Overview of Degradation Strategies for Amitriptyline.

Antidepressant drugs play a crucial role in the treatment of mental health disorders, but their efficacy and safety can be compromised by drug degradation. Recent reports point to several drugs found in concentrations ranging from the limit of detection (LOD) to hundreds of ng/L in wastewater plants around the globe; hence, antidepressants can be considered emerging pollutants with potential consequences for human health and wellbeing. Understanding and implementing effective degradation strategies are essential not only to ensure the stability and potency of these medications but also for their safe disposal in line with current environment remediation goals. This review provides an overview of degradation pathways for amitriptyline, a typical tricyclic antidepressant drug, by exploring chemical routes such as oxidation, hydrolysis, and photodegradation. Connex issues such as stability-enhancing approaches through formulation and packaging considerations, regulatory guidelines, and quality control measures are also briefly noted. Specific case studies of amitriptyline degradation pathways forecast the future perspectives and challenges in this field, helping researchers and pharmaceutical manufacturers to provide guidelines for the most effective degradation pathways employed for minimal environmental impact.

The relationship between water quality and the microbial virulome and resistome in urban streams in Brazil

Urban streams that receive untreated domestic and hospital waste can transmit infectious diseases and spread drug residues, including antimicrobials, which can then increase the selection of antimicrobial-resistant bacteria. Here, water samples were collected from three different urban streams in the state of São Paulo, Brazil, to relate their range of Water Quality Indices (WQIs) to the diversity and composition of aquatic microbial taxa, virulence genes (virulome), and antimicrobial resistance determinants (resistome), all assessed using untargeted metagenome sequencing. There was a predominance of phyla Proteobacteria, Actinobacteria, and Bacteroidetes in all samples, and Pseudomonas was the most abundant detected genus. Virulence genes associated with motility, adherence, and secretion systems were highly abundant and mainly associated with Pseudomonas aeruginosa. Furthermore, some opportunistic pathogenic genera had negative correlations with WQI. Many clinically relevant antimicrobial resistance genes (ARGs) and efflux pump-encoding genes that confer resistance to critically important antimicrobials were detected. The highest relative abundances of ARGs were β-lactams and macrolide-lincosamide-streptogramin. No statistically supported relationship was detected between the abundance of virulome/resistome and collection type/WQI. On the other hand, total solids were a weak predictor of gene abundance patterns. These results provide insights into various microbial outcomes given urban stream quality and point to its ecological complexity. In addition, this study suggests potential consequences for human health as mediated by aquatic microbial communities responding to typical urban outputs.

Tannic acid's role as both char former and blowing agent in epoxy‐based intumescent fire retardants

AbstractA novel intumescent fire‐retardant coating formulation has been developed by taking advantage of the inherent stability of large cyclic polyphenols (e.g., tannic acid) to remove the need for a dedicated blowing agent, specifically melamine. Cone calorimetry data indicate a lower fire growth rate (FIGRA) (5.0 ± 1.3 vs. 2.4 ± 0.7 kW m−2 s−1) upon removal of melamine. Total smoke release (TSR) increases following this removal (178 ± 21.4 vs. 305 ± 13.2 m2 m−2), which indicates the role of tannic acid in gas generation. Thermogravimetric analysis resulted in similar residue yield from the examined systems (36 ± 1.3% vs. 34 ± 1.7%) despite removal of a dedicated blowing agent. These results indicate that tannic acids multistep degradation allows it to behave as both a char forming and blowing agent in intumescent systems. The observed reduction of acid loading between the melamine‐tannin system and the melamine‐free composition (15.6% vs. 10.6% wt. ammonium polyphosphate, respectively) is also significant. Tannic acid occurs in agricultural waste products, which is encouraging for the pursuit of sustainable chemistry and addressing potential adverse health effects in humans combined with reducing the overall phosphorous loading.Highlights Melamine was removed from the intumescent without compromising stability. The resulting intumescent char was stronger despite less expansion. Tannic acid is attributed as both the charring and blowing agent. The tannin‐based coating requires a lower acid loading for similar performance.

Phenolic compounds occurrence and human health risk assessment in potable and treated waters in Western Cape, South Africa.

Phenolic pollutants from industrial and agricultural activities pose a major threat to the world's potable water supply. The persistent micro-pollutants often find their way into drinking water sources with possible adverse human health implications. In this study, bottled water, tap water, and wastewater treatment plant (WWTP) effluent samples from the Boland region of the Western Cape, South Africa were assessed to determine 4-chlorophenol (4-CP) and 2,4-dichlorophenol (2,4-DCP) levels using HPLC/DAD instrumentation. The selected area is known for its vast agricultural ventures and wineries. Evaluation of the human health risk (cancer risk) for the pollutants was conducted using the hazard quotient (HQ). The Ames mutagenicity test was also conducted using the Salmonella typhimurium T98 and T100 strains and the S9 activation enzyme. Trace levels of the phenolics were detected in the samples with a range of 9.32 × 10-7-1.15 × 10-4mg/L obtained for 4-CP, and 8.80 × 10-7-1.72 × 10-4mg/L recorded for 2,4-DCP. Both compounds had levels below the limit of 0.01mg/L prescribed by South African legislation. The assessed HQ for the phenolic concentrations indicates a low level of potential ecological risk and none of the samples had a cancer risk value that exceeded the regulatory limit. The possibility of the analyzed samples causing cancer is unlikely, but non-carcinogenic adverse effects were found. Strong mutagenicity was observed for the T98 strains with a potential ability to cause mutation toward the insertion or deletion of a nucleotide. The T100 bacterial strain showed very slight mutagenicity potential, however, it is unlikely to cause any mutation. The levels of phenolics in the potable water samples may pose a significant threat to human health. Hence, screening persistent organic chemicals in potable water sources and evaluating their potential human health effects is pertinent to prevent associated health challenges.

Organic Medicinal and Aromatic Plants: Consumption Profile of a Portuguese Consumer Sample.

The production and consumption of organic products have been increasing in Portugal, as well as in the European Union as a whole. The main objective of this work is to understand the consumption habits of organic medicinal and aromatic plants (OMAPs) among Portuguese adults. An online questionnaire was distributed using social networks, resulting in the collection and statistical analysis of 300 responses. Of the participants who reported consuming OMAPs, 44.3% showed a daily consumption pattern. The most frequently mentioned OMAPs for fresh consumption were parsley (Petrosselinum crispum L., 92%), garlic (Allium sativum L., 84.1%), and coriander (Coriandrum sativum L., 78.1%). The most commonly mentioned OMAP for consumption as dried plants were oregano (Origanum vulgare L., 74.6%), lemon balm (Melissa officinalis L., 49.2%), and lemon verbena (Aloysia citrodora L., 46.8%). The main reasons cited for using OMAPs were their benefits to health (58.7% of participants), benefits to the environment (33.2%), and reduced salt consumption (29.5%). Among these, the main health benefits mentioned included anti-inflammatory properties (45.0%), prevention of cardiovascular diseases (41.6%), and prevention of high cholesterol (39.9%). Furthermore, 82.5% of respondents considered themselves sufficiently, well, or excellently informed about the nutritional properties of OMAPs. This research initiates a discussion about whether profiling OMAP consumption habits can serve as a valuable tool for promoting organic farming in Portugal, increasing OMAP production and consumption, and strengthening the connection between these products and potential positive human health effects.

Albumin Proteins as Delivery Vehicles for PFAS Contaminants into Respiratory Membranes.

Poly- and perfluoroalkyl substances (PFAS) are a family of chemicals that have been used in a wide range of commercial products. While their use is declining, the prevalence of PFAS, combined with their chemical longevity, ensures that detectable levels will remain in the environment for years to come. As such, there is a pressing need to understand how PFAS contaminants interact with other elements of the human exposome and the consequences of these interactions for human health. Using serum albumin as a model system, we show that proteins can bind PFAS contaminants and facilitate their incorporation into model pulmonary surfactant systems and lipid bilayers. Protein-mediated PFAS delivery significantly altered the structure and function of both model membrane systems, potentially contributing to respiratory dysfunction and airway diseases in vivo. These results provide valuable insights into the synergistic interaction between PFAS contaminants and other elements of the human exposome and their potential consequences for human health.

Health risks and environmental influence of volatile organic compounds (VOCs) in a residential area near an industrial park in Southeast China

Industry emission is an important source of anthropogenic volatile organic compounds (VOCs) in China, which have caused elevated ground-level ozone (O3) and fine particulate matter (PM2.5) concentrations and potential adverse human health effects. This study investigated compositions, sources, and health risks of ambient VOCs in a residential area near an industrial park in Southeast China. The concentrations of total VOCs in spring and autumn were 16.7 ± 10.2 ppbv and 14.7 ± 8.35 ppbv, respectively. Alkanes and oxygenated VOCs (OVOCs) were the predominant components that contributed to the ozone formation potential (OFP), while the greatest contribution to secondary organic aerosol formation potential (SOAFP) was due to benzene, toluene, ethylbenzene, and xylene (BTEX). Based on the positive matrix factorization model analysis, the relative contributions of individual VOC sources are as follows: industrial process (49.6% and 53.5% in spring and autumn, respectively), vehicle exhausts (26.9% and 33.2%), solvent usage (17.9% and 8.6%), and biogenic source (5.6% and 4.7%). The carcinogenic risk of benzene in autumn and those of 1,2-dibromoethane in both seasons exceeded the acceptable level of 1.00 × 10−6. The hazard index of the observed 21 toxic VOCs was less than 1, suggesting no non-carcinogenic risk at the monitoring site. This study provides valuable information on public health management by taking effective measures to control benzene and halogenated hydrocarbon pollution from industry.

The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals

BackgroundThe global production and use of plastic materials has increased dramatically since the 1960s and there is increasing evidence of human health impacts related to exposure to plastic-associated chemicals. There is, however, no comprehensive, regulatory, post-market monitoring for human health effects of plastic-associated chemicals or particles and it is unclear how many of these have been investigated for effects in humans, and therefore what the knowledge gaps are. ObjectiveTo create a systematic evidence map of peer-reviewed human studies investigating the potential effects of exposure to plastic-associated particles/chemicals on health to identify research gaps and provide recommendations for future research and regulation policy. MethodsMedline and Embase databases were used to identify peer-reviewed primary human studies published in English from Jan 1960 – Jan 2022 that investigated relationships between exposures to included plastic-associated particles/chemicals measured and detected in bio-samples and human health outcomes. Plastic-associated particles/chemicals included are: micro and nanoplastics, due to their widespread occurrence and potential for human exposure; polymers, the main building blocks of plastic; plasticizers and flame retardants, the two most common types of plastic additives with the highest concentration ranges in plastic materials; and bisphenols and per- or polyfluoroalkyl substances, two chemical classes of known health concern that are common in plastics. We extracted metadata on the population and study characteristics (country, intergenerational, sex, age, general/special exposure risk status, study design), exposure (plastic-associated particle/chemical, multiple exposures), and health outcome measures (biochemical, physiological, and/or clinical), from which we produced the interactive database ‘Plastic Health Map’ and a narrative summary. ResultsWe identified 100,949 unique articles, of which 3,587 met our inclusion criteria and were used to create a systematic evidence map. The Plastic Health Map with extracted metadata from included studies are freely available at https://osf.io/fhw7d/ and summary tables, plots and overall observations are included in this report. ConclusionsWe present the first evidence map compiling human health research on a wide range of plastic-associated chemicals from several different chemical classes, in order to provide stakeholders, including researchers, regulators, and concerned individuals, with an efficient way to access published literature on the matter and determine knowledge gaps. We also provide examples of data clusters to facilitate systematic reviews and research gaps to help direct future research efforts. Extensive gaps are identified in the breadth of populations, exposures and outcomes addressed in studies of potential human health effects of plastic-associated chemicals. No studies of the human health effects of micro and/or nanoplastics were found, and no studies were found for 26/1,202 additives included in our search that are of known hazard concern and confirmed to be in active production. Few studies have addressed recent “substitution” chemicals for restricted additives such as organophosphate flame retardants, phthalate substitutes, and bisphenol analogues. We call for a paradigm shift in chemical regulation whereby new plastic chemicals are rigorously tested for safety before being introduced in consumer products, with ongoing post-introduction biomonitoring of their levels in humans and health effects throughout individuals’ life span, including in old age and across generations.

Estimation of Serum PFOA Concentrations from Drinking and Non-Drinking Water Exposures.

Estimation of Serum PFOA Concentrations from Drinking and Non-Drinking Water Exposures.

38 Physicochemical Characterisation and Potential Health Effects of Tyre Wear Particles

Abstract Tyre wear is an increasing source of ambient particulate matter pollution in the UK and around the world. Currently, tyre wear accounts for 11% of total particulate matter (PM2.5) in the UK, and over the next 10 years that figure is projected to steadily increase, with UK brake and tyre emissions projected to reach 6 kilotonnes by 2030. Being able to reliably identify and monitor tyre wear PM in ambient sources is of increasing importance due to its potential human health effects. Here we present a series of characterisation experiments on tyre particles, size-fractionated using a dynamometer. Chemical and elemental composition has been determined by inductively coupled plasma mass spectrometry (ICP-MS) and two dimensional gas chromatography time of flight mass spectrometry (GCxGC-TOF-MS), with particle morphology studied using a scanning electron microscope and energy dispersive spectroscopy (SEM-EDS) and an electrical low pressure impactor (ELPI). The potential health effects of these particles have then been assessed in vitro using human bronchial epithelial cells following the IARC characteristics of carcinogenicity, specifically looking at (pro)inflammatory cytokines, cytotoxicity and mitochondrial function. Tyre wear particles have the ability to reduce mitochondrial function significantly from doses as low as 5μg/ml after 24 hours, with the induction of cytokines and chemokines currently being profiled. Additionally, a representative elemental and chemical fingerprint of tyre rubber has now been established. By understanding the composition and morphology of these particles, we can begin to detect them in atmospheric samples, and using in vitro models, understand their potential health effects.