Aim: The aim of the study is to evaluate the effectiveness of a planned video-assisted health educational program on knowledge of health hazards and its prevention among selected sanitary workers of the city corporation Kalaburagi district of Karnataka state.Materials and Methods: This study used quasi-experimental methods. In this study, a single-group pre-test and post-test research design was used. City corporation Kalaburagi district hosted this study. This study has 100 participants. The sample size is 100. The researcher employed basic random sampling in this investigation.Results: Most subjects (50%) were 30–39 years old. The sample was 51% male. Most subjects (40%) were high school graduates. Most sanitary workers were married (65%). Hindus make up 54% of respondents. About 31% had 1–5 years of experience. About 48% of subjects obtain TV info. It also found that 98% of sanitary staff had poor pre-test knowledge. In the post-test, 46% of subjects had enough knowledge of health hazard prevention after the scheduled video-assisted health educational course The respondents’ mean pre-test knowledge scores were 19.43 (38.86%) with a standard deviation of 3.143, indicating poor knowledge. After the planned video-assisted health educational session, respondents’ mean knowledge scores improved to 37.28 (74.56%) with a standard deviation of 2.985. Furthermore, at 0.01 significance, the “t” = 40.378 was bigger than the tablevalue. Age, gender, education, marital status, religion, prior employment experience providing sanitary services, and information source were not significant at the 0.05 levels. There is no significant correlation found between the knowledge level of sanitary workers and the studied factors.Conclusion: It appears that pre- and post-test sanitary workers’ health hazard prevention knowledge differs and program of video-assisted health education on health dangers and preventive for chosen sanitation personnel of City Corporation, Kalaburagi district, Karnataka.