The Nankai trough has repeatedly experienced large megathrust earthquakes at intervals of 100–200 years. The inland region of southwest (SW) Japan has a seismically active period from 50 years before to 10 years after megathrust earthquakes. To assess the activities of inland earthquakes after megathrust earthquakes, we need to quantitatively evaluate the postseismic stress accumulation on the inland source faults considering plausible viscoelastic relaxation. Recent studies have shown the importance of low-viscosity layers along the lithosphere-asthenosphere boundary (LAB layer) in postseismic deformation. In the present study, we focus on the most recent ruptures, the 1944 M7.9 Tonankai and the 1946 M8.0 Nankai earthquakes, estimating the 4-year stress change on the source faults in SW Japan in a forward modeling approach. The 1944–1946 megathrust rupture sequence was followed by severe ~ M7 inland earthquakes, such as the 1945 M6.8 Mikawa and 1948 M7.1 Fukui earthquakes. For stress calculation, we used a highly detailed finite element model incorporating the actual topography and the plausible viscoelastic underground structure from past studies. The calculated inland stress field shows the dominance of the coseismic change during the 1944 and 1946 earthquakes and little contribution from viscoelastic relaxation. In contrast, viscoelastic relaxation has a significant effect on stress in the slab, indicating the importance of quantifying the viscosity of the LAB layer. Based on the calculated stress, we evaluated the change in the Coulomb failure stress (ΔCFS) on each source fault. The ΔCFS is generally positive on the strike-slip faults east of 135°E due to the 1944 rupture. In contrast, the ΔCFS on the faults west of 135°E, including the Median Tectonic Line segments, became positive due to the 1946 rupture. The occurrence of the damaging earthquakes in 1945 and 1948 can be explained by the calculated ΔCFS. The ΔCFS on the recent earthquake faults of the recent damaging earthquakes such as the 2016 M7.2 Kumamoto earthquake is generally negative, suggesting the delay in stress accumulation. The ΔCFS on the source faults of the intra-slab earthquakes differ significantly as large as tens of kilopascals depending on the viscosity of the LAB layer.Graphical