Background and Aim: The soft tissue defects around the knee are common and represents a challenge for surgeons due to its complexity and desired outcome. Many reconstructive treatment options are available and flaps are recommended. The current study aimed to evaluate the outcome of using saphenous artery (SA)-based flaps for the management of soft tissue defects around the knee.
 Methodology: Files of 34 patients treated by SA-based flaps were reviewed for outcome and complications. Collected data included patient demographics, etiology, size, site and side of the defect and outcome (flap survival and complications) at the end of the 6th postoperative month.
 Results: There were 26 males and 8 females. Their age ranged from 18 to 45 years; the mean age was 33.18±6.58 years. The commonest etiology was posttraumatic (64.7%) then post-burn contracture (20.6%). The majority of defects were on the right side (82.4%). The maximum length of the defect ranged between 14 and 20 cm (mean ± SD were 16.56±1.62) while the maximum width ranged between 6 and 10 cm (mean ±SD were 8.59±1.05). The flap survival rate was 97.1%. The overall complications rate was 14.7%, distal flap necrosis reported for 5.9%, wound dehiscence for 2.9% and seroma for 5.9%. All treated conservatively, except that of distal flap necrosis which need reintervention.
 Conclusion: The saphenous artery-based fasciocutaneous flap is an effective, feasible and safe option for the management of soft tissue defects around the knee.