Introduction This study aimed at evaluating the bond strength to root dentin of 2 mineral trioxide aggregate (MTA)–based sealers (Endo-CPM sealer and MTA Fillapex) and of 1 epoxy resin–based sealer (AH Plus sealer). Methods Forty-five extracted human teeth with single roots were prepared by using the step-back technique. Irrigation with 2.5% NaOCl and a final rinse with 17% ethylenediaminetetraacetic acid and distilled water were performed. Canals were filled by using Endo-CPM sealer, MTA Fillapex, or AH Plus sealer by means of the gutta-percha lateral condensation technique. After 7 days, the roots were sectioned perpendicularly to its long axis, and the push-out test was carried out. The data were analyzed by using the Kruskal-Wallis and Dunn post hoc tests. Results Endo-CPM sealer showed the highest values of bond strength to root dentin (8.265 MPa) ( P < .05). The values of push-out test were similar for MTA Fillapex (2.041 MPa) and AH Plus (3.034 MPa). Conclusions On the basis of the findings presented herein and within the limitations of this study, Endo-CPM sealer presented advantages when a post preparation was required. MTA Fillapex presented acceptable resistance to dislodgement, which was similar to that observed in samples filled with AH Plus sealer.