Post Data Research Articles

Comprehensive analysis of the associations between clinical factors and outcomes by machine learning, using post marketing surveillance data of cabazitaxel in patients with castration-resistant prostate cancer

BackgroundWe aimed to evaluate relationships between clinical outcomes and explanatory variables by network clustering analysis using data from a post marketing surveillance (PMS) study of castration-resistant prostate cancer (CRPC) patients.MethodsThe PMS was a prospective, multicenter, observational study of patients with metastatic, docetaxel-refractory CRPC treated with cabazitaxel in Japan after its launch in 2014. Graphical Markov (GM) model-based simulations and network clustering in ‘R’ package were conducted to identify correlations between clinical factors and outcomes. Factors shown to be associated with overall survival (OS) in the machine learning analysis were confirmed according to the clinical outcomes observed in the PMS.ResultsAmong the 660 patients analyzed, median patient age was 70.0 years, and median OS and time-to-treatment failure (TTF) were 319 and 116 days, respectively. In GM-based simulations, factors associated with OS were liver metastases, performance status (PS), TTF, and neutropenia (threshold 0.05), and liver metastases, PS, and TTF (threshold 0.01). Factors associated with TTF were OS and relative dose intensity (threshold 0.05), and OS (threshold 0.01). In network clustering in ‘R’ package, factors associated with OS were number of treatment cycles, discontinuation due to disease progression, and TTF (threshold 0.05), and liver and lung metastases, PS, discontinuation due to adverse events, and febrile neutropenia (threshold 0.01). Kaplan–Meier analysis of patient subgroups demonstrated that visceral metastases and poor PS at baseline were associated with worse OS, while neutropenia or febrile neutropenia and higher number of cabazitaxel cycles were associated with better OS.ConclusionsNeutropenia may be a predictive factor for treatment efficacy in terms of survival. Poor PS and distant metastases to the liver and lungs were shown to be associated with worse outcomes, while factors related to treatment duration were shown to positively correlate with better OS.

Investigating the impact of research-based professional development on teacher learning and classroom practice: Findings from computer science education

As the field of computer science (CS) is gaining increased attention, the need for qualified teachers is rapidly growing. Yet little is still known about the design features, implementation, and outcomes of professional development programs in computing. The purpose of this study is threefold: (a) examine a CS professional development program built around high-quality design features reported in the research literature, (b) investigate the impact of the program on participating teachers’ learning and classroom practice, and (c) identify specific design features that facilitated changes in teacher learning and practice. The study employed a mixed-methods design. Data were collected from multiple sources including, pre and post survey data on teacher knowledge of CS content, pedagogy, and technology (N = 94), as well as interviews and classroom implementation data from eight case study participants. Findings from this work indicated that participants reported improvements in their knowledge of CS content, pedagogy, and technology. They also applied new learning into their practice, though implementation varied among participants. Responding on the value of the professional development design features, teachers noted the importance of focusing on CS content knowledge as well as opportunities to engage with pedagogical practices for teaching computing. Findings also indicated the important role of contextualized follow-up classroom support in the implementation of new learning into practice. These findings have implications for the design of professional development programs grounded in best practices with the potential to support broad efforts intended to prepare teachers with the knowledge and skills needed to deliver CS education.

Effect of 1 Week Coherent Breathing Exercise Training on Cardiorespiratory Fitness in Healthy Young Adults: An Experimental Study

Background: CRF indicates the ability of the circulatory, respiratory and muscular systems to supply oxygen to body during sustained physical activity. Changes in physical activity levels results in changes in CRF. CRF includes the oxygen uptake, PR, RR, BP and exercise capacity. To improve CRF coherent breathing training can be performed because it has an effect on cardiovascular health. Coherent breathing exercise produce different types of physiological responses in healthy individuals. But to the best of my knowledge there is scarcity of literature which determines the material. Aim & Objective: Aim of the study is to assess the effect of 1week coherent breathing training on pulse rate, respiratory rate, vo2 max, FVC and Borg scale of perceived rate of exertion in healthy individual. Material and Methods: An experimental study was conducted among 45 healthy young adults. Participants were included in study who were able to complete queen’s college step test. All the subjects have performed coherent breathing training for a 1 week. Pre and post data were collected. The total duration of training was 30 minutes per day. Results: Results of the study showed that mean value of the PR 82.84 ± 14.41, RR 19.73 ± 3.94, oxygen uptake capacity 47.69 ± 9.26, and FVC 1.95 ± 0.54 and perceive rate of expectation 2.99 ± 1.52. The study also showed that coherent breathing training had positive effect on CRF. Conclusion: The study demonstrate that coherent breathing training is effective in improving CRF.

Effectiveness of Pursed Lip Breathing Exercise in Covid Patients

Background- Urgent threat to global health occurred in the form of Novel Corona Virus. This virus is considered to be highly contagious Respiratory Disease which leads to severe effect on physical, cardiopulmonary and psychological activities. Physiotherapists are considered highly beneficial in treating respiratory complication and physical deconditioning. Respiratory Interventions for COVID pneumonia usually involve Active Cycle of Breathing technique, Relaxation Breathing technique, Huffing Coughing technique, resistive aerobic training, Incentive Spirometry. Method- 25 patients of age group 10-75 years, with active COVID-19 infection were taken with CTSS 7/25-20/25. The patients were administered pursed lip breathing exercise 15 repetitions per set, 3sets, 3 times a day, for 10 days. Outcome measures were evaluated with BORG Scale and Respiratory Rate before and after treatment.Result-Result of this study were analysed in terms of reduced RR and BORG Score. The pre and post data comparison was done using paired‘t’ test for RR and BORG Score. This showed extremely significant improvement in RR and BORG Score post-treatment.Conclusion-As a result, we conclude that Pursed Lip Breathing Exercise is effective in improving RR and reducing dyspnoea in COVID patients

Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data.

Background and purposePoor quality radiotherapy can detrimentally affect outcomes in clinical trials. Our purpose was to explore the potential of knowledge-based planning (KBP) for quality assurance (QA) in clinical trials.Materials and methodsUsing 30 in-house post-prostatectomy radiation treatment (PPRT) plans, an iterative KBP model was created according to the multicentre clinical trial protocol, delivering 64 Gy in 32 fractions. KBP was used to replan 137 plans. The KB (knowledge based) plans were evaluated for their ability to fulfil the trial constraints and were compared against their corresponding original treatment plans (OTP). A second analysis between only the 72 inversely planned OTPs (IP-OTPs) and their corresponding KB plans was performed.ResultsAll dose constraints were met in 100% of KB plans versus 69% of OTPs. KB plans demonstrated significantly less variation in PTV coverage (Mean dose range: KB plans 64.1 Gy-65.1 Gy vs OTP 63.1 Gy-67.3 Gy, p < 0.01). KBP resulted in significantly lower doses to OARs. Rectal V60Gy and V40Gy were 17.7% vs 27.7% (p < 0.01) and 40.5% vs 53.9% (p < 0.01) for KB plans and OTP respectively. Left femoral head (FH) V45Gy and V35Gy were 0.4% vs 7.4% (p < 0.01) and 7.9% vs 34.9% (p < 0.01) respectively. In the second analysis plan improvements were maintained.ConclusionsKBP created high quality PPRT plans using the data from a multicentre clinical trial in a single optimisation. It is a powerful tool for utilisation in clinical trials for patient specific QA, to reduce dose to surrounding OARs and variations in plan quality which could impact on clinical trial outcomes.

Investigation of physical activity, sleep, and mental health recovery in treatment resistant depression (TRD) patients receiving repetitive transcranial magnetic stimulation (rTMS) treatment.

Repetitive transcranial magnetic stimulation (rTMS) is effective in treating depression; however, the effect on physical activity, sleep and recovery is unclear. This study investigated rTMS effect on physical activity and sleep through providing patients with a Fitbit and software apps; and reports the impact of rTMS on depression, anxiety and mental health recovery. Study design was a pre and post data collection without a control, with twenty-four participants with treatment-resistant depression (TRD). Measures used were Fitbit activity and sleep data, and patient-rated Recovering Quality of Life (ReQoL-20), Patient Health Questionnaire (PHQ-9) and Generalised Anxiety Disorder (GAD-7). Response and remission rates were, respectively: 34.8% and 39% for PHQ-9; 34.8% and 47.8% for GAD-7. ReQoL-20 response and reliable improvement were 29.4% and 53%. PHQ-9, GAD-7 and ReQol-20 scores significantly improved, with large effect sizes. Analysis of Fitbit activity and sleep data yielded non-significant results. The Fitbit data machine learning model classified two levels of depression to 82% accuracy. rTMS treatment was open-label and adjunct to existing antidepressant medication. No control group. Female patients were overrepresented. Improvements on the ReQoL-20 and aspects of sleep and activity indicate the positive impact of rTMS on the individual's real world functioning and quality of life. A wearable activity tracker can provide feedback to patients and clinicians on sleep, physical activity and depression levels. Further research could be undertaken through a sufficiently powered RCT comparing rTMS versus rTMS with use of a Fitbit, its software applications, and sleep and physical activity advice.

Evaluating the impact of a Risk Evaluation and Mitigation Strategy with tolvaptan to monitor liver safety in patients with autosomal dominant polycystic kidney disease.

On approval of JYNARQUE (tolvaptan) for use in patients with autosomal dominant polycystic kidney disease (ADPKD) at risk for rapid progression, the US Food and Drug Administration required a Risk Evaluation and Mitigation Strategy (REMS) from the sponsor, which includes collection of post marketing liver safety data. This is a retrospective interim analysis of the ongoing REMS. The period evaluated was from REMS implementation (14 May 2018) at tolvaptan commercialization to the analysis cutoff date (23 February 2021). Patients were previously tolvaptan-naïve and initiated tolvaptan in the post marketing setting. Reports of possible severe drug-induced liver injury (DILI) were evaluated for severity based on the evidence obtained (e.g. liver enzyme levels, symptoms, diagnostic tests and event outcomes). The incidence of DILI was compared between the REMS and tolvaptan clinical trials in ADPKD. Among 6711 REMS patients, 60 (0.9%) cases of possible severe DILI were reported, 4 of which were confirmed as serious and potentially fatal by the sponsor. One of these four patients met Hy's law criteria. In all four patients, liver enzymes normalized after tolvaptan discontinuation. The duration of tolvaptan exposure in the REMS is currently shorter than in completed clinical trials, but within this limitation, the incidence of possible severe DILI was lower in the REMS than in clinical trials (incidence rate ratio 0.587; P = .000411). In interim data on >6000 tolvaptan REMS patients, <1% experienced possible severe DILI. Monthly monitoring, as described in the tolvaptan prescribing information, enables the prompt detection of liver enzyme abnormalities and appropriate drug discontinuation.

Effect of Nordic Hamstring Curl Exercise to Prevent Hamstring Injury in Sprinters

Background: Hamstring strain injuries comprise a substantial percentage of acute musculoskeletal injuries. Nordic hamstring curl may effective in reducing the risk of Hamstring Strain Injury. High-speed running is generally occurring of hamstring strain injuries. FASH may help in prevention of hamstring injury Aim: The aim of the study is to find out the effect of Nordic hamstring curl exercise in Sprinters, as these are the muscles mainly getting affected and resulting in improper movements and gait pattern. Objective: To improve the functional activities of the participant. And to find out the effect of Nordic hamstring curl exercise in Sprinters. To increase the functional measures of the participants Method: In a10 week intervention study 30 participants with hamstring injury were studied they were participated in a group by convenience sampling, pre and post data was collected and analyzed using SPSS 22.0 paired t-test were used to find out the significance of the treatment. Results: A significant prevention in injury (p&lt;0.05) after the treatment was found. Conclusions: The study concluded that effect of Nordic hamstring curl exercise is more effective to prevent hamstring injury in sprinters. Keywords: Sprinters, Hamstring injury, FASH, NHC, gait.

Effectiveness of Plyometric Exercises to Improve Speed and Agility in Young Beginner Swimmers: A Randomized Control Trial

Background: Swimming is a great sport enjoyed by all age group at all level of ability that combines upper and lower limb strength. It could be a recreational and extremely competitive sport which requires a high level of training and performance. There is various power and stamina based exercise in order to increase performance of athlete as per their physical properties. Plyometric exercise, as it is a type of exercise which helps work every muscle of an athlete used as an effective method in increasing power and speed capacity of athlete. It involves quick, explosive movement designed to increase speed, agility, balance, co-ordination and power. Objective: The aim of the study is to analyze the effects of plyometric exercises to get better speed and agility improvement in young beginner swimmers. Study design: A randomized controlled trial Methods: In a 6-week study, 30 young beginner male swimmers were studied. They were divided into 2 groups by a simple random sampling (Lottery method); Group A: Plyometric exercise program and Group B: Control. Pre and post treatment data was collected and analyzed using SPSS 22.0. Paired and unpaired t test were used to find out the significance of the treatment. Results: A significant improvement in Speed and Agility (p&lt;0.05) after the treatment were found. Greater statistical significant improvement was seen in Group A as compared to Group B. Conclusion: The study concluded that Plyometric exercises are effective to improve speed and agility in young beginner swimmers. Keywords: Plyometric, Speed, Agility, Swimming, Beginners.

EFFECTIVENESS OF CONVENTIONAL THERAPY ON GOLDSMITH WORKERS WITH NECK PAIN– AN EXPERIMENTAL STUDY

Goldsmith workers are used to work for long time with cross legged posture, they may lead to develop different kinds of musculoskeletal disorder among them. The study aimed to nd the effectiveness of conventional therapy on Gol AIM: - Objective: dsmith workers with neck pain. To provide benets and improve the working pattern, ergonomics, strength, posture and overall condition of Goldsmith workers. An Study Design: - Experimental In 4 weeks of intervention; 30participants with features of neck pai Methods:- n were studied. They will be collected by Study convenience sampling. They were received conventional exercises program. The outcome was measured using the Numerical Pain rating scale (NPRS) &amp; the Neck Disability index (NDI). Pre and post data were collected and analyzed using SPSS 22.0. Paired t - test was used to nd out the signicance of the treatment. A signicant improvement in pain &amp; disabil Result: - ity (p&lt;0.05) after the treatment was found. Greater statistically signicant improvement was seen in all the participants. The study concl Conclusion:- ude that conventional exercises program was more effective in treating neck pain on Goldsmith Workers.

EFFECT OF CLAY THERAPY AND FREE EXERCISE FOR REDUCTION OF ANXIETY IN GERIATRICS- AN EXPERIMENTAL STUDY

Geriatic medicine is a specially categorized that focuses on health care of elderly people. It helps in preventing and treating diseases and disabilities in older adults. Nowadays, anxiety, depression and stress are very common in adults and in geriatrics. Anxiety is one type of felling of uneasiness and worry, which is generalized as an overreaction to any situation. Anxiety is closely related to fear which is response to a real or immediate situation. Clay is a very known material known from prehistoric time in forms such as vases, pots and symbolic gure. Clay therapy involves an intense and powerful tactile experience of touching. Clay therapy having evidence of reduction of anxiety and gave benecial result and free exercise also having evidence of reduction of anxiety .Combination of these two treatment gives remarkable result on reduction of anxiety in geriatric people. The aim of study is to reduce anxiety in old AIM: OBJECTIVE: age people. The objective of the study is to educate the patient about anxiety and to nd out whether clay therapy and free exercise are effective in reduction of anxiety in geriatric. An STUDY DESIGN: Experimental Study in highlight In 6 weeks of intervention; 30 participants with fe METHODS: atures of anxiety were studied. They will be collected by convenience sampling. Pre and post data is collected and analyzed using SPSS 26.0. A signicant improvement is seen in RESULTS: anxiety (p‹0.05) after the treatment was found. Greater statistical signicant improvement was seen in geriatic. The study CONCLUSION: concluded that clay therapy and free exercise is effective in reduction of anxiety for geriatric.

EFFECTIVENESS OF MUSIC THERAPY ALONG WITH PHYSIO -THERAPY TO IMPROVE GROSS MOTOR FUNCTION AND BEHAVIOUR IN SPASTIC CEREBRAL PALSY

Background: Cerebral palsy affects approximately 1 out of 500 new-born s, with an estimated prevalence of 17 million people worldwide, which establishes it as the most common motor disability during childhood. There are different therapeutic strategies such as physiotherapy and music therapy for the treatment of cerebral palsy. Intervention protocols using both therapies to unify the measurement of motor function have not been investigated. AIM &amp; OBJECTIVES: AIM: The aim of the study is to nd out the Effectiveness of music therapy to improve gross motor function and behavior in cerebral palsy children as these mainly lead more participation and restriction for patient and as well as family. OBJECTIVES: 1.The main objective is to improve the functional activities of the patient. Therefore, this study focuses on to nd out the effect of music therapy to improve gross motor function 2.Study improve behavior in cerebral palsy children and increase independent measure of the patient. Methods: In a 6-week intervention study, 30 participants with features of spastic cerebral palsy studied. Pre and post treatment data was collected and analyzed using gross motor function measures were used to nd out the signicance of the treatment. Result: The data was analyzed using SPSS version 22.0. Parametric test was used within the group analysis. AGreater signicant improvement in sensory &amp; motor function was found after 6 weeks. Conclusion: In the experimental condition used in the study, both the groups showed signicant improvement in strength and gross motor function. The use of music therapy with conventional therapy (GROUP B) evidenced a signicant greater improvement in behavior and gross motor function when compared to conventional therapy (GROUPA).

Effect of Hydrogen Pressure on the Intrinsic Kinetics of Hydrogen Evolution Reaction at Pt(111) Electrode

Many kinetic studies on hydrogen evolution reaction (HER) were done in N2 saturated solutions in order to avoid possible H2 leakage, which results in a variation of H2 concentration at the electrode/electrolyte interface (). It will induce the drift of equilibrium potential (Eeq) and applied activation overpotential (η act) for HER. Consequently, it may result in errors for estimating the kinetic parameters for HER. By taking HER at Pt(111) under RDE configuration as a model reaction, quantitative relation among and the reaction current density (j) is established based on the mass transport equations. From the j–η act plots, our results reveal that i) with the increase of HER current, the equivalent increases, which accompanies with a drift of thermodynamic equilibrium potential (Eeq) for HER decreases; ii) when η act is negative of −50 mV, the j–η act plot for HER is the same in N2 and H2 saturated solution, with a slope of 30 mV Dec−1; Our results suggest that HER activity should be compared in solutions with the same composition and at the same activation overpotential instead of at the same applied potential. Proper experimental methods for post data analysis are proposed in order to derive the intrinsic HER kinetics.

Analisis Perbedaan Tingkat Online Engagement Antara Tipe Dan Waktu Post Pada Akun Instagram Klien Kenalkan.Co Di Samarinda

Companies can use social media, Instagram to interact and share information. This study aims to determine how post type and time post have effect on online engagement and as a recommendation for managing posts to increase online engagement. This research uses post data from December 2018 to November 2019 on Kenalkan.co client's. The hypothesis was tested using comparison test. The result is type post has significant effect on likes and does’nt have a significant effect on comments. Month post has a significant influence on online engagement. Days post does’nt have a significant effect on online engagement.

Tracing the invisible rich: A new approach to modelling Pareto tails in survey data

This paper is concerned with the problem of modelling the tail of the wealth distribution with survey data when the data does not adequately cover the tail of the distribution. In order to deal with the problem post data collection, it is standard practice to either fit a Pareto tail to the data or to combine wealth survey data with observations from rich lists before fitting such a Pareto tail. This paper proposes a novel approach (‘rank correction’) to address such cases which does not require additional data-sources. Applying the rank correction approach to wealth survey data (HFCS, SCF, WAS) yields estimates of top wealth shares, which are closely in line with estimates from the World Inequality Database and therefore represent a significant improvement over the raw survey data. While the paper focuses on the distribution of wealth as a case in point the rank correction approach might generally prove useful in contexts, where the tail of a Pareto-distributed variable is not adequately covered by the available data.

MPD: Introduction of a single player prisoner's dilemma application for medical experiments

BackgroundPrisoner's dilemma is one of the most popular concepts among scientific literature. In medical literature the majority of prisoner's dilemma experiments with human participants implement computerized means. Despite this, there is no shared validated tool for prisoner's dilemma tasks. MethodsThe application is developed in Javascript programming language and makes use of the pixijs library for WebGL rendering. To create a custom trial, a set of variables have to be set. These refer to the linguistics, user controls, available choices, computer strategy, interaction flow (simultaneous or sequential), opponent's choice prediction requirement, noise induction, human opponent behavior simulation, the way resulted data will be handled and more. Results are in JSON format and include time interval data. ResultsWe have developed an application which, given the various parameters experimenter can modify, is able to simulate a large number of single player prisoner's dilemma versions. It is open source with no installation requirement, executable by any modern internet browser remotely or locally with the ability to post data results either locally or remotely. Experimenter only has to modify certain starting values in order to create his design of choice. Two examples are included, with initial settings and results, to demonstrate the use and validity of the application. ConclusionsOur aim is to assist future researchers in their methodological designs. In this scope, our application, has the minimum requirements, can be served either locally or remotely, has a wide range of modifiable parameters and takes care of the resulted data. In the long term, a shared and validated tool would contribute to increasing methodologies’ credibility and mitigating cross-validation discrepancies.

COVID-19: Physical Activity and Quality of Life in a Sample of Swiss School Children during and after the First Stay-at-Home.

COVID-19 restrictions and the instructions to stay at home (SaH) may have had an impact on child behavior including physical activity (PA) and health-related quality of life (HRQoL) in Switzerland. Therefore, we investigated PA and HRQoL during and after the SaH in 57 Swiss school children aged 7 to 12 years (M = 10.44; SD = 1.34). PA was measured using accelerometry (Actigraph GT3X) and HRQoL using the Kid-KINDLR questionnaire. During and post data was compared using paired sample t-tests. Independent t-tests were used to compare the HRQoL of physically active children with non-physically active children. PA in light (d = −0.56), moderate (d = −0.44), moderate-to-vigorous (d = −0.28) as well as overall HRQoL (d = −0.66), psychological well-being (d = −0.48), self-esteem (d = −0.39), friends (d = −0.70) and everyday functioning (d = −0.44), were significantly lower during SaH than afterwards. Children who adhered to PA recommendations (+60 min of moderate-to-vigorous PA) during SaH had a better overall HRQoL (d = 0.61) and psychological well-being (d = 0.56) than those who did not. Since PA levels and HRQoL were lower during SaH compared to afterwards, it seems that the restrictions negatively impacted children’s PA and HRQoL. During future SaHs, promoting children’s PA and HRQoL seems important.

Adsorptive performance of a synthesized Mg-Al Hydrotalcite compound for removal of malachite green: kinetic, isotherm, thermodynamic, and mechanism study

ABSTRACT The use of new synthetised materials as adsorbents for wastewater disposal is gaining importance due to their outstanding advantages. A Hydrotalcite-like compound Mg-Al-CO3 (HT2) with a molar ratio of Mg/Al = 2 was synthesised by the constant pH co-precipitation procedure and then characterised by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and volumetric analysis (BET). The adsorption capacity of the solid was estimated against a textile dye such as malachite green (MG). Approximately 98% MG (5.10−5M) was adsorbed onto 100 mg of Hydrotalcite in 60 min. The effect of MG concentration, the influences of pH, and contact time on adsorption, studied by a factor-by-factor approach, revealed that adsorption was influenced by all factors. A maximum adsorption of 98 ± 0.51% was achieved at 46 mg L−1 MG, 100 mg Hydrotalcite, 400 rpm in 60 min with a maximum adsorption capacity of 14 mg g−1. The nonlinear form of the kinetic and isothermal models was used to verify the experimental data. According to the error of the calculated values of R2 (Coefficient of determination), χ2 (Chi-square) and standard deviation (Δq (%)), it was found that the form of the second-order kinetic model and Langmuir isotherm model are the most suitable for the experimental data of HT2. However, thermodynamic studies and post adsorption characterisation data show that the adsorption of MG dye on Hydrotalcite is a spontaneous and endothermic physical process.

Efficacy of Ferulic Acid Peel as a Monotherapy for Photoaging.

Objectives: Chemical peels are used to treat photoaging and skin discoloration. Ferulic peel is a non-exfoliating peel having antioxidant properties. The aim of this study is to validate the efficacy of ferulic acid peel as a monotherapy for photoaging. It is a technique-sensitive procedure, and injury must be in a proper tissue plane to achieve the desired results. Materials and Methods: This is a prospective study from Feb 2018 to Feb 2020 in which 55 patients were treated with Ferulic acid peel 12 % (hydro alcohol base) with L-ascorbic acid 15% as a monotherapy. The patients were followed up for 6 months. Data were summarised in Mean ± SD. Pre and post data were compared by paired t test. A two-tailed (α=2) p&lt;0.05 was considered statistically significant. Two scales were used for assessing the results; Allergan Skin Roughness Scale (ASRS) and Allergan Fine Line Scale (AFLS). Results: The scores were assessed at pre-treatment (pre) and post treatment (post). The results achieved were highly satisfactory as measured using the ASRS and AFLS Scale with p-value &lt;0.001(statistically significant). No complications were observed in our study. Conclusion: Ferulic Peel with L-Ascorbic Acid is very useful as a monotherapy in Photoaging cases; initial results of our six-month follow-up study have yielded promising results.

Metabolic Changes In Living Kidney Donors After Donation In University Malaya Medical Centre

The short- and long-term outcome of donations from living donors of kidneys (LKDs) remains controversial. Information regarding metabolic changes after donation in Malaysia remains limited despite Malaysia having the highest record prevalence of diabetes, obesity, and hypertension in Asia. There were 159 LKDs in our center from 2010 to 2020. We analyzed pre and post donation clinical data and laboratory results from 140 LKDs, retrospectively, from electronic medical records and looked for any metabolic changes. Among these 140 LKDs, 99 were women (70.7%), with a mean age of 47.23 ± 11.67 before donation. The median follow-up was 4 years (range, 2-6 years). Median body mass index increased from 24.35 kg/m2 (range, 22.11-26.93) to 25.56 kg/m2 (range, 22.78-28.57; Z=-3.934, P=.000) after donation. Prevalence of obesity increased from 24.18% to 30.77%. Only 2.8% of LKDs developed proteinuria postnephrectomy (P=.250). Serum creatinine increased from 60 mmol/L (range, 52-74) to 87 mmol/L (range, 74-108) 1 year after donation (P=.000), and the latest results decrease to 83 mmol/L (range, 73-101; P=.000). Systolic blood pressure increased from 127.83 ± 12.25 mm Hg to 131.30 ± 18.16 mm Hg, (t[97]=-2.012; P=.047); and prevalence of hypertension increased from 19.81% to 23.58% (P=.125), with 22.64% requiring treatment. We noted that 22.54% of the LKDs had dyslipidemia before donation, a number that increased to 50% after donation (P=.000). LKDs with hyperuricemia increased significantly from 7.92% to 34.65%, with uric acid level increasing from 311.94 ± 78.51umol/L to 381.87 ± 86.96 umol/L (t[94]=-10.805; P=.000). Fasting blood glucose and glycated hemoglobin level recorded no significant changes after donation. Post donation kidney function of LKDs compensated well and stable in short term. We noted statistically significant increment of weight, post donation body mass index, systolic blood pressure, uric acid, and lipids. We suggest prospective studies with longer follow-up and more subjects for clinical correlation.