Alternative Possibilities Research Articles

Does moral valence influence the construal of alternative possibilities?

It is often thought that an agent may be held morally responsible for bringing about a negative outcome only if they could have done otherwise. Inspired by previous research linking moral judgment to free will ascriptions and representations of possibility, we probe the reverse link: Does learning about a morally undesirable outcome make preferable alternatives appear more possible? We find modest evidence that this could be the case. In a preregistered experiment, we presented 317 participants with animated footage of a traffic accident in which two bystanders fail to intervene as a third person gets run over by bus, and manipulated whether the victim was evil, virtuous, or neutral. Judging from the same visual input, people indicate that saving an evil victim would have been slightly less possible than saving a virtuous or neutral victim, and arriving at the conclusion that it would have been possible demanded more time. Using drift-diffusion modeling to better understand the underlying cognitive processes, we found that participants were biased against counterfactual attempts to save the evil victim’s life, but then gathered evidence toward their decisions at the same rate regardless of the victim’s morality.

Reframing the public/private debate on healthcare services: Tracking boundaries in the National Health Service.

This paper intervenes in the dichotomous debate on the 'privatisation' of the UK's National Health Service (NHS). Whilst research suggests that involving private-sector actors and principles deviates from the founding aims of the NHS to deliver equitable healthcare for all, the opposing argument to 'keep our NHS public' also limits understanding and alternative possibilities. Through focusing on maintaining overarching structures, these campaigns fail to address everyday medical practices that have long been critiqued by those allied with the sociology of health and illness. This paper draws on feminist critiques of public/private to expand the structural economic lens of mainstream political debates and explore how multiple forms of economic, social, cultural, and symbolic capital, operate in everyday healthcare practices. Through an historically-informed ethnographic exploration of routine hip replacements, I find that capital itself emerges through relations between people and things, and that public/private boundaries play an integral role in forming these relations to instil value on particular patients and forms of labour, demarcating what kind of healthcare is given to whom. I therefore suggest future action should focus on assembling healthcare relations beyond the dualism of public/private categories, to create multiple safe places and relations for all.

Peasant Agency and Community Mutual Aid: An Alternative to Capital and Market Dominance

Abstract Formalist legal and economic theories axiomatically assume the “rational economic man” and the “inevitable optimal resource allocation by perfectly competitive markets,” thereby justifying the ownership of corporate entities by the holders of capital assets. Professional cooperatives, guided by this formalist logic, predominantly serve the interests of capitalized large-scale peasants. In contrast, the organizational practices from mutual aid to comprehensive cooperation during the Chinese revolutionary period reveal an alternative possibility diverging from formalist logic. This alternative centers on community-based rationality of small-scale peasant households, promoting agricultural development by enhancing resource use efficiency through community mutual aid among smallholders to meet their collective production and living needs. This substantivist logic, grounded in mutual aid practices, can also provide direction for integrating small-scale peasant households into large markets in the contemporary context.

Utilizing Integrated UHPLC-Q-Exactive Orbitrap-MS, Multivariate Analysis, and Bioactive Evaluation to Distinguish between Wild and Cultivated Niudali (Millettia speciosa Champ.).

Millettia speciosa Champ. (MSCP) enjoys widespread recognition for its culinary and medicinal attributes. Despite the extensive history of MSCP cultivation, the disparities in quality and bioactivity between wild and cultivated varieties have remained unexplored. In this study, 20 wild and cultivated MSCP samples were collected from different regions in China. We embarked on a comprehensive investigation of the chemical constituents found in both wild and cultivated MSCP utilizing UHPLC-Q-Exactive Orbitrap-MS technology and multivariate analysis such as principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). In total, 62 chemical components were unequivocally identified or tentatively characterized. Via the multivariate statistical analysis, we successfully pinpointed nine compounds with the potential to serve as chemical markers, enabling the differentiation between wild and cultivated MSCP varieties. Moreover, both genotypes exhibited substantial antioxidant and anti-fatigue properties. The bioactivities of wild MSCP were marginally higher when compared to their cultivated counterparts. This study illuminates the impressive antioxidant and anti-fatigue potential present in both wild and cultivated MSCP genotypes, further augmenting the allure of this species and opening new avenues for the economic valorization of MSCP. Hence, this study provides a valuable method for the identification and quality control of MSCP and a method in chemistry and pharmacology to assess an alternative possibility for cultivated MSCP.

Synergistic-potential engineering enables high-efficiency graphene photodetectors for near- to mid-infrared light

High quantum efficiency and wide-band detection capability are the major thrusts of infrared sensing technology. However, bulk materials with high efficiency have consistently encountered challenges in integration and operational complexity. Meanwhile, two-dimensional (2D) semimetal materials with unique zero-bandgap structures are constrained by the bottleneck of intrinsic quantum efficiency. Here, we report a near-mid infrared ultra-miniaturized graphene photodetector with configurable 2D potential well. The 2D potential well constructed by dielectric structures can spatially (laterally and vertically) produce a strong trapping force on the photogenerated carriers in graphene and inhibit their recombination, thereby improving the external quantum efficiency (EQE) and photogain of the device with wavelength-immunity, which enable a high responsivity of 0.2 A/W–38 A/W across a broad infrared detection band from 1.55 to 11 µm. Thereafter, a room-temperature detectivity approaching 1 × 109 cm Hz1/2 W−1 is obtained under blackbody radiation. Furthermore, a synergistic effect of electric and light field in the 2D potential well enables high-efficiency polarization-sensitive detection at tunable wavelengths. Our strategy opens up alternative possibilities for easy fabrication, high-performance and multifunctional infrared photodetectors.

Natural Gas Matters: LNG and India’s Quest for Clean Energy

India, the world’s most populous country, is the world’s third-largest emitter of greenhouse gases (GHGs). Despite employing several energy sources, it still relies heavily on coal, its primary energy source. Given India’s swiftly rising energy demand, this challenges meeting emission reduction targets. In recent years, India has significantly increased investments in renewables like solar and hydrogen. While commendable, these initiatives alone cannot meet the country’s expanding energy demands. In the short term, India must rely on both domestic and imported fossil fuels, with natural gas being the most environmentally friendly option. In this context, this paper attempts to forecast energy consumption, natural gas production, and consumption in India until 2050, using both univariate and multivariate forecasting methods. For multivariate forecasting, we have assumed two alternative possibilities for GDP growth: the business-as-usual and the high-growth scenarios. Each of our forecasts indicates a notable shortfall in the projected production of natural gas compared to the expected demand, implying our results are robust. Our model predicts that nearly 30–50 percent of India’s natural gas consumption will be met by imports, mainly in the form of LNG. Based on these findings, this paper recommends that Indian government policies emphasize increasing domestic natural gas production, importing LNG, and expanding renewable energy resources.

Control of successive unequal cell divisions by neural cell fate regulators determines embryonic neuroblast cell size.

Asymmetric cell divisions often generate daughter cells of unequal size in addition to different fates. In some contexts, daughter cell size asymmetry is thought to be a key input to specific binary cell fate decisions. An alternative possibility is that unequal division is a mechanism by which a variety of cells of different sizes are generated during embryonic development. We show here that two unequal cell divisions precede neuroblast formation in the C lineage of Caenorhabditis elegans. The equalisation of these divisions in a pig-1/MELK mutant background has little effect on neuroblast specification. Instead, we demonstrate that let-19/MDT13 is a regulator of the proneural basic helix-loop-helix transcription factor hlh-14/ASCL1 and find that both are required to concomitantly regulate the acquisition of neuroblast identity and neuroblast cell size. Thus, embryonic neuroblast cell size in this lineage is progressively regulated in parallel with identity by key neural cell fate regulators. We propose that key cell fate determinants have a previously unappreciated function in regulating unequal cleavage, and therefore cell size, of the progenitor cells whose daughter cell fates they then go on to specify.

“If You Say You Believe This, Then Why Did You Vote Like That?”: Reasoning as Questioning in Dialogue

AbstractThis article draws on the philosophical work on dialogic rationality offered by Charles Taylor as well as qualitative studies of dialogues between politically opposed college students to argue that these conversations succeed as tools of democracy precisely because they fail as interventions. That is, the democratic strength of such dialogue is the way in which it is unreliable as a means of producing particular outcomes. Students whose political views eventually shifted partly in response to dialogue understood this not as a process of changing their commitments, but rather of finding a better expression for the commitments they already held. But the interviews show, too, just how rare it is for such shifts to occur at all, at least for these students in a period of political polarization and mutual distrust. The interviews suggest as well that the appeal to already shared ground is not the whole story of what prompts people to change their minds in these kinds of conversations. Rather the asking of direct but respectful questions was a crucial ingredient. Finally, dialogue did not independently cause the most profound changes in political views. Instead, it was the direction of students' lives that over time shifted their outlook. Their dialogue experience then gained meaning in retrospect, as the beginning of a process of self‐questioning that was brought to fruition only later, as a first time that they had heard alternative possibilities for how value commitments can be expressed through politics.

Nurturing youth film literacy: Post-qualitative arts-based inquiry into critical self-awareness

Post-digital, as a timeframe set, raises specific concerns for young adults engaged in artistic and cultural activities, seeking to establish a sustainable livelihood within a semi-rural South African context. They grapple with issues such as determining their positionality within a world marked by fading boundaries between the physical and digital. To better understand the post-digital impact on experiential learning opportunities for young adults, the authors explored the specific ways and extent to which active engagement in shortfilm-making contributes to developing critical self-awareness among the participating post-school youth. An assemblage of transformative theories and concepts, rather than pre-determined methodologies, guided this inquiry that extended beyond the development of career and workplace competencies. The strengths of spaciousness and in-between boundary positions provided by the spider’s thread metaphor served as a useful methodological tool. Moving beyond the limitations of traditional discourse and content analysis, multimodal discourse analysis in combination with a modified, six-category measuring instrument was used to explore (analyse) the evidence (data) created as products of active participant engagement in a shortfilm-making project, over a 10-month period in 2020. Findings revealed that, for the participants, it was by moving from physical self-centred understandings of reality to experiential creations of authentic reality (shortfilm-productions) and involving an expanded awareness of those alternative possibilities that nurtured their potential transpersonal growth.Transdisciplinary Contribution: A synthesis of arts-based, post-qualitative and developmental phenomenographic approaches was employed to create, explore and communicate evidence in ways that present a holistic picture of alternative pathways to knowledge production.

Antibacterial effect of eucalyptus (Melaleuca leucadendra) ecoenzyme produced by Lamongan’s MSMEs against Salmonella Typhi

Typhoid fever is a disease with extensive epidemiological distribution, causing high morbidity and mortality. The lack of effectiveness in prevention and treatment contributes to its continued mass occurrence. Salmonella Typhi bacteria are the main etiological cause of typhoid fever and have demonstrated resistance to various typhoidal antibiotics. This study aims to explore alternative possibilities for these issues, both curatively and preventively. Eucalyptus (Melaleuca leucadendra) is known to contain numerous antibacterial compounds, with 1.8 cineole as the main antibacterial compound. This compound exerts antibacterial effects by disrupting bacterial cell membranes and walls. Ecoenzyme are also recognized for their antibacterial effects, containing antibacterial compounds such as acetic acid, citric acid, lipase enzyme, trypsin enzyme, and amylase enzymes. This research is a laboratory experimental study conducted using the agar-well diffusion method on Mueller Hinton agar media, with the diameter of the inhibition zone as the test result. The findings indicate that all tested concentrations of eucalyptus ecoenzyme (10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%) show no inhibitory zone in all three test replications. This result suggests that eucalyptus (Melaleuca leucadendra) ecoenzyme produced by Lamongan’s MSMEs does not exhibit antibacterial effects on Salmonella Typhi.

Osteosclerotic disease and bone cyst in a prehispanic burial from Las Cañadas del Teide (Tenerife, Canary Islands).

Skeletal remains of two prehispanic male adult individuals (antiquity ≈ 550 BP) recovered from a burial cave located in Montaña Blanca (Las Cañadas del Teide) at an altitude of 2450 m above sea level, in the highlands of Tenerife (Canary Islands) showed some unusual features. Femora and tibiae of both individuals showed increased bone density, with irregular thickening of the midshaft diaphyses. One individual showed a cystic lesion in the distal third of the left femoral diaphysis, surrounded by a subtle sclerotic reaction of the spongiosa and a thin cortex that was partially fractured. Periosteal thickening was present, but not around the cystic lesion. A thoracic vertebra with rachischisis was also recovered. The bone density of vertebrae and iliac bones were normal, and one recovered jaw was also normal. The tibiae of one individual showed an abnormal location of the foramen nutritium. Hypoplasia of the lesser trochanter and an abnormally thin left femoral neck were also observed. It is possible that both individuals were affected by diaphyseal dysplasia (possibly Camurati Engelmann or Ribbing disease). One of them also showed a lesion compatible with a unicameral bone cyst. The alternative possibility of a Klippel-Trenaunay-Weber disease, with a bone aneurysmal cyst, also exists.

Cell shape and orientation control galvanotactic accuracy.

Eukaryotic cells sense and follow electric fields during wound healing and embryogenesis - this is called galvanotaxis. Galvanotaxis is believed to be driven by the redistribution of "sensors" - potentially transmembrane proteins or other molecules - through electrophoresis and electroosmosis. Here, we update our previous model of the limits of galvanotaxis due to the stochasticity of sensor movements to account for cell shape and orientation. Computing the Fisher information shows that, in principle, cells have more information about the electric field direction when their long axis is parallel to the field. However, for weak fields, maximum-likelihood estimators may have lower variability when the cell's long axis is perpendicular to the field. In an alternate possibility, we find that if cells instead estimate the field direction by taking the average of all the sensor locations as its directional cue ("vector sum"), this introduces a bias towards the short axis, an effect not present for isotropic cells. We also explore the possibility that cell elongation arises downstream of sensor redistribution. We argue that if sensors migrate to the cell's rear, the cell will tend to expand perpendicular the field - as is more commonly observed - but if sensors migrate to the front, the cell will tend to elongate parallel to the field.

Observation of spin-splitting energies on sp-d exchange interactions tailored in colloidal CdSe/CdMnS core/shell nanoplatelets: an atomistic tight-binding model.

Using the atomistic tight-binding model plus sp-d exchange term, the embedding of magnetic ions into CdSe/CdMnS core/shell nanoplatelets (NPLs) at different effective temperatures resulted in sp-d exchange interactions, which in turn cause modifications in electronic and magnetic characteristics. The influence of CdMnS monolayers on single-particle spectra, optical band gaps, wave function overlaps and exciton binding energies is more pronounced than that of the effective temperature. Due to the electron, hole and Zeeman splitting energies, with the growth of CdMnS shell monolayers, electron g-factor values are unchanged, but hole and exciton g-factor values are enhanced. Additionally, all g values decrease with increasing temperature, thus representing decreased magnetization of the paramagnetic system. By changing nanoplatelet architectures and temperatures, manipulation of s-d and p-d exchange interactions is accomplished. Overall, studied materials combine the merits of NPLs and magnetic ions, hence leading to alternate possibilities for active applications in spin-based devices.

Bridging the gap: viable reaction pathways from tetrahedrane to benzyne.

The addition of sp-carbon-containing molecules to polycyclic sp3 tetrahedrane (c-C4H4) results in the formation of both o-benzyne (c-C6H4) and benzene (c-C6H6). Since both c-C6H4 and c-C6H6 have been detected in the interstellar medium (ISM), providing additional pathways for their possible astrochemical formation mechanisms can lead to the discovery of other molecules, such as c-C4H4, benzvalyne, and vinylidene (:CCH2). Addition of diatomic carbon (C2), the ethynyl radical (C2H), vinylidene, and acetylene (HCCH) to c-C4H4 is undertaken in individual pathways through high-level quantum chemical computations at the CCSD(T)-F12b/cc-pVTZ-F12 level of theory. The resulting C2 addition pathway proceeds barrierlessly through benzvalyne as an intermediate and reaches a true minimum at c-C6H4, but no leaving groups are produced which is required to dissipate excess energy within an interstellar chemical scheme. Similarly, the C2H addition to c-C4H4 produces benzvalyne as well as its related isomers. This pathway allows for the loss of a hydrogen leaving group to dissipate the resulting energy. Lastly, the HCCH and :CCH2 addition pathways follow through both benzvalene and benzvalyne in order to reach c-C6H6 (benzene) and c-C6H4 (o-benzyne) as well as H2 as the required leaving group. Although there is a barrier to the HCCH addition, the :CCH2 addition presents the contrary with only submerged barriers. These proposed mechanisms provide alternative possibilities for the formation of complex organic molecules in space.

Innovative potential of apitechnology development in the modern world

This scientific material shows an alternative possibility of using larval raw materials of bee origin to justify its use in the latest food technology - apitechnology. We have studied all types of larvae of the bee family, however, drone larvae at the age of seven to nine days (until the moment of their sealing) were promising. Further, a paste was prepared from them by grinding to a finely dispersed consistency, sublimation dried in a vacuum environment according to an individually developed technology with the preservation of biologically active substances (beta-carotene, alpha-tocopherol) and biopolymers (proteins, fats, sugars) almost one hundred percent. The resultent powdery form - apiproduct is called BilarAccording to the research results, the following statements can be made: Bilar is a protein product with a mass fraction of protein of more than fifty percent, it contains reducing carbohydrates and high-quality fats. The amino acid composition of the Bilar protein fraction is represented by all essential amino acids. A new scientific result has been obtained namely apitechnology using bee products of larval origin with a high protein content, the technological parameters of growing drone larvae on an industrial scale.

An Alternative Possibility of Digital Transformation for Taiwan’s Traditional Media: The Case of Business Today Magazine

<p>二十一世紀的媒體產業並非處於一個太平盛世，數位化已衝擊傳統媒體生態。本研究以強調紙本價值並採取非主流數位轉型模式的傳統媒體組織《今周刊》為例，以Dąbrowska et al.（2022）三層次的數位轉型模型，分別從鉅觀至微觀角度分析生態、組織、個人等數位轉型的三面向，探究臺灣傳統紙媒在主流數位轉型模式之外的另一可能。本研究發現：一、傳統媒體數位轉型的不同模式，例如：「平網並進」、「紙本先行」模式，和「數位優先」、「中央廚房制」有明顯的差異；二、華人社會企業組織常見「家父長制領導」風格在《今周刊》數位轉型過程中扮演重要角色且有極大的影響；三、《今周刊》強調「紙本優先」的「雙廚房制」模式，重新提醒「紙本媒體」的定位和價值。</p> <p> </p><p>The media industry of the 21st century is not in a period of peace and prosperity. Digitization has already impacted the traditional media ecosystem. This case study focuses on Business Today magazine, a traditional media company that values the importance of print media while adopting an unconventional approach to digital transformation. Using Dąbrowska et al.’s three-level digital transformation model, the study analyzes the three dimensions of digital transformation—ecology, organization, and individual—from a macro to a micro perspective. The study explores an alternative possibility for traditional print media in Taiwan beyond the Western mainstream digital transformation models. The findings of this study are as follows: First, there are significant differences among the various models of digital transformation for traditional media. The “simultaneous development of digital and print media” and “print-first” strategies are distinctly different from the strategies of “digital-first” and “central kitchen system.” Second, the common “paternalistic leadership” organizational style prevalent in Chinese society plays a crucial role and has a significant impact on the digital transformation process of Business Today magazine. Third, Business Today magazine emphasizes the “print-first” and “dual-kitchen” model, reminding people once again of the positioning and value of “print media.”</p> <p> </p>

Violence, Plasticity, and Rhetoric

ABSTRACT Catherine Malabou builds on neuroscience to offer a theory of the plasticity of the brain, arguing that trauma holds transformative potential. This article argues, however, that her theory prioritizes resilience in the face of episodic moments of violence and trauma, which undertheorizes the trauma of chronic conditions experienced by racialized, particularly Black, subjects. Instead, this article turns to Christina Sharpe’s theory of wake work and, more specifically, Black annotation and Black redaction, to demonstrate how, in the wake of transatlantic slavery, there is space for the collective disruption of symbolic structures to generate openings for imagining and circulating alternative possibilities to the hegemonic institutions of the past and present. Contrasting Malabou’s focus on the transformation of the brain during episodic violence and trauma, this article contends that Sharpe may demonstrate the possibility of plasticity in form and the symbolic in quotidian experiences and practices.

Sequence-dependent and -independent information in a combined random energy model for protein folding and coding.

Random energy models (REMs) provide a simple description of the energy landscapes that guide protein folding and evolution. The requirement of a large energy gap between the native structure and unfolded conformations, considered necessary for cooperative, protein-like, folding behavior, indicates that proteins differ markedly from random heteropolymers. It has been suggested, therefore, that natural selection might have acted to choose nonrandom amino acid sequences satisfying this particular condition, implying that a large fraction of possible, unselected random sequences, would not fold to any structure. From an informational perspective, however, this scenario could indicate that protein structures, regarded as messages to be transmitted through a communication channel, would not be efficiently encoded in amino acid sequences, regarded as the communication channel for this transmission, since a large fraction of possible channel states would not be used. Here, we use a combined REM for conformations and sequences, with previously estimated parameters for natural proteins, to explore an alternative possibility in which the appropriate shape of the landscape results mainly from the deviation from randomness of possible native structures instead of sequences. We observe that this situation emerges naturally if the distribution of conformational energies happens to arise from two independent contributions corresponding to sequence-dependent and -independent terms. This construction is consistent with the hypothesis of a protein burial folding code, with native structures being determined by a modest amount of sequence-dependent atomic burial information with sequence-independent constraints imposed by unspecific hydrogen bond formation. More generally, an appropriate combination of sequence-dependent and -independent information accommodates the possibility of an efficient structural encoding with the main physical requirement for folding, providing possible insight not only on the folding process but also on several aspects sequence evolution such as neutral networks, conformational coverage, and de novo gene emergence.

A micropolar model accounting for asymmetric behavior of cold‐box sand in relation to tensile and compression tests

AbstractCold‐box sand (CBS) belongs to the granular materials and consists of sand and a binder. The behavior of CBS is simulated with a micropolar model, whereby the additional degree of freedom of the model describes the rotation of the sand grains. The model is used to generate a shear band under pressure for three different meshes, where the force‐displacement curves of the three meshes converge so that no mesh dependence occurs. Another requirement of the model is the consideration of asymmetric behavior for compression and tension. Due to the additional degree of freedom the implicit implementation of the micropolar continuum is very time‐consuming. Therefore, an explicit implementation is considered as an alternative possibility. This paper compares the advantages and disadvantages of both methods and the results for both calculations.

Actin-binding protein profilin1 is an important determinant of cellular phosphoinositide control

Membrane polyphosphoinositides (PPIs) are lipid-signaling molecules that undergo metabolic turnover and influence a diverse range of cellular functions. PPIs regulate the activity and/or spatial localization of a number of actin-binding proteins (ABPs) through direct interactions; however, it is much less clear whether ABPs could also be an integral part in regulating PPI signaling. In this study, we show that ABP profilin1 (Pfn1) is an important molecular determinant of the cellular content of PI(4,5)P2 (the most abundant PPI in cells). In growth factor (EGF) stimulation setting, Pfn1 depletion does not impact PI(4,5)P2 hydrolysis but enhances plasma membrane (PM) enrichment of PPIs that are produced downstream of activated PI3-kinase, including PI(3,4,5)P3 and PI(3,4)P2, the latter consistent with increased PM recruitment of SH2-containing inositol 5' phosphatase (SHIP2) (a key enzyme for PI(3,4)P2 biosynthesis). Although Pfn1 binds to PPIs invitro, our data suggest that Pfn1's affinity to PPIs and PM presence in actual cells, if at all, is negligible, suggesting that Pfn1 is unlikely to directly compete with SHIP2 for binding to PM PPIs. Additionally, we provide evidence for Pfn1's interaction with SHIP2 in cells and modulation of this interaction upon EGF stimulation, raising an alternative possibility of Pfn1 binding as a potential restrictive mechanism for PM recruitment of SHIP2. In conclusion, our findings challenge the dogma of Pfn1's binding to PM by PPI interaction, uncover a previously unrecognized role of Pfn1 in PI(4,5)P2 homeostasis and provide a new mechanistic avenue of how an ABP could potentially impact PI3K signaling byproducts in cells through lipid phosphatase control.