Positive Correlation Research Articles

Economic value assessment of industrial heritage in Tangshan, China

Industrial heritage is a legacy from the past that we live with today and pass on to future generations. The economic value of this heritage can be defined as the amount of welfare that it generates for society, and this value should not be ignored. However, current research based on economic analysis has mostly focused on qualitative statements instead of quantitative assessment. This study proposes an innovative methodology combining qualitative (field research) and quantitative (willingness to pay and contingent valuation) methods to assess the economic value of industrial heritage. The industrial heritage of Tangshan, China, was chosen as a case study, and the research found that museums and cultural creative parks are effective ways to conserve industrial heritage. The entrance fee can be used to represent the economic value of the heritage site. There was a positive correlation between the influence of economic value and the entrance fees residents would prefer to pay. The results indicate the locals would prefer lower entrance fees for the transformed heritage museums (The average current cost: $2.23). Locals were most concerned about the entrance fees for the Kailuan Coal Mine and Qixin Cement Plant Museums, which have both been renewed as urban landmarks for city tourism. Renewal methods have been applied to six industrial heritage sites in Tangshan; these sites have their own conservation and renewal practices based on city-level development or industrial attributes. Thus, when residents recognize the economic value of a heritage site, they are willing to pay a higher entrance fee. This research demonstrates the economic value of industrial heritage using a mixed methods approach and provides a basis for assessing the value of cultural heritage for urban tourism analysis.

Evaluation of genetic parameters of growth traits in G2 selected generation of Penaeus monodon

Fifteen whole sib families of the second-generation Penaeus monodon were constructed using artificial mating design in 2020. After labeling the families with fluorescent markers, the growth traits and genetic parameters were evaluated in a cement pond for 56 days. The results showed that the coefficient of variation of growth traits was 11.52-47.53%, indicating a high genetic variation. The heritability range of growth traits of the G2 population of P. monodon was 0.25±0.03-0.41±0.13, which belonged to medium and high heritability, and the statistical test results were significant (P<0.01). The heritability of body length and body weight were 0.38±0.11 and 0.41±0.13, respectively. The evaluation results of genetic correlation among growth traits were highly positive, and the statistical test results were significant (P<0.01). The genetic correlation between body weight and body length was the highest (0.99), and the genetic correlation between the width of the first carapace and the height of the first abdominal segment was the lowest (0.71). The phenotypic correlation between body weight and body length was the highest (0.93), and the lowest was head breastplate width and first abdominal segment height (0.53). These results showed that the G2 generation population of P. monodon has high genetic improvement potential, and the combination of family selection and individual selection achieved better genetic gain. The growth traits were highly positively correlated. Body length and body weight could be selected as the key traits for fast growth line selection, while the other growth traits could be indirectly selected through positive genetic correlation.

Evaluation of Inflammation Markers in Elderly Patients Undergoing Hip Fracture Surgery

Objectives: High inflammatory markers are thought to be important in evaluating poor postoperative outcomes in older orthopedic patients. We aim to investigate the effect of inflammatory markers in patients over 80 who have undergone a hip fracture surgery regarding 30-day mortality and preoperative evaluation.
 Materials and Methods: Patients over 80 who had undergone hip fracture surgery were included. Age, gender, type of anesthesia, comorbidities, anticoagulant, intensive care unit (ICU) admission, hospitalization period, 30-day mortality rates, were recorded and platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR) and systemic immune inflammation index (SII) values were calculated.
 Results: The mean age was 85.48±4.07 years old. Postoperative ICU admission was found to be 41.1%, and the 30-day mortality rate was 3.3%. The PLR value was 191±105, the NLR value was 6.4±4.5, and the SII value was 1410±1210. A significant correlation was found between ICU hospitalization and mortality, preoperative and postoperative hospital stay.
 Conclusion: While there was a positive correlation between intensive care hospitalization and mortality, although no statistically significant correlation was found between the PLR, NLR and SII values and mortality rates, high values close to those stated in the literature were found.

A clinical study on cognitive dysfunction in depressed patients

ABSTRACT Background: Major depression is a commonly occuring, seriously impairing, and often recurrent mental disorder. Depression and cognitive impairement have enormous implications for public health. Cognitive symptoms represent one of the core features of depression and have an impact on many functional outcomes. Different cognitive domains such as attention and concentration, psychomotor speed, executive functioning, and memory have been found to be implicated. Aim: This study aimed at assessing the cognitive domains affected and severity of cognitive dysfunction in first-episode patients of the unipolar depressive episode without psychosis and to assess the correlation of association of severity of cognitive deficit with severity of depression. Materials and Methods: A total of 40 patients with depression diagnosed according to International Classification of Diseases Research Diagnostic Criteria and 40 healthy controls were included. PGI Battery of Brain Dysfunction, Frontal Assessement Battery, and Hamilton Depression Rating scale (HAM–D) were adminstered, and analysis was done using Chi-square test, unpaired t-test, and Pearson’s correlation. Results: The study revealed significant differences in the dysfunction scores between the study and control populations. In the study group, more than 80% of patients had cognitive dysfunction and a positive correlation was found between dysfunction and HAM–D scores. Conclusion: Depression is associated with significant disturbance in cognitive functioning, and the cognitive dysfunction increases with an increase in the severity of depression.

The effect of frailty levels of older individuals on their mental well-being and depression levels.

Frailty has become an important public health issue. This study was conducted to determine the effect of frailty levels of older individuals on their mental well-being and depression levels. This descriptive cross-sectional study was conducted with a total of 325 older individuals aged 60 years and over. A demographic questionnaire form, the FRAIL Frailty Scale, the Warwick-Edinburgh Mental Well-Being Scale, and the Geriatric Depression Scale-Short Form were used to collect data. Data were evaluated using the SPSS 25.0 package program. Number, percentage, mean, standard deviation, Chi-square, correlation, and multiple regression analyses were used. The mean age of the older individuals was 69.56 ± 7.75 years, and the variables of age, education level, income status, the person they were living with, regular medication use, forgetting to take medication, urinary incontinence, hospitalisation, and accidents were found to affect both frailty and depression (P < 0.05). There was a positive correlation between frailty and depression (r: 0.460, P < 0.001) and a negative correlation between mental frailty and well-being (r: -0.391, P < 0.001). Socio-demographic variables, depression, and mental well-being had a 40% effect on frailty (P < 0.001). Depression status and mental well-being level are related to frailty, so negativity in one of them negatively affects the other. In line with these results, it is recommended to determine the level of depression and mental well-being of older individuals with high risk of frailty, and according to the results of the research, to provide care and support regarding the predictors affecting frailty.

Third-trimester fetal pancreas imaging in uncomplicated pregnancies and association with pregnancy outcomes.

To examine third-trimester sonographic imaging of the fetal pancreas in uncomplicated pregnancies and its association with pregnancy outcomes. This was a prospective cohort study including 274 pregnant women. Uncomplicated pregnancies in the third trimester (28-40 weeks) were included in the study. Maternal chronic disease, pregnancy-related disorders such as hypertension, diabetes, cholestasis, smoking, and fetal abnormalities were determined as exclusion criteria. Sonographic fetal pancreatic measurement and echogenicity were evaluated in all participants. For intra-observer reliability, each participant's fetal pancreatic circumference was measured two times. The echogenicity of the pancreas was compared with the liver and ribs and classified as grade 1, 2, and 3. The pregnancy outcomes of all participants were obtained from the hospital digital registration system. The average fetal pancreatic circumference in the third trimester was 70.7 ± 0.6 mm (median, 70 [44-100.7]), with high intra-observer agreement (ICC 0.996 [0.995; 0.997]). A significant positive correlation was found between pancreatic circumference, body mass index (BMI), gestational age, and birth weight. Pancreatic measurements were significantly higher in composite adverse outcomes cases that included at least one of respiratory distress syndrome, hyperbilirubinemia, neonatal pneumonia, infection, and sepsis (p < 0.001). No relationship was found between pancreatic echogenicity and perinatal outcomes. Fetal pancreas size was positively correlated with gestational age, BMI, and birth weight, and increased fetal pancreas size was associated with composite adverse neonatal outcomes.

Contamination levels, influencing factors, and risk assessment of polybrominated diphenyl ethers in house dust of northern Serbia.

Polybrominated diphenyl ethers (PBDEs) are a group of compounds that, due to their applications, are considered mainly indoor contaminants. To obtain the first information about the presence of PBDEs in Serbia, dust samples (n = 50) were collected in settlements in the northern Serbian province of Vojvodina. The selected/target congeners (BDE-28, 47, 99, 100, 153, 154, and 183) were extracted from house dust by microwave-assisted extraction technique, and purified extracts were analyzed on a dual-column gas chromatograph with micro-electron capture detectors. A wide range of ΣPBDEs was detected (0.295 to 394 ng g-1 dust), which reflects large differences in contamination among the examined homes. For the majority of samples (72%), ΣPBDEs were lower than 5 ng g-1 indicating that people living in Vojvodina province are exposed to low concentrations of PBDEs present in their households. Based on principal component analysis (PCA), balcony areas and age of the house positively correlate with the PBDE congeners with higher detection frequencies (≥ 50%), namely, with BDE-99, BDE-153, and BDE-183. Statistically significant positive correlation (p < 0.01) was obtained for BDE-99 and the number of household's members. Estimated daily intakes (EDItot) were calculated for ingestion and dermal absorption of dust for two age groups-adults and toddlers. These arethe first data on PBDE status in the area of the Western Balkan, and the health risk assessment indicates that PBDE levels obtained in household dust do not pose a risk for human health.

Imbalance of Tfollicular helper cell subsets trigger the differentiation of pathogenic B cells in idiopathic membranous nephropathy.

This study aims to elucidate the role of T follicular helper (Tfh) cells and their subsets in idiopathic membranous nephropathy (IMN). The frequencies of Tfh cell subsets and B cell subsets in peripheral blood (PB) were detected in both IMN patients and healthy controls (HCs). The involvement of Tfh cells in the disease pathogenesis was examined by coculturing human Tfh cells with B cells. The dynamic changes of Tfh cells in PB or spleen were monitored in passive Heymann nephritis (PHN) rats. The frequencies of circulating Tfh (cTfh) cells, cTfh2 cells, and plasmablasts were enriched in the PB of patients with IMN. cTfh cells expressed higher ICOS, and lower BTLA than healthy counterparts. The frequency of ICOS + cTfh2 was associated with the severity of IMN, including 24h urine protein, IgG4 concentration and the IgG4: IgG ratio. Positive correlations were also observed between the frequency of cTfh2 cells with plasmablasts, serum IL-21 and IL-4 levels. Importantly, cTfh cells isolated from IMN patients were able to induce the differentiation of B cells to memory B cells (MBC) and plasmablasts, this process could be substantially attenuated by blocking the IL-21. Similar increases of ICOS + cTfh cells were also detected in spleen of PHN rats, concomitant with elevated urine protein levels. Collectively, our results demonstrate that the imbalance of cTfh cell subsets play a crucial pathogenic role in IMN by inducing the differentiation of B cells through IL-21, and cTfh2 cells might serve as useful markers to evaluate the progression of IMN.

Reading Literacy and Academic Performance of Grade 11 Learners Towards the Development of a Study Guide

The study investigated the reading literacy and academic performance of Grade 11 learners towards the development of a study guide. The study aimed to 1) determine the demographic profile of the respondents in terms of their age, sex, and learning strand; 2) analyze a significant difference between the reading literacy of learners when grouped according to their demographic characteristics; 3) evaluate the level of reading literacy of Grade 11 learners in terms of locating information, understanding and evaluating and reflecting, 4) know the academic performance of Grade 11 learners for Academic Year 2022-2023; 5) analyze the significant relationship between the reading literacy and academic performance of learners; 6) determine the significant relationships among the skills in reading literacy of learners; And; What study guide can be proposed to enhance the reading literacy of Grade 11 learners? A correlational research design was used as the research design of the study. Three hundred fifty-one learners from five senior high schools in SDO Bacoor City were used as the respondents. Demographic profiles, reading literacy, and academic performance of learners were obtained through a survey. Results showed that the ability of learners to locate information was found to be very satisfactory. Meanwhile, learners’ understanding, and evaluating and reflecting were found to be fairly satisfactory. It was found that there were significant differences among the reading literacy of Grade 11 learners from various learning strands. A positive correlation between text processing skills and academic performance was also found. Furthermore, significant relationships among these skills were determined. The study recommends ensuring an effective utilization of the study guide created by the researcher to address the needs of the learners on their reading literacy enhancement. Keywords: Reading Literacy, Academic Performance, Study Guide, Grade 11

Awareness and Practice on Road Safety among Adults in Selected Area of Jalandhar Cantt, Punjab

It has been estimated that one million death and 15 million road side accident occur on the road worldwide. Globally road side accidents are the 7th leading cause of death in all age groups. In India we have 1% of the world vehicle population, but 6% of the world accidents 1. The aim of the study is to assess the awareness and practice on road safety among adults in in selected area of Jalandhar Cantt, Punjab. A total of 108 samples were selected for the study and samples were the adults with in the age group of 18-60 years. The major findings of the study were as follows: The study analysis showed that majority (69%) of the samples were males and 60% belonged to the group of 18-30 years of age. 15% of samples were drivers by profession, 63.8% had a valid driving license. Majority of samples, (83.2%) had good awareness on road safety and 94% of samples had good practice on pedestrian road safety. The study showed that there was a low positive and significant correlation between awareness and practice among pedestrians (n=400) as the p value is .001 and spearman’s rho value is 0.269. And there was a low and significant correlation between awareness and practice of drivers the p value is .001 and spearman’s rho value for 0.322.

Academic Motivation and Career Decidedness of STEM and HASS Students during Higher Education

The present paper justifies the design of the research, which centers on examining the intricate relationship between students' academic motivation and career decidedness within the context of Portuguese higher education. The study is underpinned by an extensive review of literature from the last seven years, delving into students' career motivation, and unveils a promising path for investigation. Grounded in the conceptual framework of Self-Determination Theory, as proposed by Deci and Ryan in 1985, intrinsic motivation, often synonymous with autonomy, is considered the keystone of individual self-regulation and behavioral performance, and exhibits positive correlations with academic motivation and career decidedness. Therefore, a thorough analysis of the interplay between the various types of academic motivation and career decidedness among higher education students becomes imperative. This exploration encompasses multiple factors, including gender, age, field of study (STEM, humanitarian, arts, and social sciences), and educational level. To conduct this investigation, a quantitative methodology is employed, utilizing questionnaires to assess participants' academic motivation types and levels of career decidedness. The research results bear significant potential for practical implications aimed at enhancing academic practices within higher education institutions, ultimately contributing to a positive impact on students' career decidedness and related outcomes.

Atmospheric Air Pollution in Niamey, Niger: Assessment of Particulate Matter From Road Traffic (PM2.5 and PM10)

The aim of this study was to characterise the air based on atmospheric particles in the city of Niamey. To do this, a mass concentration detector type PCE-RCM 11 and station type Davis Pro were used as collection equipment. Particulate matter with diameters of less than 2.5 μm and 10 μm, PM2.5 and PM10, respectively, as well as meteorological parameters, temperature and humidity were determined. The study was carried out over 15 days in 5 districts of Niamey between 7.30 am and 10.10 pm at the main roundabouts in each district. According to the results obtained, the average concentrations of PM2.5 in the air measured ranged from 75.34 μg/m3 to 162.34 μg/m3, whereas the WHO recommends 15 μg/m3 for PM2.5 for daily exposure, which would cause cardiovascular or pulmonary disease in those exposed. The PM10 values recorded ranged from 100.43 μg/m3 to 221.90 μg/m3, well in excess of the WHO standards published in 2021, which recommend 45 μg/m3 for PM10, indicating a probable risk of throat and respiratory disorders. Average temperature values ranged from 23.051 °C ± 0.1 °C to 34.186 °C ± 0.1 °C. The average relative humidity measured ranged from 17.164% ± 1% to 26.910% ± 1%. The results of the correlation analysis showed a strong correlation between PM2.5 and PM10. The latter has a strong positive correlation with temperature. PM2.5 is strongly negatively correlated with relative humidity, while PM10 is moderately negatively correlated with relative humidity. Temperature and humidity show a weak negative correlation with each other. Each of the particles studied is present in the communes of Niamey at the 5 roundabouts representing the study area. It should be confirmed that these particles emitted into the air could have come from urban transport. The correlation circle obtained from the PCA explains the relationship between the variables measured (PM and meteorological parameters). The first two dimensions explain 97.55% of the total information, with 81.62% for dimension 1% and 15.93% for dimension 2.

Seasonal Incidence and Infestation Pattern of Sunflower Head Borer (Helicoverpa armigera) and Leaf Eating Caterpillar (Spodoptera litura) under the Influence of Climatic Factors

Field experiments were conducted at Regional Research and Technology Transfer Station (RRTTS), Ranital, Bhadrak, OUAT during the summer seasons of 2019-20 and 2020-21 to study the seasonal incidence of sunflower head borer and leaf-eating caterpillar in sunflower in relation to the abiotic factor. The seasonal incidence of the target insects, Spodoptera litura and Helicoverpa armigera, was investigated using pheromone traps installed in the unprotected sunflower plots (10 m x 5 m) at the research block. The trap catches of male adults were expressed as a number of males trapped per trap per week. In the observation plots, the sunflower hybrid Aruna was cultivated with the approved agronomic package of techniques without any plant protection measures. Weekwise larval populations of Spodoptera litura and Helicoverpa armigera were counted from 10 randomly selected tagged plants starting from the initiation of damage and expressed as larval intensity i.e. average larval population per plant. Besides, weekwise incidence of the pest (leaf damage by tobacco caterpillar and head damage by head borer) were also recorded. The findings of the investigation indicated that tobacco caterpillars' adult activity commenced from the 5th to 6th standard weeks (1st and 2nd week of February) and peak activity in the 11th standard week (3rd week of March). Similarly, the larval population began to appear in the 6th to 7th standard weeks in 2020 and 2021, respectively with a peak population build-up stage during the 12th standard week and their activity steadily decreased as the cropping season progressed. The peak infestation stage coincided with the period of maximum larval activity and the pest caused sizable damage from the early vegetative stage to the peak flowering stage of the crop. The sunflower head borer (Helicoverpa armigera) infested sunflower crops throughout the reproductive stage of the plant with adult activity beginning in the 9th to 10th standard weeks (last week of February-first week of March) and attaining the peak in the 12th to 13th standard weeks (3rd-4th week of March). Similarly, the larval population began to appear in the 10th to 11th standard week and reached the peak in the 13th to 14th standard week (last week of March to first week of April). Various environmental parameters viz. temperature, relative humidity and rainfall were collected from the automated weather station of Gramin Krishi Mausam Sewa (GKMS) located at RRTTS, Ranital., These abiotic factors were correlated with trap catch, larval intensity, leaf damage head damage to study the influence of ecological parameters on pest incidence and infestation. The findings of the investigation indicated that among the abiotic factors temperature had a positive influence and relative humidity exhibited a negative effect on the population and damage of Spodoptera litura. All the temperature variables and bright sunshine hour (BSH) exhibited a significant positive correlation and relative humidity (afternoon) had a significant negative correlation with the head damage Helicoverpa armigera.

Spatial-temporal evolution and driving factors of rural resilience in the urban agglomerations in the middle reaches of the Yangtze River, China.

How to maintain the balanced stability and resilient development of rural systems is an important issue that needs urgent attention in the field of sustainable rural development at present. In this paper, the entropy method, spatial autocorrelation model, and Geodetector were used to explore the rural resilience level, spatial distribution characteristics, and driving factors of 31 cities in the urban agglomerations in the middle reaches of the Yangtze River (UAMRYR), and to put forward corresponding policy suggestions. The results are as follows: (1) From 2005 to 2020, rural resilience in the UAMRYR showed an upward trend with an average annual growth rate of 8.26%. The ranking of the three major urban agglomerations is Changsha-Zhuzhou-Xiangtan urban agglomerations > Wuhan urban agglomerations > Poyang Lake urban agglomerations. (2) During the study period, the spatial distribution of rural resilience gradually developed from a negative correlation to a strong positive correlation and generally showed the characteristics of high in the west and low in the east. (3) The urbanization rate, the size and structure of the economy, the difference in consumption and income between urban and rural areas, the local fiscal revenue, and the number of village committees are the key factors affecting the level of rural resilience. On this basis, we proposed policy recommendations to improve the economic, social, and ecological resilience of rural areas in the UAMRYR. The findings of this paper are expected to provide insights into the policy formulation of China's rural revitalization strategy.

Towards a better understanding of anticipatory postural adjustments in people with Parkinson's disease.

Previous studies have shown that anticipatory postural adjustments (APAs) are altered in people with Parkinson's disease but its meaning for locomotion is less understood. This study aims to investigate the association between APAs and gait initiation, gait and freezing of gait and how a dynamic postural control challenging training may induce changes in these features. Gait initiation was quantified using wearable sensors and subsequent straight walking was assessed via marker-based motion capture. Additionally, turning and FOG-related outcomes were measured with wearable sensors. Assessments were conducted one week before (Pre), one week after (Post) and 4 weeks after (Follow-up) completion of a training intervention (split-belt treadmill training or regular treadmill training), under single task and dual task (DT) conditions. Statistical analysis included a linear mixed model for training effects and correlation analysis between APAs and the other outcomes for Pre and Post-Pre delta. 52 participants with Parkinson's disease (22 freezers) were assessed. We found that APA size in the medio-lateral direction during DT was positively associated with gait speed (p<0.001) and stride length (p<0.001) under DT conditions at Pre. The training effect was largest for first step range of motion and was similar for both training modes. For the associations between changes after the training (pooled sample) medio-lateral APA size showed a significant positive correlation with first step range of motion (p = 0.033) only in the DT condition and for the non-freezers only. The findings of this work revealed new insights into how APAs were not associated with first step characteristics and freezing and only baseline APAs during DT were related with DT gait characteristics. Training-induced changes in the size of APAs were related to training benefits in the first step ROM only in non-freezers. Based on the presented results increasing APA size through interventions might not be the ideal target for overall improvement of locomotion.

Improving wear and corrosion resistance of U71Mn rail steel subjected to laser in-situ fabrication of Fe based Cr–V coatings

With purpose of improving wear and corrosion resistance of U71Mn railroad switch, Fe based Cr–V coating was designed and in-situ fabricated on the surface of U71Mn rail steel using laser alloying technology. The phase constituents, effect of V content on the grain size, the microstructure, wear and corrosion resistance were investigated. Grain size refinement effect was observed due to more content of V content in the raw powder. The microhardness and wear resistance of the obtained Fe based Cr–V coatings presented a positive correlation with the content of V addition. The coating with more content of V addition presented a nobler Ecorr and a lower passivation current density icorr, indicating a more excellent corrosion resistance performance.

Prognostic significance and immunological role of HPRT1 in human cancers.

Hypoxanthine phosphoribosyl transferase 1 (HPRT1), once considered a housekeeping gene, has been identified as playing an important role in several tumors. Its role in pan-cancer, however, has not been systematically studied. This study evaluates the relationship between HPRT1 and clinical parameters, survival prognosis, and tumor immunity based on multi omics data from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Drug sensitivity analysis screened 16 effective drugs against HPRT1, exploring the interactions with chemicals and genes. The significance of HPRT1 in tumor immunotherapy has also been investigated. Immunohistochemistry confirmed significant differences in the expression of HPRT1 between five tumor types (colon adenocarcinoma [COAD], head-neck squamous cell carcinoma [HNSC], lung adenocarcinoma [LUAD], thyroid carcinoma [THCA], and uterine corpus endometrial carcinoma [UCEC]) and adjacent normal tissues (P < 0.05). HPRT1 competitive endogenous RNA network was constructed in HNSC. Through cytological experiments, it was verified that HPRT1 plays a carcinogenic role in HNSC and is associated with tumor cell proliferation, migration, invasion, and apoptosis. In addition, there was a significant positive correlation between HPRT1 and programmed cell death-1 (PD-1) expression in HNSC (P < 0.05). These findings suggest that HPRT1 may be a potential biomarker for predicting and treating cancer.

Cytomolecular diversity among Vigna Savi (Leguminosae) subgenera.

The genus Vigna (Leguminosae) comprises about 150 species grouped into five subgenera. The present study aimed to improve the understanding of karyotype diversity and evolution in Vigna, using new and previously published data through different cytogenetic and DNA content approaches. In the Vigna subgenera, we observed a random distribution of rDNA patterns. The 35S rDNA varied in position, from terminal to proximal, and in number, ranging from one (V. aconitifolia, V. subg. Ceratotropis) to seven pairs (V. unguiculata subsp. unguiculata, V. subg. Vigna). On the other hand, the number of 5S rDNA was conserved (one or two pairs), except for V. radiata (V. subg. Ceratotropis), which had three pairs. Genome size was relatively conserved within the genus, ranging from 1C = 0.43 to 0.70pg in V. oblongifolia and V. unguiculata subsp. unguiculata, respectively, both belonging to V. subg. Vigna. However, we observed a positive correlation between DNA content and the number of 35S rDNA sites. In addition, data from chromosome-specific BAC-FISH suggest that the ancestral 35S rDNA locus is conserved on chromosome 6 within Vigna. Considering the rapid diversification in the number and position of rDNA sites, such conservation is surprising and suggests that additional sites may have spread out from this ancestral locus.

Kynurenines Dynamics in the Periphery and Central Nervous System Steers Behavioral Deficits in Rats under Hypobaric Hypoxia.

People travel to high-altitude regions as tourists, workers, and military personnel on duty. Despite the consistent 21% oxygen content in the atmosphere, ascending to higher altitudes results in a decrease in the partial pressure of oxygen, inducing a state known as hypobaric hypoxia (HH). HH is an environmental stress that is responsible for neuroinflammation and behavioral deficits (anxiety, depression, mood disturbance, etc.), but little is known about its metabolic pathways. The kynurenine pathway (KP) is a promising candidate to uncover the mysteries of HH stress, as it is an important regulator of the immune system and is associated with behavioral deficits. To investigate the role of KP under HH, the levels of KP metabolites in the serum, cerebrospinal fluid (CSF), and brain tissue (prefrontal cortex-PFC, neocortex, and hippocampus) of male Sprague-Dawley rats exposed to HH at 7620 m for 1, 3, and 7 days were estimated utilizing high-performance liquid chromatography (HPLC). The behavioral analogs for anxiety-like and depression-like behavior were assessed using the open field test and forced swim test, respectively. Upon HH exposure, crosstalk between the periphery and central nervous system and KP metabolite region-dependent differential expression in the brain were observed. KP metabolites showed a positive correlation with behavioral parameters. The results of our study are indicative that KP can be proposed as the etiology of behavioral deficits, and KP metabolite levels in serum or CSF can be used as plausible markers for anxiety-like and depression-like behaviors under HH stress with a scope of targeted therapeutic interventions.

Correlation between maternal and infant vitamin B12 levels in severe malnutrition in infants under 6months.

Malnutrition poses a significant global health challenge, affecting various age groups, with infants under 6months being particularly vulnerable. Vitamin B12, an essential micronutrient critical for neurological development, has been identified as a key player in the overall health of both mothers and infants. To find the correlation between serum vitamin B12 levels in infants, 1-6months of age with severe malnutrition and maternal levels at tertiary care hospitals in western Rajasthan. The cross-sectional study was conducted in the UNICEF Regional Center of Excellence-supported Nutrition Rehabilitation Center in Rajasthan, India, through simple random sampling. One hundred ten infants with their mothers were enrolled after consent and approval from the Institutional Ethics Committee. Severe malnutrition predominantly affected infants aged 1-2months, with 77% born small for gestational age and 66.4% belonging to the multiple birth order group. Serum vitamin B12 levels showed a significant positive correlation between mothers and infants (p < 0.001), while exclusive breastfeeding correlated positively with age-appropriate milestones (p = 0.033). The findings emphasize the importance of targeted interventions addressing maternal and infant nutrition, with a focus on ensuring adequate vitamin B12 levels.