Portion Of Body Research Articles

Antifungal Drug Resistance in Candida albicans: Identifying Novel Targets for the Development of Effective Antifungal Agents.

Candidiasis, a fungal infection initiated primarily through Candida albicans, affects various portions of the human body and is particularly prevalent in immunocompromised individuals. The pathogenicity of C. albicans is facilitated by numerous virulence causes, including adhesins, morphogenesis, and phenotypic switching. The organism’s capability in the direction of switching between yeast and hyphal forms contributes to the severity of infections. The appearance of resistant strains has rendered current treatments less effective, necessitating the exploration of new drug targets and the progress of novel antifungal agents. Antifungal drug resistance is a multifaceted phenomenon involving genetic mutations, overexpression of efflux pumps, epigenetic changes, and biofilm formation, all regulated by complex genetic and transcriptional networks. These resistance mechanisms can cause treatment failures, highlighting the need for new antifungal agents and improved diagnostic tools. The identification of potential drug targets in C. albicans is critical due to increasing resistance to existing antifungal agents. Recent studies have identified promising targets, for example the riboflavin metabolic pathway and unique protein kinases involved in regulating virulence and pathogenicity. Developing new antifungals is difficult due to C. albicans’ eukaryotic nature and resistance. Ongoing research is essential to find novel targets and strategies, especially with the limited antifungal drug classes available.

Biphasic burrowing in Atlantic hagfish (Myxine limosa).

Myxine limosa is a burrowing species of hagfish that occurs in the western north Atlantic in areas with muddy substrate and at depths generally greater than 100 meters. Burrowing of M. limosa has been observed from submersibles, but little is known about the behavior of these animals within the substrate or the biomechanical mechanisms involved. Here we investigated burrowing in M. limosa by observing individuals as they burrowed through transparent gelatin. A photoelastic setup using crossed polarizers allowed us to visualize stress development in the gelatin as the hagfish moved through it. We found that M. limosa created U-shaped burrows in gelatin using a stereotyped, two-phase burrowing behavior. In the first ("Thrash") phase, hagfish drove their head and their anterior body into the substrate using vigorous sinusoidal swimming movements, with their head moving side-to-side. In the second ("Wriggle") phase, swimming movements ceased, with propulsion coming exclusively from the anterior, submerged portion of body. The Wriggle phase involved side-to-side head movements and movements of the submerged part of the body that resembled the "internal concertina" strategy used by caecilians and uropeltid snakes. The entire burrowing process took on average 7.6 minutes to complete and ended with the hagfish's head protruding from the substrate and the rest of its body generally concealed. Understanding the burrowing activities of hagfishes could lead to improved understanding of sediment turnover in marine benthic habitats, new insights into the reproductive behavior of hagfishes, or even inspiration for the design of burrowing robots.

The Lived Experiences of Asian International Students in the U.S. Higher Education

Asian international students have long constituted the largest portion of the international student body in the United States (U.S.), a trend that persists despite the hurdles presented by the COVID-19 pandemic. These students play an essential role in stimulating the U.S. economy, facilitating cross-cultural exchange, and nurturing international collaboration and understanding. During the 2022-2023 academic year, Asian international students comprised 70.3% of the total international student population in the U.S. higher education. The number of Asian international students in the U.S. higher education institutions is so considerable that their lived experiences within the U.S. higher education system deserves a thorough examination. Existing empirical research demonstrates that plenty of Asian international students are underserved, mainly facing culture shock, linguistic barriers, racial discrimination, and mental health issues. This systematic literature review aims to: 1. Investigate whether Asian international students face any challenges in the U.S. higher education; 2. Classify the challenges (if any) encountered by Asian international students in the U.S. higher education; 3. Offer valuable insights to key stakeholders in international education, empowering them to refine current administrative policies and teaching pedagogies to best support the well-being and success of Asian international students in the U.S. higher education.

In/visible hurdles: US collegiate esports participants’ perceived barriers to play and involvement

Gaming and esports communities possess cultural barriers that exclude potential participants, limiting their access to social, cultural, and economic opportunities. In the United States, for instance, varsity esports players are increasingly supported by scholarships and tournament prizes, but persistent challenges make these benefits accessible to only a limited portion of the student body. Using a grounded theory analysis of 31 in-depth interviews with collegiate esports players, administrators, and student workers, this study examines perceived barriers and their (in)visibility to different participants. We find that gender and race are readily acknowledged, while other identities (age, physical ability, etc.) are overlooked. Moreover, visibility did not necessarily correlate with meaningful strategies for inclusion. While collegiate esports could be a welcoming and equitable environment, these findings suggest it will not be so until all hurdles are (1) made visible and (2) addressed relative to a university’s own student body composition.

Developing Fluency In Spoken English To B2

Oral fluency is a skill that requires constant practice in an ESL classroom in order to make meaningful development. In general, when we discuss fluency, we are referring to the ease with which pupils speak, their speech rate, their pauses, and the language they can easily create in between. In an ideal scenario, the greatest method to learn to speak English effectively is to be exposed to the language on a daily basis through frequent discussion with English speakers on a range of themes. Regretfully, hardly many English language learners get the chance to practice speaking in a situation that is genuinely immersive. It is astonishing how many foreign students, who have low English proficiency despite spending years in an English-speaking nation, come home. They frequently discover that a large portion of the student body speaks their language in their town. They might not be having as many opportunities as we might think to use English outside of the classroom as a result. This just serves to emphasize how crucial it is to give students frequent opportunity to speak in class. This article focuses on how educators may provide kids these kinds of chances in the classroom to help them become more confident and fluent. When it comes to supporting students in improving their oral fluency, there are a few factors to take into account. [1:36]

A Cognitive Linguistic Study on the Polysemous Chinese Word “头”

The prototype category serves as the foundation for polysemy which is extended via metonymy and metaphor. As cognitive linguistics advances, it has become apparent that metaphor and metonymy are not merely poetic embellishments for language. Rather, they constitute a mode of thought and a form of cognition, by which we gain comprehension of new concepts. Due to the fact that the head is the most significant portion of the human body, it is frequently used in linguistic expressions. This study adopts qualitative descriptive study through the framework of prototype theory, metaphor, metonymy, and iconicity to make an analysis of the polysemous Chinese character “头” (head), which contributes to our understanding of the intricate interplay between language, cognition, and cultural associations.

Recent developments in wearable piezoelectric energy harvesters.

Wearable piezoelectric energy harvesters (WPEHs) have gained popularity and made significant development in recent decades. The harvester is logically built by the movement patterns of various portions of the human body to harvest the movement energy and immediately convert it into usable electrical energy. To directly power different microelectronic devices on the human body, a self-powered device that does not require an additional power supply is being created. This Review provides an in-depth review of WPEHs, explaining the fundamental concepts of piezoelectric technology and the materials employed in numerous widely used piezoelectric components. The harvesters are classed according to the movement characteristics of several portions of a person's body, such as pulses, joints, skin, and shoes (feet). Each technique is introduced, followed by extensive analysis. Some harvesters are compared, and the benefits and drawbacks of each technique are discussed. Finally, this Review presents future goals and objectives for WPEH improvement, and it will aid researchers in understanding WPEH to the point of more efficient wireless energy delivery to wearable electronic components.

SIZE AND ORGAN-SPECIFIC VARIATIONS IN PROXIMATE COMPOSITION OF FRIGATE TUNA (Auxis thazard)

Different species of tuna are well-known seafood items for their economic importance and nutritional profiles. Tuna is a cheap marine fish of Bangladesh but is not popular with consumers compared to other coastal and marine fishes. In this study, the proximate composition of tuna (Auxis thazard) was compared based on their size and body portions because size and body portions might have a significant impact on the nutritional value of the fish. Three different sizes, i.e., ≤500 g, ≤750 g, and ≥1 kg, and three different body portions, i.e., head, middle, and tail, were subjected to study for proximate analysis. Standard methods (Kjeldal and AOAC) were followed for the determination of biochemical parameters. Among different sizes of fish, the highest average percentage of protein (23.07±0.82), lipid (2.80±0.41), and ash (1.62±0.12) were calculated in the ≥1 kg size group, and among different body portions, the highest average percentage of protein (23.03±0.91), ash (1.62±0.09), and lipid (2.85±0.39) were calculated in the muscle from the middle portion of the fish. The highest average percentage of moisture (73.91±0.95) was found in the tail portion of the small-sized group. This study revealed that the comparatively larger fish and the middle portion of the body are nutritionally rich compared to the other sizes and body parts. Therefore, it is of utmost importance to raise awareness among consumers to ensure adequate nutrition at a cheap price.

Transoral endoscopic vestibular approach Sistrunk procedure (TEVAS)-case report and scoping review.

Thyroglossal duct cyst (TGDC) is the most common congenital neck mass among the pediatric population. Less than 10% of the cases occur in adults. The standard of care for TGDC is surgical treatment with the Sistrunk procedure via a traditional transverse cervicotomy. This technique involves the resection of the cyst with its tract and the central portion of the hyoid bone body to avoid recurrence. The transoral vestibular approach has gained popularity as an alternative approach to open neck surgery in order to eliminate the transcervical scar associated with these procedures. We describe a case of an endoscopic Sistrunk procedure performed by the transoral vestibular approach. A scoping review of the transoral endoscopic vestibular approach Sistrunk procedure (TEVAS) was performed. The PubMed, Medline, Cochrane, Lilacs, Scielo, Mary Ann Libert and Scopus databases were systematically searched by using a Medical Subject Heading (MeSH)-optimized search strategy. The selection of papers followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines after setting inclusion and exclusion criteria. The case was successful and without complications. Five studies were included in the final analysis for this review. This novel approach to the Sistrunk procedure is an effective alternative way to treat TGDC in selected patients who are motivated to avoid a visible neck scar.

An equatorial mid-Atlantic Ocean archipelago as nursery area for the cookiecutter shark: Investigating foraging strategies of neonates through bite mark inferences.

This study delves into the foraging ecology of the cookiecutter shark (Isistius brasiliensis) in the Saint Peter and Saint Paul Archipelago (SPSPA), assessing bite marks on pelagic fishes collected between March and September 2018. Examination of 200 individuals from five species revealed the shark's predilection for targeting adult fish, ensuring efficient removal of energy-rich tissue layers. However, a notable exception is Thunnus albacares, preyed on predominantly during its juvenile stage, possibly due to vertical spatial segregation. Recent bites were pervasive across species, with wahoo displaying a distinctive pattern. Cookiecutter shark bites predominantly targeted the lateral body portion (>55%) except for yellowfin tuna, which exhibited a preference for the ventral region (95%). The estimated length distribution suggests the SPSPA as a potential nursery area for cookiecutter sharks. Bite mark positions and frequencies may be linked to fish behavior, swimming velocity, and fishing gear strategy, highlighting the complex interplay in pelagic ecosystems.

Electrical Structure of Southwestern Longmenshan Fault Zone: Insights into Seismogenic Structure of 2013 and 2022 Lushan Earthquakes

On 1 June 2022, a magnitude 6.1 earthquake struck the southern segment of the Longmenshan fault zone on the eastern edge of the Tibetan Plateau, once again causing casualties and economic losses. Understanding the deep-seated dynamic mechanisms that lead to seismic events in the Lushan earthquake area and assessing the potential hazards in seismic gap areas are of significant importance. In this study, we utilized 118 magnetotelluric datasets collected from the Lushan earthquake area and employed three-dimensional electromagnetic inversion with topographic considerations to characterize the deep-seated three-dimensional resistivity structure of the Lushan earthquake area. The results reveal that the Shuangshi–Dachuan fault in the Lushan earthquake area can be divided into two relatively low-resistivity zones: a western zone dipping southeastward and an eastern zone with a steeper slightly northwestern dip. These two zones intersect at a depth of approximately 20 km, forming an extensional pattern resembling a “Y” shape. The epicenters of both the 2013 and 2022 Lushan earthquakes are primarily located in the upper constricted portion of the pocket-like low-resistivity body at depth. The distribution of seismic aftershocks is confined within the region enclosed by the high-resistivity body, following the pattern of the Y-shaped low-resistivity zone.

Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit.

Achieving successful fusion during spine surgery is dependent on rigid pedicle screw fixation. To assess fixation strength, the insertional torque can be measured during intraoperative screw fixation. This study aimed to explore the technical feasibility of measuring the insertional torque of a pedicle screw, while investigating its relationship with bone density. Thoraco-lumbar screw fixation fusion surgery was performed on 53 patients (mean age, 65.5 ± 9.8 years). The insertional torque of 284 screws was measured at the point passing through the pedicle using a calibrated torque wrench, with a specially designed connector to the spine screw system. The Hounsfield units (HU) value was determined by assessing the trabecular portion of the index vertebral body on sagittal computed tomography images. We analyzed the relationship between the measured insertional torque and the following bone strength parameters: bone mineral density (BMD) and HU of the vertebral body. The mean insertion torque was 105.55 ± 58.08 N∙cm and T-score value (BMD) was -1.14 ± 1.49. Mean HU value was 136.37 ± 57.59. Screw insertion torque was positively correlated with BMD and HU in whole patients. However, in cases of osteopenia, all variables showed very weak correlations with insertional torque. In patients with osteoporosis, there was no statistically significant correlation between BMD and torque strength; HU showed a significant correlation. The insertional torque of screw fixation significantly correlated with bone density (BMD and HU). HU measurements showed greater clinical significance than did BMD values in patients with osteoporosis.

Triaxial tactile sensor utilizing standing laser-induced graphene cantilevers on polyimide film

Microelectromechanical systems (MEMS) multiaxial tactile sensors have been developed in various fields to leverage their small size, high accuracy, and high sensitivity. Although various measurement principles have been proposed, most tactile sensors are fabricated using conventional and complicated Si processes. Conversely, laser-induced graphene (LIG) has recently attracted significant attention as a material for fabricating physical sensors due to its high sensitivity as a piezoresistor through simple laser processing. Therefore, the application of LIG to MEMS processes is expected to yield unprecedented MEMS sensor devices. In this paper, we propose a triaxial tactile sensor using standing LIG cantilevers embedded in an elastic body. The proposed sensing element was fabricated using ultraviolet (UV) laser irradiation to shape a polyimide film into cantilever structures and CO2 laser irradiation to form LIG strain gauges. Subsequently, the flat LIG cantilevers were stood up using thermal deformation. These multiple three-dimensional LIG cantilever elements enable multiaxial force measurements. The cantilever and elastic body portion of the sensor had dimensions of 3 × 3 × 0.2 mm and 12.5 × 12.5 × 3 mm, respectively. The fabricated sensor response was evaluated, and its capability to independently measure triaxial forces was verified. Therefore, the proposed simple and reproducible fabrication process is useful for realizing compact multiaxial tactile sensors.

A Mummers Farce – Retractions of Medical Papers Conducted in Egyptian Institutions

Egypt currently holds the record for the most retractions in the continent of Africa according to the Retraction Watch database, and the 2nd highest of countries in the Middle East. The purpose of this study was to analyse the retracted medical publications from Egyptian affiliations, in order to delineate specific problems and solutions. We examined databases including Pubmed, Google Scholar and others, for all retracted medical publications that were conducted in an Egyptian institution, up to the date of August 31st 2022. We observed for the reason(s) for retraction, number of citations of the retracted work, the length of time between publication and retraction, and where the work was published (journal, publisher and impact factor). 68 retractions were identified. Most retractions were from the speciality of Obstetrics and Gynecology (n = 22), followed by Anesthesia (n = 7). The top 3 reasons for retraction were unreliable results, FFP level misconduct, and duplicate publication. The number of retractions significantly increased over the years, especially in 2022. When taking into account the number of medical publications per institution, the institute with the highest rate of retractions was Mansoura University, while the lowest rate was Cairo University. The number of retracted medical Egyptian publications continues to increase over time, although they represent a small portion of the overall body of Egyptian medical research. Future studies on retracted articles should employ a methodology that considers the institutions where the studies were conducted. This could allow a better understanding of specific problems in certain countries or regions.

A modified 23-G trocar and cannula system with lateral micropores for drainage of vitreous humor.

When primary angle-closure glaucoma occurs during an acute attack, routine phacoemulsification is challenging because of the high intra-ocular pressure (IOP) and shallow anterior chamber (AC). To reduce IOP and deepen the AC before phacoemulsification, a portion of the vitreous body is often removed. In this report, we introduce an extended trocar/cannula system with lateral micropores to drain the liquid vitreous before routine phacoemulsification to solve this problem. A modified trocar was used to drain the liquefied vitreous before routine phacoemulsification. We demonstrated that this novel trocar/cannula system is safe and effective for draining liquefied vitreous before routine phacoemulsification. It also facilitates the transition to smooth phacoemulsification.

Mechanical and Acoustic Emission Characteristics of Grouted Reinforcement in Fissure-Containing Rock-like Specimens

In order to study the reinforcing effect of the different grouting materials applied in fissure rock engineering, ultra-fine cement slurry, cement–silicate slurry, and MARITHAN® were used to carry out grouting tests on specimens of fissure-containing rocks. With the help of a uniaxial compression acoustic emission test system, the mechanical characteristics of the grouted specimens were obtained, and the damage process of the specimens was revealed by using the acoustic emission signals. The tested results showed the following: the residual strength of the grouted specimens using the three grouting materials increased by 16.931%, 13.075%, and 39.998%, respectively; the ultra-fine cement grouting and cement–silicate grouting specimens showed damage patterns of shear-slip damage along the original rupture surface; the specimens of MARITHAN® grouting cracked from a position near the end of the specimen with no damage to the grouted body portion; the cumulative acoustic emission energy curves of the grouted specimens showed obvious stage characteristics; and the acoustic emission energy distribution characteristics of the grouted specimens differed depending on the grouting materials.

Understanding Trauma in Nandini Sahu’s That Elusive Orgasm of An Incest Victim

Nandini Sahu’s narratorial oeuvre vociferously yet delicately contributes towards the study of the female psyche and the body from a nuanced feminine perspective. That Elusive Orgasm of an Incest Victim, for instance, charts the anatomy of the psychological trauma of the victim, Jhumpa. This paper attempts to course through the inexpressible, unintelligible, and indescribable vestibules of trauma responses evident and resident in the tangible and intangible portions of the female body. It explores the traditional and pluralistic models of trauma that seek to delve into the problematics of the linguistic representation of the experience of the traumatised consciousness. The paper asserts the potential of the voice of Sahu’s Jhumpa as a critical document in pluralistic critical trauma studies given its narrative from a cultural physio-psychoanalytical perspective.

MPM vs. CEL: Numerical modelling of penetration processes

MPM vs. CEL: Numerical modelling of penetration processes

Learning disentangled representations for controllable human motion prediction

Generative model-based motion prediction techniques have recently realized predicting controlled human motions, such as predicting multiple upper human body motions with similar lower-body motions. However, to achieve this, the state-of-the-art methods require either subsequently learning mapping functions to seek similar motions or training the model repetitively to enable control over the desired portion of body. In this paper, we propose a novel framework to learn disentangled representations for controllable human motion prediction. Our task is to predict multiple future human motions based on the past observed sequence, with the control of partial-body movements. Our network involves a conditional variational auto-encoder (CVAE) architecture to model full-body human motion, and an extra CVAE path to learn only the corresponding partial-body (e.g., lower-body) motion. Specifically, the inductive bias imposed by the extra CVAE path encourages two latent variables in two paths to respectively govern separate representations for each partial-body motion. With a single training, our model is able to provide two types of controls for the generated human motions: (i) strictly controlling one portion of human body and (ii) adaptively controlling the other portion, by sampling from a pair of latent spaces. Additionally, we extend and adapt a sampling strategy to our trained model to diversify the controllable predictions. Our framework also potentially allows new forms of control by flexibly customizing the input for the extra CVAE path. Extensive experimental results and ablation studies demonstrate that our approach is capable of predicting state-of-the-art controllable human motions both qualitatively and quantitatively.

Insecticidal Activity of Tannins from Selected Brown Macroalgae against the Cotton Leafhopper Amrasca devastans.

Seaweeds, also known as marine macroalgae, are renewable biological resources that are found worldwide and possess a wide variety of secondary metabolites, including tannins. Drifted brown seaweed (DBSW) is particularly rich in tannins and is regarded as biological trash. The cotton leaf hopper Amrasca devastans (Distant) has caused both quantitative and qualitative losses in cotton production. Drifted brown seaweeds (DBSWs) were used in this study to extract, qualitatively profile, and quantify the levels of total tannins, condensed tannins, hydrolyzable tannins, and phlorotannins in the seaweeds; test their insecticidal activity; and determine the mechanism of action. The largest amount of tannin extract was found in Sargassum wightii Greville (20.62%) using the Soxhlet method (SM). Significantly higher amounts of hydrolyzable tannins (p = 0.005), soluble phlorotannins (p = 0.005), total tannins in the SM (p = 0.003), and total tannins in the cold percolation method (p = 0.005) were recorded in S. wightii. However, high levels of condensed tannins (CTAs) were observed in Turbinaria ornata (Turner) J. Agardh (p = 0.004). A. devastans nymphs and adults were examined for oral toxicity (OT) and contact toxicity (CT) against DBSW tannin crude extract and column chromatographic fractions 1 (Rf = 0.86) and 2 (Rf = 0.88). Stoechospermum polypodioides (J.V. Lamouroux) J. Agardh crude tannin was highly effective against A. devastans using the OT method (LC50, 0.044%) when compared with the standard gallic acid (LC50, 0.044%) and tannic acid (LC50, 0.122%). Similarly, S. wightii fraction 2 (LC50, 0.007%) showed a greater insecticidal effect against A. devastans adults in OT than gallic acid (LC50, 0.034%) and tannic acid (LC50, 0.022%). The mechanism of action results show that A. devastans adults treated with crude tannin of T. ornata had significantly decreased amylase, protease (p = 0.005), and invertase (p = 0.003) levels when compared with the detoxification enzymes. The levels of glycosidase, lactate dehydrogenase, esterase, lipase, invertase, and acid phosphate activities (p = 0.005) of S. wightii were reduced when compared with those of the Vijayneem and chemical pesticide Monocrotophos. In adult insects treated with LC50 concentrations of S. wightii tannin fraction 1, the total body protein (9.00 µg/µL) was significantly reduced (OT, LC50-0.019%). The SDS-PAGE analysis results also show that S. wightii tannin fraction 1 (OT and CT), fraction 2 (OT), and S. polypodioides fraction 2 (CT) had a significant effect on the total body portion level, appearance, and disappearance of some proteins and polypeptides. This study shows that the selected brown macroalgae can be utilized for the safer management of cotton leaf hoppers.