This study investigates the phenomena of fluid flows, general heat transfer and entropy generation on transient natural convection in a square cavity occupied with a saturated non-Darcy porous medium with dissipation effects and thermal radiation. The governing equations for the fluid flows and heat transfer, with corresponding boundary and initial conditions in the porous system are solved with the use of the alternate direct implicit method (ADI). The impact of the dimensionless parameters on the flow and thermal effect including entropy generation, with the fluid structure interaction cases are discussed. The following ranges have been used for simulations for the relevant dimensionless parameters: Grashof Number (103≤Gr≤107), Rayleigh number (103≤Ra≤106), Eckert number (0≤Ec≤5×10-5), the Forschheimer resistance (0≤Γ,γ≤10), radiation parameter (0≤Rd≤5) and Prandtl number (0≤Pr≤10). The present numerical work, compared with previously published work are made, and excellent agreement is discovered. According to the simulation results, the top right wall and base of the heated wall are where entropy is being generated most. Furthermore, as the Forschheimer resistance increases the flow rate, the heat transfer, and entropy production reduce. As Pr decreases at Ra=105 the buoyancy force takes control of the flow fields when the porous medium’s resistance weakens. As a result, the fluid flow becomes stronger.