In thermodynamics, engineering, and environmental science, entropy generation are useful for comprehending complicated phenomena like heat transfer and fluid dynamics, analysing irreversibility, and optimising energy systems. Particulate-fluid flow with chemical reactions are employed in pharmaceutical manufacturing, catalytic converters, and combustion processes. This study provides insights into mass and thermal transmission analysis and influences of electroosmosis on flow of the Prandtl fluid in peristaltic micro-channel. The flow is also investigated considering the multiphase phenomenon influenced by chemical reaction. The flow problem modelling utilises lubrication theory with lengthy wavelengths and creeping flow assumptions. Furthermore, using Debye linearisation, the Poisson equation is simplified. The consequent structures for coupled ordinary differential equations have been handled by numerical solutions computed by using a highly efficient shooting technique with the help of NDSolve tool in Mathematica. It is concluded graphically that the profile of velocity declines with the increasing variation of porosity factor while enhances with the rise in Helmholtz-Smoluchowski velocity parameter. Thermal distribution increases with higher values of solid particle concentration and porous surface. It is evident that the concentration profile diminishes with the porosity coefficient but rises with the Helmholtz-Smoluchowski velocity factor.
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